Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins von Lim, Junghyun, Park, Hyunjoo, Heisler, Jason, Maculins, Timurs, Roose-Girma, Merone, Xu, Min, Mckenzie, Brent, van Lookeren Campagne, Menno, Newton, Kim, Murthy, Aditya

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Structural and Functional Analysis of HtrA1 and Its Subdomains von Eigenbrot, Charles, Ultsch, Mark, Lipari, Michael T., Moran, Paul, Lin, S. Jack, Ganesan, Rajkumar, Quan, Clifford, Tom, Jeffrey, Sandoval, Wendy, van Lookeren Campagne, Menno, Kirchhofer, Daniel

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Mechanisms of age-related macular degeneration and therapeutic opportunities von van Lookeren Campagne, Menno, LeCouter, Jennifer, Yaspan, Brian L, Ye, Weilan

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A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3 von Murthy, Aditya, Li, Yun, Peng, Ivan, Reichelt, Mike, Katakam, Anand Kumar, Noubade, Rajkumar, Roose-Girma, Merone, DeVoss, Jason, Diehl, Lauri, Graham, Robert R., van Lookeren Campagne, Menno

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Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer’s disease von Ellwanger, Daniel C., Wang, Shoutang, Brioschi, Simone, Shao, Zhifei, Green, Lydia, Case, Ryan, Yoo, Daniel, Weishuhn, Dawn, Rathanaswami, Palaniswami, Bradley, Jodi, Rao, Sara, Cha, Diana, Luan, Peng, Sambashivan, Shilpa, Gilfillan, Susan, Hasson, Samuel A., Foltz, Ian N., van Lookeren Campagne, Menno, Colonna, Marco

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Selective autophagy of the adaptor TRIF regulates innate inflammatory signaling von Samie, Mohammad, Lim, Junghyun, Verschueren, Erik, Baughman, Joshua M., Peng, Ivan, Wong, Aaron, Kwon, Youngsu, Senbabaoglu, Yasin, Hackney, Jason A., Keir, Mary, Mckenzie, Brent, Kirkpatrick, Donald S., van Lookeren Campagne, Menno, Murthy, Aditya

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RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases von Patel, Snahel, Webster, Joshua D., Varfolomeev, Eugene, Kwon, Youngsu C., Cheng, Jason H., Zhang, Juan, Dugger, Debra L., Wickliffe, Kate E., Maltzman, Allie, Sujatha-Bhaskar, Swathi, Bir Kohli, Pawan, Ramaswamy, Sreema, Deshmukh, Gauri, Liederer, Bianca M., Fong, Rina, Hamilton, Greg, Lupardus, Patrick, Caplazi, Patrick, Lee, Wyne P., van Lookeren Campagne, Menno, Johnson, Adam, McKenzie, Brent S., Junttila, Melissa R., Newton, Kim, Vucic, Domagoj

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Dual-Track Clearance of Circulating Bacteria Balances Rapid Restoration of Blood Sterility with Induction of Adaptive Immunity von Broadley, Steven P., Plaumann, Ann, Coletti, Raffaele, Lehmann, Christin, Wanisch, Andreas, Seidlmeier, Amelie, Esser, Knud, Luo, Shanshan, Rämer, Patrick C., Massberg, Steffen, Busch, Dirk H., van Lookeren Campagne, Menno, Verschoor, Admar

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Integration of eQTL and a Single-Cell Atlas in the Human Eye Identifies Causal Genes for Age-Related Macular Degeneration von Orozco, Luz D., Chen, Hsu-Hsin, Cox, Christian, Katschke, Kenneth J., Arceo, Rommel, Espiritu, Carmina, Caplazi, Patrick, Nghiem, Sarajane Saturnio, Chen, Ying-Jiun, Modrusan, Zora, Dressen, Amy, Goldstein, Leonard D., Clarke, Christine, Bhangale, Tushar, Yaspan, Brian, Jeanne, Marion, Townsend, Michael J., van Lookeren Campagne, Menno, Hackney, Jason A.

