Blocking Metabotropic Glutamate Receptor Subtype 7 (mGlu7) via the Venus Flytrap Domain (VFTD) Inhibits Amygdala Plasticity, Stress, and Anxiety-related Behavior von Gee, Christine E., Peterlik, Daniel, Neuhäuser, Christoph, Bouhelal, Rochdi, Kaupmann, Klemens, Laue, Grit, Uschold-Schmidt, Nicole, Feuerbach, Dominik, Zimmermann, Kaspar, Ofner, Silvio, Cryan, John F., van der Putten, Herman, Fendt, Markus, Vranesic, Ivo, Glatthar, Ralf, Flor, Peter J.

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CPCCOEt, a Noncompetitive Metabotropic Glutamate Receptor 1 Antagonist, Inhibits Receptor Signaling Without Affecting Glutamate Binding von Litschig, S, Gasparini, F, Rueegg, D, Stoehr, N, Flor, P J, Vranesic, I, Prézeau, L, Pin, J P, Thomsen, C, Kuhn, R

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The Non-competitive Antagonists 2-Methyl-6-(phenylethynyl)pyridine and 7-Hydroxyiminocyclopropan[b]chromen-1a-carboxylic Acid Ethyl Ester Interact with Overlapping Binding Pockets... von Pagano, Adriana, Rüegg, Doris, Litschig, Stephane, Stoehr, Natacha, Stierlin, Christine, Heinrich, Micheline, Floersheim, Philipp, Prezèau, Laurent, Carroll, Fiona, Pin, Jean-Philippe, Cambria, Antonio, Vranesic, Ivo, Flor, Peter Josef, Gasparini, Fabrizio, Kuhn, Rainer

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ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: Identification, in vitro pharmacology, pharmacokinetic and biodistribution studies von Hintermann, Samuel, Vranesic, Ivo, Allgeier, Hans, Brülisauer, Armin, Hoyer, Daniel, Lemaire, Michel, Moenius, Thomas, Urwyler, Stephan, Whitebread, Steven, Gasparini, Fabrizio, Auberson, Yves P.

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AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: Identification, SAR and pharmacological characterization von Vranesic, Ivo, Ofner, Silvio, Flor, Peter Josef, Bilbe, Graeme, Bouhelal, Rochdi, Enz, Albert, Desrayaud, Sandrine, McAllister, Kevin, Kuhn, Rainer, Gasparini, Fabrizio

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The acute antiparkinsonian and antidyskinetic effect of AFQ056, a novel metabotropic glutamate receptor type 5 antagonist, in l -Dopa-treated parkinsonian monkeys von Grégoire, Laurent, Morin, Nicolas, Ouattara, Bazoumana, Gasparini, Fabrizio, Bilbe, Graeme, Johns, Donald, Vranesic, Ivo, Sahasranaman, Srikumar, Gomez-Mancilla, Baltazar, Di Paolo, Thérèse

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Metabotropic glutamate receptor type 5 in levodopa-induced motor complications von Ouattara, Bazoumana, Grégoire, Laurent, Morissette, Marc, Gasparini, Fabrizio, Vranesic, Ivo, Bilbe, Graeme, Johns, Donald R, Rajput, Alex, Hornykiewicz, Oleh, Rajput, Ali H, Gomez-Mancilla, Baltazar, Di Paolo, Thérèse

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Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity von Spanka, Carsten, Glatthar, Ralf, Desrayaud, Sandrine, Fendt, Markus, Orain, David, Troxler, Thomas, Vranesic, Ivo

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Differential roles of mGlu(7) and mGlu(8) in amygdala-dependent behavior and physiology von Fendt, Markus, Imobersteg, Stefan, Peterlik, Daniel, Chaperon, Frédérique, Mattes, Catherine, Wittmann, Christina, Olpe, Hans-Rudolf, Mosbacher, Johannes, Vranesic, Ivo, van der Putten, Herman, McAllister, Kevin H, Flor, Peter J, Gee, Christine E

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Differential roles of mGlu7 and mGlu8 in amygdala-dependent behavior and physiology von Fendt, Markus, Imobersteg, Stefan, Peterlik, Daniel, Chaperon, Frédérique, Mattes, Catherine, Wittmann, Christina, Olpe, Hans-Rudolf, Mosbacher, Johannes, Vranesic, Ivo, van der Putten, Herman, McAllister, Kevin H., Flor, Peter J., Gee, Christine E.

