Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma von Montagut, Clara, Sharma, Sreenath V, Shioda, Toshi, McDermott, Ultan, Ulman, Matthew, Ulkus, Lindsey E, Dias-Santagata, Dora, Stubbs, Hannah, Lee, Diana Y, Singh, Anurag, Drew, Lisa, Haber, Daniel A, Settleman, Jeffrey

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Lipid catabolism via CPT1 as a therapeutic target for prostate cancer von Schlaepfer, Isabel R, Rider, Leah, Rodrigues, Lindsey Ulkus, Gijón, Miguel A, Pac, Colton T, Romero, Lina, Cimic, Adela, Sirintrapun, S Joseph, Glodé, L Michael, Eckel, Robert H, Cramer, Scott D

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Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors von McDermott, Ultan, Iafrate, A John, Gray, Nathanael S, Shioda, Toshi, Classon, Marie, Maheswaran, Shyamala, Zhou, Wenjun, Choi, Hwan Geun, Smith, Shannon L, Dowell, Lori, Ulkus, Lindsey E, Kuhlmann, Georgiana, Greninger, Patricia, Christensen, James G, Haber, Daniel A, Settleman, Jeffrey

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Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling von McDermott, Ultan, Sharma, Sreenath V, Dowell, Lori, Greninger, Patricia, Montagut, Clara, Lamb, Jennifer, Archibald, Heidi, Raudales, Raul, Tam, Angela, Lee, Diana, Rothenberg, S. Michael, Supko, Jeffrey G, Sordella, Raffaella, Ulkus, Lindsey E, Iafrate, A. John, Maheswaran, Shyamala, Njauw, Ching Ni, Tsao, Hensin, Drew, Lisa, Hanke, Jeff H, Ma, Xiao-Jun, Erlander, Mark G, Gray, Nathanael S, Haber, Daniel A, Settleman, Jeffrey

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The T790M “gatekeeper” mutation in EGFR mediates resistance to low concentrations of an irreversible EGFR inhibitor von Godin-Heymann, Nadia, Ulkus, Lindsey, Brannigan, Brian W, McDermott, Ultan, Lamb, Jennifer, Maheswaran, Shyamala, Settleman, Jeffrey, Haber, Daniel A

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Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation von GODIN-HEYMANN, Nadia, BRYANT, Lanthe, RIVERA, Miguel N, ULKUS, Lindsey, BELL, Daphne W, RIESE, David J, SETTLEMAN, Jeffrey, HABER, Daniel A

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Ligand-Dependent Platelet-Derived Growth Factor Receptor (PDGFR)-α Activation Sensitizes Rare Lung Cancer and Sarcoma Cells to PDGFR Kinase Inhibitors von MCDERMOTT, Ultan, AMES, Rachel Y, LUCIEN, Laury, BRANNIGAN, Brian W, ULKUS, Lindsey E, MA, Xiao-Jun, ERLANDER, Mark G, HABER, Daniel A, SHARMA, Sreenath V, SETTLEMAN, Jeffrey, IAFRATE, A. John, MAHESWARAN, Shyamala, STUBBS, Hannah, GRENINGER, Patricia, MCCUTCHEON, Kaitlin, MILANO, Randy, TAM, Angela, LEE, Diana Y

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MAP3K7 and CHD1 Are Novel Mediators of Resistance to Oncolytic Vesicular Stomatitis Virus in Prostate Cancer Cells von Bayne, Robert S., Puckett, Shelby, Rodrigues, Lindsey Ulkus, Cramer, Scott D., Lee, Jingyun, Furdui, Cristina M., Chou, Jeff W., Miller, Lance D., Ornelles, David A., Lyles, Douglas S.

