Therapeutic implications of tumor interstitial acidification von Kolosenko, Iryna, Avnet, Sofia, Baldini, Nicola, Viklund, Jenny, De Milito, Angelo

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Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib von Dyczynski, Matheus, Yu, Yasmin, Otrocka, Magdalena, Parpal, Santiago, Braga, Tiago, Henley, Aine Brigette, Zazzi, Henric, Lerner, Mikael, Wennerberg, Krister, Viklund, Jenny, Martinsson, Jessica, Grandér, Dan, De Milito, Angelo, Pokrovskaja Tamm, Katja

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Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti‐tumor efficacy von Yu, Yasmin, Bogdan, Madhumita, Noman, Muhammad Zaeem, Parpal, Santiago, Bartolini, Elisabetta, Van Moer, Kris, Kleinendorst, Simone Caroline, Bilgrav Saether, Kristine, Trésaugues, Lionel, Silvander, Camilla, Lindström, Johan, Simeon, Jodi, Timson, Mary Jane, Al‐Hashimi, Hikmat, Smith, Bryan D., Flynn, Daniel L., Alexeyenko, Andrey, Viklund, Jenny, Andersson, Martin, Martinsson, Jessica, Pokrovskaja Tamm, Katja, De Milito, Angelo, Janji, Bassam

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Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design von Rahm, Fredrik, Viklund, Jenny, Trésaugues, Lionel, Ellermann, Manuel, Giese, Anja, Ericsson, Ulrika, Forsblom, Rickard, Ginman, Tobias, Günther, Judith, Hallberg, Kenth, Lindström, Johan, Persson, Lars Boukharta, Silvander, Camilla, Talagas, Antoine, Díaz-Sáez, Laura, Fedorov, Oleg, Huber, Kilian V. M, Panagakou, Ioanna, Siejka, Paulina, Gorjánácz, Mátyás, Bauser, Marcus, Andersson, Martin

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Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target von Ellermann, Manuel, Eheim, Ashley, Rahm, Fredrik, Viklund, Jenny, Guenther, Judith, Andersson, Martin, Ericsson, Ulrika, Forsblom, Rickard, Ginman, Tobias, Lindström, Johan, Silvander, Camilla, Trésaugues, Lionel, Giese, Anja, Bunse, Stefanie, Neuhaus, Roland, Weiske, Jörg, Quanz, Maria, Glasauer, Andrea, Nowak-Reppel, Katrin, Bader, Benjamin, Irlbacher, Horst, Meyer, Hanna, Queisser, Nina, Bauser, Marcus, Haegebarth, Andrea, Gorjánácz, Mátyás

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Ligand-based design of [18F]OXD-2314 for PET imaging in non-Alzheimer’s disease tauopathies von Lindberg, Anton, Murrell, Emily, Tong, Junchao, Mason, N. Scott, Sohn, Daniel, Sandell, Johan, Ström, Peter, Stehouwer, Jeffrey S., Lopresti, Brian J., Viklund, Jenny, Svensson, Samuel, Mathis, Chester A., Vasdev, Neil

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Studies on the active site of deacetoxycephalosporin C synthase von Lloyd, Matthew D, Lee, Hwei-Jen, Harlos, Karl, Zhang, Zhi-Hong, Baldwin, Jack E, Schofield, Christopher J, Charnock, John M, Garner, C.David, Hara, Takane, Terwisscha van Scheltinga, Anke C, Valegård, Karin, Viklund, Jenny A.C, Hajdu, Janos, Andersson, Inger, Danielsson, Åke, Bhikhabhai, Rama

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Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy von Noman, Muhammad Zaeem, Parpal, Santiago, Van Moer, Kris, Xiao, Malina, Yu, Yasmin, Viklund, Jenny, De Milito, Angelo, Hasmim, Meriem, Andersson, Martin, Amaravadi, Ravi K., Martinsson, Jessica, Berchem, Guy, Janji, Bassam

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Ligand-based design of 18FOXD-2314 for PET imaging in non-Alzheimer's disease tauopathies von Lindberg, Anton, Murrell, Emily, Tong, Junchao, Mason, N Scott, Sohn, Daniel, Sandell, Johan, Ström, Peter, Stehouwer, Jeffrey S, Lopresti, Brian J, Viklund, Jenny, Svensson, Samuel, Mathis, Chester A, Vasdev, Neil

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Potency Prediction of β‑Secretase (BACE-1) Inhibitors Using Density Functional Methods von Roos, Katarina, Viklund, Jenny, Meuller, Johan, Kaspersson, Karin, Svensson, Mats

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Potency Prediction of [Beta]-Secretase (BACE-1) Inhibitors Using Density Functional Methods von Roos, Katarina, Viklund, Jenny, Meuller, Johan, Kaspersson, Karin, Svensson, Mats

