Molecular Properties That Influence the Oral Bioavailability of Drug Candidates von Veber, Daniel F, Johnson, Stephen R, Cheng, Hung-Yuan, Smith, Brian R, Ward, Keith W, Kopple, Kenneth D

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Potent and Selective Inhibition of Human Cathepsin K Leads to Inhibition of Bone Resorption In Vivo in a Nonhuman Primate von Stroup, George B., Lark, Michael W., Veber, Daniel F., Bhattacharyya, Amit, Blake, Simon, Dare, Lauren C., Erhard, Karl F., Hoffman, Sandra J., James, Ian E., Marquis, Robert W., Ru, Yu, Vasko‐Moser, Janice A., Smith, Brian R., Tomaszek, Thadeus, Gowen, Maxine

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Evaluation of Potent and Selective Small-Molecule Antagonists for the CXCR2 Chemokine Receptor von Widdowson, Katherine L, Elliott, John D, Veber, Daniel F, Nie, Hong, Rutledge, Melvin C, McCleland, Brent W, Xiang, Jia-Ning, Jurewicz, Anthony J, Hertzberg, Robert P, Foley, James J, Griswold, Don E, Martin, Lenox, Lee, Judithann M, White, John R, Sarau, Henry M

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Peptide Aldehyde Inhibitors of Cathepsin K Inhibit Bone Resorption Both In Vitro and In Vivo von Votta, Bartholomew J., Levy, Mark A., Badger, Alison, Bradbeer, Jeremy, Dodds, Robert A., James, Ian E., Thompson, Scott, Bossard, Mary J., Carr, Thomas, Connor, Janice R., Tomaszek, Thaddeus A., Szewczuk, Lawrence, Drake, Fred H., Veber, Daniel F., Gowen, Maxine

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Human Osteoclast Cathepsin K Is Processed Intracellularly Prior to Attachment and Bone Resorption von Dodds, Robert A., James, Ian E., Rieman, David, Ahern, Reina, Hwang, Shing Mei, Connor, Janice R., Thompson, Scott D., Veber, Daniel F., Drake, Fred H., Holmes, Stephen, Lark, Michael W., Gowen, Maxine

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Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists von Evans, B. E, Rittle, K. E, Bock, M. G, DiPardo, R. M, Freidinger, R. M, Whitter, W. L, Lundell, G. F, Veber, D. F, Anderson, P. S, Chang, R. S. L, Lotti, V. J, Cerino, D. J, Chen, T. B, Kling, P. J, Kunkel, K. A, Springer, J. P, Hirshfield, J

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Azepanone-Based Inhibitors of Human Cathepsin L von Marquis, Robert W, James, Ian, Zeng, Jin, Trout, Robert E. Lee, Thompson, Scott, Rahman, Attiq, Yamashita, Dennis S, Xie, Ren, Ru, Yu, Gress, Catherine J, Blake, Simon, Lark, Michael A, Hwang, Shing-Mei, Tomaszek, Thaddeus, Offen, Priscilla, Head, Martha S, Cummings, Maxwell D, Veber, Daniel F

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Use of Papain as a Model for the Structure-Based Design of Cathepsin K Inhibitors:  Crystal Structures of Two Papain−Inhibitor Complexes Demonstrate Binding to S‘-Subsites von LaLonde, Judith M, Zhao, Baoguang, Smith, Ward W, Janson, Cheryl A, DesJarlais, Renee L, Tomaszek, Thaddeus A, Carr, Thomas J, Thompson, Scott K, Oh, Hye-Ja, Yamashita, Dennis S, Veber, Daniel F, Abdel-Meguid, Sherin S

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Structure and Design of Potent and Selective Cathepsin K Inhibitors von Yamashita, Dennis S., Smith, Ward W., Zhao, Baoguang, Janson, Cheryl A., Tomaszek, Thaddeus A., Bossard, Mary J., Levy, Mark A., Oh, Hye-Ja, Carr, Thomas J., Thompson, Scott K., Ijames, Carl F., Carr, Steven A., McQueney, Michael, D'Alessio, Karla J., Amegadzie, Bernard Y., Hanning, Charles R., Abdel-Meguid, Sherin, DesJarlais, Renee L., Gleason, John G., Veber, Daniel F.

