Germline Mutations in FAN1 Cause Hereditary Colorectal Cancer by Impairing DNA Repair von Seguí, Nuria, Mina, Leonardo B, Lázaro, Conxi, Sanz-Pamplona, Rebeca, Pons, Tirso, Navarro, Matilde, Bellido, Fernando, López-Doriga, Adriana, Valdés-Mas, Rafael, Pineda, Marta, Guinó, Elisabet, Vidal, August, Soto, José Luís, Caldés, Trinidad, Durán, Mercedes, Urioste, Miguel, Rueda, Daniel, Brunet, Joan, Balbín, Milagros, Blay, Pilar, Iglesias, Silvia, Garré, Pilar, Lastra, Enrique, Sánchez-Heras, Ana Beatriz, Valencia, Alfonso, Moreno, Victor, Pujana, Miguel Ángel, Villanueva, Alberto, Blanco, Ignacio, Capellá, Gabriel, Surrallés, Jordi, Puente, Xose S, Valle, Laura

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Epigenetic Differences Arise during the Lifetime of Monozygotic Twins von Fraga, Mario F., Ballestar, Esteban, Paz, Maria F., Ropero, Santiago, Setien, Fernando, Ballestar, Maria L., Heine-Suñer, Damia, Cigudosa, Juan C., Urioste, Miguel, Benitez, Javier, Boix-Chornet, Manuel, Sanchez-Aguilera, Abel, Ling, Charlotte, Carlsson, Emma, Poulsen, Pernille, Vaag, Allan, Stephan, Zarko, Spector, Tim D., Wu, Yue-Zhong, Plass, Christoph, Esteller, Manel, Gartler, Stanley M.

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Genetic anticipation is associated with telomere shortening in hereditary breast cancer von Martinez-Delgado, Beatriz, Yanowsky, Kira, Inglada-Perez, Lucia, Domingo, Samuel, Urioste, Miguel, Osorio, Ana, Benitez, Javier

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A clinico-pathological and molecular analysis reveals differences between solitary (early and late-onset) and synchronous rectal cancer von Perea, José, García, Juan L., Corchete, Luis, Tapial, Sandra, Olmedillas-López, Susana, Vivas, Alfredo, García-Olmo, Damián, Urioste, Miguel, Goel, Ajay, González-Sarmiento, Rogelio

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Clinical and Molecular Comparative Study of Colorectal Cancer Based on Age-of-onset and Tumor Location: Two Main Criteria for Subclassifying Colorectal Cancer von Álvaro, Edurne, Cano, Juana M, García, Juan L, Brandáriz, Lorena, Olmedillas-López, Susana, Arriba, María, Rueda, Daniel, Rodríguez, Yolanda, Cañete, Ángel, Arribas, Julia, Inglada-Pérez, Lucía, Pérez, Jessica, Gómez, Carlos, García-Arranz, Mariano, García-Olmo, Damián, Goel, Ajay, Urioste, Miguel, González-Sarmiento, Rogelio, Perea, José

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Intermediate-onset colorectal cancer: A clinical and familial boundary between both early and late-onset colorectal cancer von Arriba, María, Sánchez, Carmen, Vivas, Alfredo, Nutu, O A, Rueda, Daniel, Tapial, Sandra, Rodríguez, Yolanda, Brandáriz, Lorena, García, Juan L, García-Olmo, Damián, Goel, Ajay, González-Sarmiento, Rogelio, Urioste, Miguel, Perea, José

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Germline mutations in the spindle assembly checkpoint genes BUB1 and BUB3 are infrequent in familial colorectal cancer and polyposis von Mur, Pilar, De Voer, Richarda M, Olivera-Salguero, Rubén, Rodríguez-Perales, Sandra, Pons, Tirso, Setién, Fernando, Aiza, Gemma, Valdés-Mas, Rafael, Bertini, Angelo, Pineda, Marta, Vreede, Lilian, Navarro, Matilde, Iglesias, Silvia, González, Sara, Brunet, Joan, Valencia, Alfonso, Esteller, Manel, Lázaro, Conxi, Kops, Geert J P L, Urioste, Miguel, Puente, Xose S, Capellá, Gabriel, Valle, Laura

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Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors von Hafner, Christian, Toll, Agustí, Fernández-Casado, Alejandro, Earl, Julie, Marqués, Miriam, Acquadro, Francesco, Méndez-Pertuz, Marinela, Urioste, Miguel, Malats, Núria, Burns, Julie E., Knowles, Margaret A., Cigudosa, Juan C., Hartmann, Arndt, Vogt, Thomas, Landthaler, Michael, Pujol, Ramón M., Real, Francisco X., Vogt, Peter K.

