Predicting base editing outcomes with an attention-based deep learning algorithm trained on high-throughput target library screens von Marquart, Kim F., Allam, Ahmed, Janjuha, Sharan, Sintsova, Anna, Villiger, Lukas, Frey, Nina, Krauthammer, Michael, Schwank, Gerald

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Treatment of a metabolic liver disease by in vivo genome base editing in adult mice von Villiger, Lukas, Grisch-Chan, Hiu Man, Lindsay, Helen, Ringnalda, Femke, Pogliano, Chiara B., Allegri, Gabriella, Fingerhut, Ralph, Häberle, Johannes, Matos, Joao, Robinson, Mark D., Thöny, Beat, Schwank, Gerald

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In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels von Rothgangl, Tanja, Dennis, Melissa K., Lin, Paulo J. C., Oka, Rurika, Witzigmann, Dominik, Villiger, Lukas, Qi, Weihong, Hruzova, Martina, Kissling, Lucas, Lenggenhager, Daniela, Borrelli, Costanza, Egli, Sabina, Frey, Nina, Bakker, Noëlle, Walker, John A., Kadina, Anastasia P., Victorov, Denis V., Pacesa, Martin, Kreutzer, Susanne, Kontarakis, Zacharias, Moor, Andreas, Jinek, Martin, Weissman, Drew, Stoffel, Markus, van Boxtel, Ruben, Holden, Kevin, Pardi, Norbert, Thöny, Beat, Häberle, Johannes, Tam, Ying K., Semple, Sean C., Schwank, Gerald

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Growth of Epithelial Organoids in a Defined Hydrogel von Broguiere, Nicolas, Isenmann, Luca, Hirt, Christian, Ringel, Till, Placzek, Silja, Cavalli, Emma, Ringnalda, Femke, Villiger, Lukas, Züllig, Richard, Lehmann, Roger, Rogler, Gerhard, Heim, Markus H., Schüler, Julia, Zenobi‐Wong, Marcy, Schwank, Gerald

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In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA von Villiger, Lukas, Rothgangl, Tanja, Witzigmann, Dominik, Oka, Rurika, Lin, Paulo J. C., Qi, Weihong, Janjuha, Sharan, Berk, Christian, Ringnalda, Femke, Beattie, Mitchell B., Stoffel, Markus, Thöny, Beat, Hall, Jonathan, Rehrauer, Hubert, van Boxtel, Ruben, Tam, Ying K., Schwank, Gerald

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Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope von Villiger, Lukas, Schmidheini, Lukas, Mathis, Nicolas, Rothgangl, Tanja, Marquart, Kim, Schwank, Gerald

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Drug screening and genome editing in human pancreatic cancer organoids identifies drug-gene interactions and candidates for off-label therapy von Hirt, Christian K., Booij, Tijmen H., Grob, Linda, Simmler, Patrik, Toussaint, Nora C., Keller, David, Taube, Doreen, Ludwig, Vanessa, Goryachkin, Alexander, Pauli, Chantal, Lenggenhager, Daniela, Stekhoven, Daniel J., Stirnimann, Christian U., Endhardt, Katharina, Ringnalda, Femke, Villiger, Lukas, Siebenhüner, Alexander, Karkampouna, Sofia, De Menna, Marta, Beshay, Janette, Klett, Hagen, Kruithof-de Julio, Marianna, Schüler, Julia, Schwank, Gerald

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Elevated HbA1c is not associated with recurrent venous thromboembolism in the elderly, but with all-cause mortality– the SWEETCO 65+ study von Mathis, Alexandra, Villiger, Lukas, Reiner, Martin F., Egloff, Michael, Schmid, Hans Ruedi, Stivala, Simona, Limacher, Andreas, Mean, Marie, Aujesky, Drahomir, Rodondi, Nicolas, Angelillo-Scherrer, Anna, Righini, Marc, Staub, Daniel, Aschwanden, Markus, Frauchiger, Beat, Osterwalder, Joseph, Kucher, Nils, Matter, Christian M., Banyai, Martin, Hugli, Oliver, Beer, Juerg H.

