Exosomal delivery of doxorubicin enables rapid cell entry and enhanced in vitro potency von Schindler, Christina, Collinson, Andie, Matthews, Carl, Pointon, Amy, Jenkinson, Lesley, Minter, Ralph R, Vaughan, Tristan J, Tigue, Natalie J

Volltext

Overcoming the Refractory Expression of Secreted Recombinant Proteins in Mammalian Cells through Modification of the Signal Peptide and Adjacent Amino Acids von Güler-Gane, Gülin, Kidd, Sara, Sridharan, Sudharsan, Vaughan, Tristan J, Wilkinson, Trevor C I, Tigue, Natalie J

Volltext

Experimentally guided computational antibody affinity maturation with de novo docking, modelling and rational design von Cannon, Daniel A, Shan, Lu, Du, Qun, Shirinian, Lena, Rickert, Keith W, Rosenthal, Kim L, Korade, 3rd, Martin, van Vlerken-Ysla, Lilian E, Buchanan, Andrew, Vaughan, Tristan J, Damschroder, Melissa M, Popovic, Bojana

Volltext

Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation von Cohen, E. Suzanne, Scott, Ian C., Majithiya, Jayesh B., Rapley, Laura, Kemp, Benjamin P., England, Elizabeth, Rees, D. Gareth, Overed-Sayer, Catherine L., Woods, Joanne, Bond, Nicholas J., Veyssier, Christel Séguy, Embrey, Kevin J., Sims, Dorothy A., Snaith, Michael R., Vousden, Katherine A., Strain, Martin D., Chan, Denice T. Y., Carmen, Sara, Huntington, Catherine E., Flavell, Liz, Xu, Jianqing, Popovic, Bojana, Brightling, Christopher E., Vaughan, Tristan J., Butler, Robin, Lowe, David C., Higazi, Daniel R., Corkill, Dominic J., May, Richard D., Sleeman, Matthew A., Mustelin, Tomas

Volltext

Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction von England, Elizabeth, Rees, D. Gareth, Scott, Ian Christopher, Carmen, Sara, Chan, Denice T. Y., Chaillan Huntington, Catherine E., Houslay, Kirsty F., Erngren, Teodor, Penney, Mark, Majithiya, Jayesh B., Rapley, Laura, Sims, Dorothy A., Hollins, Claire, Hinchy, Elizabeth C., Strain, Martin D., Kemp, Benjamin P., Corkill, Dominic J., May, Richard D., Vousden, Katherine A., Butler, Robin J., Mustelin, Tomas, Vaughan, Tristan J., Lowe, David C., Colley, Caroline, Cohen, E. Suzanne

Volltext

High affinity single-chain variable fragments are specific and versatile targeting motifs for extracellular vesicles von Longatti, Andrea, Schindler, Christina, Collinson, Andie, Jenkinson, Lesley, Matthews, Carl, Fitzpatrick, Laura, Blundy, Margaret, Minter, Ralph, Vaughan, Tristan, Shaw, Michael, Tigue, Natalie

Volltext

Machine learning designs new GCGR/GLP-1R dual agonists with enhanced biological potency von Puszkarska, Anna M., Taddese, Bruck, Revell, Jefferson, Davies, Graeme, Field, Joss, Hornigold, David C., Buchanan, Andrew, Vaughan, Tristan J., Colwell, Lucy J.

Volltext

Computational Design of Epitope-Specific Functional Antibodies von Nimrod, Guy, Fischman, Sharon, Austin, Mark, Herman, Asael, Keyes, Feenagh, Leiderman, Olga, Hargreaves, David, Strajbl, Marek, Breed, Jason, Klompus, Shelley, Minton, Kevin, Spooner, Jennifer, Buchanan, Andrew, Vaughan, Tristan J., Ofran, Yanay

Volltext

A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis von MacGregor, Paula, Gonzalez-Munoz, Andrea L, Jobe, Fatoumatta, Taylor, Martin C, Rust, Steven, Sandercock, Alan M, Macleod, Olivia J S, Van Bocxlaer, Katrien, Francisco, Amanda F, D'Hooge, Francois, Tiberghien, Arnaud, Barry, Conor S, Howard, Philip, Higgins, Matthew K, Vaughan, Tristan J, Minter, Ralph, Carrington, Mark

Volltext

Antibodies binding the head domain of P2X4 inhibit channel function and reverse neuropathic pain von Williams, Wendy A., Linley, John E., Jones, Clare A., Shibata, Yoko, Snijder, Arjan, Button, James, Hatcher, Jon P., Huang, Ling, Taddese, Bruck, Thornton, Peter, Schofield, Darren J., Thom, George, Popovic, Bojana, Dosanjh, Bhupinder, Wilkinson, Trevor, Hughes, Jane, Dobson, Claire L., Groves, Maria A., Webster, Carl I., Billinton, Andy, Vaughan, Tristan J., Chessell, Iain

Volltext

A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies von Macleod, Olivia J. S., Bart, Jean-Mathieu, MacGregor, Paula, Peacock, Lori, Savill, Nicholas J., Hester, Svenja, Ravel, Sophie, Sunter, Jack D., Trevor, Camilla, Rust, Steven, Vaughan, Tristan J., Minter, Ralph, Mohammed, Shabaz, Gibson, Wendy, Taylor, Martin C., Higgins, Matthew K., Carrington, Mark

