Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms von Gao, Linfeng, Emperle, Max, Guo, Yiran, Grimm, Sara A., Ren, Wendan, Adam, Sabrina, Uryu, Hidetaka, Zhang, Zhi-Min, Chen, Dongliang, Yin, Jiekai, Dukatz, Michael, Anteneh, Hiwot, Jurkowska, Renata Z., Lu, Jiuwei, Wang, Yinsheng, Bashtrykov, Pavel, Wade, Paul A., Wang, Gang Greg, Jeltsch, Albert, Song, Jikui

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Genetic correlates in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with Hyper-CVAD plus dasatinib or ponatinib von Sasaki, Yuya, Kantarjian, Hagop M., Short, Nicholas J., Wang, Feng, Furudate, Ken, Uryu, Hidetaka, Garris, Rebecca, Jain, Nitin, Sasaki, Koji, Ravandi, Farhad, Konopleva, Marina, Garcia-Manero, Guillermo, Little, Latasha, Gumbs, Curtis, Zhao, Li, Futreal, P. Andrew, Takahashi, Koichi, Jabbour, Elias

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SOD1 is a synthetic-lethal target in PPM1D -mutant leukemia cells von Zhang, Linda, Hsu, Joanne I, Braekeleer, Etienne D, Chen, Chun-Wei, Patel, Tajhal D, Martell, Alejandra G, Guzman, Anna G, Wohlan, Katharina, Waldvogel, Sarah M, Uryu, Hidetaka, Tovy, Ayala, Callen, Elsa, Murdaugh, Rebecca L, Richard, Rosemary, Jansen, Sandra, Vissers, Lisenka, de Vries, Bert B A, Nussenzweig, Andre, Huang, Shixia, Coarfa, Cristian, Anastas, Jamie, Takahashi, Koichi, Vassiliou, George, Goodell, Margaret A

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Increased iron uptake by splenic hematopoietic stem cells promotes TET2-dependent erythroid regeneration von Tseng, Yu-Jung, Kageyama, Yuki, Murdaugh, Rebecca L., Kitano, Ayumi, Kim, Jong Hwan, Hoegenauer, Kevin A., Tiessen, Jonathan, Smith, Mackenzie H., Uryu, Hidetaka, Takahashi, Koichi, Martin, James F., Samee, Md Abul Hassan, Nakada, Daisuke

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Correction: Genetic correlates in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with Hyper-CVAD plus dasatinib or ponatinib von Sasaki, Yuya, Kantarjian, Hagop M., Short, Nicholas J., Wang, Feng, Furudate, Ken, Uryu, Hidetaka, Garris, Rebecca, Jain, Nitin, Sasaki, Koji, Ravandi, Farhad, Konopleva, Marina, Garcia-Manero, Guillermo, Little, Latasha, Gumbs, Curtis, Zhao, Li, Futreal, P. Andrew, Takahashi, Koichi, Jabbour, Elias

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Synthetic retinoid Am80 ameliorates chronic graft-versus-host disease by down-regulating Th1 and Th17 von Nishimori, Hisakazu, Maeda, Yoshinobu, Teshima, Takanori, Sugiyama, Haruko, Kobayashi, Koichiro, Yamasuji, Yoshiko, Kadohisa, Sachiyo, Uryu, Hidetaka, Takeuchi, Kengo, Tanaka, Takehiro, Yoshino, Tadashi, Iwakura, Yoichiro, Tanimoto, Mitsune

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Automated urinary sediment detection for Fabry disease using deep-learning algorithms von Uryu, Hidetaka, Migita, Ohsuke, Ozawa, Minami, Kamijo, Chikako, Aoto, Saki, Okamura, Kohji, Hasegawa, Fuyuki, Okuyama, Torayuki, Kosuga, Motomichi, Hata, Kenichiro

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Breakthrough Trichosporonosis in Patients with Hematologic Malignancies Receiving Micafungin von Matsue, Kosei, Uryu, Hidetaka, Koseki, Mihoko, Asada, Noboru, Takeuchi, Masami

