Risk stratification of childhood medulloblastoma in the molecular era: the current consensus von Ramaswamy, Vijay, Remke, Marc, Bouffet, Eric, Bailey, Simon, Clifford, Steven C., Doz, Francois, Kool, Marcel, Dufour, Christelle, Vassal, Gilles, Milde, Till, Witt, Olaf, von Hoff, Katja, Pietsch, Torsten, Northcott, Paul A., Gajjar, Amar, Robinson, Giles W., Padovani, Laetitia, André, Nicolas, Massimino, Maura, Pizer, Barry, Packer, Roger, Rutkowski, Stefan, Pfister, Stefan M., Taylor, Michael D., Pomeroy, Scott L.

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Diverse Resistance Mechanisms to the Third-Generation ALK Inhibitor Lorlatinib in ALK-Rearranged Lung Cancer von Recondo, Gonzalo, Mezquita, Laura, Facchinetti, Francesco, Planchard, David, Gazzah, Anas, Bigot, Ludovic, Rizvi, Ahsan Z, Frias, Rosa L, Thiery, Jean Paul, Scoazec, Jean-Yves, Sourisseau, Tony, Howarth, Karen, Deas, Olivier, Samofalova, Dariia, Galissant, Justine, Tesson, Pauline, Braye, Floriane, Naltet, Charles, Lavaud, Pernelle, Mahjoubi, Linda, Abou Lovergne, Aurélie, Vassal, Gilles, Bahleda, Rastilav, Hollebecque, Antoine, Nicotra, Claudio, Ngo-Camus, Maud, Michiels, Stefan, Lacroix, Ludovic, Richon, Catherine, Auger, Nathalie, De Baere, Thierry, Tselikas, Lambros, Solary, Eric, Angevin, Eric, Eggermont, Alexander M, Andre, Fabrice, Massard, Christophe, Olaussen, Ken A, Soria, Jean-Charles, Besse, Benjamin, Friboulet, Luc

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Molecular Screening for Cancer Treatment Optimization (MOSCATO-01) in Pediatric Patients: A Single-Institutional Prospective Molecular Stratification Trial von Harttrampf, Anne C, Lacroix, Ludovic, Deloger, Marc, Deschamps, Frederic, Puget, Stephanie, Auger, Nathalie, Vielh, Philippe, Varlet, Pascale, Balogh, Zsofia, Abbou, Samuel, Allorant, Adrien, Valteau-Couanet, Dominique, Sarnacki, Sabine, Gamiche-Rolland, Louise, Meurice, Guillaume, Minard-Colin, Veronique, Grill, Jacques, Brugieres, Laurence, Dufour, Christelle, Gaspar, Nathalie, Michiels, Stefan, Vassal, Gilles, Soria, Jean-Charles, Geoerger, Birgit

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Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas von Puget, Stephanie, Philippe, Cathy, Bax, Dorine A, Job, Bastien, Varlet, Pascale, Junier, Marie-Pierre, Andreiuolo, Felipe, Carvalho, Dina, Reis, Ricardo, Guerrini-Rousseau, Lea, Roujeau, Thomas, Dessen, Philippe, Richon, Catherine, Lazar, Vladimir, Le Teuff, Gwenael, Sainte-Rose, Christian, Geoerger, Birgit, Vassal, Gilles, Jones, Chris, Grill, Jacques

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Molecular Characterization of Breast Cancer with High-Resolution Oligonucleotide Comparative Genomic Hybridization Array von ANDRE, Fabrice, JOB, Bastien, DELALOGE, Suzette, HORTOBAGYI, Gabriel N, SYMMANS, W. Fraser, LAZAR, Vladimir, PUSZTAI, Lajos, DESSEN, Philippe, TORDAI, Attila, MICHIELS, Stefan, LIEDTKE, Cornelia, RICHON, Catherine, KAI YAN, BAILANG WANG, VASSAL, Gilles

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Abstract IA16: Accelerating innovation for children with cancer in the new regulatory environment von Vassal, Gilles

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GX15-070 (Obatoclax), a Bcl-2 family proteins inhibitor engenders apoptosis and pro-survival autophagy and increases Chemosensitivity in neuroblastoma von Cournoyer, Sonia, Addioui, Anissa, Belounis, Assila, Beaunoyer, Mona, Nyalendo, Carine, Le Gall, Roxane, Teira, Pierre, Haddad, Elie, Vassal, Gilles, Sartelet, Hervé

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Regorafenib: Antitumor Activity upon Mono and Combination Therapy in Preclinical Pediatric Malignancy Models von Daudigeos-Dubus, Estelle, Le Dret, Ludivine, Lanvers-Kaminsky, Claudia, Bawa, Olivia, Opolon, Paule, Vievard, Albane, Villa, Irène, Pagès, Mélanie, Bosq, Jacques, Vassal, Gilles, Zopf, Dieter, Geoerger, Birgit

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New drugs for children and adolescents with cancer: the need for novel development pathways von Vassal, Gilles, Prof, Zwaan, C Michel, MD PhD, Ashley, David, Prof, Le Deley, Marie Cecile, MD PhD, Hargrave, Darren, MD PhD, Blanc, Patricia, MIM, Adamson, Peter C, MD

