Discovery of Vilaprisan (BAY 1002670): A Highly Potent and Selective Progesterone Receptor Modulator Optimized for Gynecologic Therapies von Möller, Carsten, Bone, Wilhelm, Cleve, Arwed, Klar, Ulrich, Rotgeri, Andrea, Rottmann, Antje, Schultze‐Mosgau, Marcus‐Hillert, Wagenfeld, Andrea, Schwede, Wolfgang

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Unsteady Aerodynamic Loads on a High-Agility Aircraft due to Wake Vortex Encounter von Klar, Jan-Ulrich, Breitsamter, C

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Total Synthesis and Antitumor Activity of ZK-EPO: The First Fully Synthetic Epothilone in Clinical Development von Klar, Ulrich, Buchmann, Bernd, Schwede, Wolfgang, Skuballa, Werner, Hoffmann, Jens, Lichtner, Rosemarie B.

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Sagopilone crosses the blood-brain barrier in vivo to inhibit brain tumor growth and metastases von Hoffmann, Jens, Fichtner, Iduna, Lemm, Margit, Lienau, Philip, Hess-Stumpp, Holger, Rotgeri, Andrea, Hofmann, Birte, Klar, Ulrich

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Molecular mode of action and role of TP53 in the sensitivity to the novel epothilone sagopilone (ZK-EPO) in A549 non-small cell lung cancer cells von Winsel, Sebastian, Sommer, Anette, Eschenbrenner, Julia, Mittelstaedt, Kevin, Klar, Ulrich, Hammer, Stefanie, Hoffmann, Jens

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Sagopilone Inhibits Breast Cancer Bone Metastasis and Bone Destruction Due to Simultaneous Inhibition of Both Tumor Growth and Bone Resorption von STRUBE, Anne, HOFFMANN, Jens, STEPINA, Elizaveta, HAUFF, Peter, KLAR, Ulrich, KÄKÖNEN, Sanna-Maria

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Novel Mps1 Kinase Inhibitors with Potent Antitumor Activity von Wengner, Antje M, Siemeister, Gerhard, Koppitz, Marcus, Schulze, Volker, Kosemund, Dirk, Klar, Ulrich, Stoeckigt, Detlef, Neuhaus, Roland, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Raschke, Marian, Frisk, Anna-Lena, von Ahsen, Oliver, Michels, Martin, Kreft, Bertolt, von Nussbaum, Franz, Brands, Michael, Mumberg, Dominik, Ziegelbauer, Karl

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Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase von Schulze, Volker K, Klar, Ulrich, Kosemund, Dirk, Wengner, Antje M, Siemeister, Gerhard, Stöckigt, Detlef, Neuhaus, Roland, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Holton, Simon J, Briem, Hans, Marquardt, Tobias, Schirok, Hartmut, Jautelat, Rolf, Bohlmann, Rolf, Nguyen, Duy, Fernández-Montalván, Amaury E, Bömer, Ulf, Eberspaecher, Uwe, Brüning, Michael, Döhr, Olaf, Raschke, Marian, Kreft, Bertolt, Mumberg, Dominik, Ziegelbauer, Karl, Brands, Michael, von Nussbaum, Franz, Koppitz, Marcus

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Integrated Experimental-Numerical Analysis of High-Agility Aircraft Wake Vortex Evolution von Klar, Jan-Ulrich, Breitsamter, Christian, Hickel, Stefan, Adams, Nikolaus

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Silicon-Based Building Blocks for One-Step ¹⁸F-Radiolabeling of Peptides for PET Imaging von Mu, Linjing, Höhne, Aileen, Schubiger, P. August, Ametamey, Simon M, Graham, Keith, Cyr, John E, Dinkelborg, Ludger, Stellfeld, Timo, Srinivasan, Ananth, Voigtmann, Ulrike, Klar, Ulrich

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Biocatalysis at Work: Applications in the Development of Sagopilone von Gottfried, Kathrin, Klar, Ulrich, Platzek, Johannes, Zorn, Ludwig

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Comparative Profiling of the Novel Epothilone, Sagopilone, in Xenografts Derived from Primary Non-Small Cell Lung Cancer von HAMMER, Stefanie, SOMMER, Anette, FICHTNER, Iduna, BECKER, Michael, ROLFF, Jana, MERK, Johannes, KLAR, Ulrich, HOFFMANN, Jens

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Front Cover: Discovery of Vilaprisan (BAY 1002670): A Highly Potent and Selective Progesterone Receptor Modulator Optimized for Gynecologic Therapies (ChemMedChem 21/2018) von Möller, Carsten, Bone, Wilhelm, Cleve, Arwed, Klar, Ulrich, Rotgeri, Andrea, Rottmann, Antje, Schultze‐Mosgau, Marcus‐Hillert, Wagenfeld, Andrea, Schwede, Wolfgang

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Sagopilone (ZK-EPO): from a natural product to a fully synthetic clinical development candidate von Klar, Ulrich, Hoffmann, Jens, Giurescu, Marius

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Improved Cellular Pharmacokinetics and Pharmacodynamics Underlie the Wide Anticancer Activity of Sagopilone von HOFFMANN, Jens, VILALE, Ilio, PANARETAKIS, Theocharis, SIEMEISTER, Gerhard, LAGE, Hermann, NANTY, Lisa, HAMMER, Stefanie, MITTELSTAEDT, Kevin, WINSEL, Sebastian, ESCHENBRENNER, Julia, CASTEDO, Maria, DEMARCHE, Carine, BUCHMANN, Bernd, KLAR, Ulrich, KROEMER, Guido, GALLUZZI, Lorenzo, SCHWEDE, Wolfgang, SENOVILLA, Laura, SKUBALLA, Werner, VIVET, Sonia, LICHTNER, Rosemarie B, VICENCIO, José M

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Abstract 3090: Novel Mps1 kinase inhibitors with potent anti-tumor activity von Wengner, Antje Margret, Siemeister, Gerhard, Koppitz, Marcus, Schulze, Volker, Kosemund, Dirk, Klar, Ulrich, Stoeckigt, Detlef, Neuhaus, Roland, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Doehr, Olaf, Raschke, Marian, von Ahsen, Oliver, Elbi, Cem, Bruns, Ingmar, Michels, Martin, Kreft, Bertolt, von Nussbaum, Franz, Brands, Michael, Mumberg, Dominik, Ziegelbauer, Karl

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Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors von LICHTNER, Rosemarie B, MENRAD, Andreas, SOMMER, Anette, KLAR, Ulrich, SCHNEIDER, Martin R

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Organofluorosilanes as Model Compounds for 18 F‐Labeled Silicon‐Based PET Tracers and their Hydrolytic Stability: Experimental Data and Theoretical Calculations (PET=Positron Emiss... von Höhne, Aileen, Yu, Lian, Mu, Linjing, Reiher, Markus, Voigtmann, Ulrike, Klar, Ulrich, Graham, Keith, Schubiger, P. August, Ametamey, Simon M.

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METHOD AND OPTICAL SENSOR FOR MEASURING A DISTANCE OF AN OBJECT von KLAR, Ulrich

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Organofluorosilanes as Model Compounds for 18F-Labeled Silicon-Based PET Tracers and their Hydrolytic Stability: Experimental Data and Theoretical Calculations (PET=Positron Emissi... von Höhne, Aileen, Yu, Lian, Mu, Linjing, Reiher, Markus, Voigtmann, Ulrike, Klar, Ulrich, Graham, Keith, Schubiger, P. August, Ametamey, Simon M.

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