Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock von Azkanaz, Maria, Rodríguez López, Aida, de Boer, Bauke, Huiting, Wouter, Angrand, Pierre-Olivier, Vellenga, Edo, Kampinga, Harm H, Bergink, Steven, Martens, Joost Ha, Schuringa, Jan Jacob, van den Boom, Vincent

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Non-canonical PRC1.1 Targets Active Genes Independent of H3K27me3 and Is Essential for Leukemogenesis von van den Boom, Vincent, Maat, Henny, Geugien, Marjan, Rodríguez López, Aida, Sotoca, Ana M., Jaques, Jennifer, Brouwers-Vos, Annet Z., Fusetti, Fabrizia, Groen, Richard W.J., Yuan, Huipin, Martens, Anton C.M., Stunnenberg, Hendrik G., Vellenga, Edo, Martens, Joost H.A., Schuringa, Jan Jacob

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Bleximenib, the novel menin-KMT2A inhibitor JNJ-75276617, impairs long-term proliferation and immune evasion in acute myeloid leukemia von Hogeling, Shanna M, Lê, Duy Minh, La Rose, Nikita, Kwon, Min Chul, Wierenga, Albertus T J, Van den Heuvel, Fiona A J, Van den Boom, Vincent, Kuchnio, Anna, Philippar, Ulrike, Huls, Gerwin, Schuringa, Jan Jacob

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Nonredundant and locus-specific gene repression functions of PRC1 paralog family members in human hematopoietic stem/progenitor cells von van den Boom, Vincent, Rozenveld-Geugien, Marjan, Bonardi, Francesco, Malanga, Donatella, van Gosliga, Djoke, Heijink, Anne Margriet, Viglietto, Giuseppe, Morrone, Giovanni, Fusetti, Fabrizia, Vellenga, Edo, Schuringa, Jan Jacob

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Conservation of inner nuclear membrane targeting sequences in mammalian Pom121 and yeast Heh2 membrane proteins von Kralt, Annemarie, Jagalur, Noorjahan B, van den Boom, Vincent, Lokareddy, Ravi K, Steen, Anton, Cingolani, Gino, Fornerod, Maarten, Veenhoff, Liesbeth M

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The combination of valproic acid and lithium delays hematopoietic stem/progenitor cell differentiation von Walasek, Marta A., Bystrykh, Leonid, van den Boom, Vincent, Olthof, Sandra, Ausema, Albertina, Ritsema, Martha, Huls, Gerwin, de Haan, Gerald, van Os, Ronald

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The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia von Maat, Henny, Atsma, Tjerk Jan, Hogeling, Shanna M., Rodríguez López, Aida, Jaques, Jennifer, Olthuis, Mirjam, de Vries, Marcel P., Gravesteijn, Chantal, Brouwers-Vos, Annet Z., van der Meer, Nisha, Datema, Suzan, Salzbrunn, Jonas, Huls, Gerwin, Baas, Roy, Martens, Joost H.A., van den Boom, Vincent, Schuringa, Jan Jacob

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P466: THE INTRINSICALLY DISORDERED TRANSCRIPTIONAL REGULATOR MN1 DEPENDS ON THE CHAPERONE DNAJB6B FOR ITS FULL TRANSFORMING POTENTIAL von Pereira‐Martins, Diego A, Boom, Vincent, Dijk, Noortje, Weinhauser, Isabel, Silveira, Douglas, M Bianco, Thiago, Alexander Ortiz Rojas, César, Huls, Gerwin, Quek, Lynn, R Lucena‐Araujo, Antonio, Rego, Eduardo, Jacob Schuringa, Jan

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Mitochondrial Dysfunction in Human Leukemic Stem/Progenitor Cells upon Loss of RAC2 von Capala, Marta E, Maat, Henny, Bonardi, Francesco, van den Boom, Vincent, Kuipers, Jeroen, Vellenga, Edo, Giepmans, Ben N G, Schuringa, Jan Jacob

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ATP-Dependent Chromatin Remodeling by the Cockayne Syndrome B DNA Repair-Transcription-Coupling Factor von Citterio, Elisabetta, Van Den Boom, Vincent, Schnitzler, Gavin, Kanaar, Roland, Bonte, Edgar, Kingston, Robert E., Hoeijmakers, Jan H. J., Vermeulen, Wim

