Dabrafenib; preclinical characterization, increased efficacy when combined with trametinib, while BRAF/MEK tool combination reduced skin lesions von King, Alastair J, Arnone, Marc R, Bleam, Maureen R, Moss, Katherine G, Yang, Jingsong, Fedorowicz, Kelly E, Smitheman, Kimberly N, Erhardt, Joseph A, Hughes-Earle, Angela, Kane-Carson, Laurie S, Sinnamon, Robert H, Qi, Hongwei, Rheault, Tara R, Uehling, David E, Laquerre, Sylvie G

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Recent progress on MAP kinase pathway inhibitors von Uehling, David E., Harris, Philip A.

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Functional characterization of a PROTAC directed against BRAF mutant V600E von Posternak, Ganna, Tang, Xiaojing, Maisonneuve, Pierre, Jin, Ting, Lavoie, Hugo, Daou, Salima, Orlicky, Stephen, Goullet de Rugy, Theo, Caldwell, Lauren, Chan, Kin, Aman, Ahmed, Prakesch, Michael, Poda, Gennady, Mader, Pavel, Wong, Cassandra, Maier, Stefan, Kitaygorodsky, Julia, Larsen, Brett, Colwill, Karen, Yin, Zhe, Ceccarelli, Derek F., Batey, Robert A., Taipale, Mikko, Kurinov, Igor, Uehling, David, Wrana, Jeff, Durocher, Daniel, Gingras, Anne-Claude, Al-Awar, Rima, Therrien, Marc, Sicheri, Frank

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G protein–receptor kinases 5/6 are the key regulators of G protein–coupled receptor 35–arrestin interactions von Ganguly, Amlan, Quon, Tezz, Jenkins, Laura, Joseph, Babu, Al-awar, Rima, Chevigne, Andy, Tobin, Andrew B., Uehling, David E., Hoffmann, Carsten, Drube, Julia, Milligan, Graeme

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G protein–coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin von Varney, Matthew J., Steyaert, Wouter, Coucke, Paul J., Delanghe, Joris R., Uehling, David E., Joseph, Babu, Marcellus, Richard, Al-awar, Rima, Benovic, Jeffrey L.

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Design, Synthesis, and Characterization of 4‑Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma von Uehling, David E, Joseph, Babu, Chung, Kim Chan, Zhang, Andrew X, Ler, Spencer, Prakesch, Michael A, Poda, Gennady, Grouleff, Julie, Aman, Ahmed, Kiyota, Taira, Leung-Hagesteijn, Chungyee, Konda, John David, Marcellus, Richard, Griffin, Carly, Subramaniam, Ratheesh, Abibi, Ayome, Strathdee, Craig A, Isaac, Methvin B, Al-awar, Rima, Tiedemann, Rodger E

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Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity von Mabanglo, Mark F., Wilson, Brian, Noureldin, Mahmoud, Kimani, Serah W., Mamai, Ahmed, Krausser, Chiara, González-Álvarez, Héctor, Srivastava, Smriti, Mohammed, Mohammed, Hoffer, Laurent, Chan, Manuel, Avrumutsoae, Jamie, Li, Alice Shi Ming, Hajian, Taraneh, Tucker, Sarah, Green, Stuart, Szewczyk, Magdalena, Barsyte-Lovejoy, Dalia, Santhakumar, Vijayaratnam, Ackloo, Suzanne, Loppnau, Peter, Li, Yanjun, Seitova, Almagul, Kiyota, Taira, Wang, Jue George, Privé, Gilbert G., Kuntz, Douglas A., Patel, Bhashant, Rathod, Vaibhavi, Vala, Anand, Rout, Bhimsen, Aman, Ahmed, Poda, Gennady, Uehling, David, Ramnauth, Jailall, Halabelian, Levon, Marcellus, Richard, Al-awar, Rima, Vedadi, Masoud

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Correction to “Design, Synthesis, and Characterization of 4‑Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple M... von Uehling, David E, Joseph, Babu, Chung, Kim Chan, Zhang, Andrew X, Ler, Spencer, Prakesch, Michael A, Poda, Gennady, Grouleff, Julie, Aman, Ahmed, Kiyota, Taira, Leung-Hagesteijn, Chungyee, Konda, John David, Marcellus, Richard, Griffin, Carly, Subramaniam, Ratheesh, Abibi, Ayome, Strathdee, Craig A, Isaac, Methvin B, Al-awar, Rima, Tiedemann, Rodger E

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Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B‑Raf-Driven Tumors von Rheault, Tara R., Stellwagen, John C., Adjabeng, George M., Hornberger, Keith R., Petrov, Kimberly G., Waterson, Alex G., Dickerson, Scott H., Mook, Robert A., Laquerre, Sylvie G., King, Alastair J., Rossanese, Olivia W., Arnone, Marc R., Smitheman, Kimberly N., Kane-Carson, Laurie S., Han, Chao, Moorthy, Ganesh S., Moss, Katherine G., Uehling, David E.

