Phase I Dose-Escalation Study of the Anti-CD70 Antibody ARGX-110 in Advanced Malignancies von Aftimos, Philippe, Rolfo, Christian, Rottey, Sylvie, Offner, Fritz, Bron, Dominique, Maerevoet, Marie, Soria, Jean-Charles, Moshir, Mahan, Dreier, Torsten, Van Rompaey, Luc, Michot, Jean-Marie, Silence, Karen, Hultberg, Anna, Gandini, Domenica, de Haard, Hans, Ribrag, Vincent, Peeters, Marc, Thibault, Alain, Leupin, Nicolas, Awada, Ahmad

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Screening a Broad Range of Solid and Haematological Tumour Types for CD70 Expression Using a Uniform IHC Methodology as Potential Patient Stratification Method von Flieswasser, Tal, Camara-Clayette, Valérie, Danu, Alina, Bosq, Jacques, Ribrag, Vincent, Zabrocki, Piotr, Van Rompaey, Luc, de Haard, Hans, Zwaenepoel, Karen, Smits, Evelien, Pauwels, Patrick, Jacobs, Julie

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Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents von Riether, Carsten, Pabst, Thomas, Höpner, Sabine, Bacher, Ulrike, Hinterbrandner, Magdalena, Banz, Yara, Müller, Rouven, Manz, Markus G., Gharib, Walid H., Francisco, David, Bruggmann, Remy, van Rompaey, Luc, Moshir, Mahan, Delahaye, Tim, Gandini, Domenica, Erzeel, Ellen, Hultberg, Anna, Fung, Samson, de Haard, Hans, Leupin, Nicolas, Ochsenbein, Adrian F.

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Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases von Van Rompaey, Luc, Galien, René, van der Aar, Ellen M, Clement-Lacroix, Philippe, Nelles, Luc, Smets, Bart, Lepescheux, Liên, Christophe, Thierry, Conrath, Katja, Vandeghinste, Nick, Vayssiere, Béatrice, De Vos, Steve, Fletcher, Stephen, Brys, Reginald, van 't Klooster, Gerben, Feyen, Jean H M, Menet, Christel

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Cusatuzumab for treatment of CD70‐positive relapsed or refractory cutaneous T‐cell lymphoma von Leupin, Nicolas, Zinzani, Pier Luigi, Morschhauser, Franck, Dalle, Stéphane, Maerevoet, Marie, Michot, Jean‐Marie, Ribrag, Vincent, Offner, Fritz, Beylot‐Barry, Marie, Moins‐Teisserenc, Hélène, Zwaenepoel, Karen, Winne, Koen, Battistella, Maxime, Hultberg, Anna, Gandini, Domenica, Moshir, Mahan, Jacobs, Julie, Delahaye, Tim, Khan, Aitzaz, Zabrocki, Piotr, Silence, Karen, Rompaey, Luc, Borg, Christophe, Motta, Giovanna, Melle, Federica, Calleri, Angelica, Pauwels, Patrick, Haard, Hans, Pileri, Stefano, Bagot, Martine

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The NHance® Mutation-Equipped Anti-MET Antibody ARGX-111 Displays Increased Tissue Penetration and Anti-Tumor Activity in Advanced Cancer Patients von Aftimos, Philippe, Rolfo, Christian, Rottey, Sylvie, Barthélémy, Philippe, Borg, Christophe, Park, Keunchil, Oh, Do-Youn, Kim, Sang-We, De Jonge, Natalie, Hanssens, Valérie, Zwanenpoel, Karen, Molthoff, Carla, Vugts, Daniëlle, Dreier, Torsten, Verheesen, Peter, van Dongen, Guus A.M.S., Jacobs, Julie, Van Rompaey, Luc, Hultberg, Anna, Michieli, Paolo, Pauwels, Patrick, Fung, Samson, Thibault, Alain, de Haard, Hans, Leupin, Nicolas, Awada, Ahmad