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A common SNP in the UNG gene decreases ovarian cancer risk in BRCA2 mutation carriers von Baquero, Juan Miguel, Benítez‐Buelga, Carlos, Fernández, Victoria, Urioste, Miguel, García‐Giménez, Jose Luis, Perona, Rosario, Benítez, Javier, Osorio, Ana

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Frequency and impact of KRAS mutation in early onset colorectal cancer von Perea, José, MD, PhD, Arriba, María, PhD, Rodríguez, Yolanda, MD, PhD, Rueda, Daniel, PhD, García, Juan Luis, PhD, Pérez, Jessica, González-Sarmiento, Rogelio, Urioste, Miguel, MD, PhD

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DNA repair capacity is impaired in healthy BRCA1 heterozygous mutation carriers von Vaclová, Tereza, Gómez-López, Gonzalo, Setién, Fernando, Bueno, José María García, Macías, José Antonio, Barroso, Alicia, Urioste, Miguel, Esteller, Manel, Benítez, Javier, Osorio, Ana

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Whole-Exome Sequencing Identifies MDH2 as a New Familial Paraganglioma Gene von Cascón, Alberto, Comino-Méndez, Iñaki, Currás-Freixes, María, de Cubas, Aguirre A., Contreras, Laura, Richter, Susan, Peitzsch, Mirko, Mancikova, Veronika, Inglada-Pérez, Lucía, Pérez-Barrios, Andrés, Calatayud, María, Azriel, Sharona, Villar-Vicente, Rosa, Aller, Javier, Setién, Fernando, Moran, Sebastian, Garcia, Juan F., Río-Machín, Ana, Letón, Rocío, Gómez-Graña, Álvaro, Apellániz-Ruiz, María, Roncador, Giovanna, Esteller, Manel, Rodríguez-Antona, Cristina, Satrústegui, Jorgina, Eisenhofer, Graeme, Urioste, Miguel, Robledo, Mercedes

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Commentary: Genomic Analysis Reveals Heterogeneity Between Lesions in Synchronous Primary Right-Sided and Left-Sided Colon Cancer von Perea, José, Corchete, Luis, García, Juan L, Urioste, Miguel, González-Sarmiento, Rogelio

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POT1 and Damage Response Malfunction Trigger Acquisition of Somatic Activating Mutations in the VEGF Pathway in Cardiac Angiosarcomas von Calvete, Oriol, Garcia-Pavia, Pablo, Domínguez, Fernando, Mosteiro, Lluc, Pérez-Cabornero, Lucía, Cantalapiedra, Diego, Zorio, Esther, Ramón Y Cajal, Teresa, Crespo-Leiro, Maria G, Teulé, Álex, Lázaro, Conxi, Morente, Manuel M, Urioste, Miguel, Benitez, Javier

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Unsupervised Analysis of Array Comparative Genomic Hybridization Data from Early-Onset Colorectal Cancer Reveals Equivalence with Molecular Classification and Phenotypes von Arriba, María, García, Juan L, Rueda, Daniel, Pérez, Jessica, Brandariz, Lorena, Nutu, Oana A, Alonso, Laura, Rodríguez, Yolanda, Urioste, Miguel, González-Sarmiento, Rogelio, Perea, José

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Clinicopathologic and Pedigree Differences in Amsterdam I–Positive Hereditary Nonpolyposis Colorectal Cancer Families According to Tumor Microsatellite Instability Status von VALLE, Laura, PEREA, Jose, CARBONELL, Pablo, FERNANDEZ, Victoria, DOTOR, Ana M, BENITEZ, Javier, URIOSTE, Miguel

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Cuando el cáncer es una enfermedad rara von Urioste, Miguel, Benítez, Javier

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Early-Onset Colorectal Cancer is an Easy and Effective Tool to Identify Retrospectively Lynch Syndrome von Perea, José, Rodríguez, Yolanda, Rueda, Daniel, Marín, José C., Díaz-Tasende, José, Álvaro, Edurne, Alegre, Cristina, Osorio, Irene, Colina, Francisco, Lomas, Manuel, Hidalgo, Manuel, Benítez, Javier, Urioste, Miguel

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A Predictor Based on the Somatic Genomic Changes of the BRCA1/BRCA2 Breast Cancer Tumors Identifies the Non-BRCA1/BRCA2 Tumors with BRCA1 Promoter Hypermethylation von Alvarez, Sara, Diaz-Uriarte, Ramon, Osorio, Ana, Barroso, Alicia, Melchor, Lorenzo, Paz, Maria Fe, Honrado, Emiliano, Rodríguez, Raquel, Urioste, Miguel, Valle, Laura, Díez, Orland, Cigudosa, Juan Cruz, Dopazo, Joaquin, Esteller, Manel, Benitez, Javier

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POLE and POLD1 mutations in 529 kindred with familial colorectal cancer and/or polyposis: review of reported cases and recommendations for genetic testing and surveillance von Bellido, Fernando, Pineda, Marta, Aiza, Gemma, Valdés-Mas, Rafael, Navarro, Matilde, Puente, Diana A., Pons, Tirso, González, Sara, Iglesias, Silvia, Darder, Esther, Piñol, Virginia, Soto, José Luís, Valencia, Alfonso, Blanco, Ignacio, Urioste, Miguel, Brunet, Joan, Lázaro, Conxi, Capellá, Gabriel, Puente, Xose S., Valle, Laura

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