Dabrafenib; preclinical characterization, increased efficacy when combined with trametinib, while BRAF/MEK tool combination reduced skin lesions von King, Alastair J, Arnone, Marc R, Bleam, Maureen R, Moss, Katherine G, Yang, Jingsong, Fedorowicz, Kelly E, Smitheman, Kimberly N, Erhardt, Joseph A, Hughes-Earle, Angela, Kane-Carson, Laurie S, Sinnamon, Robert H, Qi, Hongwei, Rheault, Tara R, Uehling, David E, Laquerre, Sylvie G

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Identification of RSK and TTK as Modulators of Blood Vessel Morphogenesis Using an Embryonic Stem Cell-Based Vascular Differentiation Assay von Hammoud, Lamis, Adams, Jessica R., Loch, Amanda J., Marcellus, Richard C., Uehling, David E., Aman, Ahmed, Fladd, Christopher, McKee, Trevor D., Jo, Christine E.B., Al-Awar, Rima, Egan, Sean E., Rossant, Janet

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Recent progress on MAP kinase pathway inhibitors von Uehling, David E., Harris, Philip A.

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6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases von Wood, Edgar R, Shewchuk, Lisa M, Ellis, Byron, Brignola, Perry, Brashear, Ronald L, Caferro, Thomas R, Dickerson, Scott H, Dickson, Hamilton D, Donaldson, Kelly H, Gaul, Michael, Griffin, Robert J, Hassell, Anne M, Keith, Barry, Mullin, Robert, Petrov, Kimberly G, Reno, Michael J, Rusnak, David W, Tadepalli, Sarva M, Ulrich, John C, Wagner, Craig D, Vanderwall, Dana E, Waterson, Alex G, Williams, Jon D, White, Wendy L, Uehling, David E

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G protein–receptor kinases 5/6 are the key regulators of G protein–coupled receptor 35–arrestin interactions von Ganguly, Amlan, Quon, Tezz, Jenkins, Laura, Joseph, Babu, Al-awar, Rima, Chevigne, Andy, Tobin, Andrew B., Uehling, David E., Hoffmann, Carsten, Drube, Julia, Milligan, Graeme

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G protein–coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin von Varney, Matthew J., Steyaert, Wouter, Coucke, Paul J., Delanghe, Joris R., Uehling, David E., Joseph, Babu, Marcellus, Richard, Al-awar, Rima, Benovic, Jeffrey L.

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Design, Synthesis, and Characterization of 4‑Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma von Uehling, David E, Joseph, Babu, Chung, Kim Chan, Zhang, Andrew X, Ler, Spencer, Prakesch, Michael A, Poda, Gennady, Grouleff, Julie, Aman, Ahmed, Kiyota, Taira, Leung-Hagesteijn, Chungyee, Konda, John David, Marcellus, Richard, Griffin, Carly, Subramaniam, Ratheesh, Abibi, Ayome, Strathdee, Craig A, Isaac, Methvin B, Al-awar, Rima, Tiedemann, Rodger E

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Synthesis and evaluation of aniline headgroups for alkynyl thienopyrimidine dual EGFR/ErbB-2 kinase inhibitors von Waterson, Alex G., Petrov, Kimberly G., Hornberger, Keith R., Hubbard, Robert D., Sammond, Douglas M., Smith, Stephon C., Dickson, Hamilton D., Caferro, Thomas R., Hinkle, Kevin W., Stevens, Kirk L., Dickerson, Scott H., Rusnak, David W., Spehar, Glenn M., Wood, Edgar R., Griffin, Robert J., Uehling, David E.

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Dual EGFR/ErbB-2 inhibitors from novel pyrrolidinyl-acetylenic thieno[3,2- d]pyrimidines von Hubbard, Robert D., Dickerson, Scott H., Emerson, Holly K., Griffin, Robert J., Reno, Michael J., Hornberger, Keith R., Rusnak, David W., Wood, Edgar R., Uehling, David E., Waterson, Alex G.

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Correction to “Design, Synthesis, and Characterization of 4‑Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple M... von Uehling, David E, Joseph, Babu, Chung, Kim Chan, Zhang, Andrew X, Ler, Spencer, Prakesch, Michael A, Poda, Gennady, Grouleff, Julie, Aman, Ahmed, Kiyota, Taira, Leung-Hagesteijn, Chungyee, Konda, John David, Marcellus, Richard, Griffin, Carly, Subramaniam, Ratheesh, Abibi, Ayome, Strathdee, Craig A, Isaac, Methvin B, Al-awar, Rima, Tiedemann, Rodger E

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Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B‑Raf-Driven Tumors von Rheault, Tara R., Stellwagen, John C., Adjabeng, George M., Hornberger, Keith R., Petrov, Kimberly G., Waterson, Alex G., Dickerson, Scott H., Mook, Robert A., Laquerre, Sylvie G., King, Alastair J., Rossanese, Olivia W., Arnone, Marc R., Smitheman, Kimberly N., Kane-Carson, Laurie S., Han, Chao, Moorthy, Ganesh S., Moss, Katherine G., Uehling, David E.

