Optimization of 6,7-Disubstituted-4-(arylamino)quinoline-3-carbonitriles as Orally Active, Irreversible Inhibitors of Human Epidermal Growth Factor Receptor-2 Kinase Activity von Tsou, Hwei-Ru, Overbeek-Klumpers, Elsebe G, Hallett, William A, Reich, Marvin F, Floyd, M. Brawner, Johnson, Bernard D, Michalak, Ronald S, Nilakantan, Ramaswamy, Discafani, Carolyn, Golas, Jonathan, Rabindran, Sridhar K, Shen, Ru, Shi, Xiaoqing, Wang, Yu-Fen, Upeslacis, Janis, Wissner, Allan

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Gemtuzumab Ozogamicin, A Potent and Selective Anti-CD33 Antibody−Calicheamicin Conjugate for Treatment of Acute Myeloid Leukemia von Hamann, Philip R, Hinman, Lois M, Hollander, Irwin, Beyer, Carl F, Lindh, Delores, Holcomb, Ryan, Hallett, William, Tsou, Hwei-Ru, Upeslacis, Janis, Shochat, Dan, Mountain, Andrew, Flowers, David A, Bernstein, Irwin

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Anti-tumor immunity influences cancer cell reliance upon ATG7 von Arensman, Michael D., Yang, Xiaoran S., Zhong, Wenyan, Bisulco, Stephanie, Upeslacis, Erik, Rosfjord, Edward C., Deng, Shibing, Abraham, Robert T., Eng, Christina H.

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p120 catenin is a key effector of a Ras-PKC epsilon oncogenic signaling axis von Dann, S G, Golas, J, Miranda, M, Shi, C, Wu, J, Jin, G, Rosfjord, E, Upeslacis, E, Klippel, A

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Anti-EFNA4 Calicheamicin Conjugates Effectively Target Triple-Negative Breast and Ovarian Tumor-Initiating Cells to Result in Sustained Tumor Regressions von Damelin, Marc, Bankovich, Alexander, Park, Albert, Aguilar, Jorge, Anderson, Wade, Santaguida, Marianne, Aujay, Monette, Fong, Sarah, Khandke, Kiran, Pulito, Virginia, Ernstoff, Elana, Escarpe, Paul, Bernstein, Jeffrey, Pysz, Marybeth, Zhong, Wenyan, Upeslacis, Erik, Lucas, Judy, Lucas, Justin, Nichols, Timothy, Loving, Kathryn, Foord, Orit, Hampl, Johannes, Stull, Robert, Barletta, Frank, Falahatpisheh, Hadi, Sapra, Puja, Gerber, Hans-Peter, Dylla, Scott J

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A Novel GUCY2C-CD3 T-Cell Engaging Bispecific Construct (PF-07062119) for the Treatment of Gastrointestinal Cancers von Mathur, Divya, Root, Adam R., Bugaj-Gaweda, Bozena, Bisulco, Stephanie, Tan, Xingzhi, Fang, Wei, Kearney, Jessica C., Lucas, Justin, Guffroy, Magali, Golas, Jonathan, Rohde, Cynthia M., Stevens, Chad, Kamperschroer, Cris, Kelleher, Kerry, Lawrence-Henderson, Rosemary F., Upeslacis, Erik, Yao, Johnny, Narula, Jatin, LaVallie, Edward R., Fernandez, Diane R., Buetow, Bernard S., Rosfjord, Edward, Bloom, Laird, King, Lindsay E., Tchistiakova, Lioudmila, Nguyen, Anhco, Sapra, Puja

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Abstract 2283: A novel GUCY2C - CD3 bispecific engages T cells to induce cytotoxicity in gastrointestinal tumors von Mathur, Divya, Root, Adam, Bugaj-Gaweda, Bozena, Tan, Xingzhi, Fang, Wei, Bisulco, Stephanie, Golas, Jonathan, Fernandez, Diane, Kearney, Jessica, Upeslacis, Eric, Yao, Johnny, Rosfjord, Edward, Stevens, Chad, Kobylarz, Keith, King, Lindsay, Narula, Jatin, Kelleher, Kerry, Schaer, David, Kamperschroer, Cris, Buetow, Bernard, Rohde, Cynthia, Moreau, Allison, Wong, Gilbert, Sapra, Puja

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An Anti-CD33 Antibody−Calicheamicin Conjugate for Treatment of Acute Myeloid Leukemia. Choice of Linker von Hamann, Philip R, Hinman, Lois M, Beyer, Carl F, Lindh, Delores, Upeslacis, Janis, Flowers, David A, Bernstein, Irwin

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4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile Inhibitors of Epidermal Growth Factor Receptor Kinase and Their Bioisosteric Relationship to the 4-Anilino-6,7-dialkoxyquinazoline In... von Wissner, Allan, Berger, Dan M, Boschelli, Diane H, Floyd, M. Brawner, Greenberger, Lee M, Gruber, Brian C, Johnson, Bernard D, Mamuya, Nellie, Nilakantan, Ramaswamy, Reich, Marvin F, Shen, Ru, Tsou, Hwei-Ru, Upeslacis, Erik, Wang, Yu Fen, Wu, Biqi, Ye, Fei, Zhang, Nan

