Exosomal delivery of doxorubicin enables rapid cell entry and enhanced in vitro potency von Schindler, Christina, Collinson, Andie, Matthews, Carl, Pointon, Amy, Jenkinson, Lesley, Minter, Ralph R, Vaughan, Tristan J, Tigue, Natalie J

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Overcoming the Refractory Expression of Secreted Recombinant Proteins in Mammalian Cells through Modification of the Signal Peptide and Adjacent Amino Acids von Güler-Gane, Gülin, Kidd, Sara, Sridharan, Sudharsan, Vaughan, Tristan J, Wilkinson, Trevor C I, Tigue, Natalie J

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Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation von Cohen, E. Suzanne, Scott, Ian C., Majithiya, Jayesh B., Rapley, Laura, Kemp, Benjamin P., England, Elizabeth, Rees, D. Gareth, Overed-Sayer, Catherine L., Woods, Joanne, Bond, Nicholas J., Veyssier, Christel Séguy, Embrey, Kevin J., Sims, Dorothy A., Snaith, Michael R., Vousden, Katherine A., Strain, Martin D., Chan, Denice T. Y., Carmen, Sara, Huntington, Catherine E., Flavell, Liz, Xu, Jianqing, Popovic, Bojana, Brightling, Christopher E., Vaughan, Tristan J., Butler, Robin, Lowe, David C., Higazi, Daniel R., Corkill, Dominic J., May, Richard D., Sleeman, Matthew A., Mustelin, Tomas

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Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction von England, Elizabeth, Rees, D. Gareth, Scott, Ian Christopher, Carmen, Sara, Chan, Denice T. Y., Chaillan Huntington, Catherine E., Houslay, Kirsty F., Erngren, Teodor, Penney, Mark, Majithiya, Jayesh B., Rapley, Laura, Sims, Dorothy A., Hollins, Claire, Hinchy, Elizabeth C., Strain, Martin D., Kemp, Benjamin P., Corkill, Dominic J., May, Richard D., Vousden, Katherine A., Butler, Robin J., Mustelin, Tomas, Vaughan, Tristan J., Lowe, David C., Colley, Caroline, Cohen, E. Suzanne

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Experimentally guided computational antibody affinity maturation with de novo docking, modelling and rational design von Cannon, Daniel A, Shan, Lu, Du, Qun, Shirinian, Lena, Rickert, Keith W, Rosenthal, Kim L, Korade, 3rd, Martin, van Vlerken-Ysla, Lilian E, Buchanan, Andrew, Vaughan, Tristan J, Damschroder, Melissa M, Popovic, Bojana

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Computational Design of Epitope-Specific Functional Antibodies von Nimrod, Guy, Fischman, Sharon, Austin, Mark, Herman, Asael, Keyes, Feenagh, Leiderman, Olga, Hargreaves, David, Strajbl, Marek, Breed, Jason, Klompus, Shelley, Minton, Kevin, Spooner, Jennifer, Buchanan, Andrew, Vaughan, Tristan J., Ofran, Yanay

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Antibodies binding the head domain of P2X4 inhibit channel function and reverse neuropathic pain von Williams, Wendy A., Linley, John E., Jones, Clare A., Shibata, Yoko, Snijder, Arjan, Button, James, Hatcher, Jon P., Huang, Ling, Taddese, Bruck, Thornton, Peter, Schofield, Darren J., Thom, George, Popovic, Bojana, Dosanjh, Bhupinder, Wilkinson, Trevor, Hughes, Jane, Dobson, Claire L., Groves, Maria A., Webster, Carl I., Billinton, Andy, Vaughan, Tristan J., Chessell, Iain

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A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies von Macleod, Olivia J. S., Bart, Jean-Mathieu, MacGregor, Paula, Peacock, Lori, Savill, Nicholas J., Hester, Svenja, Ravel, Sophie, Sunter, Jack D., Trevor, Camilla, Rust, Steven, Vaughan, Tristan J., Minter, Ralph, Mohammed, Shabaz, Gibson, Wendy, Taylor, Martin C., Higgins, Matthew K., Carrington, Mark

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A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis von MacGregor, Paula, Gonzalez-Munoz, Andrea L, Jobe, Fatoumatta, Taylor, Martin C, Rust, Steven, Sandercock, Alan M, Macleod, Olivia J S, Van Bocxlaer, Katrien, Francisco, Amanda F, D'Hooge, Francois, Tiberghien, Arnaud, Barry, Conor S, Howard, Philip, Higgins, Matthew K, Vaughan, Tristan J, Minter, Ralph, Carrington, Mark

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Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action von Austin, Mark, Burschowsky, Daniel, Chan, Denice T Y, Jenkinson, Lesley, Haynes, Stuart, Diamandakis, Agata, Seewooruthun, Chitra, Addyman, Alexandra, Fiedler, Sebastian, Ryman, Stephanie, Whitehouse, Jessica, Slater, Louise H, Hadjinicolaou, Andreas V, Gileadi, Uzi, Gowans, Ellen, Shibata, Yoko, Barnard, Michelle, Kaserer, Teresa, Sharma, Pooja, Luheshi, Nadia M, Wilkinson, Robert W, Vaughan, Tristan J, Holt, Sarah V, Cerundolo, Vincenzo, Carr, Mark D, Groves, Maria A T

