Humanized mice are precious tools for evaluation of hematopoietic gene therapies and preclinical modeling to move towards a clinical trial von Brendel, Christian, Rio, Paula, Verhoeyen, Els

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Genome editing in primary cells and in vivo using viral-derived Nanoblades loaded with Cas9-sgRNA ribonucleoproteins von Mangeot, Philippe E., Risson, Valérie, Fusil, Floriane, Marnef, Aline, Laurent, Emilie, Blin, Juliana, Mournetas, Virginie, Massouridès, Emmanuelle, Sohier, Thibault J. M., Corbin, Antoine, Aubé, Fabien, Teixeira, Marie, Pinset, Christian, Schaeffer, Laurent, Legube, Gaëlle, Cosset, François-Loïc, Verhoeyen, Els, Ohlmann, Théophile, Ricci, Emiliano P.

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Lentiviral Vector Pseudotypes: Precious Tools to Improve Gene Modification of Hematopoietic Cells for Research and Gene Therapy von Gutierrez-Guerrero, Alejandra, Cosset, Francois-Loic, Verhoeyen, Els

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Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells von Villa, Elodie, Proïcs, Emma, Rubio-Patiño, Camila, Obba, Sandrine, Zunino, Barbara, Bossowski, Jozef P., Rozier, Romain M., Chiche, Johanna, Mondragón, Laura, Riley, Joel S., Marchetti, Sandrine, Verhoeyen, Els, Tait, Stephen W.G., Ricci, Jean-Ehrland

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IL-34 and CSF-1 display an equivalent macrophage differentiation ability but a different polarization potential von Boulakirba, Sonia, Pfeifer, Anja, Mhaidly, Rana, Obba, Sandrine, Goulard, Michael, Schmitt, Thomas, Chaintreuil, Paul, Calleja, Anne, Furstoss, Nathan, Orange, François, Lacas-Gervais, Sandra, Boyer, Laurent, Marchetti, Sandrine, Verhoeyen, Els, Luciano, Frederic, Robert, Guillaume, Auberger, Patrick, Jacquel, Arnaud

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Genetic in vivo engineering of human T lymphocytes in mouse models von Weidner, Tatjana, Agarwal, Shiwani, Perian, Séverine, Fusil, Floriane, Braun, Gundula, Hartmann, Jessica, Verhoeyen, Els, Buchholz, Christian J.

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In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine release syndrome von Pfeiffer, Anett, Thalheimer, Frederic B, Hartmann, Sylvia, Frank, Annika M, Bender, Ruben R, Danisch, Simon, Costa, Caroline, Wels, Winfried S, Modlich, Ute, Stripecke, Renata, Verhoeyen, Els, Buchholz, Christian J

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Efficient and Robust NK-Cell Transduction With Baboon Envelope Pseudotyped Lentivector von Colamartino, Aurelien B L, Lemieux, William, Bifsha, Panojot, Nicoletti, Simon, Chakravarti, Nitin, Sanz, Joaquín, Roméro, Hugo, Selleri, Silvia, Béland, Kathie, Guiot, Mélanie, Tremblay-Laganière, Camille, Dicaire, Renée, Barreiro, Luis, Lee, Dean A, Verhoeyen, Els, Haddad, Elie

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A Distinct Subset of Highly Proliferative and Lentiviral Vector (LV)-Transducible NK Cells Define a Readily Engineered Subset for Adoptive Cellular Therapy von Bari, Rafijul, Granzin, Markus, Tsang, Kam Sze, Roy, Andre, Krueger, Winfried, Orentas, Rimas, Schneider, Dina, Pfeifer, Rita, Moeker, Nina, Verhoeyen, Els, Dropulic, Boro, Leung, Wing

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Genome-wide CRISPR-Cas9 screen identifies rationally designed combination therapies for CRLF2-rearranged Ph-like ALL von Sasaki, Kensuke, Yamauchi, Takuji, Semba, Yuichiro, Nogami, Jumpei, Imanaga, Hiroshi, Terasaki, Tatsuya, Nakao, Fumihiko, Akahane, Koshi, Inukai, Takeshi, Verhoeyen, Els, Akashi, Koichi, Maeda, Takahiro

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Engineering of α-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration von Luo, Baohong, Zhan, Yikang, Luo, Minqi, Dong, Huimin, Liu, Jun, Lin, Yingtong, Zhang, Junsong, Wang, Guanwen, Verhoeyen, Els, Zhang, Yiwen, Zhang, Hui

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In vivo CAR T cell therapy against angioimmunoblastic T cell lymphoma von Krug, Adrien, Saidane, Aymen, Martinello, Chiara, Fusil, Floriane, Michels, Alexander, Buchholz, Christian J, Ricci, Jean-Ehrland, Verhoeyen, Els