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S127: DELTATP73 IMPOSES TP53 MUTANT‐LIKE PHENOTYPES INCLUDING DRUG RESISTANCE AND POOR PROGNOSIS ON TP53‐WILD TYPE ACUTE MYELOID LEUKEMIA von Pereira‐Martins, Diego A, Alexander Ortiz Rojas, César, Weinhauser, Isabel, Silveira, Douglas, Wierenga, Albertus T J, Boom, Vincent, Bianco, Thiago M, Ammatuna, Emanuele, Quek, Lynn, Lucena‐Araujo, Antonio R, Huls, Gerwin, Rego, Eduardo, Jacob Schuringa, Jan

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UTF1 is a chromatin-associated protein involved in ES cell differentiation von van den Boom, Vincent, Kooistra, Susanne M, Boesjes, Marije, Geverts, Bart, Houtsmuller, Adriaan B, Monzen, Koshiro, Komuro, Issei, Essers, Jeroen, Drenth-Diephuis, Loes J, Eggen, Bart J.L

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HSCs: they can't live without their SINs von van den Boom, Vincent

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Undifferentiated Embryonic Cell Transcription Factor 1 Regulates ESC Chromatin Organization and Gene Expression von Kooistra, Susanne M., van den Boom, Vincent, Thummer, Rajkumar P., Johannes, Frank, Wardenaar, René, Tesson, Bruno M., Veenhoff, Liesbeth M., Fusetti, Fabrizia, O'Neill, Laura P., Turner, Bryan M., de Haan, Gerald, Eggen, Bart J. L.

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Dietary methionine starvation impairs acute myeloid leukemia progression von Cunningham, Alan, Erdem, Ayşegül, Alshamleh, Islam, Geugien, Marjan, Pruis, Maurien, Pereira-Martins, Diego Antonio, van den Heuvel, Fiona A. J., Wierenga, Albertus T. J., ten Berge, Hilde, Dennebos, Robin, van den Boom, Vincent, Hogeling, Shanna M., Weinhäuser, Isabel, Knops, Ruth, de Blaauw, Pim, Heiner-Fokkema, M. Rebecca, Woolthuis, Carolien, Günther, Ulrich L., Rego, Eduardo M., Martens, Joost H. A., Jansen, Joop H., Schwalbe, Harald, Huls, Gerwin, Schuringa, Jan Jacob

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CEBPA-Driven Expression of the Transcriptionally Inactive deltaTP73 Isoform Phenocopies TP53 mutated Poor Risk and Drug-Resistant Acute Myeloid Leukemia von Pereira-Martins, Diego, Ortiz Rojas, César Alexander, Weinhaeuser, Isabel, Wierenga, Bart-Jan, Van Den Boom, Vincent, Mojallali, Fatemeh, Sternadt, Dominique, Bianco, Thiago Mantello, van der Meer, Nisha, Silveira, Douglas RA, Quek, Lynn, Ammatuna, Emanuele, Lucena-Araujo, Antonio R, Huls, Gerwin A., Rego, Eduardo Magalhães, Schuringa, Jan Jacob

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CEBPA-Driven Expression of the Transcriptionally Inactive deltaTP73 Isoform Phenocopies TP53mutated Poor Risk and Drug-Resistant Acute Myeloid Leukemia von Pereira-Martins, Diego, Ortiz Rojas, César Alexander, Weinhaeuser, Isabel, Wierenga, Bart-Jan, Van Den Boom, Vincent, Mojallali, Fatemeh, Sternadt, Dominique, Bianco, Thiago Mantello, van der Meer, Nisha, Silveira, Douglas RA, Quek, Lynn, Ammatuna, Emanuele, Lucena-Araujo, Antonio R, Huls, Gerwin A., Rego, Eduardo Magalhães, Schuringa, Jan Jacob

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TAFII170 Interacts with the Concave Surface of TATA-Binding Protein To Inhibit Its DNA Binding Activity von Pereira, Lloyd A., van der Knaap, Jan A., van den Boom, Vincent, van den Heuvel, Fiona A. J., Timmers, H. T. Marc

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Identification of USP7 as druggable target in non-canonical PRC1.1 for human leukemias von Maat, Henny, Gravesteijn, Chantal, Wierenga, Bart-Jan, van den Boom, Vincent, Vellenga, Edo, Schuringa, Jan Jacob

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BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34+ cells von Rizo, Aleksandra, Horton, Sarah J., Olthof, Sandra, Dontje, Bert, Ausema, Albertina, van Os, Ronald, van den Boom, Vincent, Vellenga, Edo, de Haan, Gerald, Schuringa, Jan Jacob

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