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P1330: CYTOREDUCTIVE CHEMOTHERAPY COULD ACCELERATE THE LOSS OF CLONAL DIVERSITY IN HEMATOPOIETIC STEM CELLS AND PROMOTES THE CONVERGENT EVOLUTION OF THERAPY‐RELATED CLONAL HEMATOPO... von Uryu, Hidetaka, Saeki, Koichi, Nangalia, Jyoti, Chapman, Michael, Zhao, LI, Hsu, Joanne, Bueso‐Ramos, Carlos, Chen, Shujuan, Yang, Hui, Dinardo, Courtney, Daver, Naval, Colla, Simona, Ganan‐Gomez, Irene, Zhang, Jianhua, Song, Xingzhi, Thompson, Erika, Tang, Hongli, Orlowski, Robert Z, Champlin, Richard E., Qazilbash, Muzaffar H., Shpall, Elizabeth J., Futreal, Andrew, Garcia‐Manero, Guillermo, Haeno, Hiroshi, Takahashi, Koichi

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Phase separation drives aberrant chromatin looping and cancer development von Ahn, Jeong Hyun, Davis, Eric S., Daugird, Timothy A., Zhao, Shuai, Quiroga, Ivana Yoseli, Uryu, Hidetaka, Li, Jie, Storey, Aaron J., Tsai, Yi-Hsuan, Keeley, Daniel P., Mackintosh, Samuel G., Edmondson, Ricky D., Byrum, Stephanie D., Cai, Ling, Tackett, Alan J., Zheng, Deyou, Legant, Wesley R., Phanstiel, Douglas H., Wang, Gang Greg

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Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins von Eriguchi, Yoshihiro, Takashima, Shuichiro, Oka, Hideyo, Shimoji, Sonoko, Nakamura, Kiminori, Uryu, Hidetaka, Shimoda, Shinji, Iwasaki, Hiromi, Shimono, Nobuyuki, Ayabe, Tokiyoshi, Akashi, Koichi, Teshima, Takanori

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Successful Combined Use of Tranexamic Acid and Unfractionated Heparin for Life-Threatening Bleeding Associated with Intravascular Coagulation in a Patient with Chronic Myelogenous... von KOSEKI, Mihoko, ASADA, Noboru, URYU, Hidetaka, TAKEUCHI, Masami, ASAKURA, Hidesaku, MATSUE, Kosei

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Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic von Li, Dongxu, Yu, Xufen, Kottur, Jithesh, Gong, Weida, Zhang, Zhao, Storey, Aaron J., Tsai, Yi-Hsuan, Uryu, Hidetaka, Shen, Yudao, Byrum, Stephanie D., Edmondson, Rick D., Mackintosh, Samuel G., Cai, Ling, Liu, Zhijie, Aggarwal, Aneel K., Tackett, Alan J., Liu, Jing, Jin, Jian, Wang, Gang Greg

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Genome-Wide CRISPR Screen Reveals Dependency of PPM1D-mutant Cells on DNA Repair von Zhang, Linda, Hsu, Joanne I., Braekeleer, Etienne D., Uryu, Hidetaka, Callen-Moreu, Elsa, Nussenzweig, Andre, Takahashi, Koichi, Vassiliou, George S, Goodell, Margaret A.

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Histone H3 proline 16 hydroxylation regulates mammalian gene expression von Liu, Xijuan, Wang, Jun, Boyer, Joshua A., Gong, Weida, Zhao, Shuai, Xie, Ling, Wu, Qiong, Zhang, Cheng, Jain, Kanishk, Guo, Yiran, Rodriguez, Javier, Li, Mingjie, Uryu, Hidetaka, Liao, Chengheng, Hu, Lianxin, Zhou, Jin, Shi, Xiaobing, Tsai, Yi-Hsuan, Yan, Qin, Luo, Weibo, Chen, Xian, Strahl, Brian D., von Kriegsheim, Alex, Zhang, Qi, Wang, Gang Greg, Baldwin, Albert S., Zhang, Qing