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Escherichia coli Rho GTPase-activating toxin CNF1 mediates NLRP3 inflammasome activation via p21-activated kinases-1/2 during bacteraemia in mice von Dufies, Océane, Doye, Anne, Courjon, Johan, Torre, Cédric, Michel, Gregory, Loubatier, Celine, Jacquel, Arnaud, Chaintreuil, Paul, Majoor, Alissa, Guinamard, Rodolphe R., Gallerand, Alexandre, Saavedra, Pedro H. V., Verhoeyen, Els, Rey, Amaury, Marchetti, Sandrine, Ruimy, Raymond, Czerucka, Dorota, Lamkanfi, Mohamed, Py, Bénédicte F., Munro, Patrick, Visvikis, Orane, Boyer, Laurent

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Multiplex CRISPR/Cas9 system impairs HCMV replication by excising an essential viral gene von Gergen, Janina, Coulon, Flora, Creneguy, Alison, Elain-Duret, Nathan, Gutierrez, Alejandra, Pinkenburg, Olaf, Verhoeyen, Els, Anegon, Ignacio, Nguyen, Tuan Huy, Halary, Franck Albert, Haspot, Fabienne

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High SYK Expression Drives Constitutive Activation of CD21low B Cells von Keller, Baerbel, Stumpf, Ina, Strohmeier, Valentina, Usadel, Susanne, Verhoeyen, Els, Eibel, Hermann, Warnatz, Klaus

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The DNA Damage Response Regulates RAG1/2 Expression in Pre-B Cells through ATM-FOXO1 Signaling von Ochodnicka-Mackovicova, Katarina, Bahjat, Mahnoush, Maas, Chiel, van der Veen, Amélie, Bloedjes, Timon A, de Bruin, Alexander M, van Andel, Harmen, Schrader, Carol E, Hendriks, Rudi W, Verhoeyen, Els, Bende, Richard J, van Noesel, Carel J M, Guikema, Jeroen E J

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Inhibition of choline metabolism in an angioimmunoblastic T-cell lymphoma preclinical model reveals a new metabolic vulnerability as possible target for treatment von Krug, Adrien, Tosolini, Marie, Madji Hounoum, Blandine, Fournié, Jean-Jacques, Geiger, Roger, Pecoraro, Matteo, Emond, Patrick, Gaulard, Philippe, Lemonnier, François, Ricci, Jean-Ehrland, Verhoeyen, Els

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Glut1-mediated glucose transport regulates HIV infection von Loisel-Meyer, Séverine, Swainson, Louise, Craveiro, Marco, Oburoglu, Leal, Mongellaz, Cédric, Costa, Caroline, Martinez, Marion, Cosset, François-Loic, Battini, Jean-Luc, Herzenberg, Leonard A, Herzenberg, Leonore A, Atkuri, Kondala R, Sitbon, Marc, Kinet, Sandrina, Verhoeyen, Els, Taylor, Naomi

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Distinct subsets of multi-lymphoid progenitors support ontogeny-related changes in human lymphopoiesis von Keita, Seydou, Diop, Samuel, Lekiashvili, Shalva, Chabaane, Emna, Nelson, Elisabeth, Strullu, Marion, Arfeuille, Chloé, Guimiot, Fabien, Domet, Thomas, Duchez, Sophie, Evrard, Bertrand, Darde, Thomas, Larghero, Jerome, Verhoeyen, Els, Cumano, Ana, Macintyre, Elizabeth A., Kasraian, Zeinab, Jouen, François, Goodhardt, Michele, Garrick, David, Chalmel, Frederic, Alhaj Hussen, Kutaiba, Canque, Bruno

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TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells von Biroccio, Annamaria, Cherfils-Vicini, Julien, Augereau, Adeline, Pinte, Sébastien, Bauwens, Serge, Ye, Jing, Simonet, Thomas, Horard, Béatrice, Jamet, Karine, Cervera, Ludovic, Mendez-Bermudez, Aaron, Poncet, Delphine, Grataroli, Renée, de Rodenbeeke, Claire T’kint, Salvati, Erica, Rizzo, Angela, Zizza, Pasquale, Ricoul, Michelle, Cognet, Céline, Kuilman, Thomas, Duret, Helene, Lépinasse, Florian, Marvel, Jacqueline, Verhoeyen, Els, Cosset, François-Loïc, Peeper, Daniel, Smyth, Mark J., Londoño-Vallejo, Arturo, Sabatier, Laure, Picco, Vincent, Pages, Gilles, Scoazec, Jean-Yves, Stoppacciaro, Antonella, Leonetti, Carlo, Vivier, Eric, Gilson, Eric

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