BRCA2 is a moderate penetrance gene contributing to young-onset prostate cancer: implications for genetic testing in prostate cancer patients von Kote-Jarai, Z, Leongamornlert, D, Saunders, E, Tymrakiewicz, M, Castro, E, Mahmud, N, Guy, M, Edwards, S, O'Brien, L, Sawyer, E, Hall, A, Wilkinson, R, Dadaev, T, Goh, C, Easton, D, Goldgar, D, Eeles, R

Volltext

Germline BRCA1 mutations increase prostate cancer risk von Leongamornlert, D, Mahmud, N, Tymrakiewicz, M, Saunders, E, Dadaev, T, Castro, E, Goh, C, Govindasami, K, Guy, M, O'Brien, L, Sawyer, E, Hall, A, Wilkinson, R, Easton, D, Goldgar, D, Eeles, R, Kote-Jarai, Z

Volltext

Frequent germline deleterious mutations in DNA repair genes in familial prostate cancer cases are associated with advanced disease von Leongamornlert, D, Saunders, E, Dadaev, T, Tymrakiewicz, M, Goh, C, Jugurnauth-Little, S, Kozarewa, I, Fenwick, K, Assiotis, I, Barrowdale, D, Govindasami, K, Guy, M, Sawyer, E, Wilkinson, R, Antoniou, A C, Eeles, R, Kote-Jarai, Z

Volltext

Family History of Prostate Cancer and Survival Outcomes in the UK Genetic Prostate Cancer Study von Brook, Mark N., Ní Raghallaigh, Holly, Govindasami, Koveela, Dadaev, Tokhir, Rageevakumar, Reshma, Keating, Diana, Hussain, Nafisa, Osborne, Andrea, Lophatananon, Artitaya, Muir, Kenneth R., Kote-Jarai, Zsofia, Eeles, Rosalind A.

Volltext

Implications of polygenic risk-stratified screening for prostate cancer on overdiagnosis von Pashayan, Nora, Duffy, Stephen W., Neal, David E., Hamdy, Freddie C., Donovan, Jenny L., Martin, Richard M., Harrington, Patricia, Benlloch, Sara, Amin Al Olama, Ali, Shah, Mitul, Kote-Jarai, Zsofia, Easton, Douglas F., Eeles, Rosalind, Pharoah, Paul D.

Volltext

Identification of Genes with Rare Loss of Function Variants Associated with Aggressive Prostate Cancer and Survival von Saunders, Edward J., Dadaev, Tokhir, Brook, Mark N., Wakerell, Sarah, Govindasami, Koveela, Rageevakumar, Reshma, Hussain, Nafisa, Osborne, Andrea, Keating, Diana, Lophatananon, Artitaya, Muir, Kenneth R., Darst, Burcu F., Conti, David V., Haiman, Christopher A., Antoniou, Antonis C., Eeles, Rosalind A., Kote-Jarai, Zsofia

Volltext

A recurrent truncating germline mutation in the BRIP1/FANCJ gene and susceptibility to prostate cancer von Kote-Jarai, Z, Jugurnauth, S, Mulholland, S, Leongamornlert, D A, Guy, M, Edwards, S, Tymrakiewitcz, M, O'Brien, L, Hall, A, Wilkinson, R, Al Olama, A A, Morrison, J, Muir, K, Neal, D, Donovan, J, Hamdy, F, Easton, D F, Eeles, R

Volltext

African‐specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer von Karunamuni, Roshan A., Huynh‐Le, Minh‐Phuong, Fan, Chun C., Thompson, Wesley, Eeles, Rosalind A., Kote‐Jarai, Zsofia, Muir, Kenneth, Lophatananon, Artitaya, Tangen, Catherine M., Goodman, Phyllis J., Thompson, Ian M., Blot, William J., Zheng, Wei, Kibel, Adam S., Drake, Bettina F., Cussenot, Olivier, Cancel‐Tassin, Géraldine, Menegaux, Florence, Truong, Thérèse, Park, Jong Y., Lin, Hui‐Yi, Bensen, Jeannette T., Fontham, Elizabeth T. H., Mohler, James L., Taylor, Jack A., Multigner, Luc, Blanchet, Pascal, Brureau, Laurent, Romana, Marc, Leach, Robin J., John, Esther M., Fowke, Jay, Bush, William S., Aldrich, Melinda, Crawford, Dana C., Srivastava, Shiv, Cullen, Jennifer C., Petrovics, Gyorgy, Parent, Marie‐Élise, Hu, Jennifer J., Sanderson, Maureen, Mills, Ian G., Andreassen, Ole A., Dale, Anders M., Seibert, Tyler M.

