Prospective de novo drug design with deep interactome learning von Atz, Kenneth, Cotos, Leandro, Isert, Clemens, Håkansson, Maria, Focht, Dorota, Hilleke, Mattis, Nippa, David F., Iff, Michael, Ledergerber, Jann, Schiebroek, Carl C. G., Romeo, Valentina, Hiss, Jan A., Merk, Daniel, Schneider, Petra, Kuhn, Bernd, Grether, Uwe, Schneider, Gisbert

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A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature von Kemble, Alicia M, Hornsperger, Benoit, Ruf, Iris, Richter, Hans, Benz, Jörg, Kuhn, Bernd, Heer, Dominik, Wittwer, Matthias, Engelhardt, Britta, Grether, Uwe, Collin, Ludovic

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Reverse Design toward Optimized Labeled Chemical Probes - Examples from the Endocannabinoid System von Guberman, Mónica, Kosar, Miroslav, Omran, Anahid, Carreira, Erick M, Nazaré, Marc, Grether, Uwe

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Editorial: Therapeutic potential of the cannabinoid CB2 receptor von Smoum, Reem, Grether, Uwe, Karsak, Meliha, Vernall, Andrea J., Park, Frank, Hillard, Cecilia J., Pacher, Pal

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Development of a membrane-based Gi-CASE biosensor assay for profiling compounds at cannabinoid receptors von Scott-Dennis, Morgan, Rafani, Fikri A., Yi, Yicheng, Perera, Themiya, Harwood, Clare R., Guba, Wolfgang, Rufer, Arne C., Grether, Uwe, Veprintsev, Dmitry B., Sykes, David A.

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Cannabinoid CB2 Receptors Modulate Microglia Function and Amyloid Dynamics in a Mouse Model of Alzheimer’s Disease von Ruiz de Martín Esteban, Samuel, Benito-Cuesta, Irene, Terradillos, Itziar, Martínez-Relimpio, Ana M., Arnanz, M. Andrea, Ruiz-Pérez, Gonzalo, Korn, Claudia, Raposo, Catarina, Sarott, Roman C., Westphal, Matthias V., Elezgarai, Izaskun, Carreira, Erick M., Hillard, Cecilia J., Grether, Uwe, Grandes, Pedro, Grande, M. Teresa, Romero, Julián

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Selective Cannabinoid 2 Receptor Agonists as Potential Therapeutic Drugs for the Treatment of Endotoxin-Induced Uveitis von Porter, Richard Frederick, Szczesniak, Anna-Maria, Toguri, James Thomas, Gebremeskel, Simon, Johnston, Brent, Lehmann, Christian, Fingerle, Jürgen, Rothenhäusler, Benno, Perret, Camille, Rogers-Evans, Mark, Kimbara, Atsushi, Nettekoven, Matthias, Guba, Wolfgang, Grether, Uwe, Ullmer, Christoph, Kelly, Melanie E M

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Identifying opportunities for late-stage C-H alkylation with high-throughput experimentation and in silico reaction screening von Nippa, David F., Atz, Kenneth, Müller, Alex T., Wolfard, Jens, Isert, Clemens, Binder, Martin, Scheidegger, Oliver, Konrad, David B., Grether, Uwe, Martin, Rainer E., Schneider, Gisbert

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Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists von Kosar, Miroslav, Sarott, Roman C., Sykes, David A., Viray, Alexander E. G., Vitale, Rosa Maria, Tomašević, Nataša, Li, Xiaoting, Ganzoni, Rudolf L. Z., Kicin, Bilal, Reichert, Lisa, Patej, Kacper J., Gómez-Bouzó, Uxía, Guba, Wolfgang, McCormick, Peter J., Hua, Tian, Gruber, Christian W., Veprintsev, Dmitry B., Frank, James A., Grether, Uwe, Carreira, Erick M.

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Patents targeting cannabinoid receptor type 2 ligands: an interview with Uwe Grether von Grether, Uwe

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Machine Learning and Computational Chemistry for the Endocannabinoid System von Atz, Kenneth, Guba, Wolfgang, Grether, Uwe, Schneider, Gisbert

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Scintillation Proximity Assay (SPA)-Based Radioligand Binding for PPARα, PPARγ, and PPARδ Receptors von Grether, Uwe, Benz, Jörg, Hartung, Thomas, Roth, Doris

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An Enzyme-Labile Safety Catch Linker for Synthesis on a Soluble Polymeric Support von Grether, Uwe, Waldmann, Herbert

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Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years von Maccarrone, Mauro, Di Marzo, Vincenzo, Gertsch, Jürg, Grether, Uwe, Howlett, Allyn C, Hua, Tian, Makriyannis, Alexandros, Piomelli, Daniele, Ueda, Natsuo, van der Stelt, Mario

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An Oxidation-Labile Traceless Linker for Solid-Phase Synthesis von Stieber, Frank, Grether, Uwe, Waldmann, Herbert

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Mutually Rewarding Academia‐Industry Collaborations in the Field of Chemical Biology von Auberson, Yves P., Grether, Uwe, Vauzeilles, Boris, Vázquez, Olalla

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The Repertoire of Small-Molecule PET Probes for Neuroinflammation Imaging: Challenges and Opportunities beyond TSPO von Chen, Zhen, Haider, Achi, Chen, Jiahui, Xiao, Zhiwei, Gobbi, Luca, Honer, Michael, Grether, Uwe, Arnold, Steven E., Josephson, Lee, Liang, Steven H.

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NF‐κB activation in astrocytes drives a stage‐specific beneficial neuroimmunological response in ALS von Ouali Alami, Najwa, Schurr, Christine, Olde Heuvel, Florian, Tang, Linyun, Li, Qian, Tasdogan, Alpaslan, Kimbara, Atsushi, Nettekoven, Matthias, Ottaviani, Giorgio, Raposo, Catarina, Röver, Stephan, Rogers‐Evans, Mark, Rothenhäusler, Benno, Ullmer, Christoph, Fingerle, Jürgen, Grether, Uwe, Knuesel, Irene, Boeckers, Tobias M, Ludolph, Albert, Wirth, Thomas, Roselli, Francesco, Baumann, Bernd

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Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity von Soethoudt, Marjolein, Grether, Uwe, Fingerle, Jürgen, Grim, Travis W., Fezza, Filomena, de Petrocellis, Luciano, Ullmer, Christoph, Rothenhäusler, Benno, Perret, Camille, van Gils, Noortje, Finlay, David, MacDonald, Christa, Chicca, Andrea, Gens, Marianela Dalghi, Stuart, Jordyn, de Vries, Henk, Mastrangelo, Nicolina, Xia, Lizi, Alachouzos, Georgios, Baggelaar, Marc P., Martella, Andrea, Mock, Elliot D., Deng, Hui, Heitman, Laura H., Connor, Mark, Di Marzo, Vincenzo, Gertsch, Jürg, Lichtman, Aron H., Maccarrone, Mauro, Pacher, Pal, Glass, Michelle, van der Stelt, Mario

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DOTAM-Based, Targeted, Activatable Fluorescent Probes for the Highly Sensitive and Selective Detection of Cancer Cells von Brennecke, Benjamin, Wang, Qinghua, Haap, Wolfgang, Grether, Uwe, Hu, Hai-Yu, Nazaré, Marc

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