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Benzodiazepine gastrin and brain cholecystokinin receptor ligands; L-365,260 von Bock, Mark G, DiPardo, Robert M, Evans, Ben E, Rittle, Kenneth E, Whitter, Willie L, Veber, Daniel F, Anderson, Paul S, Freidinger, Roger M

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Potent and Selective Cathepsin L Inhibitors Do Not Inhibit Human Osteoclast Resorption in Vitro von James, Ian E., Marquis, Robert W., Blake, Simon M., Hwang, Shing Mei, Gress, Catherine J., Ru, Yu, Zembryki, Denise, Yamashita, Dennis S., McQueney, Michael S., Tomaszek, Thaddeus A., Oh, Hye-Ja, Gowen, Maxine, Veber, Daniel F., Lark, Michael W.

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Aspartic Protease Inhibitors:  Expedient Synthesis of 2-Substituted Statines von Travins, Jeremy M, Bursavich, Matthew G, Veber, Daniel F, Rich, Daniel H

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Simple Silyl Linker for the Solid Phase Organic Synthesis of Aryl- Containing Molecules von Newlander, Kenneth A, Chenera, Balan, Veber, Daniel F, Yim, Nelson C. F, Moore, Michael L

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Mechanism of Inhibition of Cathepsin K by Potent, Selective 1,5-Diacylcarbohydrazides:  A New Class of Mechanism-Based Inhibitors of Thiol Proteases von Bossard, Mary J, Tomaszek, Thaddeus A, Levy, Mark A, Ijames, Carl F, Huddleston, Michael J, Briand, Jacques, Thompson, Scott, Halpert, Stacie, Veber, Daniel F, Carr, Steven A, Meek, Thomas D, Tew, David G

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The new partnership of genomics and chemistry for accelerated drug development von Veber, Daniel F, Drake, Fred H, Gowen, Maxine

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Potent dipeptidylketone inhibitors of the cysteine protease cathepsin K von Marquis, Robert W, Ru, Yu, Yamashita, Dennis S, Oh, Hye-Ja, Yen, Jack, Thompson, Scott K, Carr, Thomas J, Levy, Mark A, Tomaszek, Thaddeus A, Ijames, Carl F, Smith, Ward W, Zhao, Baoguang, Janson, Cheryl A, Abdel-Meguid, Sherin S, D'Alessio, Karla J, McQueney, M.S, Veber, Daniel F

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Development of a Potent Thrombin Receptor Ligand von Feng, Dong-Mei, Veber, Daniel F, Connolly, Thomas M, Condra, Cindra, Tang, Mei-Jy, Nutt, Ruth F

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Design of Potent, Orally Effective, Nonpeptidal Antagonists of the Peptide Hormone Cholecystokinin von Evans, Ben E., Bock, Mark G., Rittle, Kenneth E., DiPardo, Robert M., Whitter, Willie L., Veber, Daniel F., Anderson, Paul S., Freidinger, Roger M.

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HIV-1 protease specificity of peptide cleavage is sufficient for processing of gag and pol polyproteins von Darke, Paul L., Nutt, Ruth F., Brady, Stephen F., Garsky, Victor M., Ciccarone, Terrence M., Leu, Chih-Tai, Lumma, Patricia K., Freidinger, Roger M., Veber, Daniel F., Sigal, Irving S.

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ANTINOCISPONSIVE EFFECTS OF NEUROTENSIN AND NEUROTENSIN-RELATED PEPTIDES von Clineschmidt, Bradley V., Martin, Gregory E., Veber, Daniel F.

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