Volltext

Cluster effect for SNP–SNP interaction pairs for predicting complex traits von Lin, Hui-Yi, Mazumder, Harun, Sarkar, Indrani, Huang, Po-Yu, Eeles, Rosalind A., Kote-Jarai, Zsofia, Muir, Kenneth R., Schleutker, Johanna, Pashayan, Nora, Batra, Jyotsna, Neal, David E., Nielsen, Sune F., Nordestgaard, Børge G., Grönberg, Henrik, Wiklund, Fredrik, MacInnis, Robert J., Haiman, Christopher A., Travis, Ruth C., Stanford, Janet L., Kibel, Adam S., Cybulski, Cezary, Khaw, Kay-Tee, Maier, Christiane, Thibodeau, Stephen N., Teixeira, Manuel R., Cannon-Albright, Lisa, Brenner, Hermann, Kaneva, Radka, Pandha, Hardev, Park, Jong Y.

Volltext

Marital status and prostate cancer incidence: a pooled analysis of 12 case–control studies from the PRACTICAL consortium von Salmon, Charlotte, Song, Lixin, Muir, Kenneth, Pashayan, Nora, Dunning, Alison M., Batra, Jyotsna, Chambers, Suzanne, Stanford, Janet L., Ostrander, Elaine A., Park, Jong Y., Lin, Hui-Yi, Cussenot, Olivier, Cancel-Tassin, Géraldine, Menegaux, Florence, Cordina-Duverger, Emilie, Kogevinas, Manolis, Llorca, Javier, Kaneva, Radka, Slavov, Chavdar, Razack, Azad, Lim, Jasmine, Gago-Dominguez, Manuela, Castelao, Jose Esteban, Kote-Jarai, Zsofia, Eeles, Rosalind A., Parent, Marie-Élise

Volltext

Polygenic hazard score is associated with prostate cancer in multi-ethnic populations von Huynh-Le, Minh-Phuong, Fan, Chun Chieh, Karunamuni, Roshan, Thompson, Wesley K., Martinez, Maria Elena, Eeles, Rosalind A., Kote-Jarai, Zsofia, Muir, Kenneth, Schleutker, Johanna, Pashayan, Nora, Batra, Jyotsna, Grönberg, Henrik, Neal, David E., Donovan, Jenny L., Hamdy, Freddie C., Martin, Richard M., Nielsen, Sune F., Nordestgaard, Børge G., Wiklund, Fredrik, Tangen, Catherine M., Giles, Graham G., Wolk, Alicja, Albanes, Demetrius, Travis, Ruth C., Blot, William J., Zheng, Wei, Sanderson, Maureen, Stanford, Janet L., Mucci, Lorelei A., West, Catharine M. L., Kibel, Adam S., Cussenot, Olivier, Berndt, Sonja I., Koutros, Stella, Sørensen, Karina Dalsgaard, Cybulski, Cezary, Grindedal, Eli Marie, Menegaux, Florence, Khaw, Kay-Tee, Park, Jong Y., Ingles, Sue A., Maier, Christiane, Hamilton, Robert J., Thibodeau, Stephen N., Rosenstein, Barry S., Lu, Yong-Jie, Watya, Stephen, Vega, Ana, Kogevinas, Manolis, Penney, Kathryn L., Huff, Chad, Teixeira, Manuel R., Multigner, Luc, Leach, Robin J., Cannon-Albright, Lisa, Brenner, Hermann, John, Esther M., Kaneva, Radka, Logothetis, Christopher J., Neuhausen, Susan L., De Ruyck, Kim, Pandha, Hardev, Razack, Azad, Newcomb, Lisa F., Fowke, Jay H., Gamulin, Marija, Usmani, Nawaid, Claessens, Frank, Gago-Dominguez, Manuela, Townsend, Paul A., Bush, William S., Roobol, Monique J., Parent, Marie-Élise, Hu, Jennifer J., Mills, Ian G., Andreassen, Ole A., Dale, Anders M., Seibert, Tyler M.

Volltext

Effect of germ-line BRCA mutations in biochemical relapse and survival after treatment for localized prostate cancer von Castro, Elena, Olmos, David, Goh, Chee Leng, Saunders, Ed, Leongamornlert, Daniel, Tymrakiewicz, Malgorzata, Bancroft, Elizabeth, Page, Elizabeth, Dadaev, Tokhir, Govindasami, Koveela, Guy, Michelle, Ellis, Steve, Frost, Debra, Peock, Susan, Antoniou, Antonis C., Easton, Douglas, Kote-Jarai, Zsofia, Eeles, Ros A.