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Neurodegeneration and unfolded-protein response in mice expressing a membrane-tethered flexible tail of PrP von Dametto, Paolo, Lakkaraju, Asvin K K, Bridel, Claire, Villiger, Lukas, O'Connor, Tracy, Herrmann, Uli S, Pelczar, Pawel, Rülicke, Thomas, McHugh, Donal, Adili, Arlind, Aguzzi, Adriano

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CRISPR technologies for genome, epigenome and transcriptome editing von Villiger, Lukas, Joung, Julia, Koblan, Luke, Weissman, Jonathan, Abudayyeh, Omar O., Gootenberg, Jonathan S.

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Treatment intensification with insulin glargine in patients with inadequately controlled type 2 diabetes improves glycaemic control with a high treatment satisfaction and no weight... von Riebenfeld, Daniela, Spirk, David, Mathis, Alexandra, Villiger, Lukas, Gerber, Philipp A, Gasser, Urs Erwin, Lehmann, Roger

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Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance von Ringel, Till, Frey, Nina, Ringnalda, Femke, Janjuha, Sharan, Cherkaoui, Sarah, Butz, Stefan, Srivatsa, Sumana, Pirkl, Martin, Russo, Giancarlo, Villiger, Lukas, Rogler, Gerhard, Clevers, Hans, Beerenwinkel, Niko, Zamboni, Nicola, Baubec, Tuncay, Schwank, Gerald

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Programmable eukaryotic protein synthesis with RNA sensors by harnessing ADAR von Jiang, Kaiyi, Koob, Jeremy, Chen, Xi Dawn, Krajeski, Rohan N., Zhang, Yifan, Volf, Verena, Zhou, Wenyuan, Sgrizzi, Samantha R., Villiger, Lukas, Gootenberg, Jonathan S., Chen, Fei, Abudayyeh, Omar O.

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Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases von Yarnall, Matthew T. N., Ioannidi, Eleonora I., Schmitt-Ulms, Cian, Krajeski, Rohan N., Lim, Justin, Villiger, Lukas, Zhou, Wenyuan, Jiang, Kaiyi, Garushyants, Sofya K., Roberts, Nathaniel, Zhang, Liyang, Vakulskas, Christopher A., Walker, John A., Kadina, Anastasia P., Zepeda, Adrianna E., Holden, Kevin, Ma, Hong, Xie, Jun, Gao, Guangping, Foquet, Lander, Bial, Greg, Donnelly, Sara K., Miyata, Yoshinari, Radiloff, Daniel R., Henderson, Jordana M., Ujita, Andrew, Abudayyeh, Omar O., Gootenberg, Jonathan S.

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Author Correction: CRISPR technologies for genome, epigenome and transcriptome editing von Villiger, Lukas, Joung, Julia, Koblan, Luke, Weissman, Jonathan, Abudayyeh, Omar O., Gootenberg, Jonathan S.

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A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management von Pi-Sunyer, Xavier, Astrup, Arne, Fujioka, Ken, Greenway, Frank, Halpern, Alfredo, Krempf, Michel, Lau, David C.W, le Roux, Carel W, Violante Ortiz, Rafael, Jensen, Christine Bjørn, Wilding, John P.H

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3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial von le Roux, Carel W, Prof, Astrup, Arne, Prof, Fujioka, Ken, MD, Greenway, Frank, Prof, Lau, David C W, Prof, Van Gaal, Luc, Prof, Ortiz, Rafael Violante, MD, Wilding, John P H, Prof, Skjøth, Trine V, MD, Manning, Linda Shapiro, MD, Pi-Sunyer, Xavier, Prof

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Predicting base editing outcomes with an attention-based deep learning algorithm trained on high-throughput target library screens von Marquart, Kim F, Allam, Ahmed, Janjuha, Sharan, Sintsova, Anna, Villiger, Lukas, Frey, Nina, Krauthammer, Michael, Schwank, Gerald

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Rapid in silico directed evolution by a protein language model with EVOLVEpro von Jiang, Kaiyi, Yan, Zhaoqing, Di Bernardo, Matteo, Sgrizzi, Samantha R, Villiger, Lukas, Kayabolen, Alisan, Kim, B J, Carscadden, Josephine K, Hiraizumi, Masahiro, Nishimasu, Hiroshi, Gootenberg, Jonathan S, Abudayyeh, Omar O

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Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope von Villiger, Lukas, Schmidheini, Lukas, Mathis, Nicolas, Rothgangl, Tanja, Marquart, Kim, Schwank, Gerald

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