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Biarylaniline Phenethanolamines as Potent and Selective β3 Adrenergic Receptor Agonists von Uehling, David E, Shearer, Barry G, Donaldson, Kelly H, Chao, Esther Y, Deaton, David N, Adkison, Kim K, Brown, Kathleen K, Cariello, Neal F, Faison, Walter L, Lancaster, Mary E, Lin, Jasmine, Hart, Robert, Milliken, Tula O, Paulik, Mark A, Sherman, Bryan W, Sugg, Elizabeth E, Cowan, Conrad

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A receptor for the immuno-suppressant FK506 is a cis-trans peptidyl-prolyl isomerase von Harding, Matthew W, Galat, Andrzej, Uehling, David E, Schreiber, Stuart L

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Synthesis and stereochemical effects of pyrrolidinyl-acetylenic thieno[3,2- d]pyrimidines as EGFR and ErbB-2 inhibitors von Stevens, Kirk L., Alligood, Krystal J., Alberti, Jennifer G. Badiang, Caferro, Thomas R., Chamberlain, Stanley D., Dickerson, Scott H., Dickson, Hamilton D., Emerson, Holly K., Griffin, Robert J., Hubbard, Robert D., Keith, Barry R., Mullin, Robert J., Petrov, Kimberly G., Gerding, Roseanne M., Reno, Michael J., Rheault, Tara R., Rusnak, David W., Sammond, Douglas M., Smith, Stephon C., Uehling, David E., Waterson, Alex G., Wood, Edgar R.

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Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor von Mamai, Ahmed, Chau, Anh M., Wilson, Brian J., Watson, Iain D., Joseph, Babu B., Subramanian, Pandiaraju R., Morshed, Monzur M., Morin, Justin A., Prakesch, Michael A., Lu, Tianbao, Connolly, Pete, Kuntz, Douglas A., Pomroy, Neil C., Poda, Gennady, Nguyen, Kong, Marcellus, Richard, Strathdee, Graig, Theriault, Brigitte, Subramaniam, Ratheesh, Mohammed, Mohammed, Abibi, Ayome, Chan, Manuel, Winston, Jeffrey, Kiyota, Taira, Undzys, Elijus, Aman, Ahmed, Austin, Nigel, Du Jardin, Marc, Packman, Kathryn, Phillippar, Ulrike, Attar, Riccardo, Edwards, James, O’Meara, Jeff, Uehling, David E., Al-awar, Rima, Privé, Gilbert G., Isaac, Methvin B.

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Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors von Rheault, Tara R., Caferro, Thomas R., Dickerson, Scott H., Donaldson, Kelly H., Gaul, Michael D., Goetz, Aaron S., Mullin, Robert J., McDonald, Octerloney B., Petrov, Kimberly G., Rusnak, David W., Shewchuk, Lisa M., Spehar, Glenn M., Truesdale, Anne T., Vanderwall, Dana E., Wood, Edgar R., Uehling, David E.

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Synthesis and Antitumor Activity of Novel Water Soluble Derivatives of Camptothecin as Specific Inhibitors of Topoisomerase I von Luzzio, Michael J, Besterman, Jeffrey M, Emerson, David L, Evans, Michael G, Lackey, Karen, Leitner, Peter L, McIntyre, Gordon, Morton, Bradley, Myers, Peter L, Peel, Michael, Sisco, Jay M, Sternbach, Daniel D, Tong, Wei-Qin, Truesdale, Ann, Uehling, David E, Vuong, Alan, Yates, Julie

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Total synthesis of FK506 and an FKBP probe reagent, [C(8),C(9)-13C2]-FK506 von Nakatsuka, Masashi, Ragan, John A, Sammakia, Tarek, Smith, David B, Uehling, David E, Schreiber, Stuart L

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Two General Routes to 1,4-Disubstituted-2,3,4,5-tetrahydro- 1H-3-benzazepines von Gerritz, Samuel W, Smith, Jennifer S, Nanthakumar, Suganthini S, Uehling, David E, Cobb, Jeffery E

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Discovery and optimization of imidazo[1,2- a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R) von Emmitte, Kyle A., Wilson, Brian J., Baum, Erich W., Emerson, Holly K., Kuntz, Kevin W., Nailor, Kristen E., Salovich, James M., Smith, Stephon C., Cheung, Mui, Gerding, Roseanne M., Stevens, Kirk L., Uehling, David E., Mook, Robert A., Moorthy, Ganesh S., Dickerson, Scott H., Hassell, Anne M., Anthony Leesnitzer, M., Shewchuk, Lisa M., Groy, Arthur, Rowand, Jason L., Anderson, Kelly, Atkins, Charity L., Yang, Jingsong, Sabbatini, Peter, Kumar, Rakesh

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