LRRC15 Is a Novel Mesenchymal Protein and Stromal Target for Antibody-Drug Conjugates von Purcell, James W, Tanlimco, Sonia G, Hickson, Jonathan, Fox, Melvin, Sho, Mien, Durkin, Lisa, Uziel, Tamar, Powers, Rick, Foster, Kelly, McGonigal, Thomas, Kumar, Subashri, Samayoa, Josue, Zhang, Dong, Palma, Joann P, Mishra, Sasmita, Hollenbaugh, Diane, Gish, Kurt, Morgan-Lappe, Susan E, Hsi, Eric D, Chao, Debra T

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Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer von Faivre, Emily J., McDaniel, Keith F., Albert, Daniel H., Mantena, Srinivasa R., Plotnik, Joshua P., Wilcox, Denise, Zhang, Lu, Bui, Mai H., Sheppard, George S., Wang, Le, Sehgal, Vasudha, Lin, Xiaoyu, Huang, Xiaoli, Lu, Xin, Uziel, Tamar, Hessler, Paul, Lam, Lloyd T., Bellin, Richard J., Mehta, Gaurav, Fidanze, Steve, Pratt, John K., Liu, Dachun, Hasvold, Lisa A., Sun, Chaohong, Panchal, Sanjay C., Nicolette, John J., Fossey, Stacey L., Park, Chang H., Longenecker, Kenton, Bigelow, Lance, Torrent, Maricel, Rosenberg, Saul H., Kati, Warren M., Shen, Yu

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HEXIM1 as a Robust Pharmacodynamic Marker for Monitoring Target Engagement of BET Family Bromodomain Inhibitors in Tumors and Surrogate Tissues von Lin, Xiaoyu, Huang, Xiaoli, Uziel, Tamar, Hessler, Paul, Albert, Daniel H, Roberts-Rapp, Lisa A, McDaniel, Keith F, Kati, Warren M, Shen, Yu

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Exploitation of Castration-Resistant Prostate Cancer Transcription Factor Dependencies by the Novel BET Inhibitor ABBV-075 von Faivre, Emily J, Wilcox, Denise, Lin, Xiaoyu, Hessler, Paul, Torrent, Maricel, He, Wei, Uziel, Tamar, Albert, Daniel H, McDaniel, Keith, Kati, Warren, Shen, Yu

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Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies von Bui, Mai H, Lin, Xiaoyu, Albert, Daniel H, Li, Leiming, Lam, Lloyd T, Faivre, Emily J, Warder, Scott E, Huang, Xiaoli, Wilcox, Denise, Donawho, Cherrie K, Sheppard, George S, Wang, Le, Fidanze, Steve, Pratt, John K, Liu, Dachun, Hasvold, Lisa, Uziel, Tamar, Lu, Xin, Kohlhapp, Fred, Fang, Guowei, Elmore, Steven W, Rosenberg, Saul H, McDaniel, Keith F, Kati, Warren M, Shen, Yu

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A Mouse Model of the Most Aggressive Subgroup of Human Medulloblastoma von Kawauchi, Daisuke, Robinson, Giles, Uziel, Tamar, Gibson, Paul, Rehg, Jerold, Gao, Cuilan, Finkelstein, David, Qu, Chunxu, Pounds, Stanley, Ellison, David W., Gilbertson, Richard J., Roussel, Martine F.

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Vulnerability of Small-Cell Lung Cancer to Apoptosis Induced by the Combination of BET Bromodomain Proteins and BCL2 Inhibitors von Lam, Lloyd T, Lin, Xiaoyu, Faivre, Emily J, Yang, Ziping, Huang, Xiaoli, Wilcox, Denise M, Bellin, Richard J, Jin, Sha, Tahir, Stephen K, Mitten, Michael, Magoc, Terry, Bhathena, Anahita, Kati, Warren M, Albert, Daniel H, Shen, Yu, Uziel, Tamar

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Targeting Lineage-specific MITF Pathway in Human Melanoma Cell Lines by A-485, the Selective Small-molecule Inhibitor of p300/CBP von Wang, Rui, He, Yupeng, Robinson, Valerie, Yang, Ziping, Hessler, Paul, Lasko, Loren M, Lu, Xin, Bhathena, Anahita, Lai, Albert, Uziel, Tamar, Lam, Lloyd T

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miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma von Uziel, Tamar, Karginov, Fedor V, Xie, Suqing, Parker, Joel S, Wang, Yong-Dong, Gajjar, Amar, He, Lin, Ellison, David, Gilbertson, Richard J, Hannon, Gregory, Roussel, Martine F

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The Volume of Three-Dimensional Cultures of Cancer Cells In Vitro Influences Transcriptional Profile Differences and Similarities with Monolayer Cultures and Xenografted Tumors von Boghaert, Erwin R., Lu, Xin, Hessler, Paul E., McGonigal, Thomas P., Oleksijew, Anatol, Mitten, Michael J., Foster-Duke, Kelly, Hickson, Jonathan A., Santo, Vitor E., Brito, Catarina, Uziel, Tamar, Vaidya, Kedar S.