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Abstract 2355: Palbociclib enhances the antitumor activity of taxanes by abrogating cell cycle checkpoints and alleviating hypoxia in squamous cell lung cancer von Cao, Joan, Zhu, Zhou, Wang, Hui, Nichols, Tim, Rosfjord, Edward, Hopf, Christine, Upeslacis, Erik, Rejto, Paul, Weinrich, Scott, Vanarsdale, Todd, Hardwick, James, Wei, Ping

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Abstract 818: NG-HER2 ADC (PF-06804103) is superior to trastuzumab emtansine in a mouse 'avatar' head-to-head clinical trial von Sung, Matthew S., Hopf, Christine, Upeslacis, Erik, Golas, Jonathon, Kaplan, Mark, Khandke, Kiran, Charati, Manoj, Kotch, Frank, Loganzo, Frank, Geles, Ken, Lucas, Judy, Gerber, Hans-Peter, Sapra, Puja, Rosfjord, Edward

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The interaction of PKN3 with RhoC promotes malignant growth von Unsal-Kacmaz, Keziban, Ragunathan, Shoba, Rosfjord, Edward, Dann, Stephen, Upeslacis, Erik, Grillo, Mary, Hernandez, Richard, Mack, Fiona, Klippel, Anke

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Discovery of Pyrano[3,4-b]indoles as Potent and Selective HCV NS5B Polymerase Inhibitors von Gopalsamy, Ariamala, Lim, Kitae, Ciszewski, Gregory, Park, Kaapjoo, Ellingboe, John W, Bloom, Jonathan, Insaf, Shabana, Upeslacis, Janis, Mansour, Tarek S, Krishnamurthy, Girija, Damarla, Murthy, Pyatski, Yelena, Ho, Douglas, Howe, Anita Y. M, Orlowski, Mark, Feld, Boris, O'Connell, John

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Abstract 2113: Caveolae-mediated endocytosis as a novel mechanism of resistance to T-DM1 ADC von Sung, Matthew S., Tan, Xingzhi, Hosselet, Christine, Cinque, Michael, Upeslacis, Erik, Golas, Jonathon, Wang, Fang, Lu, Bingwen, Tylaska, Laurie, King, Lindsay, Myers, Jeremy, Rosfjord, Edward, Lucas, Judy, Gerber, Hans-Peter, Loganzo, Frank

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p120 catenin is a key effector of a Ras-PKCζ oncogenic signaling axis von Dann, S.G, Golas, J, Miranda, M, Shi, C, Wu, J, Jin, G, Rosfjord, E, Upeslacis, E, Klippel, A

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p120 catenin is a key effector of a Ras-PKC[epsilon] oncogenic signaling axis von Dann, S G, Golas, J, Miranda, M, Shi, C, Wu, J, Jin, G, Rosfjord, E, Upeslacis, E, Klippel, A

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Abstract A16: A GUCY2c-CD3 bispecific engages T cells to induce cytotoxicity in gastrointestinal tumors von Mathur, Divya, Root, Adam, Bugaj-Gaweda, Bozena, Tan, Xingzhi, Fang, Wei, Bisulco, Stephanie, Golas, Jonathan, Kearney, Jessica, Upeslacis, Eric, Yao, Johnny, Rosfjord, Edward, Stevens, Chad, King, Lindsay, Narula, Jatin, Kelleher, Kerry, Rohde, Cynthia, Tchistiakova, Lioudmila, Nguyen, Anhco, Sapra, Puja

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Abstract 1469: Patient derived xenograft (PDX) models: improving predictability of experimental cancer therapies von Rosfjord, Edward, Han, Xin, Leahy, Danielle, Upeslacis, Erik, Lucas, Justin, Golas, Jonathon, Hooper, Andrea, Immermann, Fred, Lu, Bingwen, Myers, Jeremy, Kan, Zhengyan, Hardwick, James, Powell, Eric, Sapra, Puja, Rejto, Paul, Gerber, Hans-Peter, Lucas, Judy

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An Anti-MUC1 Antibody−Calicheamicin Conjugate for Treatment of Solid Tumors. Choice of Linker and Overcoming Drug Resistance von Hamann, Philip R, Hinman, Lois M, Beyer, Carl F, Greenberger, Lee M, Lin, Clara, Lindh, Delores, Menendez, Ana T, Wallace, Rosalyn, Durr, Frederick E, Upeslacis, Janis

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p120 catenin is a key effector of a Ras-PKCɛ oncogenic signaling axis von Dann, S G, Golas, J, Miranda, M, Shi, C, Wu, J, Jin, G, Rosfjord, E, Upeslacis, E, Klippel, A

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