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Tropism for tuft cells determines immune promotion of norovirus pathogenesis von Wilen, Craig B, Lee, Sanghyun, Hsieh, Leon L, Orchard, Robert C, Desai, Chandni, Hykes, Jr, Barry L, McAllaster, Michael R, Balce, Dale R, Feehley, Taylor, Brestoff, Jonathan R, Hickey, Christina A, Yokoyama, Christine C, Wang, Ya-Ting, MacDuff, Donna A, Kreamalmayer, Darren, Howitt, Michael R, Neil, Jessica A, Cadwell, Ken, Allen, Paul M, Handley, Scott A, van Lookeren Campagne, Menno, Baldridge, Megan T, Virgin, Herbert W

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Structural and mechanistic insights into a lysosomal membrane enzyme HGSNAT involved in Sanfilippo syndrome von Zhao, Boyang, Cao, Zhongzheng, Zheng, Yi, Nguyen, Phuong, Bowen, Alisa, Edwards, Robert H., Stroud, Robert M., Zhou, Yi, Van Lookeren Campagne, Menno, Li, Fei

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Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy von Katschke, Kenneth J., Xi, Hongkang, Cox, Christian, Truong, Tom, Malato, Yann, Lee, Wyne P., McKenzie, Brent, Arceo, Rommel, Tao, Jianhua, Rangell, Linda, Reichelt, Mike, Diehl, Lauri, Elstrott, Justin, Weimer, Robby M, van Lookeren Campagne, Menno

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Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy von Tom, Irene, Pham, Victoria C., Katschke, Kenneth J., Li, Wei, Liang, Wei-Ching, Gutierrez, Johnny, Young, Andrew Ah, Figueroa, Isabel, Eshghi, Shadi Toghi, Lee, ChingWei V., Kanodia, Jitendra, Snipas, Scott J., Salvesen, Guy S., Lai, Phillip, Honigberg, Lee, van Lookeren Campagne, Menno, Kirchhofer, Daniel, Baruch, Amos, Lill, Jennie R.

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IL-33 amplifies an innate immune response in the degenerating retina von Xi, Hongkang, Katschke, Jr, Kenneth J, Li, Yun, Truong, Tom, Lee, Wyne P, Diehl, Lauri, Rangell, Linda, Tao, Jianhua, Arceo, Rommel, Eastham-Anderson, Jeffrey, Hackney, Jason A, Iglesias, Antonio, Cote-Sierra, Javier, Elstrott, Justin, Weimer, Robby M, van Lookeren Campagne, Menno

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Humoral immunity goes hormonal von Chavarria-Smith, Joseph, Hazenbos, Wouter L. W., van Lookeren Campagne, Menno

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Integration of eQTL and a Single-Cell Atlas in the Human Eye Identifies Causal Genes for Age-Related Macular Degeneration von Orozco, Luz D., Chen, Hsu-Hsin, Cox, Christian, Katschke, Kenneth J., Rommel Arceo, Espiritu, Carmina, Caplazi, Patrick, Nghiem, Sarajane Saturnio, Chen, Ying-Jiun, Modrusan, Zora, Dressen, Amy, Goldstein, Leonard D., Clarke, Christine, Bhangale, Tushar, Yaspan, Brian, Jeanne, Marion, Townsend, Michael J., van Lookeren Campagne, Menno, Hackney, Jason A.

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Complement inhibition in cynomolgus monkeys by anti-factor d antigen-binding fragment for the treatment of an advanced form of dry age-related macular degeneration von Loyet, Kelly M, Good, Jeremy, Davancaze, Teresa, Sturgeon, Lizette, Wang, Xiangdan, Yang, Jihong, Le, Kha N, Wong, Maureen, Hass, Philip E, van Lookeren Campagne, Menno, Haughney, Peter C, Morimoto, Alyssa, Damico-Beyer, Lisa A, DeForge, Laura E

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Development of an ultra-sensitive human IL-33 biomarker assay for age-related macular degeneration and asthma drug development von Mai, Elaine, Chan, Joyce, Goon, Levina, Ego, Braeden K., Bevers, Jack, Wong, Tiffany, Wong, Manda, Corpuz, Racquel, Xi, Hongkang, Wu, Jia, Schneider, Kellen, Seshasayee, Dhaya, Grimbaldeston, Michele, Nakamura, Gerald, Indjeian, Vahan B., Campagne, Menno van Lookeren, Loyet, Kelly M., Comps-Agrar, Laetitia

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Geographic atrophy: clinical features and potential therapeutic approaches von Holz, Frank G, Strauss, Erich C, Schmitz-Valckenberg, Steffen, van Lookeren Campagne, Menno

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Structures of Neutrophil Serine Protease 4 Reveal an Unusual Mechanism of Substrate Recognition by a Trypsin-Fold Protease von Lin, S. Jack, Dong, Ken C., Eigenbrot, Charles, van Lookeren Campagne, Menno, Kirchhofer, Daniel

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