A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family von Carreras-Puigvert, Jordi, Zitnik, Marinka, Jemth, Ann-Sofie, Carter, Megan, Unterlass, Judith E., Hallström, Björn, Loseva, Olga, Karem, Zhir, Calderón-Montaño, José Manuel, Lindskog, Cecilia, Edqvist, Per-Henrik, Matuszewski, Damian J., Ait Blal, Hammou, Berntsson, Ronnie P. A., Häggblad, Maria, Martens, Ulf, Studham, Matthew, Lundgren, Bo, Wählby, Carolina, Sonnhammer, Erik L. L., Lundberg, Emma, Stenmark, Pål, Zupan, Blaz, Helleday, Thomas

Volltext

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress von Bonagas, Nadilly, Gustafsson, Nina M S, Henriksson, Martin, Marttila, Petra, Gustafsson, Robert, Wiita, Elisée, Borhade, Sanjay, Green, Alanna C, Vallin, Karl S A, Sarno, Antonio, Svensson, Richard, Göktürk, Camilla, Pham, Therese, Jemth, Ann-Sofie, Loseva, Olga, Cookson, Victoria, Kiweler, Nicole, Sandberg, Lars, Rasti, Azita, Unterlass, Judith E, Haraldsson, Martin, Andersson, Yasmin, Scaletti, Emma R, Bengtsson, Christoffer, Paulin, Cynthia B J, Sanjiv, Kumar, Abdurakhmanov, Eldar, Pudelko, Linda, Kunz, Ben, Desroses, Matthieu, Iliev, Petar, Färnegårdh, Katarina, Krämer, Andreas, Garg, Neeraj, Michel, Maurice, Häggblad, Sara, Jarvius, Malin, Kalderén, Christina, Jensen, Amanda Bögedahl, Almlöf, Ingrid, Karsten, Stella, Zhang, Si Min, Häggblad, Maria, Eriksson, Anders, Liu, Jianping, Glinghammar, Björn, Nekhotiaeva, Natalia, Klingegård, Fredrik, Koolmeister, Tobias, Martens, Ulf, Llona-Minguez, Sabin, Moulson, Ruth, Nordström, Helena, Parrow, Vendela, Dahllund, Leif, Sjöberg, Birger, Vargas, Irene L, Vo, Duy Duc, Wannberg, Johan, Knapp, Stefan, Krokan, Hans E, Arvidsson, Per I, Scobie, Martin, Meiser, Johannes, Stenmark, Pål, Berglund, Ulrika Warpman, Homan, Evert J, Helleday, Thomas

Volltext

Warburg and Krebs and related effects in cancer von Unterlass, Judith E, Curtin, Nicola J

Volltext

Kinetic and structural characterization of NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis von Scaletti, Emma R., Unterlass, Judith E., Almlöf, Ingrid, Koolmeister, Tobias, Vallin, Karl S., Kapsitidou, Despina, Tsuber, Viktoriia, Helleday, Thomas, Stenmark, Pål, Jemth, Ann‐Sofie

Volltext

Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer von Unterlass, Judith E, Baslé, Arnaud, Blackburn, Timothy J, Tucker, Julie, Cano, Céline, Noble, Martin E M, Curtin, Nicola J

Volltext

Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH) von Unterlass, Judith E, Wood, Robert J, Baslé, Arnaud, Tucker, Julie, Cano, Céline, Noble, Martin M E, Curtin, Nicola J

Volltext

A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate von Riley, Andrew M, Unterlass, Judith E, Konieczny, Vera, Taylor, Colin W, Helleday, Thomas, Potter, Barry V. L

Volltext

Abstract 2448: Towards structure-based drug design of 3-phosphoglycerate dehydrogenase inhibitors von Unterlass, Judith E., Aljufri, Nabila, Bex, Sophie, Cano, Celine, Noble, Martin E M, Curtin, Nicola J.

