Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation von Hendrick, Charles E., Jorgensen, Jeff R., Chaudhry, Charu, Strambeanu, Iulia I., Brazeau, Jean-Francois, Schiffer, Jamie, Shi, Zhicai, Venable, Jennifer D., Wolkenberg, Scott E.

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Modulating the Potency of BRD4 PROTACs at the Systems Level with Amine-Acid Coupling Reactions von McGrath, Andrew, Huang, Haiyan, Brazeau, Jean-Francois, Zhang, Zirong, Audu, Christopher O., Vellore, Nadeem A., Zhu, Lu, Shi, Zhicai, Venable, Jennifer D., Gelin, Christine F., Cernak, Tim

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Discovery of Highly Potent and Selective IRAK1 Degraders to Probe Scaffolding Functions of IRAK1 in ABC DLBCL von Fu, Liqiang, Zhang, Jing, Shen, Bin, Kong, Linglong, Liu, Yingtao, Tu, Wangyang, Wang, Wenqian, Cai, Xin, Wang, Xiaotao, Cheng, Na, Xia, Mingxuan, Zhou, Tianyuan, Liu, Qian, Xu, Yanping, Yang, Jennifer, Gavine, Paul, Philippar, Ulrike, Attar, Ricardo, Edwards, James P, Venable, Jennifer D, Dai, Xuedong

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Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation von Babbe, Holger, Sundberg, Thomas B, Tichenor, Mark, Seierstad, Mark, Bacani, Genesis, Berstler, James, Chai, Wenying, Chang, Leon, Chung, De Michael, Coe, Kevin, Collins, Bernard, Finley, Michael, Guletsky, Alexander, Lemke, Christopher T, Mak, Puiying A, Mathur, Ashok, Mercado-Marin, Eduardo V, Metkar, Shailesh, Raymond, Donald D, Rives, Marie-Laure, Rizzolio, Michele, Shaffer, Paul L, Smith, Russell, Smith, Jacqueline, Steele, Ruth, Steffens, Helena, Suarez, Javier, Tian, Gaochao, Majewski, Nathan, Volak, Laurie P, Wei, Jianmei, Desai, Prerak T, Ong, Luvena L, Koudriakova, Tatiana, Goldberg, Steven D, Hirst, Gavin, Kaushik, Virendar K, Ort, Tatiana, Seth, Nilufer, Graham, Daniel B, Plevy, Scott, Venable, Jennifer D, Xavier, Ramnik J, Towne, Jennifer E

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Identification of small-molecule protein-protein interaction inhibitors for NKG2D von Thompson, Aaron A, Harbut, Michael B, Kung, Pei-Pei, Karpowich, Nathan K, Branson, Jeffrey D, Grant, Joanna C, Hagan, Deborah, Pascual, Heather A, Bai, Guoyun, Zavareh, Reza Beheshti, Coate, Heather R, Collins, Bernard C, Côte, Marjorie, Gelin, Christine F, Damm-Ganamet, Kelly L, Gholami, Hadi, Huff, Adam R, Limon, Luis, Lumb, Kevin J, Mak, Puiying A, Nakafuku, Kohki M, Price, Edmund V, Shih, Amy Y, Tootoonchi, Mandana, Vellore, Nadeem A, Wang, Jocelyn, Wei, Na, Ziff, Jeannie, Berger, Scott B, Edwards, James P, Gardet, Agnès, Sun, Siquan, Towne, Jennifer E, Venable, Jennifer D, Shi, Zhicai, Venkatesan, Hariharan, Rives, Marie-Laure, Sharma, Sujata, Shireman, Brock T, Allen, Samantha J

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Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D) von Wang, Jocelyn, Nakafuku, Kohki M., Ziff, Jeannie, Gelin, Christine F., Gholami, Hadi, Thompson, Aaron A., Karpowich, Nathan K., Limon, Luis, Coate, Heather R., Damm-Ganamet, Kelly L., Shih, Amy Y., Grant, Joanna C., Côte, Marjorie, Mak, Puiying A., Pascual, Heather A., Rives, Marie-Laure, Edwards, James P., Venable, Jennifer D., Venkatesan, Hariharan, Shi, Zhicai, Allen, Samantha J., Sharma, Sujata, Kung, Pei-Pei, Shireman, Brock T.

