The Active Site of a Zinc-Dependent Metalloproteinase Influences the Computed pKa of Ligands Coordinated to the Catalytic Zinc Ion von CROSS, Jason B., DUCA, José S., KAMINSKI, James J., MADISON, Vincent S.

Volltext

Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors von Fischmann, Thierry O, Smith, Catherine K, Mayhood, Todd W, Myers, Joseph E, Reichert, Paul, Mannarino, Anthony, Carr, Donna, Zhu, Hugh, Wong, Jesse, Yang, Rong-Sheng, Le, Hung V, Madison, Vincent S

Volltext

Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel μM Leads for the Development of nM... von Wang, Yu-Sen, Strickland, Corey, Voigt, Johannes H, Kennedy, Matthew E, Beyer, Brian M, Senior, Mary M, Smith, Elizabeth M, Nechuta, Terry L, Madison, Vincent S, Czarniecki, Michael, McKittrick, Brian A, Stamford, Andrew W, Parker, Eric M, Hunter, John C, Greenlee, William J, Wyss, Daniel F

Volltext

Identification of Novel Cannabinoid CB1 Receptor Antagonists by Using Virtual Screening with a Pharmacophore Model von Wang, Hongwu, Duffy, Ruth A, Boykow, George C, Chackalamannil, Samuel, Madison, Vincent S

Volltext

Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor von Deng, Yongqi, Shipps, Jr, Gerald W, Zhao, Lianyun, Siddiqui, M Arshad, Popovici-Muller, Janeta, Curran, Patrick J, Duca, Jose S, Hruza, Alan W, Fischmann, Thierry O, Madison, Vincent S, Zhang, Rumin, McNemar, Charles W, Mayhood, Todd W, Syto, Rosalinda, Annis, Allen, Kirschmeier, Paul, Lees, Emma M, Parry, David A, Windsor, William T

Volltext

Solution Structure of the Ras-Binding Domain of c-Raf-1 and Identification of Its Ras Interaction Surface von Emerson, S. Donald, Madison, Vincent S, Palermo, Robert E, Waugh, David S, Scheffler, Julie E, Tsao, Kwei-Lan, Kiefer, Susan E, Liu, Shuang P, Fry, David C

Volltext

Cross-Docking of Inhibitors into CDK2 Structures. 1 von Duca, José S, Madison, Vincent S, Voigt, Johannes H

Volltext

Cross-Docking of Inhibitors into CDK2 Structures. 2 von Voigt, Johannes H, Elkin, Carl, Madison, Vincent S, Duca, José S

Volltext

Design and Synthesis of Depeptidized Macrocyclic Inhibitors of Hepatitis C NS3-4A Protease Using Structure-Based Drug Design von Venkatraman, Srikanth, Njoroge, F. George, Girijavallabhan, Viyyoor M, Madison, Vincent S, Yao, Nanua H, Prongay, Andrew J, Butkiewicz, Nancy, Pichardo, John

Volltext

Insights from ab initio quantum chemical calculations into the preferred tautomeric forms and binding affinities to CDK2 of substituted pyrazolopyridines von Duca, José S., Madison, Vincent S.

Volltext

Peptide Mimetics of Thyrotropin-Releasing Hormone Based on a Cyclohexane Framework: Design, Synthesis, and Cognition-Enhancing Properties von Olson, Gary L, Cheung, Ho-Chuen, Chiang, Elliot, Madison, Vincent S, Sepinwall, Jerry, Vincent, George P, Winokur, Andrew, Gary, Keith A

Volltext

Induced-fit docking of mometasone furoate and further evidence for glucocorticoid receptor 17α pocket flexibility von Wang, Hongwu, Aslanian, Robert, Madison, Vincent S.

Volltext

Design and synthesis of a protein .beta.-turn mimetic von Olson, Gary L, Voss, Matthew E, Hill, David E, Kahn, Michael, Madison, Vincent S, Cook, Charles M

Volltext

Structure of interleukin 1 .alpha. at 2.7-.ANG. resolution von Graves, Bradford J, Hatada, Marcos H, Hendrickson, Wayne A, Miller, Julann K, Madison, Vincent S, Satow, Yoshinori

Volltext

The Active Site of a Zinc-Dependent Metalloproteinase Influences the Computed pK a of Ligands Coordinated to the Catalytic Zinc Ion von Cross, Jason B, Duca, José S, Kaminski, James J, Madison, Vincent S

Volltext

Solution structure of an analog of vasoactive intestinal peptide as determined by two-dimensional NMR and circular dichroism spectroscopies and constrained molecular dynamics von Fry, David C, Madison, Vincent S, Bolin, David R, Greeley, David N, Toome, Voldemar, Wegrzynski, Bogda B

Volltext

N-(Carboxymethyl)-N-[3,5-bis(decyloxy)phenyl]glycine (Ro 23-9358): a potent inhibitor of secretory phospholipases A2 with antiinflammatory activity von LeMahieu, Ronald A, Carson, Mathew, Han, Ru Jen, Madison, Vincent S, Hope, William C, Chen, Ting, Morgan, Douglas W, Hendrickson, H. Stewart

Volltext

Synthesis, biological activity and conformational analysis of cyclic GRF analogs von FELIX, ARTHUR M., HEIMER, EDGAR P., WANG, CHING-TSO, LAMBROS, THEODORE J., FOURNIER, ALAIN, MOWLES, THOMAS F., MAINES, SARAH, CAMPBELL, ROBERT M., WEGRZYNSKI, BOGDA B., TOOME, VOLDEMAR, FRY, DAVID, MADISON, VINCENT S.

Volltext

Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel [mu]M Leads for the Development of... von Wang, Yu-Sen, Strickland, Corey, Voigt, Johannes H., Kennedy, Matthew E., Beyer, Brian M., Senior, Mary M., Smith, Elizabeth M., Nechuta, Terry L., Madison, Vincent S., Czarniecki, Michael, McKittrick, Brian A., Stamford, Andrew W., Parker, Eric M., Hunter, John C., Greenlee, William J., Wyss, Daniel F.

Volltext

Three-dimensional structure of porcine C5adesArg from proton nuclear magnetic resonance data von Williamson, Michael P, Madison, Vincent S

Volltext