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Discovery of 1H-pyrrolo[2,3-c]pyridine-7-carboxamides as novel, allosteric mGluR5 antagonists von Koller, Manuel, Carcache, David A., Orain, David, Ertl, Peter, Behnke, Dirk, Desrayaud, Sandrine, Laue, Grit, Vranesic, Ivo

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Discovery of 1H-pyrrolo[2,3-c]pyridine-7-carboxamides as novel, allosteric mGluRS antagonists von KOLLER, Manuel, CARCACHE, David A, ORAIN, David, ERTL, Peter, BEHNKE, Dirk, DESRAYAUD, Sandrine, LAUE, Grit, VRANESIC, Ivo

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Benzimidazoles as Potent and Orally Active mGlu5 Receptor Antagonists with an Improved PK Profile von Carcache, David, Vranesic, Ivo, Blanz, Joachim, Desrayaud, Sandrine, Fendt, Markus, Glatthar, Ralf

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2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist von Gasparini, Fabrizio, Lingenhöhl, Kurt, Stoehr, Natacha, Flor, Peter J, Heinrich, Micheline, Vranesic, Ivo, Biollaz, Michel, Allgeier, Hans, Heckendorn, Roland, Urwyler, Stephan, Varney, Mark A, Johnson, Edwin C, Hess, Stephen D, Rao, Sara P, Sacaan, Aida I, Santori, Emily M, Veliçelebi, Gönul, Kuhn, Rainer

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[ 3H]-M-MPEP, a Potent, Subtype-Selective Radioligand for the Metabotropic Glutamate Receptor Subtype 5 von Gasparini, Fabrizio, Andres, Hendrik, Flor, Peter Josef, Heinrich, Micheline, Inderbitzin, Werner, Lingenhöhl, Kurt, Müller, Hanspeter, Munk, Veronica Cecilia, Omilusik, Kyla, Stierlin, Christine, Stoehr, Natacha, Vranesic, Ivo, Kuhn, Rainer

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Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid... von Amori, Laura, Costantino, Gabriele, Marinozzi, Maura, Pellicciari, Roberto, Gasparini, Fabrizio, Flor, Peter J, Kuhn, Rainer, Vranesic, Ivo

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Signal Transmission in the Parallel Fiber-Purkinje Cell System Visualized by High-Resolution Imaging von Vranesic, Ivo, Iijima, Toshio, Ichikawa, Michinori, Matsumoto, Gen, Knopfel, Thomas

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Activation of metabotropic glutamate receptors induces an outward current which is potentiated by methylxanthines in rat cerebellar Purkinje cells von Vranesic, Ivo, Staub, Christoph, Knöpfel, Thomas

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Discovery and characterization of non-competitive antagonists of group I metabotropic glutamate receptors von Gasparini, Fabrizio, Floersheim, Philipp, Flor, Peter Josef, Heinrich, Micheline, Inderbitzin, Werner, Ott, David, Pagano, Adriana, Stierlin, Christine, Stoehr, Natacha, Vranesic, Ivo, Kuhn, Rainer

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The synaptic potential mediated by metabotropic glutamate receptors is not associated with a substantial elevation of cytosolic free calcium concentration in Purkinje cells von Batchelor, Andrew M, Vranesic, Ivo, Principe, Franco Del, Garthwaite, John, Knöpfel, Thomas

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