mRNA therapeutics in cancer immunotherapy von Beck, Jan D., Reidenbach, Daniel, Salomon, Nadja, Sahin, Ugur, Tureci, Ozlem, Vormehr, Mathias, Kranz, Lena M.

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Multi-Omics Characterization of the 4T1 Murine Mammary Gland Tumor Model von Schroers, Barbara, Boegel, Sebastian, Albrecht, Christian, Bukur, Thomas, Bukur, Valesca, Holtstraeter, Christoph, Ritzel, Christoph, Manninen, Katja, Tadmor, Arbel D., Vormehr, Mathias, Sahin, Ugur, Loewer, Martin

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MC38 colorectal tumor cell lines from two different sources display substantial differences in transcriptome, mutanome and neoantigen expression von Schrörs, Barbara, Hos, Brett J, Yildiz, Ikra G, Löwer, Martin, Lang, Franziska, Holtsträter, Christoph, Becker, Julia, Vormehr, Mathias, Sahin, Ugur, Ossendorp, Ferry, Diken, Mustafa

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Intravenous delivery of the toll-like receptor 7 agonist SC1 confers tumor control by inducing a CD8+ T cell response von Vascotto, Fulvia, Petschenka, Jutta, Walzer, Kerstin C., Vormehr, Mathias, Brkic, Magdalena, Strobl, Stefan, Rösemann, Roman, Diken, Mustafa, Kreiter, Sebastian, Türeci, Özlem, Sahin, Ugur

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Dexamethasone premedication suppresses vaccine-induced immune responses against cancer von Vormehr, Mathias, Lehar, Sophie, Kranz, Lena M., Tahtinen, Siri, Oei, Yoko, Javinal, Vincent, Delamarre, Lélia, Walzer, Kerstin C., Diken, Mustafa, Kreiter, Sebastian, Mellman, Ira, Sahin, Ugur, Schartner, Jill M., Türeci, Özlem

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A transplantable tumor model allowing investigation of NY-BR-1-specific T cell responses in HLA-DRB10401 transgenic mice von Das, Krishna, Eisel, David, Vormehr, Mathias, Müller-Decker, Karin, Hommertgen, Adriane, Jäger, Dirk, Zörnig, Inka, Feuerer, Markus, Kopp-Schneider, Annette, Osen, Wolfram, Eichmüller, Stefan B

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Mutanome Engineered RNA Immunotherapy: Towards Patient-Centered Tumor Vaccination von Türeci, Özlem, Löwer, Martin, Boegel, Sebastian, Schrörs, Barbara, Vormehr, Mathias, Sahin, Ugur

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561 DuoBody®-PD-L1×4–1BB (GEN1046) induces superior immune-cell activation, cytokine production and cytotoxicity by combining PD-L1 blockade with conditional 4–1BB co-stimulation... von Muik, Alexander, Altintas, Isil, Kosoff, Rachelle, Gieseke, Friederike, Schödel, Kristina, Salcedo, Theodora, Burm, Saskia, Toker, Aras, Kranz, Lena, Vormehr, Mathias, Eisel, David, Fereshteh, Mark, Türeci, Özlem, Breij, Esther, Ahmadi, Tahamtan, Sahin, Ugur, Jure-Kunkel, Maria

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An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma von Sahin, Ugur, Oehm, Petra, Derhovanessian, Evelyna, Jabulowsky, Robert A., Vormehr, Mathias, Gold, Maike, Maurus, Daniel, Schwarck-Kokarakis, Doreen, Kuhn, Andreas N., Omokoko, Tana, Kranz, Lena M., Diken, Mustafa, Kreiter, Sebastian, Haas, Heinrich, Attig, Sebastian, Rae, Richard, Cuk, Katarina, Kemmer-Brück, Alexandra, Breitkreuz, Andrea, Tolliver, Claudia, Caspar, Janina, Quinkhardt, Juliane, Hebich, Lisa, Stein, Malte, Hohberger, Alexander, Vogler, Isabel, Liebig, Inga, Renken, Stephanie, Sikorski, Julian, Leierer, Melanie, Müller, Verena, Mitzel-Rink, Heidrun, Miederer, Matthias, Huber, Christoph, Grabbe, Stephan, Utikal, Jochen, Pinter, Andreas, Kaufmann, Roland, Hassel, Jessica C., Loquai, Carmen, Türeci, Özlem