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A novel IgE-neutralizing antibody for the treatment of severe uncontrolled asthma von Cohen, E Suzanne, Dobson, Claire L, Käck, Helena, Wang, Bing, Sims, Dorothy A, Lloyd, Christopher O, England, Elizabeth, Rees, D Gareth, Guo, Hongwei, Karagiannis, Sophia N, O'Brien, Siobhan, Persdotter, Sofia, Ekdahl, Helena, Butler, Robin, Keyes, Feenagh, Oakley, Sarah, Carlsson, Mats, Briend, Emmanuel, Wilkinson, Trevor, Anderson, Ian K, Monk, Phillip D, von Wachenfeldt, Karin, Eriksson, Per-Olof F, Gould, Hannah J, Vaughan, Tristan J, May, Richard D

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Machine learning designs new GCGR/GLP-1R dual agonists with enhanced biological potency von Puszkarska, Anna M., Taddese, Bruck, Revell, Jefferson, Davies, Graeme, Field, Joss, Hornigold, David C., Buchanan, Andrew, Vaughan, Tristan J., Colwell, Lucy J.

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Evolution of biologics screening technologies von Cariuk, Peter, Gardener, Matthew J, Vaughan, Tristan J

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Rate of Asparagine Deamidation in a Monoclonal Antibody Correlating with Hydrogen Exchange Rate at Adjacent Downstream Residues von Phillips, Jonathan J, Buchanan, Andrew, Andrews, John, Chodorge, Matthieu, Sridharan, Sudharsan, Mitchell, Laura, Burmeister, Nicole, Kippen, Alistair D, Vaughan, Tristan J, Higazi, Daniel R, Lowe, David

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Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo von Dobson, Claire L., Devine, Paul W. A., Phillips, Jonathan J., Higazi, Daniel R., Lloyd, Christopher, Popovic, Bojana, Arnold, Joanne, Buchanan, Andrew, Lewis, Arthur, Goodman, Joanne, van der Walle, Christopher F., Thornton, Peter, Vinall, Lisa, Lowne, David, Aagaard, Anna, Olsson, Lise-Lotte, Ridderstad Wollberg, Anna, Welsh, Fraser, Karamanos, Theodoros K., Pashley, Clare L., Iadanza, Matthew G., Ranson, Neil A., Ashcroft, Alison E., Kippen, Alistair D., Vaughan, Tristan J., Radford, Sheena E., Lowe, David C.

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A direct role for SNX9 in the biogenesis of filopodia von Jarsch, Iris K, Gadsby, Jonathan R, Nuccitelli, Annalisa, Mason, Julia, Shimo, Hanae, Pilloux, Ludovic, Marzook, Bishara, Mulvey, Claire M, Dobramysl, Ulrich, Bradshaw, Charles R, Lilley, Kathryn S, Hayward, Richard D, Vaughan, Tristan J, Dobson, Claire L, Gallop, Jennifer L

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Human monomeric antibody fragments to TRAIL-R1 and TRAIL-R2 that display potent in vitro agonism von Dobson, Claire L., Main, Sarah, Newton, Philip, Chodorge, Matthieu, Cadwallader, Karen, Humphreys, Robin C., Albert, Vivian, Vaughan, Tristan J., Minter, Ralph R., Edwards, Bryan M.

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MEDI1814 selectively reduces free Aβ42 in cerebrospinal fluid of non‐clinical species and Alzheimer's disease patients von Lloyd, Christopher, Freskgård, Per‐Ola, Newton, Philip, Lowne, David, Nickson, Adrian, Bogstedt, Anna, Eketjäll, Susanna, Höglund, Kina, Gustavsson, Susanne, Welsh, Fraser, Chessell, Tharani, McFarlane, Mary, Bhat, Ratan V., Turner, Richard, Perkinton, Michael S., Santisteban Valencia, Zulma, Lindqvist, Eva, Pomfret, Michael, Dudley, Amanda D., Vaughan, Tristan J., Groves, Maria T., Natanegara, Fanni, Feng, Yingdong, Sims, John R., Proctor, Nicholas Kyle, Dage, Jeffrey L., Shering, Craig, Tan, Keith, Ostenfeld, Thor, Billinton, Andy, Chessell, Iain P.

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Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1 von Vousden, Katherine A., Lundqvist, Tomas, Popovic, Bojana, Naiman, Brian, Carruthers, Alan M., Newton, Philip, Johnson, Daniel J. D., Pomowski, Anja, Wilkinson, Trevor, Dufner, Patrick, de Mendez, Isabelle, Mallinder, Philip R., Murray, Clare, Strain, Martin, Connor, Jane, Murray, Lynne A., Sleeman, Matthew A., Lowe, David C., Huntington, James A., Vaughan, Tristan J.

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Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation von Chan, Denice T. Y., Jenkinson, Lesley, Haynes, Stuart W., Austin, Mark, Diamandakis, Agata, Burschowsky, Daniel, Seewooruthun, Chitra, Addyman, Alexandra, Fiedler, Sebastian, Ryman, Stephanie, Whitehouse, Jessica, Slater, Louise H., Gowans, Ellen, Shibata, Yoko, Barnard, Michelle, Wilkinson, Robert W., Vaughan, Tristan J., Holt, Sarah V., Cerundolo, Vincenzo, Carr, Mark D., Groves, Maria A. T.

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