CBL Exon 8/9 Mutants Activate the FLT3 Pathway and Cluster in Core Binding Factor/11q Deletion Acute Myeloid Leukemia/Myelodysplastic Syndrome Subtypes von REINDL, Carola, QUENTMEIER, Hilmar, BOHLANDER, Stefan K, HUMPHRIES, Keith R, HIDDEMANN, Wolfgang, SPIEKERMANN, Karsten, PETROPOULOS, Konstantin, GREIF, Philipp A, BENTHAUS, Tobias, ARGIROPOULOS, Bob, MELLERT, Gudrun, VEMPATI, Sridhar, DUYSTER, Justus, BUSKE, Christian

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Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML von Reindl, Carola, Bagrintseva, Ksenia, Vempati, Sridhar, Schnittger, Susanne, Ellwart, Joachim W., Wenig, Katja, Hopfner, Karl-Peter, Hiddemann, Wolfgang, Spiekermann, Karsten

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Transformation by Oncogenic Mutants and Ligand-Dependent Activation of FLT3 Wild-type Requires the Tyrosine Residues 589 and 591 von Vempati, Sridhar, Reindl, Carola, Wolf, Ulla, Kern, Ruth, Petropoulos, Konstantin, Naidu, Vegi M, Buske, Christian, Hiddemann, Wolfgang, Kohl, Tobias M, Spiekermann, Karsten

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Different population histories of the Mundari- and Mon-Khmer-speaking Austro-Asiatic tribes inferred from the mtDNA 9-bp deletion/insertion polymorphism in Indian populations von THANGARAJ, Kumarasamy, SRIDHAR, Vempati, CHANDANA BASU MALLICK, KUMAR, Niraj, VELAVAN, Thrimulaisamy P, SUGANTHAN, Rajanbabu, UDAYKUMAR, Divi, KUMAR, Rashmi, MISHRA, Rachana, KHAN, Arif, ANNAPURNA, Chitikineni, SINGH, Lalji, KIVISILD, Toomas, REDDY, Alla G, CHAUBEY, Gyaneshwer, VIJAY KUMAR SINGH, KAUR, Suminder, AGARAWAL, Pooja, RAI, Amit, GUPTA, Jalaj

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H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias von Krivtsov, Andrei V., Feng, Zhaohui, Lemieux, Madeleine E., Faber, Joerg, Vempati, Sridhar, Sinha, Amit U., Xia, Xiaobo, Jesneck, Jonathan, Bracken, Adrian P., Silverman, Lewis B., Kutok, Jeffery L., Kung, Andrew L., Armstrong, Scott A.

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Selective Inhibition of HDAC1 and HDAC2 as a Potential Therapeutic Option for B-ALL von Stubbs, Matthew C, Kim, Wonil, Bariteau, Megan, Davis, Tina, Vempati, Sridhar, Minehart, Janna, Witkin, Matthew, Qi, Jun, Krivtsov, Andrei V, Bradner, James E, Kung, Andrew L, Armstrong, Scott A

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Abstract 1664: Discovery of a novel and potent TACC3 protein-protein interaction inhibitor targeting highly aggressive cancers von Sahin, Ozgur, Banoglu, Erden, Lim, Chaemin, Caliskan, Burcu, Cruz, Emmanuel, Stergiopoulos, Sotirios, Vempati, Sridhar

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MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L von Bernt, Kathrin M., Zhu, Nan, Sinha, Amit U., Vempati, Sridhar, Faber, Joerg, Krivtsov, Andrei V., Feng, Zhaohui, Punt, Natalie, Daigle, Amanda, Bullinger, Lars, Pollock, Roy M., Richon, Victoria M., Kung, Andrew L., Armstrong, Scott A.

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Different population histories of the Mundari- and Mon-Khmer-speaking Austro-Asiatic tribes inferred from the mtDNA 9-bp deletion/insertion polymorphism in Indian populations von Thangaraj, Kumarasamy, Sridhar, Vempati, Kivisild, Toomas, Reddy, Alla G, Chaubey, Gyaneshwer, Singh, Vijay Kumar, Kaur, Suminder, Agarawal, Pooja, Rai, Amit, Gupta, Jalaj, Mallick, Chandana Basu, Kumar, Niraj, Velavan, Thrimulaisamy P, Suganthan, Rajanbabu, Udaykumar, Divi, Kumar, Rashmi, Mishra, Rachana, Khan, Arif, Annapurna, Chitikineni, Singh, Lalji

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Arginine 595 is duplicated in patients with acute leukemias carrying internal tandem duplications of FLT3 and modulates its transforming potential von Vempati, Sridhar, Reindl, Carola, Kaza, Seshu Kumar, Kern, Ruth, Malamoussi, Theodora, Dugas, Martin, Mellert, Gudrun, Schnittger, Susanne, Hiddemann, Wolfgang, Spiekermann, Karsten

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The JAK2-V617F Mutant Found in Myeloproliferative Disorders and Acute Myeloid Leukemia Cooperates with the EpoR, but Not with FLT3 To Promote Proliferation of IL-3 Dependent Cells von Kaza, Seshu K., Vempati, Sridhar, Carola, Reindl, Hiddemann, Wolfgang, Spiekermann, Karsten

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Oncogenic CBL Mutants Have Transforming Potential in Cells Expressing the FLT3 Tyrosine Kinase von Reindl, Carola, Vempati, Sridhar, Quentmeier, Hilmar, Mellert, Gudrun, Hiddemann, Wolfgang, Spiekermann, Karsten

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COMPOSITIONS AND METHODS FOR TREATING CANCER von LIM, Chaemin, SAHIN, Ozgur, BANOGLU, Erden, CALISKAN, Burcu, VEMPATI, Sridhar

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Compositions and methods for treating cancer von Sahin, Ozgur, Vempati, Sridhar, Lim, Chaemin, Caliskan, Burcu, Banoglu, Erden

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Arginine (R) at Position 595 in FLT3 Is Critical for Transforming Potential of FLT3-Length Mutations von Vempati, Sridhar, Schwab, Ruth, Malamoussi, Theodora, Dugas, Martin, Mellert, Gudrun, Schnittger, Susanne, Hiddemann, Wolfgang, Spiekermann, Karsten

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COMPOSITIONS AND METHODS FOR TREATING CANCER von Sahin, Ozgur, Vempati, Sridhar, Lim, Chaemin, Caliskan, Burcu, Banoglu, Erden

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The Role of the Juxtamembrane Domain of FLT3-ITDs in Acute Myeloid Leukemia von Vempati, Sridhar

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COMPOSITIONS AND METHODS FOR TREATING CANCER von LIM, Chaemin, SAHIN, Ozgur, BANOGLU, Erden, CALISKAN, Burcu, VEMPATI, Sridhar

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N-[4-[4-(4-MORPHOLINYL)-7H-PYRROLO[2,3-d]PYRIMIDIN-6-YL]PHENYL]-4-[[3(R)-[(1-OXO-2-PROPEN-1-YL)AMINO]-1-PIPERIDINYL]METHYL]-2-PYRIDINE CARBOXAMIDE AND USES THEREOF von BUTLER, Thomas, PALMER, Jim, PAINTER, Edward, UPASANI, Ravi, KELLY, Brendan, WELSCH, Matthew, VEMPATI, Sridhar

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COMPOSITIONS AND METHODS FOR TREATING CANCER von Cruz, Emmanuel, Sahin, Ozgur, Ibis, Kubra, Vempati, Sridhar, Lim, Chaemin, Lengerli, Deniz, Caliskan, Burcu, Banoglu, Erden

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