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Mutant MHC class II epitopes drive therapeutic immune responses to cancer von Kreiter, Sebastian, Vormehr, Mathias, van de Roemer, Niels, Diken, Mustafa, Löwer, Martin, Diekmann, Jan, Boegel, Sebastian, Schrörs, Barbara, Vascotto, Fulvia, Castle, John C., Tadmor, Arbel D., Schoenberger, Stephen P., Huber, Christoph, Türeci, Özlem, Sahin, Ugur

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Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy von Kranz, Lena M., Diken, Mustafa, Haas, Heinrich, Kreiter, Sebastian, Loquai, Carmen, Reuter, Kerstin C., Meng, Martin, Fritz, Daniel, Vascotto, Fulvia, Hefesha, Hossam, Grunwitz, Christian, Vormehr, Mathias, Hüsemann, Yves, Selmi, Abderraouf, Kuhn, Andreas N., Buck, Janina, Derhovanessian, Evelyna, Rae, Richard, Attig, Sebastian, Diekmann, Jan, Jabulowsky, Robert A., Heesch, Sandra, Hassel, Jessica, Langguth, Peter, Grabbe, Stephan, Huber, Christoph, Türeci, Özlem, Sahin, Ugur

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BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans von Sahin, Ugur, Muik, Alexander, Vogler, Isabel, Derhovanessian, Evelyna, Kranz, Lena M., Vormehr, Mathias, Quandt, Jasmin, Bidmon, Nicole, Ulges, Alexander, Baum, Alina, Pascal, Kristen E., Maurus, Daniel, Brachtendorf, Sebastian, Lörks, Verena, Sikorski, Julian, Koch, Peter, Hilker, Rolf, Becker, Dirk, Eller, Ann-Kathrin, Grützner, Jan, Tonigold, Manuel, Boesler, Carsten, Rosenbaum, Corinna, Heesen, Ludwig, Kühnle, Marie-Cristine, Poran, Asaf, Dong, Jesse Z., Luxemburger, Ulrich, Kemmer-Brück, Alexandra, Langer, David, Bexon, Martin, Bolte, Stefanie, Palanche, Tania, Schultz, Armin, Baumann, Sybille, Mahiny, Azita J., Boros, Gábor, Reinholz, Jonas, Szabó, Gábor T., Karikó, Katalin, Shi, Pei-Yong, Fontes-Garfias, Camila, Perez, John L., Cutler, Mark, Cooper, David, Kyratsous, Christos A., Dormitzer, Philip R., Jansen, Kathrin U., Türeci, Özlem

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Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer von Sahin, Ugur, Derhovanessian, Evelyna, Miller, Matthias, Kloke, Björn-Philipp, Simon, Petra, Löwer, Martin, Bukur, Valesca, Tadmor, Arbel D., Luxemburger, Ulrich, Schrörs, Barbara, Omokoko, Tana, Vormehr, Mathias, Albrecht, Christian, Paruzynski, Anna, Kuhn, Andreas N., Buck, Janina, Heesch, Sandra, Schreeb, Katharina H., Müller, Felicitas, Ortseifer, Inga, Vogler, Isabel, Godehardt, Eva, Attig, Sebastian, Rae, Richard, Breitkreuz, Andrea, Tolliver, Claudia, Suchan, Martin, Martic, Goran, Hohberger, Alexander, Sorn, Patrick, Diekmann, Jan, Ciesla, Janko, Waksmann, Olga, Brück, Alexandra-Kemmer, Witt, Meike, Zillgen, Martina, Rothermel, Andree, Kasemann, Barbara, Langer, David, Bolte, Stefanie, Diken, Mustafa, Kreiter, Sebastian, Nemecek, Romina, Gebhardt, Christoffer, Grabbe, Stephan, Höller, Christoph, Utikal, Jochen, Huber, Christoph, Loquai, Carmen, Türeci, Özlem

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Steatohepatitis Impairs T-cell–Directed Immunotherapies Against Liver Tumors in Mice von Heinrich, Bernd, Brown, Zachary J., Diggs, Laurence P., Vormehr, Mathias, Ma, Chi, Subramanyam, Varun, Rosato, Umberto, Ruf, Benjamin, Walz, Juliane S., McVey, John C., Wabitsch, Simon, Fu, Qiong, Yu, Su Jong, Zhang, Qianfei, Lai, Chunwei W., Sahin, Ugur, Greten, Tim F.

