Phase 0 Clinical Trial of the Poly (ADP-Ribose) Polymerase Inhibitor ABT-888 in Patients With Advanced Malignancies von KUMMAR, Shivaani, KINDERS, Robert, MURGO, Anthony J, COLLINS, Jerry, STEINBERG, Seth M, ELIOPOULOS, Helen, GIRANDA, Vincent L, GORDON, Gary, HELMAN, Lee, WILTROUT, Robert, TOMASZEWSKI, Joseph E, DOROSHOW, James H, GUTIERREZ, Martin E, RUBINSTEIN, Larry, PARCHMENT, Ralph E, PHILLIPS, Lawrence R, JIUPING JI, MONKS, Anne, LOW, Jennifer A, CHEN, Alice

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Discovery of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the Treatment of Cancer von Penning, Thomas D, Zhu, Gui-Dong, Gandhi, Viraj B, Gong, Jianchun, Liu, Xuesong, Shi, Yan, Klinghofer, Vered, Johnson, Eric F, Donawho, Cherrie K, Frost, David J, Bontcheva-Diaz, Velitchka, Bouska, Jennifer J, Osterling, Donald J, Olson, Amanda M, Marsh, Kennan C, Luo, Yan, Giranda, Vincent L

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ABT-888 Confers Broad In vivo Activity in Combination with Temozolomide in Diverse Tumors von PALMA, Joann P, WANG, Yi-Chun, ZHU, Gui-Dong, PENNING, Thomas D, GIRANDA, Vincent L, ROSENBERG, Saul H, FROST, David J, DONAWHO, Cherrie K, RODRIGUEZ, Luis E, MONTGOMERY, Debra, ELLIS, Paul A, BUKOFZER, Gail, NIQUETTE, Amanda, XUESONG LIU, YAN SHI, LASKO, Loren

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Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells von Gallia, Gary L, Tyler, Betty M, Hann, Christine L, Siu, I-Mei, Giranda, Vincent L, Vescovi, Angelo L, Brem, Henry, Riggins, Gregory J

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Ubiquitin-specific Cysteine Protease 2a (USP2a) Regulates the Stability of Aurora-A von Shi, Yan, Solomon, Larry R., Pereda-Lopez, Ana, Giranda, Vincent L., Luo, Yan, Johnson, Eric F., Shoemaker, Alexander R., Leverson, Joel, Liu, Xuesong

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Small interfering RNA-mediated polo-like kinase 1 depletion preferentially reduces the survival of p53-defective, oncogenic transformed cells and inhibits tumor growth in animals von RAN GUAN, TAPANG, Paul, LEVERSON, Joel D, ALBERT, Daniel, GIRANDA, Vincent L, YAN LUO

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Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1) von Miyashiro, Julie, Woods, Keith W., Park, Chang H., Liu, Xuesong, Shi, Yan, Johnson, Eric F., Bouska, Jennifer J., Olson, Amanda M., Luo, Yan, Fry, Elizabeth H., Giranda, Vincent L., Penning, Thomas D.

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Discovering novel ligands for macromolecules using X-ray crystallographic screening von Nienaber, Vicki L, Richardson, Paul L, Klighofer, Vered, Bouska, Jennifer J, Giranda, Vincent L, Greer, Jonathan

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Acquired Resistance to Combination Treatment with Temozolomide and ABT-888 Is Mediated by Both Base Excision Repair and Homologous Recombination DNA Repair Pathways von Liu, Xuesong, Han, Edward K, Anderson, Mark, Shi, Yan, Semizarov, Dimitri, Wang, Gang, McGonigal, Thomas, Roberts, Lisa, Lasko, Loren, Palma, Joann, Zhu, Gui-Dong, Penning, Thomas, Rosenberg, Saul, Giranda, Vincent L, Luo, Yan, Leverson, Joel, Johnson, Eric F, Shoemaker, Alexander R

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Potentiation of Temozolomide Cytotoxicity by Poly(ADP)Ribose Polymerase Inhibitor ABT-888 Requires a Conversion of Single-Stranded DNA Damages to Double-Stranded DNA Breaks von Liu, Xuesong, Shi, Yan, Guan, Ran, Donawho, Cherrie, Luo, Yanping, Palma, Joann, Zhu, Gui-Dong, Johnson, Eric F, Rodriguez, Luis E, Ghoreishi-Haack, Nayereh, Jarvis, Ken, Hradil, Vincent P, Colon-Lopez, Milagros, Cox, Bryan F, Klinghofer, Vered, Penning, Thomas, Rosenberg, Saul H, Frost, David, Giranda, Vincent L, Luo, Yan