Volltext

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress von Bonagas, Nadilly, Gustafsson, Nina M. S, Henriksson, Martin, Marttila, Petra, Gustafsson, Robert, Wiita, Elisee, Borhade, Sanjay, Green, Alanna C, Vallin, Karl S. A, Sarno, Antonio, Svensson, Richard, Gokturk, Camilla, Pham, Therese, Jemth, Ann-Sofie, Loseva, Olga, Cookson, Victoria, Kiweler, Nicole, Sandberg, Lars, Rasti, Azita, Unterlass, Judith E, Haraldsson, Martin, Andersson, Yasmin, Scaletti, Emma R, Bengtsson, Christoffer, Paulin, Cynthia B. J, Sanjiv, Kumar, Abdurakhmanov, Eldar, Pudelko, Linda, Kunz, Ben, Desroses, Matthieu, Iliev, Petar, Farnegardh, Katarina, Kramer, Andreas, Garg, Neeraj, Michel, Maurice, Haggblad, Sara, Jarvius, Malin, Kalderen, Christina, Jensen, Amanda Bogedahl, Almlof, Ingrid, Karsten, Stella, Zhang, Si Min, Haggblad, Maria, Eriksson, Anders, Liu, Jianping, Glinghammar, Bjorn, Nekhotiaeva, Natalia, Klingegard, Fredrik, Koolmeister, Tobias, Martens, Ulf, Llona-Minguez, Sabin, Moulson, Ruth, Nordström, Helena, Parrow, Vendela, Dahllund, Leif, Sjoberg, Birger, Vargas, Irene L, Vo, Duy Duc, Wannberg, Johan, Knapp, Stefan, Krokan, Hans E, Arvidsson, Per, I, Scobie, Martin, Meiser, Johannes, Stenmark, Pal, Berglund, Ulrika Warpman, Homan, Evert J, Helleday, Thomas

Volltext bestellen

A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family von Carreras-Puigvert, Jordi, Zitnik, Marinka, Jemth, Ann-Sofie, Carter, Megan, Unterlass, Judith E, Hallström, Björn, Loseva, Olga, Karem, Zhir, Calderón-Montaño, José Manuel, Lindskog, Cecilia, Edqvist, Per-Henrik D, Matuszewski, Damian J, Ait Blal, Hammou, Berntsson, Ronnie P A, Häggblad, Maria, Martens, Ulf, Studham, Matthew, Lundgren, Bo, Wählby, Carolina, Sonnhammer, Erik L L, Lundberg, Emma, Stenmark, Pål, Zupan, Blaz, Helleday, Thomas

Volltext bestellen

Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target von Škerlová, Jana, Unterlass, Judith, Göttmann, Mona, Marttila, Petra, Homan, Evert, Helleday, Thomas, Jemth, Ann-Sofie, Stenmark, Pål

Volltext

Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase von Hicks, Kevin G, Cluntun, Ahmad A, Schubert, Heidi L, Hackett, Sean R, Berg, Jordan A, Leonard, Paul G, Ajalla Aleixo, Mariana A, Zhou, Youjia, Bott, Alex J, Salvatore, Sonia R, Chang, Fei, Blevins, Aubrie, Barta, Paige, Tilley, Samantha, Leifer, Aaron, Guzman, Andrea, Arok, Ajak, Fogarty, Sarah, Winter, Jacob M, Ahn, Hee-Chul, Allen, Karen N, Block, Samuel, Cardoso, Iara A, Ding, Jianping, Dreveny, Ingrid, Gasper, William C, Ho, Quinn, Matsuura, Atsushi, Palladino, Michael J, Prajapati, Sabin, Sun, Pengkai, Tittmann, Kai, Tolan, Dean R, Unterlass, Judith, VanDemark, Andrew P, Vander Heiden, Matthew G, Webb, Bradley A, Yun, Cai-Hong, Zhao, Pengkai, Wang, Bei, Schopfer, Francisco J, Hill, Christopher P, Nonato, Maria Cristina, Muller, Florian L, Cox, James E, Rutter, Jared

Volltext

Targeting OGG1 arrests cancer cell proliferation by inducing replication stress von Visnes, Torkild, Benítez-Buelga, Carlos, Cázares-Körner, Armando, Sanjiv, Kumar, Hanna, Bishoy M F, Mortusewicz, Oliver, Rajagopal, Varshni, Albers, Julian J, Hagey, Daniel W, Bekkhus, Tove, Eshtad, Saeed, Baquero, Juan Miguel, Masuyer, Geoffrey, Wallner, Olov, Müller, Sarah, Pham, Therese, Göktürk, Camilla, Rasti, Azita, Suman, Sharda, Torres-Ruiz, Raúl, Sarno, Antonio, Wiita, Elisée, Homan, Evert J, Karsten, Stella, Marimuthu, Karthick, Michel, Maurice, Koolmeister, Tobias, Scobie, Martin, Loseva, Olga, Almlöf, Ingrid, Unterlass, Judith Edda, Pettke, Aleksandra, Boström, Johan, Pandey, Monica, Gad, Helge, Herr, Patrick, Jemth, Ann-Sofie, El Andaloussi, Samir, Kalderén, Christina, Rodriguez-Perales, Sandra, Benítez, Javier, Krokan, Hans E, Altun, Mikael, Stenmark, Pål, Berglund, Ulrika Warpman, Helleday, Thomas

Volltext