Enhancing Fc‐mediated effector functions of monoclonal antibodies: The example of HexaBodies von Horst, Hilma J., Mutis, Tuna

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Epcoritamab induces potent anti-tumor activity against malignant B-cells from patients with DLBCL, FL and MCL, irrespective of prior CD20 monoclonal antibody treatment von van der Horst, Hilma J., de Jonge, A. Vera, Hiemstra, Ida H., Gelderloos, Anne T., Berry, Daniella R. A. I., Hijmering, Nathalie J., van Essen, Hendrik F., de Jong, Daphne, Chamuleau, Martine E. D., Zweegman, Sonja, Breij, Esther C. W., Roemer, Margaretha G. M., Mutis, Tuna

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Fc-Engineered Antibodies with Enhanced Fc-Effector Function for the Treatment of B-Cell Malignancies von van der Horst, Hilma J., Nijhof, Inger S., Mutis, Tuna, Chamuleau, Martine E. D.

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CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering von Oostindie, Simone C, van der Horst, Hilma J, Lindorfer, Margaret A, Cook, Erika M, Tupitza, Jillian C, Zent, Clive S, Burack, Richard, VanDerMeid, Karl R, Strumane, Kristin, Chamuleau, Martine E D, Mutis, Tuna, de Jong, Rob N, Schuurman, Janine, Breij, Esther C W, Beurskens, Frank J, Parren, Paul W H I, Taylor, Ronald P

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DuoHexaBody-CD37®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies von Oostindie, Simone C., van der Horst, Hilma J., Kil, Laurens P., Strumane, Kristin, Overdijk, Marije B., van den Brink, Edward N., van den Brakel, Jeroen H. N., Rademaker, Hendrik J., van Kessel, Berris, van den Noort, Juliette, Chamuleau, Martine E. D., Mutis, Tuna, Lindorfer, Margaret A., Taylor, Ronald P., Schuurman, Janine, Parren, Paul W. H. I., Beurskens, Frank J., Breij, Esther C. W.

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Preclinical evidence for an effective therapeutic activity of FL118, a novel survivin inhibitor, in patients with relapsed/refractory multiple myeloma von Holthof, Lisa C, van der Horst, Hilma J, van Hal-van Veen, Susan E, Ruiter, Ruud W J, Li, Fengzhi, Buijze, Marijke, Andersen, Morten N, Yuan, Huipin, de Bruijn, Joost, van de Donk, Niels W C J, Lokhorst, Henk M, Zweegman, Sonja, Groen, Richard W J, Mutis, Tuna

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Bone Marrow Mesenchymal Stromal Cell‐mediated Resistance in Multiple Myeloma Against NK Cells can be Overcome by Introduction of CD38‐CAR or TRAIL‐variant von Holthof, Lisa C., Stikvoort, Arwen, Horst, Hilma J., Gelderloos, Anne T., Poels, Renée, Li, Fengzhi, Groen, Richard W. J., Zweegman, Sonja, Donk, Niels W. C. J., O'Dwyer, Michael, Mutis, Tuna

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Potent Preclinical Efficacy of DuoHexaBody‐CD37 in B‐Cell Malignancies von Horst, Hilma J., Oostindie, Simone C., Cillessen, Saskia. A. G. M., Gelderloos, Anne T., Overdijk, Marije B., Nijhof, Inger. S., Zweegman, Sonja, Chamuleau, Martine E. D., Breij, Esther C. W., Mutis, Tuna

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Potent preclinical activity of HexaBody-DR5/DR5 in relapsed and/or refractory multiple myeloma von van der Horst, Hilma J., Gelderloos, Anne T., Chamuleau, Martine E.D., Breij, Esther C.W., Zweegman, Sonja, Nijhof, Inger S., Overdijk, Marije B., Mutis, Tuna

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mTOR plays an important role in cow's milk allergy-associated behavioral and immunological deficits von Wu, Jiangbo, de Theije, Caroline G.M., da Silva, Sofia Lopes, van der Horst, Hilma, Reinders, Margot T.M., Broersen, Laus M., Willemsen, Linette E.M., Kas, Martien J.H., Garssen, Johan, Kraneveld, Aletta D.

