Optimization of a PEGylated Glucuronide-Monomethylauristatin E Linker for Antibody-Drug Conjugates von Burke, Patrick J, Hamilton, Joseph Z, Jeffrey, Scott C, Hunter, Joshua H, Doronina, Svetlana O, Okeley, Nicole M, Miyamoto, Jamie B, Anderson, Martha E, Stone, Ivan J, Ulrich, Michelle L, Simmons, Jessica K, McKinney, Erica E, Senter, Peter D, Lyon, Robert P

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Targeted Delivery of Cytotoxic NAMPT Inhibitors Using Antibody-Drug Conjugates von Neumann, Christopher S, Olivas, Kathleen C, Anderson, Martha E, Cochran, Julia H, Jin, Steven, Li, Fu, Loftus, Luke V, Meyer, David W, Neale, Jason, Nix, Jay C, Pittman, Paul G, Simmons, Jessica K, Ulrich, Michelle L, Waight, Andrew B, Wong, Abbie, Zaval, Margo C, Zeng, Weiping, Lyon, Robert P, Senter, Peter D

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Mouse Strains Influence Clearance and Efficacy of Antibody and Antibody-Drug Conjugate Via Fc-FcγR Interaction von Li, Fu, Ulrich, Michelle L, Shih, Vincent Feng-Sheng, Cochran, Julia H, Hunter, Joshua H, Westendorf, Lori, Neale, Jason, Benjamin, Dennis R

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1155 Activated regulatory T cells in solid tumors express CD30, which are selectively targeted by the novel anti-CD30 antibody drug conjugate SGN-35T von O’Connor, Brian P, Grogan, Bryan M, James, Reice D, Ulrich, Michelle L, Berndt, Jason D, Lu, Hailing, Conerly, Melissa, Clarke, Astrid, Hamblett, Kevin J, Heiser, Ryan A

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1114 Targeted delivery of a potent STING agonist payload via an antibody drug conjugate drives robust antitumor activity in preclinical models von Cummins, Elizabeth, Gruber, David, Zeng, Weiping, Ulrich, Michelle L, Smith, Kaleb, Long, Mallory, Spahr, Kellie, Snead, Katie, Hinricher, Katelyn, Langalia, Aditi, Gupta, Priyanka, Smith, Alyson J, Burke, Patrick, Gardai, Shyra, Senter, Peter, Hill, Adam, Gray, Elizabeth

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Abstract 1962: Preclinical characterization of tucatinib in HER2-amplified xenograft and CNS implanted tumors von Olson, Devra J., Kulukian, Anita, Taylor, Janelle D., Zaval, Margo C., Nesterova, Albina, Hensley, Kelly M., Ulrich, Michelle L., Stevens, Nicole S., Peterson, Scott R.

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Abstract 3253: CD30 is a marker of activated effector regulatory T cells in solid tumors providing clinical rationale for the combination of brentuximab vedotin and PD-1 inhibitors von Heiser, Ryan A., Grogan, Bryan M., James, Reice D., Ulrich, Michelle L., Berndt, Jason D., O'Connor, Brian P., Gardai, Shyra J., Lu, Hailing, Knowles, Scott M.

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Abstract 983: Antibody-drug conjugates of NAMPT inhibitors: Discovery, optimization, and preclinical characterization von Neumann, Chris, Olivas, Kathleen C., Wang, Kung Pern, Waight, Andrew B., Meyer, David W., Loftus, Luke V., Zaval, Margo C., Anderson, Martha E., Jin, Steven, Cochran, Julia H., Simmons, Jessica K., Pittman, Paul G., Li, Fu, Ulrich, Michelle L., Wong, Abbie, Zeng, Weiping, Lyon, Robert P., Senter, Peter D.

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What We Breathe Impacts Our Health: Improving Understanding of the Link between Air Pollution and Health von West, J. Jason, Cohen, Aaron, Dentener, Frank, Brunekreef, Bert, Zhu, Tong, Armstrong, Ben, Bell, Michelle L, Brauer, Michael, Carmichael, Gregory, Costa, Dan L, Dockery, Douglas W, Kleeman, Michael, Krzyzanowski, Michal, Künzli, Nino, Liousse, Catherine, Lung, Shih-Chun Candice, Martin, Randall V, Pöschl, Ulrich, Pope, C. Arden, Roberts, James M, Russell, Armistead G, Wiedinmyer, Christine