Volltext

KLK3 SNP–SNP interactions for prediction of prostate cancer aggressiveness von Lin, Hui-Yi, Huang, Po-Yu, Cheng, Chia-Ho, Tung, Heng-Yuan, Fang, Zhide, Berglund, Anders E., Chen, Ann, French-Kwawu, Jennifer, Harris, Darian, Pow-Sang, Julio, Yamoah, Kosj, Cleveland, John L., Awasthi, Shivanshu, Rounbehler, Robert J., Gerke, Travis, Dhillon, Jasreman, Eeles, Rosalind, Kote-Jarai, Zsofia, Muir, Kenneth, Schleutker, Johanna, Pashayan, Nora, Neal, David E., Nielsen, Sune F., Nordestgaard, Børge G., Gronberg, Henrik, Wiklund, Fredrik, Giles, Graham G., Haiman, Christopher A., Travis, Ruth C., Stanford, Janet L., Kibel, Adam S., Cybulski, Cezary, Khaw, Kay-Tee, Maier, Christiane, Thibodeau, Stephen N., Teixeira, Manuel R., Cannon-Albright, Lisa, Brenner, Hermann, Kaneva, Radka, Pandha, Hardev, Srinivasan, Srilakshmi, Clements, Judith, Batra, Jyotsna, Park, Jong Y.

Volltext

The CHEK2 Variant C.349AG Is Associated with Prostate Cancer Risk and Carriers Share a Common Ancestor von Brandao, Andreia, Paulo, Paula, Maia, Sofia, Pinheiro, Manuela, Peixoto, Ana, Cardoso, Marta, Silva, Maria P., Santos, Catarina, Eeles, Rosalind A., Kote-Jarai, Zsofia, Muir, Kenneth, Schleutker, Johanna, Wang, Ying, Pashayan, Nora, Batra, Jyotsna, Gronberg, Henrik, Neal, David E., Nordestgaard, Borge G., Tangen, Catherine M., Southey, Melissa C., Wolk, Alicja, Albanes, Demetrius, Haiman, Christopher A., Travis, Ruth C., Stanford, Janet L., Mucci, Lorelei A., West, Catharine M. L., Nielsen, Sune F., Kibel, Adam S., Cussenot, Olivier, Berndt, Sonja I., Koutros, Stella, Sorensen, Karina Dalsgaard, Cybulski, Cezary, Grindedal, Eli Marie, Park, Jong Y., Ingles, Sue A., Maier, Christiane, Hamilton, Robert J., Rosenstein, Barry S., Vega, Ana, Kogevinas, Manolis, Wiklund, Fredrik, Penney, Kathryn L., Brenner, Hermann, John, Esther M., Kaneva, Radka, Logothetis, Christopher J., Neuhausen, Susan L., De Ruyck, Kim, Razack, Azad, Newcomb, Lisa F., Lessel, Davor, Usmani, Nawaid, Claessens, Frank, Gago-Dominguez, Manuela, Townsend, Paul A., Roobol, Monique J., Teixeira, Manuel R.

Volltext

Correlation of germ-line BRCA2 mutations with aggressive prostate cancer and outcome von Castro, E., Goh, C. L., Olmos, D., Leongamornlert, D., Saunders, E., Tymrakiewicz, M., Mahmud, N., Dadaev, T., Govindasami, K., Guy, M., OBrien, L., Sawyer, E., Hall, A., Wilkinson, R., Kote-Jarai, Z., Eeles, R. A.

Volltext

The CHEK2 Variant C.349A>G Is Associated with Prostate Cancer Risk and Carriers Share a Common Ancestor von Brandão, Andreia, Paulo, Paula, Maia, Sofia, Pinheiro, Manuela, Peixoto, Ana, Cardoso, Marta, Silva, Maria P, Santos, Catarina, Eeles, Rosalind A, Kote-Jarai, Zsofia, Muir, Kenneth, Ukgpcs Collaborators, Schleutker, Johanna, Wang, Ying, Pashayan, Nora, Batra, Jyotsna, Apcb BioResource, Grönberg, Henrik, Neal, David E, Nordestgaard, Børge G, Tangen, Catherine M, Southey, Melissa C, Wolk, Alicja, Albanes, Demetrius, Haiman, Christopher A, Travis, Ruth C, Stanford, Janet L, Mucci, Lorelei A, West, Catharine M L, Nielsen, Sune F, Kibel, Adam S, Cussenot, Olivier, Berndt, Sonja I, Koutros, Stella, Sørensen, Karina Dalsgaard, Cybulski, Cezary, Grindedal, Eli Marie, Park, Jong Y, Ingles, Sue A, Maier, Christiane, Hamilton, Robert J, Rosenstein, Barry S, Vega, Ana, The Impact Study Steering Committee And Collaborators, Kogevinas, Manolis, Wiklund, Fredrik, Penney, Kathryn L, Brenner, Hermann, John, Esther M, Kaneva, Radka, Logothetis, Christopher J, Neuhausen, Susan L, Ruyck, Kim De, Razack, Azad, Newcomb, Lisa F, Canary Pass Investigators, Lessel, Davor, Usmani, Nawaid, Claessens, Frank, Gago-Dominguez, Manuela, Townsend, Paul A, Roobol, Monique J, The Profile Study Steering Committee, The Practical Consortium, Teixeira, Manuel R