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Antibodies That Efficiently Form Hexamers upon Antigen Binding Can Induce Complement-Dependent Cytotoxicity under Complement-Limiting Conditions von Cook, Erika M, Lindorfer, Margaret A, van der Horst, Hilma, Oostindie, Simone, Beurskens, Frank J, Schuurman, Janine, Zent, Clive S, Burack, Richard, Parren, Paul W H I, Taylor, Ronald P

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Potent Ex Vivo Anti-Tumor Activity in Relapsed Refractory Multiple Myeloma Using Novel DR5-Specific Antibodies with Enhanced Capacity to Form Hexamers upon Target Binding von van der Horst, Hilma J, Overdijk, Marije B, Breij, Esther CW, Chamuleau, Martine, Lokhorst, Henk M, Mutis, Tuna

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Duobody-CD3xCD20 Induces Potent Anti-Tumor Activity in Malignant Lymph Node B Cells from Patients with DLBCL, FL and MCL Ex Vivo, Irrespective of Prior Treatment with CD20 Monoclon... von Van Der Horst, Hilma J, de Jonge, A. Vera, Hiemstra, Ida H, Gelderloos, Anne T, Berry, Daniella RAI, Hijmering, Nathalie J, de Jong, Daphne, Chamuleau, Martine E.D., Zweegman, Sonja, Breij, Esther CW, Roemer, Margaretha GM, Mutis, Tuna

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Abstract 4544: Multifaceted mechanism of action of DuoHexaBody-CD37 involves both complement- and Fc gamma receptor-mediated cytotoxicity in pre-clinical B-cell lymphoma models von Kil, Laurens P., Oostindie, Simone C., Strumane, Kristin, van der Horst, Hilma J., van Kessel, Berris, Overdijk, Marije B., Lingnau, Andreas, Brandhorst, Marcel, van den Brakel, Jeroen, Lindorfer, Margaret A., Taylor, Ronald P., Chamuleau, Martine E., Mutis, Tuna, Sasser, A. Kate, Schuurman, Janine, Parren, Paul W., Beurskens, Frank J., Breij, Esther C.

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The Impact and Modulation of Microenvironment-Induced Immune Resistance Against CAR T Cell and Antibody Treatments in Multiple Myeloma von Holthof, Lisa C., Van Der Horst, Hilma J., Poels, Renée, van der Schans, Jort T., Gelderloos, Anne T., Li, Fengzhi, Lokhorst, Henk, Zweegman, Sonja, Themeli, Maria, Van De Donk, Niels W. C.J., Groen, Richard W.J., Mutis, Tuna

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Targeting CD37 in B-Cell Malignancies Using the Novel Therapeutic Duohexabody-CD37 Results in Efficient Killing of Tumor B-Cells Ex Vivo Via Complement-Dependent Cytotoxicity, Even... von Van Der Horst, Hilma J., Oostindie, Simone C., Cillessen, Saskia AGM, Gelderloos, Anne T, Overdijk, Marije B, Chamuleau, Martine E.D., Breij, Esther C.W., Mutis, Tuna

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Dietary interventions that reduce mTOR activity rescue autistic-like behavioral deficits in mice von Wu, Jiangbo, de Theije, Caroline G.M, da Silva, Sofia Lopes, Abbring, Suzanne, van der Horst, Hilma, Broersen, Laus M, Willemsen, Linette, Kas, Martien, Garssen, Johan, Kraneveld, Aletta D

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Duohexabody-CD37, a Novel Bispecific Antibody with a Hexamerization-Enhancing Mutation Targeting CD37, Demonstrates Superior Complement-Dependent Cytotoxicity in Preclinical B-Cell... von Oostindie, Simone C., Van Der Horst, Hilma J., Overdijk, Marije B., Strumane, Kristin, Verploegen, Sandra, Lindorfer, Margaret A., Cook, Erica M., Chamuleau, Martine E.D., Mutis, Tuna, Schuurman, Janine, Sasser, A. Kate, Taylor, Ronald P., Parren, Paul W. H.I., Beurskens, Frank J., Breij, Esther C.W.

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MTOR plays an important role in cow's milk allergy-associated behavioral and immunological deficits von Wu, Jiangbo, De Theije, Caroline M G, Da Silva, Sofia Lopes, Van Der Horst, Hilma, Reinders, Margot T M, Broersen, Laus M, Willemsen, Linette E M, Kas, Martien J H, Garssen, Johan, Kraneveld, Aletta D

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mTOR plays an important role in cow's milk allergy-associated behavioral and immunological deficits von Wu, Jiangbo, de Theije, Caroline G M, da Silva, Sofia Lopes, van der Horst, Hilma, Reinders, Margot T M, Broersen, Laus M, Willemsen, Linette E M, Kas, Martien J H, Garssen, Johan, Kraneveld, Aletta D

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