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TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model von Wang, Yaming, Cella, Marina, Mallinson, Kaitlin, Ulrich, Jason D., Young, Katherine L., Robinette, Michelle L., Gilfillan, Susan, Krishnan, Gokul M., Sudhakar, Shwetha, Zinselmeyer, Bernd H., Holtzman, David M., Cirrito, John R., Colonna, Marco

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Lack of the receptor for advanced glycation end-products attenuates E. coli pneumonia in mice von Ramsgaard, Lasse, Englert, Judson M, Manni, Michelle L, Milutinovic, Pavle S, Gefter, Julia, Tobolewski, Jacob, Crum, Lauren, Coudriet, Gina M, Piganelli, Jon, Zamora, Ruben, Vodovotz, Yoram, Enghild, Jan J, Oury, Tim D

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Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells von Vilaplana-Lopera, Nuria, Cuminetti, Vincent, Almaghrabi, Ruba, Papatzikas, Grigorios, Rout, Ashok Kumar, Jeeves, Mark, González, Elena, Alyahyawi, Yara, Cunningham, Alan, Erdem, Ayşegül, Schnütgen, Frank, Raghavan, Manoj, Potluri, Sandeep, Cazier, Jean-Baptiste, Schuringa, Jan Jacob, Reed, Michelle A C, Arranz, Lorena, Günther, Ulrich L, Garcia, Paloma

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A framework for tracer-based metabolism in mammalian cells by NMR von Saborano, Raquel, Eraslan, Zuhal, Roberts, Jennie, Khanim, Farhat L., Lalor, Patricia F., Reed, Michelle A. C., Günther, Ulrich L.

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Metabolomic Evidence for a Field Effect in Histologically Normal and Metaplastic Tissues in Patients with Esophageal Adenocarcinoma von Reed, Michelle A.C, Singhal, Rishi, Ludwig, Christian, Carrigan, John B, Ward, Douglas G, Taniere, Phillipe, Alderson, Derek, Günther, Ulrich L

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Mouse repeated electroconvulsive seizure (ECS) does not reverse social stress effects but does induce behavioral and hippocampal changes relevant to electroconvulsive therapy (ECT)... von van Buel, Erin M, Sigrist, Hannes, Seifritz, Erich, Fikse, Lianne, Bosker, Fokko J, Schoevers, Robert A, Klein, Hans C, Pryce, Christopher R, Eisel, Ulrich Lm

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The glutamate/aspartate transporter EAAT1 is crucial for T-cell acute lymphoblastic leukemia proliferation and survival von Stanulović, Vesna S, Al Omair, Shorog, Reed, Michelle A C, Roberts, Jennie, Potluri, Sandeep, Fulton-Ward, Taylor, Gudgeon, Nancy, Bishop, Emma L, Roels, Juliette, Perry, Tracey A, Sarkar, Sovan, Pratt, Guy, Taghon, Tom, Dimeloe, Sarah, Günther, Ulrich L, Ludwig, Christian, Hoogenkamp, Maarten

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Risk of Progression to Alzheimer's Disease for Different Neuropsychological Mild Cognitive Impairment Subtypes: A Hierarchical Meta-Analysis of Longitudinal Studies von Oltra-Cucarella, Javier, Ferrer-Cascales, Rosario, Alegret, Montserrat, Gasparini, Ruth, Díaz-Ortiz, Leslie Michelle, Ríos, Rocío, Martínez-Nogueras, Ángel Luis, Onandia, Iban, Pérez-Vicente, José A, Cabello-Rodríguez, Luis, Sánchez-SanSegundo, Miriam

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Changes in human hepatic metabolism in steatosis and cirrhosis von Schofield, Zoe, Reed, Michelle Ac, Newsome, Philip N, Adams, David H, Günther, Ulrich L, Lalor, Patricia F

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Quantitative Isotopomer Rates in Real‐Time Metabolism of Cells Determined by NMR Methods von Reed, Michelle A. C., Roberts, Jennie, Gierth, Peter, Kupče, Ēriks, Günther, Ulrich L.

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Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9 von Schneider, Rebekka K, Schenone, Monica, Ferreira, Monica Ventura, Kramann, Rafael, Joyce, Cailin E, Hartigan, Christina, Beier, Fabian, Brümmendorf, Tim H, Germing, Ulrich, Platzbecker, Uwe, Büsche, Guntram, Knüchel, Ruth, Chen, Michelle C, Waters, Christopher S, Chen, Edwin, Chu, Lisa P, Novina, Carl D, Lindsley, R Coleman, Carr, Steven A, Ebert, Benjamin L

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