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Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2... von Schwaller, Juerg, Frantsve, Julie, Aster, Jon, Williams, Ifor R., Tomasson, Michael H., Ross, Theodora S., Peeters, Pieter, Van Rompaey, Luc, Van Etten, Richard A., Ilaria Jr, Robert, Marynen, Peter, Gilliland, D.Gary

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Arrayed adenoviral expression libraries for functional screening von van Es, Helmuth, Michiels, Frits, van Rompaey, Luc, Merchiers, Pascal, Francken, Bart, Pittois, Karen, van der Schueren, Jan, Brys, Reginald, Vandersmissen, Johan, Beirinckx, Filip, Herman, Sofie, Dokic, Kristina, Klaassen, Hugo, Narinx, Evi, Hagers, Annick, Laenen, Wendy, Piest, Ivo, Pavliska, Heidi, Rombout, Yvonne, Langemeijer, Ellen, Ma, Libin, Schipper, Christel, Raeymaeker, Marc De, Schweicher, Stephane, Jans, Mia, van Beeck, Kris, Tsang, Ing-Ren, van de Stolpe, Onno, Tomme, Peter

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Anti-CD70 Monoclonal Antibodies Show Efficacy in Preclinical Models for Chronic Lymphoblastic Leukemia von Chen, Shih-Shih, Yan, Xiao-Jie, Van Rompaey, Luc, Zabrocki, Piotr, Chiorazzi, Nicholas

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The MN1-TEL Fusion Protein, Encoded by the Translocation (12;22)(p13;q11) in Myeloid Leukemia, Is a Transcription Factor with Transforming Activity von Buijs, Arjan, van Rompaey, Luc, Molijn, Anco C., Davis, J. Nathan, Vertegaal, Alfred C. O., Potter, Mark D., Adams, Constantin, van Baal, Sjozèf, Zwarthoff, Ellen C., Roussel, Martine F., Grosveld, Gerard C.

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Triazolopyridines as Selective JAK1 Inhibitors: From Hit Identification to GLPG0634 von Menet, Christel J, Fletcher, Stephen R, Van Lommen, Guy, Geney, Raphael, Blanc, Javier, Smits, Koen, Jouannigot, Nolwenn, Deprez, Pierre, van der Aar, Ellen M, Clement-Lacroix, Philippe, Lepescheux, Liên, Galien, René, Vayssiere, Béatrice, Nelles, Luc, Christophe, Thierry, Brys, Reginald, Uhring, Muriel, Ciesielski, Fabrice, Van Rompaey, Luc

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Generic design principles for antibody-based tumour necrosis factor (TNF) receptor 2 (TNFR2) agonists with FcγR-independent agonism von Anany, Mohamed A, Haack, Stefanie, Lang, Isabell, Dahlhoff, Julia, Vargas, Juan Gamboa, Steinfatt, Tim, Päckert, Lea, Weisenberger, Daniela, Zaitseva, Olena, Medler, Juliane, Kucka, Kirstin, Zhang, Tengyu, Van Belle, Tom, van Rompaey, Luc, Beilhack, Andreas, Wajant, Harald

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Blocking CD70/CD27 Signaling in Combination with Hypomethylating Agents Eradicates Human CD34+ AML Stem and Progenitor Cells in Vitro and In Vivo von Hinterbrandner, Magdalena, Kallen, Nils Maria, Lüthi, Ursina, Pabst, Thomas, Van Rompaey, Luc, Leupin, Nicolas, De Haard, Hans, Ochsenbein, Adrian F, Riether, Carsten

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Targeting CD70 with Cusatuzumab Eliminates Acute Myeloid Leukemia Stem Cells in Humans von Ochsenbein, Adrian F, Pabst, Thomas, Höpner, Sabine, Bacher, Vera Ulrike, Hinterbrandner, Magdalena, Banz, Yara, Müller, Rouven, Manz, Markus G., Gharib, Walid, Francisco, David, Bruggmann, Rémy, Van Rompaey, Luc, Moshir, Mahan, Delahaye, Tim, Gandini, Domenica, Erzeel, Ellen, Hultberg, Anna, Fung, Samson, De Haard, Hans, Leupin, Nicolas, Riether, Carsten