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New Aminoimidazoles as β‑Secretase (BACE-1) Inhibitors Showing Amyloid‑β (Aβ) Lowering in Brain von Gravenfors, Ylva, Viklund, Jenny, Blid, Jan, Ginman, Tobias, Karlström, Sofia, Kihlström, Jacob, Kolmodin, Karin, Lindström, Johan, von Berg, Stefan, von Kieseritzky, Fredrik, Slivo, Can, Swahn, Britt-Marie, Olsson, Lise-Lotte, Johansson, Patrik, Eketjäll, Susanna, Fälting, Johanna, Jeppsson, Fredrik, Strömberg, Kia, Janson, Juliette, Rahm, Fredrik

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Development of Inhibitors of PIP4K2 As a Treatment for Patients with Hematologic Malignancies von McElligott, David L, Kesicki, Edward, Karukarichi, Kannan, Shim, Hyeseok, Wang, Rui, Yu, Albert S., Zolfaghari, Parisa, Linstrom, Johan, Persson, Lars, Hoglund, Andreas, Ericsson, Ulrika, Trésaugues, Lionel, Livendahl, Madeleine, Santangelo, Ellen, Viklund, Jenny, Pettersson, Mariell, Wähling, Horst, Forsblom, Rickard, Karlsson, Fredrik, Ginman, Tobias, Braga, Tiago, Henley, Aine Brigette, Talagas, Antoine, Rahm, Fredrik, Johansson, Tommy, Martinsson, Jessica, Andersson, Martin, Cantley, Lewis

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Core Refinement toward Permeable β‑Secretase (BACE-1) Inhibitors with Low hERG Activity von Ginman, Tobias, Viklund, Jenny, Malmström, Jonas, Blid, Jan, Emond, Rikard, Forsblom, Rickard, Johansson, Anh, Kers, Annika, Lake, Fredrik, Sehgelmeble, Fernando, Sterky, Karin J, Bergh, Margareta, Lindgren, Anders, Johansson, Patrik, Jeppsson, Fredrik, Fälting, Johanna, Gravenfors, Ylva, Rahm, Fredrik

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Abstract 5226: Novel class of potent and selective inhibitors efface MTH1 as broad-spectrum cancer target von Ellermann, Manuel, Giese, Anja, Eheim, Ashley, Bunse, Stefanie, Neuhaus, Roland, Weiske, Jörg, Quanz, Maria, Glasauer, Andrea, Rahm, Fredrik, Viklund, Jenny, Andersson, Martin, Ginman, Tobias, Forsblom, Rickard, Lindström, Johan, Trésaugues, Lionel, Gorjanacz, Matyas

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Abstract 2116: VPS34 inhibitor SB02024 activates cGAS-STING signaling and sensitizes tumors to STING agonist von Yu, Yasmin, Noman, Muhammad Z., Parpal, Santiago, Kleinendorst, Simone C., Saether, Kristine B., Alexeyenko, Andrey, Viklund, Jenny, Andersson, Martin, Martinsson, Jessica, Tamm, Katja P., De Milito, Angelo, Janji, Bassam

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Synthesis and structure-activity relationship of 4-(1,3-benzothiazol-2-yl)-thiophene-2-sulfonamides as cyclin-dependent kinase 5 (cdk5)/p25 inhibitors von Malmström, Jonas, Viklund, Jenny, Slivo, Can, Costa, Ana, Maudet, Mickaël, Sandelin, Catrin, Hiller, Gösta, Olsson, Lise-Lotte, Aagaard, Anna, Geschwindner, Stefan, Xue, Yafeng, Vasänge, Mervi

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Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy (vol 6, eaax7881, 2020) von Noman, Muhammad Zaeem, Parpal, Santiago, Van Moer, Kris, Xiao, Malina, Yu, Yasmin, Arakelian, Tsolere, Viklund, Jenny, De Milito, Angelo, Hasmim, Meriem, Andersson, Martin, Amaravadi, Ravi K., Martinsson, Jessica, Berchem, Guy, Janji, Bassam

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Creation of Novel Cores for β‑Secretase (BACE-1) Inhibitors: A Multiparameter Lead Generation Strategy von Viklund, Jenny, Kolmodin, Karin, Nordvall, Gunnar, Swahn, Britt-Marie, Svensson, Mats, Gravenfors, Ylva, Rahm, Fredrik

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Design and synthesis of 2′-anilino-4,4′-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3 von Swahn, Britt-Marie, Xue, Yafeng, Arzel, Erwan, Kallin, Elisabet, Magnus, Angelika, Plobeck, Niklas, Viklund, Jenny

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