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Prevalence and Functional Analysis of Sequence Variants in the ATR Checkpoint Mediator Claspin von Zhang, Jianmin, Song, Young-Han, Brannigan, Brian W, Wahrer, Doke C R, Schiripo, Taryn A, Harris, Patricia L, Haserlat, Sara M, Ulkus, Lindsey E, Shannon, Kristen M, Garber, Judy E, Freedman, Matthew L, Henderson, Brian E, Zou, Lee, Sgroi, Dennis C, Haber, Daniel A, Bell, Daphne W

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Isolation of rare circulating tumour cells in cancer patients by microchip technology von Toner, Mehmet, Nagrath, Sunitha, Sequist, Lecia V, Maheswaran, Shyamala, Bell, Daphne W, Irimia, Daniel, Ulkus, Lindsey, Smith, Matthew R, Kwak, Eunice L, Digumarthy, Subba, Muzikansky, Alona, Ryan, Paula, Balis, Ulysses J, Tompkins, Ronald G, Haber, Daniel A

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Detection of Mutations in EGFR in Circulating Lung-Cancer Cells von Maheswaran, Shyamala, Sequist, Lecia V, Nagrath, Sunitha, Ulkus, Lindsey, Brannigan, Brian, Collura, Chey V, Inserra, Elizabeth, Diederichs, Sven, Iafrate, A. John, Bell, Daphne W, Digumarthy, Subba, Muzikansky, Alona, Irimia, Daniel, Settleman, Jeffrey, Tompkins, Ronald G, Lynch, Thomas J, Toner, Mehmet, Haber, Daniel A

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Coordinate loss of MAP3K7 and CHD1 promotes aggressive prostate cancer von Rodrigues, Lindsey Ulkus, Rider, Leah, Nieto, Cera, Romero, Lina, Karimpour-Fard, Anis, Loda, Massimo, Lucia, M Scott, Wu, Min, Shi, Lihong, Cimic, Adela, Sirintrapun, S Joseph, Nolley, Rosalie, Pac, Colton, Chen, Haitao, Peehl, Donna M, Xu, Jianfeng, Liu, Wennuan, Costello, James C, Cramer, Scott D

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Exquisite Sensitivity to Dual BRG1/BRM ATPase Inhibitors Reveals Broad SWI/SNF Dependencies in Acute Myeloid Leukemia von Rago, Florencia, Rodrigues, Lindsey Ulkus, Bonney, Megan, Sprouffske, Kathleen, Kurth, Esther, Elliott, GiNell, Ambrose, Jessi, Aspesi, Peter, Oborski, Justin, Chen, Julie T, McDonald, E Robert, Mapa, Felipa A, Ruddy, David A, Kauffmann, Audrey, Abrams, Tinya, Bhang, Hyo-Eun C, Jagani, Zainab

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Abstract A1-04: The role of chromatin remodeler CHD1 in genomic alterations and prostate cancer progression von Liu, Wennuan, Rodrigues, Lindsey Ulkus, Li, Tao, Zhang, Zheng, Rider, Leah, Romero, Lina, Zheng, Lilly S., Isaacs, William B., Cramer, Scott, Xu, Jianfeng

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Abstract 445: Coordinate loss of CHD1 and MAP3K7 promotes aggressive prostate cancer von Ulkus, Lindsey, Rider, Leah, Nieto, Cera, Romero, Lina, Chen, Haitao, Loda, Massimo, Liu, Wennuan, Xu, Jianfeng, Cramer, Scott

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Abstract 1136: Detection and characterization of circulating tumor cells in localized and metastatic prostate cancer patients using CTC-Chip microfluidic technology von Nagrath, Sunitha, Stott, Shannon L., Lee, Richard J., Yu, Min, Ulkus, Lindsey L., Iafrate, John A., Smith, Mathew R., Tompkins, Ronald G., Sequist, Lecia V., Haber, Daniel A., Maheswaran, Shyamala, Toner, Mehmet

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Ligand-dependent PDGF receptor-alpha activation sensitizes rare lung cancer and sarcoma cells to PDGF receptor kinase inhibitors von McDermott, Ultan, Ames, Rachel Y., Iafrate, A. John, Maheswaran, Shyamala, Stubbs, Hannah, Greninger, Patricia, McCutcheon, Kaitlin, Milano, Randy, Tam, Angela, Lee, Diana Y., Lucien, Laury, Brannigan, Brian W., Ulkus, Lindsey E., Ma, Xiao-Jun, Erlander, Mark G., Haber, Daniel A., Sharma, Sreenath V., Settleman, Jeffrey

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