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Requirement of the MRN complex for ATM activation by DNA damage von Uziel, Tamar, Lerenthal, Yaniv, Moyal, Lilach, Andegeko, Yair, Mittelman, Leonid, Shiloh, Yosef

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Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours von Lasko, Loren M., Jakob, Clarissa G., Edalji, Rohinton P., Qiu, Wei, Montgomery, Debra, Digiammarino, Enrico L., Hansen, T. Matt, Risi, Roberto M., Frey, Robin, Manaves, Vlasios, Shaw, Bailin, Algire, Mikkel, Hessler, Paul, Lam, Lloyd T., Uziel, Tamar, Faivre, Emily, Ferguson, Debra, Buchanan, Fritz G., Martin, Ruth L., Torrent, Maricel, Chiang, Gary G., Karukurichi, Kannan, Langston, J. William, Weinert, Brian T., Choudhary, Chunaram, de Vries, Peter, Kluge, Arthur F., Patane, Michael A., Van Drie, John H., Wang, Ce, McElligott, David, Kesicki, Ed, Marmorstein, Ronen, Sun, Chaohong, Cole, Philip A., Rosenberg, Saul H., Michaelides, Michael R., Lai, Albert, Bromberg, Kenneth D.

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Venetoclax Increases Intratumoral Effector T Cells and Antitumor Efficacy in Combination with Immune Checkpoint Blockade von Kohlhapp, Frederick J, Haribhai, Dipica, Mathew, Rebecca, Duggan, Ryan, Ellis, Paul A, Wang, Rui, Lasater, Elisabeth A, Shi, Yan, Dave, Nimita, Riehm, Jacob J, Robinson, Valerie A, Do, An D, Li, Yijin, Orr, Christine J, Sampath, Deepak, Raval, Aparna, Merchant, Mark, Bhathena, Anahita, Salem, Ahmed Hamed, Hamel, Keith M, Leverson, Joel D, Donawho, Cherrie, Pappano, William N, Uziel, Tamar

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Genomic analysis and prediction of therapeutic vulnerabilities of small cell lung cancer from rovalpituzumab tesirine phase III trial (MERU) von Zhao, Weilong, McLaughlin, Robert Tyler, Masica, David, Huntzicker, Erik, Uziel, Tamar, Flister, Michael, Bankovich, Alex, Samayoa, Josue, French, Dorothy, Zhao, Xi

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Activity of eftozanermin alfa plus venetoclax in preclinical models and patients with acute myeloid leukemia von Tahir, Stephen K., Calvo, Emiliano, Carneiro, Benedito A., Yuda, Junichiro, Shreenivas, Aditya, Jongen-Lavrencic, Mojca, Gort, Eelke, Ishizawa, Kenichi, Morillo, Daniel, Biesdorf, Carla, Smith, Morey, Cheng, Dong, Motwani, Monica, Sharon, David, Uziel, Tamar, Modi, Dimple A., Buchanan, Fritz G., Morgan-Lappe, Susan, Medeiros, Bruno C., Phillips, Darren C.

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Ataxia-telangiectasia locus: sequence analysis of 184 kb of human genomic DNA containing the entire ATM gene von Platzer, M, Rotman, G, Bauer, D, Uziel, T, Savitsky, K, Bar-Shira, A, Gilad, S, Shiloh, Y, Rosenthal, A

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Selective Inhibition of the Second Bromodomain of BET Family Proteins Results in Robust Antitumor Activity in Preclinical Models of Acute Myeloid Leukemia von Zhang, Lu, Cai, Tianyu, Lin, Xiaoyu, Huang, Xiaoli, Bui, Mai H, Plotnik, Joshua P, Bellin, Richard J, Faivre, Emily J, Kuruvilla, Vinitha M, Lam, Lloyd T, Lu, Xin, Zha, Zheng, Feng, Weiguo, Hessler, Paul, Uziel, Tamar, Zhang, Qi, Cavazos, Antonio, Han, Lina, Ferguson, Debra C, Mehta, Gaurav, Shanmugavelandy, Sriram S, Magoc, Terrance J, Rowe, Jenny, Goodwin, Neal C, Dorritie, Kathleen A, Boyiadzis, Michael, Albert, Daniel H, McDaniel, Keith F, Kati, Warren M, Konopleva, Marina, Shen, Yu

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Abstract 3812: JAK2 and PTPN11 mutations as potential biomarkers for BCL-xL inhibition as monotherapy and in combination therapy for acute myeloid leukemia von Bellin, Richard J., Hilgenberg, Valerie, Popovic, Relja, Uziel, Tamar, Lam, Lloyd T.

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Immune Profiling of Relapsed/Refractory Multiple Myeloma Patients Treated with Venetoclax in Combination with Dexamethasone (VenDex), Daratumumab and Dexamethasone (VenDd), and Dar... von Vishwamitra, Deeksha, Mantis, Christine, Haribhai, Dipica, Uziel, Tamar, Leverson, Joel D., Pauff, James M., Bueno, Orlando F., Maciag, Paulo C., Ross, Jeremy A.

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Selective Targeting BET Family Bdii Bromodomain with Abbv-744 and BCL-2 with Venetoclax (ABT-199) Is Synergistic in Primary Acute Myeloid Leukemia Models von Cai, Tianyu, Kuruvilla, Vinitha Mary, Lin, Xiaoyu, Uziel, Tamar, Lu, Xin, Zhang, Lu, Huang, Xiaoli, Zhang, Qi, Cavazos, Antonio, Han, Lina, Shen, Yu, Konopleva, Marina Y

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