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New policies to address the global burden of childhood cancers von Sullivan, Richard, Prof, Kowalczyk, Jerzy R, Prof, Agarwal, Bharat, MD, Ladenstein, Ruth, Prof, Fitzgerald, Edel, PhD, Barr, Ronald, Prof, Steliarova-Foucher, Eva, PhD, Magrath, Ian, Prof, Howard, Scott C, MD, Kruger, Mariana, Prof, Valsecchi, Maria Grazia, MD, Biondi, Andrea, Prof, Grundy, Paul, MD, Smith, Malcolm A, MD, Adamson, Peter, MD, Vassal, Gilles, Prof, Pritchard-Jones, Kathy, Prof

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Long-term efficacy of crizotinib in a metastatic papillary renal carcinoma with MET amplification: a case report and literature review von Rochigneux, Philippe, Thomassin-Piana, Jeanne, Laibe, Sophy, Brunelle, Serge, Salem, Naji, Escudier, Bernard, Vassal, Gilles, Gravis, Gwenaelle

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Rationale and design of ON-TRK: a novel prospective non-interventional study in patients with TRK fusion cancer treated with larotrectinib von Yang, James C H, Brose, Marcia S, Castro, Gilberto, Kim, Edward S, Lassen, Ulrik N, Leyvraz, Serge, Pappo, Alberto, López-Ríos, Fernando, Reeves, John A, Fellous, Marc, Penault-Llorca, Frédérique, Rudzinski, Erin R, Tabatabai, Ghazaleh, Vassal, Gilles, Drilon, Alexander, Trent, Jonathan

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Dual inhibition using cabozantinib overcomes HGF/MET signaling mediated resistance to pan-VEGFR inhibition in orthotopic and metastatic neuroblastoma tumors von Daudigeos-Dubus, Estelle, Le Dret, Ludivine, Bawa, Olivia, Opolon, Paule, Vievard, Albane, Villa, Irène, Bosq, Jacques, Vassal, Gilles, Geoerger, Birgit

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Involvement of the CXCR7/CXCR4/CXCL12 axis in the malignant progression of human neuroblastoma von Liberman, Julie, Sartelet, Hervé, Flahaut, Marjorie, Mühlethaler-Mottet, Annick, Coulon, Aurélie, Nyalendo, Carine, Vassal, Gilles, Joseph, Jean-Marc, Gross, Nicole

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Population Pharmacokinetics and Pharmacogenetics of Imatinib in Children and Adults von RETAIN, Aurélie, KATTYGNARATH, Darouna, AZARD, Julie, CHATELUT, Etienne, DELBALDO, Catherine, GEOERGER, Birgit, BARROIS, Michel, SERONIE-VIVIEN, Sophie, LECESNE, Axel, VASSAL, Gilles

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Longitudinal characterization of primary osteosarcoma and derived subcutaneous and orthotopic relapsed patient-derived xenograft models von da Costa, Maria Eugenia Marques, Droit, Robin, Khneisser, Pierre, Gomez-Brouchet, Anne, Adam-de-Beaumais, Tiphaine, Nolla, Marie, Signolles, Nicolas, Torrejon, Jacob, Lombard, Bérangère, Loew, Damarys, Ayrault, Olivier, Scoazec, Jean-Yves, Geoerger, Birgit, Vassal, Gilles, Marchais, Antonin, Gaspar, Nathalie

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SIOPE and ESOP recommendations for extemporaneous compounding of oral liquid medicine formulations in paediatric oncology von Otsokolhich, Marko, Annereau, Maxime, Bauters, Tiene, Horvath, Laszlo, Nehal, Chahinez, Kamal, Sherif, Vassal, Gilles, Buraja, Svetlana

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How Can Genomic Innovations in Pediatric Brain Tumors Transform Outcomes in Low- and Middle-Income Countries? von Bailey, Simon, Davidson, Alan, Parkes, Jeannette, Tabori, Uri, Figaji, Anthony, Epari, Shridar, Chinnaswamy, Girish, Dias-Coronado, Rosaldi, Casavilca-Zambrano, Sandro, Amayiri, Nisreen, Vassal, Gilles, Bouffet, Eric, Clifford, Steven C

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The Activity of Crizotinib in Chemo-Refractory MET-Amplified Esophageal and Gastric Adenocarcinomas: Results from the AcSé-Crizotinib Program von Aparicio, Thomas, Cozic, Nathalie, de la Fouchardière, Christelle, Meriaux, Emeline, Plaza, Jérome, Mineur, Laurent, Guimbaud, Rosine, Samalin, Emmanuelle, Mary, Florence, Lecomte, Thierry, Gomez-Roca, Carlos, Haineaux, Paul-Arthur, Gratet, Alain, Selves, Jannick, Menu, Yves, Colignon, Nikias, Johnson, Laetitia, Legrand, Frédéric, Vassal, Gilles

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Changing incentives to ACCELERATE drug development for paediatric cancer von Rojas, Teresa, Kearns, Pamela, Blanc, Patricia, Skolnik, Jeffrey, Fox, Elizabeth, Knox, Leona, Rousseau, Raphael, Doz, François, Bird, Nick, Pearson, Andrew J., Vassal, Gilles

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