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Argx-110 Targeting CD70, in Combination with Azacitidine, Shows Favorable Safety Profile and Promising Anti-Leukemia Activity in Newly Diagnosed AML Patients in an Ongoing Phase 1/... von Ochsenbein, Adrian F, Riether, Carsten, Bacher, Ulrike, Müller, Rouven, Höpner, Sabine, Banz, Yara, Hinterbrandner, Magdalena, Bargetzi, Mario, Manz, Markus G., Van Rompaey, Luc, Moshir, Mahan, Delahaye, Tim, Gandini, Domenica, Erzeel, Ellen, Hultberg, Anna, Fung, Samson, De Haard, Hans, Leupin, Nicolas, Pabst, Thomas

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Argx-110 for Treatment of CD70-Positive Advanced Cutaneous T-Cell Lymphoma in a Phase 1/2 Clinical Trial von Bagot, Martine, Maerevoet, Marie, Zinzani, Pier Luigi, Offner, Fritz, Morschhauser, Franck, Michot, Jean-Marie, Ribrag, Vincent, Battistella, Maxime, Moins, Helene, Calleri, Angelica, Dalle, Stéphane, Beylot-Barry, Marie, Zwaenepoel, Karen, De Winnie, Koen, Marie-Cardine, Anne, Cayuela, Jean-Michel, Tabanelli, Valentina, Motta, Giovanna, Melle, Federica, Hultberg, Anna, Gandini, Domenica, Marafioti, Teresa, Moshir, Mahan, Delahaye, Tim, Zabrocki, Piotr, Silence, Karen, Van Rompaey, Luc, Bensussan, Armand, De Haard, Hans, Pauwels, Patrick, Leupin, Nicolas, Pileri, Stefano A.

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Clinical response observed in a phase I study in T cell lymphoma patients treated with anti-CD70 SIMPLE Antibody ARGX-110 von Michot, Jean-Marie, Maerevoet, Marie, Aftimos, Philippe Georges, Rottey, Sylvie, Rolfo, Christian Diego, Offner, Fritz, Van Rompaey, Luc, Moshir, Mahan, de Haard, Hans, Silence, Karen, Pauwels, Patrick, Zwaenepoel, Karen, Awada, Ahmad, Bron, Dominique, Ribrag, Vincent

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ARGX-111 shows activity in MET-amplified patients in a phase-I study and in preclinical models of myeloid-derived suppressor cell (MDSC) depletion in the tumor microenvironment von Rolfo, Christian Diego, Aftimos, Philippe Georges, Pallandre, Jean-Rene, Morello, Virginia, Bouard, Adeline, Cazzanti, Manuela, Barthelemy, Philippe, Rottey, Sylvie, Awada, Ahmad, Hanssens, Valerie, De Jonge, Natalie, Van Rompaey, Luc, Fung, Samson Sau-Sing, Michieli, Paolo, Borg, Christophe

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Abstract 1753: GLPG1790: The first Ephrin (EPH) receptor tyrosine kinase inhibitor for the treatment of triple negative breast cancer von Pujuguet, Philippe, Beirinckx, Filip, Delachaume, Carole, Huck, Jacques, Aar, Ellen Van der, Brys, Reginald, Rompaey, Luc Van, Wigerinck, Piet, Saniere, Laurent

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Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9; 12) in a lymphoid and t(9; 15;12) in a myeloid leukemia von PEETERS, P, RAYNAUD, S. D, MARYNEN, P, COOLS, J, WLODARSKA, I, GROSGEORGE, J, PHILIP, P, MONPOUX, F, VAN ROMPAEY, L, BAENS, M, VAN DEN BERGHE, H

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