Volltext

A direct role for SNX9 in the biogenesis of filopodia von Jarsch, Iris K, Gadsby, Jonathan R, Nuccitelli, Annalisa, Mason, Julia, Shimo, Hanae, Pilloux, Ludovic, Marzook, Bishara, Mulvey, Claire M, Dobramysl, Ulrich, Bradshaw, Charles R, Lilley, Kathryn S, Hayward, Richard D, Vaughan, Tristan J, Dobson, Claire L, Gallop, Jennifer L

Volltext

Rate of Asparagine Deamidation in a Monoclonal Antibody Correlating with Hydrogen Exchange Rate at Adjacent Downstream Residues von Phillips, Jonathan J, Buchanan, Andrew, Andrews, John, Chodorge, Matthieu, Sridharan, Sudharsan, Mitchell, Laura, Burmeister, Nicole, Kippen, Alistair D, Vaughan, Tristan J, Higazi, Daniel R, Lowe, David

Volltext

Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo von Dobson, Claire L., Devine, Paul W. A., Phillips, Jonathan J., Higazi, Daniel R., Lloyd, Christopher, Popovic, Bojana, Arnold, Joanne, Buchanan, Andrew, Lewis, Arthur, Goodman, Joanne, van der Walle, Christopher F., Thornton, Peter, Vinall, Lisa, Lowne, David, Aagaard, Anna, Olsson, Lise-Lotte, Ridderstad Wollberg, Anna, Welsh, Fraser, Karamanos, Theodoros K., Pashley, Clare L., Iadanza, Matthew G., Ranson, Neil A., Ashcroft, Alison E., Kippen, Alistair D., Vaughan, Tristan J., Radford, Sheena E., Lowe, David C.

Volltext

MEDI1814 selectively reduces free Aβ42 in cerebrospinal fluid of non‐clinical species and Alzheimer's disease patients von Lloyd, Christopher, Freskgård, Per‐Ola, Newton, Philip, Lowne, David, Nickson, Adrian, Bogstedt, Anna, Eketjäll, Susanna, Höglund, Kina, Gustavsson, Susanne, Welsh, Fraser, Chessell, Tharani, McFarlane, Mary, Bhat, Ratan V., Turner, Richard, Perkinton, Michael S., Santisteban Valencia, Zulma, Lindqvist, Eva, Pomfret, Michael, Dudley, Amanda D., Vaughan, Tristan J., Groves, Maria T., Natanegara, Fanni, Feng, Yingdong, Sims, John R., Proctor, Nicholas Kyle, Dage, Jeffrey L., Shering, Craig, Tan, Keith, Ostenfeld, Thor, Billinton, Andy, Chessell, Iain P.

Volltext

Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation von Chan, Denice T. Y., Jenkinson, Lesley, Haynes, Stuart W., Austin, Mark, Diamandakis, Agata, Burschowsky, Daniel, Seewooruthun, Chitra, Addyman, Alexandra, Fiedler, Sebastian, Ryman, Stephanie, Whitehouse, Jessica, Slater, Louise H., Gowans, Ellen, Shibata, Yoko, Barnard, Michelle, Wilkinson, Robert W., Vaughan, Tristan J., Holt, Sarah V., Cerundolo, Vincenzo, Carr, Mark D., Groves, Maria A. T.

Volltext

Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1 von Vousden, Katherine A., Lundqvist, Tomas, Popovic, Bojana, Naiman, Brian, Carruthers, Alan M., Newton, Philip, Johnson, Daniel J. D., Pomowski, Anja, Wilkinson, Trevor, Dufner, Patrick, de Mendez, Isabelle, Mallinder, Philip R., Murray, Clare, Strain, Martin, Connor, Jane, Murray, Lynne A., Sleeman, Matthew A., Lowe, David C., Huntington, James A., Vaughan, Tristan J.

Volltext

Haplosaurus computes protein haplotypes for use in precision drug design von Spooner, William, McLaren, William, Slidel, Timothy, Finch, Donna K., Butler, Robin, Campbell, Jamie, Eghobamien, Laura, Rider, David, Kiefer, Christine Mione, Robinson, Matthew J., Hardman, Colin, Cunningham, Fiona, Vaughan, Tristan, Flicek, Paul, Huntington, Catherine Chaillan

Volltext

Interactions Between the Gravitostat and the Fibroblast Growth Factor System for the Regulation of Body Weight von Palsdottir, Vilborg, Windahl, Sara H, Hägg, Daniel A, Keantar, Hanna, Bellman, Jakob, Buchanan, Andrew, Vaughan, Tristan J, Lindén, Daniel, Jansson, John-Olov, Ohlsson, Claes

Volltext

Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors von Colley, Caroline S, Popovic, Bojana, Sridharan, Sudharsan, Debreczeni, Judit E, Hargeaves, David, Fung, Michael, An, Ling-Ling, Edwards, Bryan, Arnold, Joanne, England, Elizabeth, Eghobamien, Laura, Sivars, Ulf, Flavell, Liz, Renshaw, Jonathan, Wickson, Kate, Warrener, Paul, Zha, Jingying, Bonnell, Jessica, Woods, Rob, Wilkinson, Trevor, Dobson, Claire, Vaughan, Tristan J

Volltext