Statins induce apoptosis in rat and human myotube cultures by inhibiting protein geranylgeranylation but not ubiquinone von Johnson, Timothy E., Zhang, Xiaohua, Bleicher, Kimberly B., Dysart, Gary, Loughlin, Amy F., Schaefer, William H., Umbenhauer, Diane R.

Volltext

Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice von Lankas, George R, Wise, L.David, Cartwright, Mark E, Pippert, Todd, Umbenhauer, Diane R

Volltext

Altered Expression of Hepatic Cytochromes P-450 in Mice Deficient in One or More mdr1 Genes von Schuetz, E G, Umbenhauer, D R, Yasuda, K, Brimer, C, Nguyen, L, Relling, M V, Schuetz, J D, Schinkel, A H

Volltext

Identification of a P-Glycoprotein-Deficient Subpopulation in the CF-1 Mouse Strain Using a Restriction Fragment Length Polymorphism von Umbenhauer, Diane R., Lankas, George R., Pippert, Todd R., Wise, L.David, Cartwright, Mark E., Hall, Steven J., Beare, Carolann M.

Volltext

The subpopulation of CF-1 mice deficient in P-glycoprotein contains a murine retroviral insertion in the mdr1a gene von Pippert, Todd R., Umbenhauer, Diane R.

Volltext

Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase von GED, C, UMBENHAUER, D. R, BELLEW, T. M, BORK, R. W, SRIVASTAVA, P. K, NARIKO SHINRIKI, LLOYD, R. S, GUENGERICH, F. P

Volltext

Statins and PPAR{alpha} agonists induce myotoxicity in differentiated rat skeletal muscle cultures but do not exhibit synergy with co-treatment von Johnson, Timothy E., Zhang, Xiaohua, Shi, Shu, Umbenhauer, Diane R.

Volltext

Alkylation of intracellular and extracellular DNA by dimethylnitrosamine following activation by isolated rat hepatocytes von Umbenhauer, D R, Pegg, A E

Volltext

Isolation and Sequence Determination of a cDNA Clone Related to Human Cytochrome P-450 Nifedipine Oxidase von Beaune, Philippe H., Umbenhauer, Diane R., Bork, Richard W., Lloyd, R. Stephen, Guengerich, F. Peter

Volltext

Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase von Ged, Cecile, Umbenhauer, Diane R, Bellew, Teresa M, Bork, Richard W, Srivastava, Pramod K, Shinriki, Nariko, Lloyd, R. Stephen, Guengerich, F. Peter

Volltext

Mutagenic response of the endogenous hprt gene and lacl transgene in benzo[a]pyrene-treated Big Blue B6C3F1 mice von SKOPEK, T. R, KORT, K. L, MARINO, D. R, MITTAL, L. V, UMBENHAUER, D. R, LAWS, G. M, ADAMS, S. P

Volltext

Differential Gene Regulation in Human Versus Rodent Hepatocytes by Peroxisome Proliferator-activated Receptor (PPAR) α von Lawrence, Jeffrey W., Li, Ying, Chen, Shiying, DeLuca, John G., Berger, Joel P., Umbenhauer, Diane R., Moller, David E., Zhou, Gaochao

Volltext

Human liver S-9 metabolic activation : Proficiency in cytogenetic assays and comparison with phenobarbital/β-naphthoflavone or aroclor 1254 induced rat S-9 von JOHNSON, T. E, UMBENHAUER, D. R, GALLOWAY, S. M

Volltext

Karyotypic and phenotypic changes during in vitro aging of human endothelial cells von Johnson, Timothy E., Umbenhauer, Diane R., Hill, Rosina, Bradt, Carole, Mueller, Stephen N., Levine, Elliot M., Nichols, Warren W.

Volltext

Cell-Specific Differences in O6-alkylguanine DNA Repair Activity during Continuous Exposure to Carcinogen von Swenberg, James A., Bedell, Mary A., Billings, Kathryn C., Umbenhauer, Diane R., Pegg, Anthony E.

Volltext

System Issues: Mutagenic response of the endogenous hprt gene and lacl transgene in benzo[a]pyrene-treated Big Blue™ B6C3F1 mice von Skopek, Thomas R., Kort, Kristy L., Marino, Deborah R., Mittal, Lakshmi V., Umbenhauer, Diane R., Laws, George M., Adams, Stephen P.

Volltext

Metabolism of dimethylnitrosamine and subsequent removal of O 6-methylguanine from DNA by isolated rat hepatocytes von Umbenhauer, Diane R., Pegg, Anthony E.

Volltext

Human Liver Mephenytoin 4 -Hydroxylase Cytochrome P-450 Proteins and Genes von Brian, William R., Gedt, Cecile, Bellew, Teresa M., Srivastava, Pramod K., Bork, Richard W., Umbenhauer, Diane R., Lloyd, R. Stephen, Guengerich, F. Peter

Volltext

System Issues: Mutagenic response of the endogenoushprt gene andlacl transgene in benzo[a]pyrene-treated Big Blue™ B6C3F1 mice von Skopek, Thomas R., Kort, Kristy L., Marino, Deborah R., Mittal, Lakshmi V., Umbenhauer, Diane R., Laws, George M., Adams, Stephen P.

Volltext

P-Glycoprotein Deficiency in a Subpopulation of CF-1 Mice Enhances Avermectin-Induced Neurotoxicity von Lankas, George R., Cartwright, Mark E., Umbenhauer, Diane

Volltext