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Long-lasting mRNA-encoded interleukin-2 restores CD8+ T cell neoantigen immunity in MHC class I-deficient cancers von Beck, Jan D., Diken, Mustafa, Suchan, Martin, Streuber, Michael, Diken, Elif, Kolb, Laura, Allnoch, Lisa, Vascotto, Fulvia, Peters, Daniel, Beißert, Tim, Akilli-Öztürk, Özlem, Türeci, Özlem, Kreiter, Sebastian, Vormehr, Mathias, Sahin, Ugur

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Abstract 1728: Nonalcoholic steatohepatitis (NASH) impairs treatment of intrahepatic metastases with CD4+ T cell dependent RNA vaccine von Heinrich, Bernd, Brown, Zachary J., Mathias, Vormehr, Fu, Qiong, Ma, Chi, Yu, Su Jong, Sahin, Ugur, Greten, Tim F.

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Publisher Correction: COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses von Sahin, Ugur, Muik, Alexander, Derhovanessian, Evelyna, Vogler, Isabel, Kranz, Lena M., Vormehr, Mathias, Baum, Alina, Pascal, Kristen, Quandt, Jasmin, Maurus, Daniel, Brachtendorf, Sebastian, Lörks, Verena, Sikorski, Julian, Hilker, Rolf, Becker, Dirk, Eller, Ann-Kathrin, Grützner, Jan, Boesler, Carsten, Rosenbaum, Corinna, Kühnle, Marie-Cristine, Luxemburger, Ulrich, Kemmer-Brück, Alexandra, Langer, David, Bexon, Martin, Bolte, Stefanie, Karikó, Katalin, Palanche, Tania, Fischer, Boris, Schultz, Armin, Shi, Pei-Yong, Fontes-Garfias, Camila, Perez, John L., Swanson, Kena A., Loschko, Jakob, Scully, Ingrid L., Cutler, Mark, Kalina, Warren, Kyratsous, Christos A., Cooper, David, Dormitzer, Philip R., Jansen, Kathrin U., Türeci, Özlem

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Abstract 5012: Establishment of a transplantable, NY-BR-1 expressing breast cancer model in HLA-transgenic mice von Das, Krishna, Gardyan, Adriane, Vormehr, Mathias, Mueller-Decker, Karin, Zörnig, Inka, Jäger, Dirk, Osen, Wolfram, Eichmüller, Stefan B.

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Abstract CT022: IVAC® MUTANOME - A first-in-human phase I clinical trial targeting individual mutant neoantigens for the treatment of melanoma von Miller, Matthias, Loquai, Carmen, Kloke, Björn-Philipp, Attig, Sebastian, Bidmon, Nicole, Bolte, Stefanie, Bukur, Valesca, Derhovanessian, Evelyna, Diekmann, Jan, Filbry, Angela, Heesch, Sandra, Hoeller, Christoph, Kuehlcke, Klaus, Langer, David, Loewer, Martin, Mueller, Felicitas, Ortseifer, Inga, Otte, Burkhard, Paruzynski, Anna, Rae, Richard, Schroers, Barbara, Seck, Christine, Spiess, Kristina, Tadmor, Arbel D., Vogler, Isabel, Vormehr, Mathias, Kemmer-Brueck, Alexandra, Kuhn, Andreas N., Luxemburger, Ulrich, Kreiter, Sebastian, Utikal, Jochen, Grabbe, Stephan, Tuereci, Oezlem, Sahin, Ugur

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Abstract A110: Mutant MHC class II epitopes drive therapeutic immune responses to cancer von Vormehr, Mathias, Kreiter, Sebastian, Roemer, Niels van de, Diken, Mustafa, Löwer, Martin, Vascotto, Fulvia, Diekmann, Jan, Boegel, Sebastian, Schroers, Barbara, Tadmor, Arbel D., Türeci, Özlem, Sahin, Ugur

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