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Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease von Leonard, Kristi A, Madge, Lisa A, Krawczuk, Paul J, Wang, Aihua, Kreutter, Kevin D, Bacani, Genesis M, Chai, Wenying, Smith, Russell C, Tichenor, Mark S, Harris, Michael C, Malaviya, Ravi, Seierstad, Mark, Johnson, Marguerite E, Venable, Jennifer D, Kim, Suzie, Hirst, Gavin C, Mathur, Ashok S, Rao, Tadimeti S, Edwards, James P, Rizzolio, Michele C, Koudriakova, Tatiana

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Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase von Tichenor, Mark S., Wiener, John J. M., Rao, Navin L., Bacani, Genesis M., Wei, Jianmei, Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D., Chang, Leon, Clancy, Kathleen W., Murrey, Heather E., Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J., Wu, Jiejun, Rui, Haopeng, Sepassi, Kia, Gaudiano, Marcello, Bekkers, Mariette, Cornelissen, Ivo, Packman, Kathryn, Seierstad, Mark, Xiouras, Christos, Bembenek, Scott D., Alexander, Richard, Milligan, Cynthia, Balasubramanian, Sriram, Lebsack, Alec D., Venable, Jennifer D., Philippar, Ulrike, Edwards, James P., Hirst, Gavin

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Functional Profiling of 2-Aminopyrimidine Histamine H4 Receptor Modulators von Tichenor, Mark S, Thurmond, Robin L, Venable, Jennifer D, Savall, Brad M

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A Prospective Virtual Screening Study: Enriching Hit Rates and Designing Focus Libraries To Find Inhibitors of PI3Kδ and PI3Kγ von Damm-Ganamet, Kelly L, Bembenek, Scott D, Venable, Jennifer W, Castro, Glenda G, Mangelschots, Lieve, Peeters, Daniëlle C. G, Mcallister, Heather M, Edwards, James P, Disepio, Daniel, Mirzadegan, Taraneh

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Discovery of a Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase with Oral Anti-Inflammatory Activity von Tichenor, Mark S, Wiener, John J. M, Rao, Navin L, Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D, Bacani, Genesis M, Wei, Jianmei, Chang, Leon, Murrey, Heather E, Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J, Wu, JieJun, Seierstad, Mark, Bembenek, Scott D, Leonard, Kristi A, Lebsack, Alec D, Venable, Jennifer D, Edwards, James P

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The histamine H4 receptor in autoimmune disease von Zhang, Mai, Venable, Jennifer D, Thurmond, Robin L

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The First Potent and Selective Non-Imidazole Human Histamine H4 Receptor Antagonists von Jablonowski, Jill A, Grice, Cheryl A, Chai, Wenying, Dvorak, Curt A, Venable, Jennifer D, Kwok, Annette K, Ly, Kiev S, Wei, Jianmei, Baker, Sherry M, Desai, Pragnya J, Jiang, Wen, Wilson, Sandy J, Thurmond, Robin L, Karlsson, Lars, Edwards, James P, Lovenberg, Timothy W, Carruthers, Nicholas I

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Preparation and Biological Evaluation of Indole, Benzimidazole, and Thienopyrrole Piperazine Carboxamides:  Potent Human Histamine H4 Antagonists von Venable, Jennifer D, Cai, Hui, Chai, Wenying, Dvorak, Curt A, Grice, Cheryl A, Jablonowski, Jill A, Shah, Chandra R, Kwok, Annette K, Ly, Kiev S, Pio, Barbara, Wei, Jianmei, Desai, Pragnya J, Jiang, Wen, Nguyen, Steven, Ling, Ping, Wilson, Sandy J, Dunford, Paul J, Thurmond, Robin L, Lovenberg, Timothy W, Karlsson, Lars, Carruthers, Nicholas I, Edwards, James P

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The histamine H 4 receptor in autoimmune disease von Zhang, Mai, Venable, Jennifer D, Thurmond, Robin L

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Agonist/antagonist modulation in a series of 2-aryl benzimidazole H4 receptor ligands von Savall, Brad M., Edwards, James P., Venable, Jennifer D., Buzard, Daniel J., Thurmond, Robin, Hack, Michael, McGovern, Patricia

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Immunological characterization of HM5023507, an orally active PI3Kδ/γ inhibitor von Cai, Yu, Yu, Jun, Ren, Ping, He, Jianlin, Wu, Zhipeng, Xiao, Kun, Jia, Hong, Wang, Jian, Sai, Yang, Dai, Guangxiu, Li, Xiong, Su, Weiguo, Ngo, Karen, Castro, Glenda, Acton, Paul D., Fung‐Leung, Wai‐Ping, Edwards, James P., Venable, Jennifer, Rao, Tadimeti S.

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Some reactions of persistent benzofuranone radicals related to the ‘old’ diazonamide structure von Magnus, Philip, Venable (nee Kreisberg), Jennifer D., Shen, Lan, Lynch, Vince

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Discovery, Optimization, and Evaluation of Potent and Highly Selective PI3Kγ–PI3Kδ Dual Inhibitors von Jia, Hong, Dai, Guangxiu, Su, Weiguo, Xiao, Kun, Weng, Jianyang, Zhang, Zhulin, Wang, Qing, Yuan, Tianhai, Shi, Fuying, Zhang, Zheng, Chen, Wei, Sai, Yang, Wang, Jian, Li, Xiong, Cai, Yu, Yu, Jun, Ren, Ping, Venable, Jennifer, Rao, Tadimeti, Edwards, James P, Bembenek, Scott D

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Functional Profiling of 2-Aminopyrimidine Histamine H 4 Receptor Modulators: Miniperspective von Tichenor, Mark S., Thurmond, Robin L., Venable, Jennifer D., Savall, Brad M.

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