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Mutation order in acute myeloid leukemia identifies uncommon patterns of evolution and illuminates phenotypic heterogeneity von Schwede, Matthew, Jahn, Katharina, Kuipers, Jack, Miles, Linde A., Bowman, Robert L., Robinson, Troy, Furudate, Ken, Uryu, Hidetaka, Tanaka, Tomoyuki, Sasaki, Yuya, Ediriwickrema, Asiri, Benard, Brooks, Gentles, Andrew J., Levine, Ross, Beerenwinkel, Niko, Takahashi, Koichi, Majeti, Ravindra

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Single-Cell Proteogenomics Analysis of AML Samples Treated with Decitabine and Venetoclax Reveals Divergent Treatment Escape Mechanisms von Kim, Yi June, Li, Zongrui, Maiti, Abhishek, Tanaka, Tomoyuki, Uryu, Hidetaka, Furudate, Ken, Hayes, Kala, Daver, Naval, Pemmaraju, Naveen, Kadia, Tapan M., Ravandi, Farhad, Short, Nicholas J., Ohanian, Maro, Borthakur, Gautam, Jain, Nitin, Issa, Ghayas C., Masarova, Lucia, Kornblau, Steven M., Wierda, William G., Loghavi, Sanam, Wang, Sa A., Garcia-Manero, Guillermo, Kantarjian, Hagop, DiNardo, Courtney D., Konopleva, Marina Y., Takahashi, Koichi

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Mutant Natural Killer Cell Dysfunction Enables the Immune Escape of Premalignant MDS Cell Clones von Ganan-Gomez, Irene, Kumar, Bijender, Rodriguez Sevilla, Juan Jose, Ma, Feiyang, Kim, Yi June, Chien, Kelly S., Nelson, Kate, Yang, Hui, Tan, Roselyn, Li, Zongrui, Tanaka, Tomoyuki, Uryu, Hidetaka, Kanagal-Shamanna, Rashmi, Loghavi, Sanam, Alatrash, Gheath, Bejar, Rafael, Rezvani, Katayoun, Takahashi, Koichi, Garcia-Manero, Guillermo, Daher, MD, May, Colla, Simona

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Cancer Chemotherapy Accelerates the Loss of Clonal Diversity in Hematopoietic Stem Cells and Promotes the Convergent Evolution of Therapy-Related Clonal Hematopoiesis von Uryu, Hidetaka, Saeki, Koichi, Nangalia, Jyoti, Spencer Chapman, Michael, Zhao, Li, Hsu, Joanne I., Bueso-Ramos, Carlos E., Chen, Shujuan, Yang, Hui, Kantarjian, Hagop, DiNardo, Courtney D., Daver, Naval, Colla, Simona, Ganan-Gomez, Irene, Zhang, Jianhua, Song, Xingzhi, Thompson, Erika, Tang, Hongli, Orlowski, Robert Z., Champlin, Richard E, Qazilbash, Muzaffar H, Shpall, Elizabeth J, Garcia-Manero, Guillermo, Haeno, Hiroshi, Takahashi, Koichi, Futreal, Andrew

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A Phase Ib/II Study of Ivosidenib with Venetoclax ± Azacitidine in IDH1-Mutated Myeloid Malignancies von Lachowiez, Curtis A, Loghavi, Sanam, Zeng, Zhihong, Tanaka, Tomoyuki, Kim, Yi June, Uryu, Hidetaka, Turkalj, Sven, Jakobsen, Niels Asger, Luskin, Marlise R, Duose, Dzifa Y, Tidwell, Rebecca S S, Short, Nicholas J, Borthakur, Gautam, Kadia, Tapan M, Masarova, Lucia, Tippett, George D, Bose, Prithviraj, Jabbour, Elias J, Ravandi, Farhad, Daver, Naval G, Garcia-Manero, Guillermo, Kantarjian, Hagop, Garcia, Jacqueline S, Vyas, Paresh, Takahashi, Koichi, Konopleva, Marina, DiNardo, Courtney D

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