Abstract 361: Analysis of Cardiotoxic Mechanisms Associated With Tyrosine Kinase Inhibitor Ponatinib von Singh, Anand P, Glennon, Michael S, Umbarkar, Prachi P, Gupte, Manisha, Galindo, Cristi L, Zhang, Qinkun, Force, Thomas, Becker, Jason R, Lal, Hind

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Fibroblast GSK-3α Promotes Fibrosis via RAF-MEK-ERK Pathway in the Injured Heart von Umbarkar, Prachi, Tousif, Sultan, Singh, Anand P., Anderson, Joshua C., Zhang, Qinkun, Tallquist, Michelle D., Woodgett, James, Lal, Hind

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Repurposing Nintedanib for pathological cardiac remodeling and dysfunction von Umbarkar, Prachi, Singh, Anand P., Tousif, Sultan, Zhang, Qinkun, Sethu, Palaniappan, Lal, Hind

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Ponatinib Drives Cardiotoxicity by S100A8/A9-NLRP3-IL-1β Mediated Inflammation von Tousif, Sultan, Singh, Anand P., Umbarkar, Prachi, Galindo, Cristi, Wheeler, Nicholas, Toro Cora, Angelica, Zhang, Qinkun, Prabhu, Sumanth D., Lal, Hind

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Ponatinib-induced cardiotoxicity: delineating the signalling mechanisms and potential rescue strategies von Singh, Anand P, Glennon, Michael S, Umbarkar, Prachi, Gupte, Manisha, Galindo, Cristi L, Zhang, Qinkun, Force, Thomas, Becker, Jason R, Lal, Hind

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Abstract 530: Cardiac Fibroblast GSK-3α Contributes to Ventricular Remodeling and Dysfunction of the Failing Heart von UMBARKAR, Prachi, Singh, Anand P, Zhang, Qinkun, Lal, Hind

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Abstract P317: Cardiac Fibroblast GSK3α Promotes Myocardial Fibrotic Remodeling Through GSK3α-ERK-IL11 Signaling Circuit von Umbarkar, Prachi, Tousif, Sultan, Singh, Anand P, Anderson, Joshua C, zhang, qinkun, Lal, Hind

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Cardiomyocyte SMAD4-Dependent TGF-β Signaling is Essential to Maintain Adult Heart Homeostasis von Umbarkar, Prachi, PhD, Singh, Anand P., PhD, Gupte, Manisha, PhD, Verma, Vipin K., PhD, Galindo, Cristi L., PhD, Guo, Yuanjun, MD, Zhang, Qinkun, MD, McNamara, James W., PhD, Force, Thomas, MD, Lal, Hind, PhD

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Fibroblast GSK-3α Promotes Fibrosis via RAF-MEK-ERK Pathway in the Injured Heart von Umbarkar, Prachi, Tousif, Sultan, Singh, Anand P., Anderson, Joshua C., Zhang, Qinkun, Tallquist, Michelle D., Woodgett, James, Lal, Hind

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Abstract GS109: Ponatinib-induced Cardiotoxicity Is Driven By S100A8/A9-NLRP3-IL1β Signaling Mediated Excessive Inflammation von Sultan, Tousif, Singh, Anand P, Umbarkar, Prachi, Galindo, Cristi, Wheeler, Nicholas, zhang, qinkun, Prabhu, Sumanth D, Lal, Hind

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Abstract 285: High Throughput Profiling of Gsk3α Regulated Fibroblast Kinome Reveals Raf as a Mediator of Fibrosis in Failing Heart von Umbarkar, Prachi, Tousif, Sultan, Singh, Anand P, Anderson, Joshua C, Zhang, Qinkun, Lal, Hind

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Abstract MP151: Cardiomyocyte HIPK2 is a Critical Regulator of Purinergic Signaling Regulated Myocardial Inflammation von Sultan, Tousif, Singh, Anand P, Umbarkar, Prachi, Zhang, QinKun, Lal, Hind

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Abstract 365: Ponatinib Triggers Cardiac Inflammation by STAT-3 Dependent Immune Checkpoint Blockade von Singh, Anand P, Sultan, Tousif, Umbarkar, Prachi, Zhang, Qinkun, Lal, Hind

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Abstract 117: Ponatinib Mediated Cardiotoxicity Is Driven By Pro-inflammatory S100A8/A9-NLRP3-IL-1β Signaling Circuit von Singh, Anand P, Tousif, Sultan, Umbarkar, Prachi, Galindo, Cristi L, Wheeler, Nicholas, Zhang, Qinkun, Prabhu, Sumanth, Lal, Hind

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Ponatinib Drives Cardiotoxicity by S100A8/A9-NLRP3-IL-1β Mediated Inflammation von Tousif, Sultan, Singh, Anand P., Umbarkar, Prachi, Galindo, Cristi, Wheeler, Nicholas, Toro Coro, Angelica, Zhang, Qinkun, Prabhu, Sumanth D., Lal, Hind

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The BDNF rs6265 Polymorphism is a Modifier of Cardiomyocyte Contractility and Dilated Cardiomyopathy von Raucci, Jr, Frank J, Singh, Anand Prakash, Soslow, Jonathan, Markham, Larry W, Zhong, Lin, Aljafar, Wejdan, Lessiohadi, Natasja, Awgulewitsch, Cassandra P, Umbarkar, Prachi, Zhang, Qinkun, Cannon, Presley L, Buchowski, Maciej, Roland, Joseph T, Carrier, Erica J, Burnette, William B, Hatzopoulos, Antonis K, Lal, Hind, Galindo, Cristi L

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Abstract 738: Comparative Cardiotoxicity of Tyrosine Kinase Inhibitors Ponatinib and PF114 von Singh, Anand P, Umbarkar, Prachi, Glennon, Michael S, Zhang, Qinkun, Chilov, Ghermes, Becker, Jason R, Lal, Hind

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Abstract 41: Cardiomyocyte-specific Conditional Deletion of GSK-3β Leads to Cardiac Dysfunction in a High Fat Diet Induced Obesity Model von Gupte, Manisha, Tumuluru, Samvruta, Singh, Anand P, Umbarkar, Prachi, Zhang, Qinkun, Ahmad, Firdos, Parikh, Shan, Force, Thomas, Lal, Hind

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Abstract 98: Canonical TGF-β1 Signaling in Cardiomyocytes is Essential to Maintain Basal Cardiac Function von Umbarkar, Prachi, Singh, Anand P, Verma, Vipin K, Gupte, Manisha, Guo, Yuanjun, Zhang, Qinkun, Force, Thomas L, Lal, Hind

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Abstract 184: Cardioprotective Effects of Brain-derived Neurotrophic Factor rs6265 Polymorphism in Duchenne Cardiomyopathy von Raucci, Frank J, Singh, Anand P, Soslow, Jonathan H, Zhong, Lin, Aljafar, Wejdan, Lessiohadi, Natasja, Awgulewitsch, Cassandra P, Umbarkar, Prachi, Zhang, Qinkun, Smith, Holly M, Cannon, Presley L, Carrier, Erica J, Hatzopoulos, Antonis K, Lal, Hind, Galindo, Cristi L

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