TPX-0131, a Potent CNS-penetrant, Next-generation Inhibitor of Wild-type ALK and ALK-resistant Mutations von Murray, Brion W, Zhai, Dayong, Deng, Wei, Zhang, Xin, Ung, Jane, Nguyen, Vivian, Zhang, Han, Barrera, Maria, Parra, Ana, Cowell, Jessica, Lee, Dong J, Aloysius, Herve, Rogers, Evan

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Total synthesis of the novel benzophenone NP-011694 von Noncovich, Alain, Ung, Jane, Patron, Andrew

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Abstract 1469: TPX-0131, a potent inhibitor of wild type ALK and a broad spectrum of both single and compound ALK resistance mutations von Murray, Brion W., Zhai, Dayong, Deng, Wei, Rogers, Evan, Zhang, Xin, Ung, Jane, Nguyen, Vivian, Zhang, Han, Barrera, Maria, Parra, Ana, Cowell, Jessica, Lee, Dong, Aloysius, Herve

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Abstract 5226: TPX-0131: A next generation macrocyclic ALK inhibitor that overcomes ALK resistant mutations refractory to current approved ALK inhibitors von Cui, J. Jean, Rogers, Evan, Zhai, Dayong, Deng, Wei, Ung, Jane, Nguyen, Vivian, Zhang, Han, Zhang, Xin, Parra, Ana, Barrera, Maria, Lee, Dong, Murray, Brion

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The next-generation RET inhibitor TPX-0046 is active in drug-resistant and naïve RET-driven cancer models von Drilon, Alexander E., Zhai, Dayong, Rogers, Evan, Deng, Wei, Zhang, Xin, Ung, Jane, Lee, Dong, Rodon, Laura, Graber, Armin, Zimmerman, Zachary Franklin, Murray, Brion W, Subbiah, Vivek

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Abstract 1321: TPX-0022, a polypharmacology inhibitor of MET/CSF1R/SRC for treatment of cancers with abnormal HGF/MET signaling von Zhai, Dayong, Rogers, Evan, Deng, Wei, Zhang, Xin, Lee, Dong, Ung, Jane, Zhang, Han, Liu, Jing, Lu, Yuelie, Huang, John, Graber, Armin, Zimmerman, Zach, Lim, John, Whitten, Jeffrey, Cui, J. Jean

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Abstract 1325: TPX-0022, a polypharmacology inhibitor of MET/CSF1R/SRC inhibits tumor growth by promoting anti-tumor immune responses von Deng, Wei, Zhai, Dayong, Rogers, Evan, Zhang, Xin, Lee, Dong, Ung, Jane, Zhang, Han, Liu, Jing, Lu, Yuelie, Huang, John, Graber, Armin, Zimmerman, Zach, Lim, John, Whitten, Jeffrey, Cui, J. Jean

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P3.02a-009 TPX-0005: A Multi-Faceted Approach to Overcoming Clinical Resistances from Current ALK or ROS1 Inhibitor Treatment in Lung Cancer: Topic: ALK Biomarkers von Cui, J. Jean, Zhai, Dayong, Deng, Wei, Huang, Zhongdong, Rogers, Evan, Ung, Jane, Whitten, Jeffrey, Li, Yishan

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P3.02a-009 TPX-0005: A Multi-Faceted Approach to Overcoming Clinical Resistances from Current ALK or ROS1 Inhibitor Treatment in Lung Cancer von Cui, J. Jean, Zhai, Dayong, Deng, Wei, Huang, Zhongdong, Rogers, Evan, Ung, Jane, Whitten, Jeffrey, Li, Yishan

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Discovery and development of a novel class of phenoxyacetyl amides as highly potent TRPM8 agonists for use as cooling agents von Noncovich, Alain, Priest, Chad, Ung, Jane, Patron, Andrew P., Servant, Guy, Brust, Paul, Servant, Nicole, Faber, Nathan, Liu, Hanghui, Gonsalves, Nicole S., Ditschun, Tanya L.

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COMPOUNDS USEFUL AS MODULATORS OF TRPM8 von Noncovich, Alain, Ung, Jane, Priest, Chad, Patron, Andrew

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INDAZOLE CONTAINING MACROCYCLES AND THEIR USE von RUI, Eugene Yuanjin, UNG, Jane, CUI, Jingrong Jean, ROGERS, Evan W, SARKAR, Anindya

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MACROCYCLES FOR USE IN TREATING DISEASE von NGUYEN, Vivian, UNG, Jane, DENG, Wei, ZHAI, Dayong, CUI, Jingrong J, ROGERS, Evan W

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INDAZOLE MACROCYCLES AND THEIR USE von JIANG, Ping, RUI, Eugene Yuanjin, UNG, Jane, DENG, Wei, ZHAI, Dayong, CUI, Jingrong Jean, ROGERS, Evan W

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EGFR INHIBITORS FOR TREATING DISEASE von RUI, Eugene Yuanjin, UNG, Jane, DENG, Wei, ZHAI, Dayong, CUI, Jingrong Jean, ROGERS, Evan W, SARKAR, Anindya

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EGFR INHIBITORS FOR TREATING DISEASE von RUI, Eugene Yuanjin, UNG, Jane, DENG, Wei, ZHAI, Dayong, CUI, Jingrong Jean, ROGERS, Evan W, SARKAR, Anindya

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INDAZOLE CONTAINING MACROCYCLES AND THEIR USE von RUI, Eugene Yuanjin, UNG, Jane, CUI, Jingrong Jean, ROGERS, Evan W, SARKAR, Anindya

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MACROCYCLES FOR USE IN TREATING DISEASE von Cui, Jingrong J, Rogers, Evan W, Ung, Jane, Deng, Wei, Nguyen, Vivian, Zhai, Dayong

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Macrocyclic compounds for treating disease von UNG, Jane, DENG, Wei, ZHANG, Han, ZHAI, Dayong, ROGERS, Evan W, CUI, Jingrong Jean, WHITTEN, Jeffrey

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ChemInform Abstract: Total Synthesis of the Novel Benzophenone NP-011694 von Noncovich, Alain, Ung, Jane, Patron, Andrew

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