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Small Molecule Kinase Inhibitor Screen Identifies Polo-Like Kinase 1 as a Target for Neuroblastoma Tumor-Initiating Cells von GRINSHTEIN, Natalie, DATTI, Alessandro, FUJITANI, Mayumi, UEHLING, David, PRAKESCH, Michael, ISAAC, Methvin, IRWIN, Meredith S, WRANA, Jeffrey L, AI-AWAR, Rima, KAPLAN, David R

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Combined deletion of Pten and p53 in mammary epithelium accelerates triple‐negative breast cancer with dependency on eEF2K von Liu, Jeff C, Voisin, Veronique, Wang, Sharon, Wang, Dong‐Yu, Jones, Robert A, Datti, Alessandro, Uehling, David, Al‐awar, Rima, Egan, Sean E, Bader, Gary D, Tsao, Ming, Mak, Tak W, Zacksenhaus, Eldad

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Virus-Tumor Interactome Screen Reveals ER Stress Response Can Reprogram Resistant Cancers for Oncolytic Virus-Triggered Caspase-2 Cell Death von Mahoney, Douglas J., Lefebvre, Charles, Allan, Kristina, Brun, Jan, Sanaei, Cina A., Baird, Stephen, Pearce, Nelson, Grönberg, Susanna, Wilson, Brian, Prakesh, Mikael, Aman, Ahmed, Isaac, Methvin, Mamai, Ahmed, Uehling, David, Al-Awar, Rima, Falls, Theresa, Alain, Tommy, Stojdl, David F.

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Identification of RSK and TTK as Modulators of Blood Vessel Morphogenesis Using an Embryonic Stem Cell-Based Vascular Differentiation Assay von Hammoud, Lamis, Adams, Jessica R., Loch, Amanda J., Marcellus, Richard C., Uehling, David E., Aman, Ahmed, Fladd, Christopher, McKee, Trevor D., Jo, Christine E.B., Al-Awar, Rima, Egan, Sean E., Rossant, Janet

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6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases von Wood, Edgar R, Shewchuk, Lisa M, Ellis, Byron, Brignola, Perry, Brashear, Ronald L, Caferro, Thomas R, Dickerson, Scott H, Dickson, Hamilton D, Donaldson, Kelly H, Gaul, Michael, Griffin, Robert J, Hassell, Anne M, Keith, Barry, Mullin, Robert, Petrov, Kimberly G, Reno, Michael J, Rusnak, David W, Tadepalli, Sarva M, Ulrich, John C, Wagner, Craig D, Vanderwall, Dana E, Waterson, Alex G, Williams, Jon D, White, Wendy L, Uehling, David E

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Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor von Mamai, Ahmed, Chau, Anh M., Wilson, Brian J., Watson, Iain D., Joseph, Babu B., Subramanian, Pandiaraju R., Morshed, Monzur M., Morin, Justin A., Prakesch, Michael A., Lu, Tianbao, Connolly, Pete, Kuntz, Douglas A., Pomroy, Neil C., Poda, Gennady, Nguyen, Kong, Marcellus, Richard, Strathdee, Graig, Theriault, Brigitte, Subramaniam, Ratheesh, Mohammed, Mohammed, Abibi, Ayome, Chan, Manuel, Winston, Jeffrey, Kiyota, Taira, Undzys, Elijus, Aman, Ahmed, Austin, Nigel, Du Jardin, Marc, Packman, Kathryn, Phillippar, Ulrike, Attar, Riccardo, Edwards, James, O’Meara, Jeff, Uehling, David E., Al-awar, Rima, Privé, Gilbert G., Isaac, Methvin B.

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The PKN1- TRAF1 signaling axis as a potential new target for chronic lymphocytic leukemia von Edilova, Maria I., Law, Jaclyn C., Zangiabadi, Safoura, Ting, Kenneth, Mbanwi, Achire N., Arruda, Andrea, Uehling, David, Isaac, Methvin, Prakesch, Michael, Al-awar, Rima, Minden, Mark D., Abdul-Sater, Ali A., Watts, Tania H.

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Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors von Rheault, Tara R., Caferro, Thomas R., Dickerson, Scott H., Donaldson, Kelly H., Gaul, Michael D., Goetz, Aaron S., Mullin, Robert J., McDonald, Octerloney B., Petrov, Kimberly G., Rusnak, David W., Shewchuk, Lisa M., Spehar, Glenn M., Truesdale, Anne T., Vanderwall, Dana E., Wood, Edgar R., Uehling, David E.

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Synthesis and evaluation of aniline headgroups for alkynyl thienopyrimidine dual EGFR/ErbB-2 kinase inhibitors von Waterson, Alex G., Petrov, Kimberly G., Hornberger, Keith R., Hubbard, Robert D., Sammond, Douglas M., Smith, Stephon C., Dickson, Hamilton D., Caferro, Thomas R., Hinkle, Kevin W., Stevens, Kirk L., Dickerson, Scott H., Rusnak, David W., Spehar, Glenn M., Wood, Edgar R., Griffin, Robert J., Uehling, David E.

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Dual EGFR/ErbB-2 inhibitors from novel pyrrolidinyl-acetylenic thieno[3,2- d]pyrimidines von Hubbard, Robert D., Dickerson, Scott H., Emerson, Holly K., Griffin, Robert J., Reno, Michael J., Hornberger, Keith R., Rusnak, David W., Wood, Edgar R., Uehling, David E., Waterson, Alex G.

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Pharmacological Targeting of Executioner Proteins: Controlling Life and Death von Pogmore, Justin P, Uehling, David, Andrews, David W

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