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Inhibition of the phosphatidylinositol 3-kinase/Akt pathway sensitizes MDA-MB468 human breast cancer cells to cerulenin-induced apoptosis von Liu, Xuesong, Shi, Yan, Giranda, Vincent L, Luo, Yan

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Characterization of Akt Overexpression in MiaPaCa-2 Cells: Prohibitin Is an Akt Substrate both In Vitro and in Cells von Han, Edward Kyu-Ho, Mcgonigal, Thomas, Butler, Chris, Giranda, Vincent L, Luo, Yan

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Akt Inhibitor A-443654 Interferes with Mitotic Progression by Regulating Aurora A Kinase Expression von Liu, Xuesong, Shi, Yan, Woods, Keith W., Hessler, Paul, Kroeger, Paul, Wilsbacher, Julie, Wang, Jieyi, Wang, Jean Y., Li, Chunying, Li, Qun, Rosenberg, Saul H., Giranda, Vincent L., Luo, Yan

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Optimal two-stage designs for exploratory basket trials von Zhou, Heng, Liu, Fang, Wu, Cai, Rubin, Eric H., Giranda, Vincent L., Chen, Cong

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The PARP Inhibitor, ABT-888 Potentiates Temozolomide: Correlation with Drug Levels and Reduction in PARP Activity In Vivo von PALMA, Joann P, RODRIGUEZ, Luis E, XUESONG LIU, OLSON, Amanda, SALTARELLI, Mary J, YAN SHI, STAVROPOULOS, Jason A, ZHU, Gui-Dong, PENNING, Thomas D, YAN LUO, GIRANDA, Vincent L, ROSENBERG, Saul H, BONTCHEVA-DIAZ, Velitchka D, FROST, David J, DONAWHO, Cherrie K, BOUSKA, Jennifer J, BUKOFZER, Gail, COLON-LOPEZ, Milagros, RAN GUAN, JARVIS, Kenneth, JOHNSON, Eric F, KLINGHOFER, Vered

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Targeting DNA repair with combination veliparib (ABT-888) and temozolomide in patients with metastatic castration-resistant prostate cancer von Hussain, Maha, Carducci, Michael A., Slovin, Susan, Cetnar, Jeremy, Qian, Jiang, McKeegan, Evelyn M., Refici-Buhr, Marion, Chyla, Brenda, Shepherd, Stacie P., Giranda, Vincent L., Alumkal, Joshi J.

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Population Pharmacokinetic Modeling of Veliparib (ABT-888) in Patients with Non-Hematologic Malignancies von Salem, Ahmed Hamed, Giranda, Vincent L., Mostafa, Nael M.

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A phase 1 study of veliparib (ABT-888) plus weekly carboplatin and paclitaxel in advanced solid malignancies, with an expansion cohort in triple negative breast cancer (TNBC) (ETCT... von Malhotra, Monica K., Pahuja, Shalu, Kiesel, Brian F., Appleman, Leonard J., Ding, Fei, Lin, Yan, Tawbi, Hussein A., Stoller, Ronald G., Lee, James J., Belani, Chandra P., Chen, Alice P., Giranda, Vincent L., Shepherd, Stacie Peacock, Emens, Leisha A., Ivy, S. Percy, Chu, Edward, Beumer, Jan H., Puhalla, Shannon

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Discovery and SAR of oxindole–pyridine-based protein kinase B/Akt inhibitors for treating cancers von Zhu, Gui-Dong, Gandhi, Viraj B., Gong, Jianchun, Luo, Yan, Liu, Xuesong, Shi, Yan, Guan, Ran, Magnone, Shayna R., Klinghofer, Vered, Johnson, Eric F., Bouska, Jennifer, Shoemaker, Alexander, Oleksijew, Anatol, Jarvis, Ken, Park, Chang, Jong, Ron De, Oltersdorf, Tilman, Li, Qun, Rosenberg, Saul H., Giranda, Vincent L.

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Immunohistochemical detection of poly(ADP-ribose) polymerase inhibition by ABT-888 in patients with refractory solid tumors and lymphomas von Yang, Sherry X., Kummar, Shivaani, Steinberg, Seth M., Murgo, Anthony J., Gutierrez, Martin, Rubinstein, Larry, Nguyen, Dat, Kaur, Gurmeet, Chen, Alice P., Giranda, Vincent L, Tomaszewski, Joseph E., Doroshow, James H., Phase 0 Working Group, The National Cancer Institute

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