The role of ABC transporters in progression and clinical outcome of colorectal cancer von Hlavata, I., Mohelnikova-Duchonova, B., Vaclavikova, R., Liska, V., Pitule, P., Novak, P., Bruha, J., Vycital, O., Holubec, L., Treska, V., Vodicka, P., Soucek, P.

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Whole Exome Sequencing Analysis of ABCC8 and ABCD2 Genes Associating With Clinical Course of Breast Carcinoma von SOUCEK, P., HLAVAC, V., ELSNEROVA, K., VACLAVIKOVA, R., KOZEVNIKOVOVA, R., RAUS, K.

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1045 Efficiency and Transport of Taxanes in Human Cancer Cell Lines and Solid Tumors von Ehrlichova, M, Vaclavikova, R, Brynychova, V, Nemcova, V, Pecha, V, Mrhalova, M, Rob, R, Ojima, I, Gut, I, Soucek, P

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Clinical and Functional Importance of Selected CASP8 and CASP9 Polymorphisms in Breast Carcinoma von Brynychová, V, Václavíková, R, Kubáčková, K, Mrhalová, M, Kodet, R, Rauš, K, Vrána, D, Gatěk, J, Bendová, M, Souček, P

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5030 POSTER Expression Profile of ABC Transporter Genes in Breast Carcinoma von Hlavac, V, Vaclavikova, R, Ehrlichova, M, Hlavata, I, Pecha, V, Trnkova, M, Gut, I, Soucek, P

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ESTABLISHING PATIENT DERIVED XENOGRAFT MODELS USING IMMUNODEFICIENT MICE IN THE STUDY OF VARIOUS PANCREATIC CANCERS von Sychra, T, Vaclavikova, R, Szabo, A, Spalenkova, A, Seborova, K, Balatka, S, Tesarova, T, Koci, K, Soucek, P, Oliverius, M

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Patient-derived xenografts of pancreatic carcinoma – our experience with acinar cell carcinoma von Sychra, T., Vaclavikova, R., Szabo, A., Spalenkova, A., Seborova, K., Tesarova, T., Koci, K., Hlavac, V., Soucek, P., Oliverius, M.

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6021 POSTER The Role of ABC Transporter Genes in Colorectal Cancer Resistance von Hlavata, I, Mohelnikova-Duchonova, B, Vaclavikova, R, Liska, V, Novak, P, Holubec, L, Pitule, P, Vycital, O, Bruha, J, Soucek, P

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An Experimental Immunodeficient Mouse Model of Human Pancreatic Carcinoma for the Study of Optimal Therapeutic Regimens von Oliverius, M., Sychra, T., Vaclavikova, R., Szabo, A., Spalenkova, A., Seborova, K., Balatka, S., Gurlich, R., Soucek, P.

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IN VIVO EFFICACY OF NEW MDR-REVERSAL TAXANE ANALOGS PRESELECTED BY IN VITRO METHODS von Vaclavikova, R, Seborova, K, Spalenkova, A, Ehrlichova, M, Sychra, T, Chen, L, Bendale, H, Ojima, I, Sandoval-Acuna, C, Truksa, J, Soucek, P

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Metabolism of new-generation taxanes in human, pig, minipig and rat liver microsomes von Gut, I., Ojima, I., Vaclavikova, R., Simek, P., Horsky, S., Linhart, I., Soucek, P., Kondrova, E., Kuznetsova, L. V., Chen, J.

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Paclitaxel metabolism in rat and human liver microsomes is inhibited by phenolic antioxidants von Václavíková, Radka, Horský, Stanislav, Simek, Petr, Gut, Ivan

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The effect of flavonoid derivatives on doxorubicin transport and metabolism von Václavíková, Radka, Kondrová, Eliška, Ehrlichová, Marie, Boumendjel, Ahcene, Kovář, Jan, Stopka, Pavel, Souček, Pavel, Gut, Ivan

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568 Taxanes: Antitumor effects and interspecies differences in metabolism von Václavíková, R., Horský, S., Svobodová, L., Otová, B., Šimek, P., Gut, I.

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268 Expression profile of genes influencing the efficiency of taxanes in breast cancer therapy von Ehrlichova, M, Vaclavikova, R, Pecha, V, Kozevnikovova, R, Trnkova, M, Kristensen, V.N, Soucek, P, Kovar, J, Gut, I

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Modulation of paclitaxel transport by flavonoid derivatives in human breast cancer cells. Is there a correlation between binding affinity to NBD of P-gp and modulation of transport... von Václavíková, Radka, Boumendjel, Ahcene, Ehrlichová, Marie, Kovář, Jan, Gut, Ivan

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Beta-3 agonist-induced lipolysis and nitric oxide production: relationship to PPARgamma agonist/antagonist and AMP kinase modulation von Hodis, Jiří, Vaclavíková, Radka, Farghali, Hassan

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Cell Death Induced by Taxanes in Breast Cancer Cells: Cytochrome c is Released in Resistant but not in Sensitive Cells von EHRLICHOVA, Marie, KOC, Michal, TRUKSA, Jaroslav, NALDOVA, Zuzana, VACLAVIKOVA, Radka, KOVARR, Jan

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DNA damage, DNA repair rates and mRNA expression levels of cell cycle genes (TP53, p21CDKN1A, BCL2 and BAX) with respect to occupational exposure to styrene von HANOVA, Monika, VODICKOVA, Ludmila, KUMAR, Rajiv, HEMMINKI, Kari, VODICKA, Pavel, VACLAVIKOVA, Radka, SMERHOVSKY, Zdenek, STETINA, Rudolf, HLAVAC, Pavel, NACCARATI, Alessio, SLYSKOVA, Jana, POLAKOVA, Veronika, SOUCEK, Pavel

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Protein levels of NAD(P)H:quinone oxidoreductase 1 and p53 correlate in breast tumors von Hubackova, M, Vaclavikova, R, Kodet, R, Mrhalova, M, Kubackova, K, Gut, I, Soucek, P

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