Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV‑1 NNRTIs against Wild-... von Huang, Boshi, Chen, Wenmin, Zhao, Tong, Li, Zhenyu, Jiang, Xiangyi, Ginex, Tiziana, Vílchez, David, Luque, Francisco Javier, Kang, Dongwei, Gao, Ping, Zhang, Jian, Tian, Ye, Daelemans, Dirk, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong

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Holistic approach to anti-knock agents: A high-throughput screening of aniline-like compounds von Viayna, Antonio, Ghashghaei, Ouldouz, Vílchez, David, Estarellas, Carolina, López, Manuel, Gómez-Catalán, Jesús, Lavilla, Rodolfo, Delgado, Jesús, Luque, F. Javier

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Experiences of insecurity among non-standard workers across different welfare states: A qualitative cross-country study von Bosmans, Kim, Vignola, Emilia F., Álvarez-López, Valentina, Julià, Mireia, Ahonen, Emily Q., Bolíbar, Mireia, Gutiérrez-Zamora, Mariana, Ivarsson, Lars, Kvart, Signild, Muntaner, Carles, O'Campo, Patricia, Ruiz, Marisol E., Vänerhagen, Kristian, Cuervo, Isabel, Davis, Letitia, Diaz, Ignacio, Escrig-Piñol, Astrid, Gunn, Virginia, Lewchuk, Wayne, Östergren, Per-Olof, Padrosa, Eva, Vílchez, David, Vives, Alejandra, Vos, Mattias, Zaupa, Alessandro, Bodin, Theo, Baron, Sherry L.

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The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases von Saez, Isabel, Vilchez, David

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First homology model of Plasmodium falciparum glucose-6-phosphate dehydrogenase: Discovery of selective substrate analog-based inhibitors as novel antimalarial agents von Alencar, Nelson, Sola, Irene, Linares, María, Juárez-Jiménez, Jordi, Pont, Caterina, Viayna, Antonio, Vílchez, David, Sampedro, Cristina, Abad, Paloma, Pérez-Benavente, Susana, Lameira, Jerónimo, Bautista, José M., Muñoz-Torrero, Diego, Luque, F. Javier

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The emerging role and therapeutic implications of bacterial and parasitic deubiquitinating enzymes von Wehrmann, Markus, Vilchez, David

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The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy von Kumsta, Caroline, Chang, Jessica T., Lee, Reina, Tan, Ee Phie, Yang, Yongzhi, Loureiro, Rute, Choy, Elizabeth H., Lim, Shaun H. Y., Saez, Isabel, Springhorn, Alexander, Hoppe, Thorsten, Vilchez, David, Hansen, Malene

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Increased proteasome activity in human embryonic stem cells is regulated by PSMD11 von Vilchez, David, Boyer, Leah, Morantte, Ianessa, Lutz, Margaret, Merkwirth, Carsten, Joyce, Derek, Spencer, Brian, Page, Lesley, Masliah, Eliezer, Berggren, W. Travis, Gage, Fred H., Dillin, Andrew

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The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington’s disease patients von Koyuncu, Seda, Saez, Isabel, Lee, Hyun Ju, Gutierrez-Garcia, Ricardo, Pokrzywa, Wojciech, Fatima, Azra, Hoppe, Thorsten, Vilchez, David

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Mechanisms of protein homeostasis (proteostasis) maintain stem cell identity in mammalian pluripotent stem cells von Noormohammadi, Alireza, Calculli, Giuseppe, Gutierrez-Garcia, Ricardo, Khodakarami, Amirabbas, Koyuncu, Seda, Vilchez, David

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DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis von Thiruvalluvan, Arun, de Mattos, Eduardo P., Brunsting, Jeanette F., Bakels, Rob, Serlidaki, Despina, Barazzuol, Lara, Conforti, Paola, Fatima, Azra, Koyuncu, Seda, Cattaneo, Elena, Vilchez, David, Bergink, Steven, Boddeke, Erik H.W.G., Copray, Sjef, Kampinga, Harm H.

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Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan von Noormohammadi, Alireza, Khodakarami, Amirabbas, Gutierrez-Garcia, Ricardo, Lee, Hyun Ju, Koyuncu, Seda, König, Tim, Schindler, Christina, Saez, Isabel, Fatima, Azra, Dieterich, Christoph, Vilchez, David

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Resveratrol confers neuroprotection against high-fat diet in a mouse model of Alzheimer's disease via modulation of proteolytic mechanisms von Sarroca, Sara, Gatius, Alaó, Rodríguez-Farré, Eduard, Vilchez, David, Pallàs, Mercè, Griñán-Ferré, Christian, Sanfeliu, Coral, Corpas, Rubén

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Root cap cell corpse clearance limits microbial colonization in Arabidopsis thaliana von Charura, Nyasha, Llamas, Ernesto, De Quattro, Concetta, Vilchez, David, Nowack, Moritz K, Zuccaro, Alga

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A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells von Ju Lee, Hyun, Bartsch, Deniz, Xiao, Cally, Guerrero, Santiago, Ahuja, Gaurav, Schindler, Christina, Moresco, James J., Yates, John R., Gebauer, Fátima, Bazzi, Hisham, Dieterich, Christoph, Kurian, Leo, Vilchez, David

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Insights Into the Links Between Proteostasis and Aging From C. elegans von Zhang, William Hongyu, Koyuncu, Seda, Vilchez, David

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ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes von Alirzayeva, Hafiza, Loureiro, Rute, Koyuncu, Seda, Hommen, Franziska, Nabawi, Yara, Zhang, William Hongyu, Dao, Thien T.P., Wehrmann, Markus, Lee, Hyun Ju, Vilchez, David

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The role of protein clearance mechanisms in organismal ageing and age-related diseases von Vilchez, David, Saez, Isabel, Dillin, Andrew

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Neurotoxic effects of trimethyltin and triethyltin on human fetal neuron and astrocyte cultures: A comparative study with rat neuronal cultures and human cell lines von Cristòfol, Rosa M, Gassó, Sergi, Vı́lchez, David, Pertusa, Marı́a, Rodrı́guez-Farré, Eduardo, Sanfeliu, Coral

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Kinesin-5 inhibition improves neural regeneration in experimental autoimmune neuritis von Kohle, Felix, Ackfeld, Robin, Hommen, Franziska, Klein, Ines, Svačina, Martin K R, Schneider, Christian, Fink, Gereon R, Barham, Mohammed, Vilchez, David, Lehmann, Helmar C

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