Volltext

Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score von Huynh-Le, Minh-Phuong, Karunamuni, Roshan, Fan, Chun Chieh, Asona, Lui, Thompson, Wesley Kurt, Martinez, Maria Elena, Eeles, Rosalind A, Kote-Jarai, Zsofia, Muir, Kenneth R, Lophatananon, Artitaya, Schleutker, Johanna, Pashayan, Nora, Batra, Jyotsna, Grönberg, Henrik, Neal, David E, Nordestgaard, Børge G, Tangen, Catherine M, MacInnis, Robert J, Wolk, Alicja, Albanes, Demetrius, Haiman, Christopher A, Travis, Ruth C, Blot, William J, Stanford, Janet L, Mucci, Lorelei A, West, Catharine M L, Nielsen, Sune F, Kibel, Adam S, Cussenot, Olivier, Berndt, Sonja I, Koutros, Stella, Sørensen, Karina Dalsgaard, Cybulski, Cezary, Grindedal, Eli Marie, Menegaux, Florence, Park, Jong Y, Ingles, Sue A, Maier, Christiane, Hamilton, Robert J, Rosenstein, Barry S, Lu, Yong-Jie, Watya, Stephen, Vega, Ana, Kogevinas, Manolis, Wiklund, Fredrik, Penney, Kathryn L, Huff, Chad D, Teixeira, Manuel, Multigner, Luc, Leach, Robin J, Brenner, Hermann, John, Esther M, Kaneva, Radka, Logothetis, Christopher J, Neuhausen, Susan L, De Ruyck, Kim, Ost, Piet, Razack, Azad, Newcomb, Lisa F, Fowke, Jay H, Gamulin, Marija, Abraham, Aswin, Claessens, Frank, Castelao, Jose Esteban, Townsend, Paul A, Crawford, Dana C, Petrovics, Gyorgy, van Schaik, Ron H N, Parent, Marie-Élise, Hu, Jennifer J, Zheng, Wei, Mills, Ian, Andreassen, Ole, Dale, Anders, Seibert, Tyler Michael

Volltext

Additional SNPs improve risk stratification of a polygenic hazard score for prostate cancer von Karunamuni, RA, Huynh-Le, MP, Fan, CC, Thompson, W, Eeles, RA, Kote-Jarai, Z, Muir, K, Lophatananon, A, Schleutker, J, Pashayan, N, Batra, J, Gronberg, H, Walsh, EI, Turner, EL, Lane, A, Martin, RM, Neal, DE, Donovan, JL, Hamdy, FC, Nordestgaard, BG, Tangen, CM, MacInnis, RJ, Wolk, A, Albanes, D, Haiman, CA, Travis, RC, Stanford, JL, Mucci, LA, West, CML, Nielsen, SF, Kibel, AS, Wiklund, F, Cussenot, O, Berndt, SI, Koutros, S, Sorensen, KD, Cybulski, C, Grindedal, EM, Park, JY, Ingles, SA, Maier, C, Hamilton, RJ, Rosenstein, BS, Vega, A, Kogevinas, M, Penney, KL, Teixeira, MR, Brenner, H, John, EM, Kaneva, R, Logothetis, CJ, Neuhausen, SL, Razack, A, Newcomb, LF, Gamulin, M, Usmani, N, Claessens, F, Gago-Dominguez, M, Townsend, PA, Roobol, MJ, Zheng, W, Mills, IG, Andreassen, OA, Dale, AM, Seibert, TM

Volltext

Abstract 3810: BRCA2 is a moderate penetrance gene contributing to young onset prostate cancer, but not disease over 65 years von Kote-Jarai, Zsofia, Leongamornlert, Daniel, Saunders, Ed, Tymrakiewicz, Malgorzata, Castro, Elena, Mahmud, Nadiya, Guy, Michelle, Edwards, Stephen, O'Brien, Lynne, Hall, Amanda, Wilkinson, Rosemary, Goh, Chee, Goldgar, David, Easton, Douglas, Eeles, Rosalind

Volltext

Abstract 2546: Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression von Kote-Jarai, Zsofia, Saunders, Edward, Leongamornlert, Daniel, Tymrakiewicz, Malgorzata, Dadaev, Tokhir, Jugurnauth, Sarah, Benlloch, Sara, Amin Al Olama, Ali, Ross-Adams, Helen, Neal, David, Eeles, Rosalind

Volltext