Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors von Flanagan, Mark E, Abramite, Joseph A, Anderson, Dennis P, Aulabaugh, Ann, Dahal, Upendra P, Gilbert, Adam M, Li, Chao, Montgomery, Justin, Oppenheimer, Stacey R, Ryder, Tim, Schuff, Brandon P, Uccello, Daniel P, Walker, Gregory S, Wu, Yan, Brown, Matthew F, Chen, Jinshan M, Hayward, Matthew M, Noe, Mark C, Obach, R. Scott, Philippe, Laurence, Shanmugasundaram, Veerabahu, Shapiro, Michael J, Starr, Jeremy, Stroh, Justin, Che, Ye

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A covalent BTK ternary complex compatible with targeted protein degradation von Schiemer, James, Maxwell, Andrew, Horst, Reto, Liu, Shenping, Uccello, Daniel P., Borzilleri, Kris, Rajamohan, Nisha, Brown, Matthew F., Calabrese, Matthew F.

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Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes von Schiemer, James, Horst, Reto, Meng, Yilin, Montgomery, Justin I., Xu, Yingrong, Feng, Xidong, Borzilleri, Kris, Uccello, Daniel P., Leverett, Carolyn, Brown, Stephen, Che, Ye, Brown, Matthew F., Hayward, Matthew M., Gilbert, Adam M., Noe, Mark C., Calabrese, Matthew F.

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Delineating the role of cooperativity in the design of potent PROTACs for BTK von Zorba, Adelajda, Nguyen, Chuong, Xu, Yingrong, Starr, Jeremy, Borzilleri, Kris, Smith, James, Zhu, Hongyao, Farley, Kathleen A., Ding, WeiDong, Schiemer, James, Feng, Xidong, Chang, Jeanne S., Uccello, Daniel P., Young, Jennifer A., Garcia-Irrizary, Carmen N., Czabaniuk, Lara, Schuff, Brandon, Oliver, Robert, Montgomery, Justin, Hayward, Matthew M., Coe, Jotham, Chen, Jinshan, Niosi, Mark, Luthra, Suman, Shah, Jaymin C., El-Kattan, Ayman, Qiu, Xiayang, West, Graham M., Noe, Mark C., Shanmugasundaram, Veerabahu, Gilbert, Adam M., Brown, Matthew F., Calabrese, Matthew F.

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Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes von Schiemer, James, Horst, Reto, Meng, Yilin, Montgomery, Justin I., Xu, Yingrong, Feng, Xidong, Borzilleri, Kris, Uccello, Daniel P., Leverett, Carolyn, Brown, Stephen, Che, Ye, Brown, Matthew F., Hayward, Matthew M., Gilbert, Adam M., Noe, Mark C., Calabrese, Matthew F.

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Synthesis of PEG-Functionalized Amines Using Ruthenium-Catalyzed Hydrogen Borrowing von Rossi, Federico V, Starr, Jeremy T, Uccello, Daniel P, Young, Jennifer A

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One-Pot Oxidation and Rearrangement of Propargylamines and in Situ Pyrazole Synthesis von Chen, Jinshan, Properzi, Roberta, Uccello, Daniel P, Young, Jennifer A, Dushin, Russell G, Starr, Jeremy T

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Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation von McAllister, Laura A, Butler, Christopher R, Mente, Scot, O’Neil, Steven V, Fonseca, Kari R, Piro, Justin R, Cianfrogna, Julie A, Foley, Timothy L, Gilbert, Adam M, Harris, Anthony R, Helal, Christopher J, Johnson, Douglas S, Montgomery, Justin I, Nason, Deane M, Noell, Stephen, Pandit, Jayvardhan, Rogers, Bruce N, Samad, Tarek A, Shaffer, Christopher L, da Silva, Rafael G, Uccello, Daniel P, Webb, Damien, Brodney, Michael A

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Novel 3-fluoro-6-methoxyquinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV von Mitton-Fry, Mark J., Brickner, Steven J., Hamel, Judith C., Barham, Rose, Brennan, Lori, Casavant, Jeffrey M., Ding, Xiaoyuan, Finegan, Steven, Hardink, Joel, Hoang, Thuy, Huband, Michael D., Maloney, Meghan, Marfat, Anthony, McCurdy, Sandra P., McLeod, Dale, Subramanyam, Chakrapani, Plotkin, Michael, Reilly, Usa, Schafer, John, Stone, Gregory G., Uccello, Daniel P., Wisialowski, Todd, Yoon, Kwansik, Zaniewski, Richard, Zook, Christopher

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Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5) von Huard, Kim, Brown, Janice, Jones, Jessica C., Cabral, Shawn, Futatsugi, Kentaro, Gorgoglione, Matthew, Lanba, Adhiraj, Vera, Nicholas B., Zhu, Yimin, Yan, Qingyun, Zhou, Yingjiang, Vernochet, Cecile, Riccardi, Keith, Wolford, Angela, Pirman, David, Niosi, Mark, Aspnes, Gary, Herr, Michael, Genung, Nathan E., Magee, Thomas V., Uccello, Daniel P., Loria, Paula, Di, Li, Gosset, James R., Hepworth, David, Rolph, Timothy, Pfefferkorn, Jeffrey A., Erion, Derek M.

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Pyridone Methylsulfone Hydroxamate LpxC Inhibitors for the Treatment of Serious Gram-Negative Infections von Montgomery, Justin I, Brown, Matthew F, Reilly, Usa, Price, Loren M, Abramite, Joseph A, Arcari, Joel, Barham, Rose, Che, Ye, Chen, Jinshan Michael, Chung, Seung Won, Collantes, Elizabeth M, Desbonnet, Charlene, Doroski, Matthew, Doty, Jonathan, Engtrakul, Juntyma J, Harris, Thomas M, Huband, Michael, Knafels, John D, Leach, Karen L, Liu, Shenping, Marfat, Anthony, McAllister, Laura, McElroy, Eric, Menard, Carol A, Mitton-Fry, Mark, Mullins, Lisa, Noe, Mark C, O’Donnell, John, Oliver, Robert, Penzien, Joseph, Plummer, Mark, Shanmugasundaram, Veerabahu, Thoma, Christy, Tomaras, Andrew P, Uccello, Daniel P, Vaz, Alfin, Wishka, Donn G

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Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family von Huard, Kim, Gosset, James R, Montgomery, Justin I, Gilbert, Adam, Hayward, Matthew M, Magee, Thomas V, Cabral, Shawn, Uccello, Daniel P, Bahnck, Kevin, Brown, Janice, Purkal, Julie, Gorgoglione, Matthew, Lanba, Adhiraj, Futatsugi, Kentaro, Herr, Michael, Genung, Nathan E, Aspnes, Gary, Polivkova, Jana, Garcia-Irizarry, Carmen N, Li, Qifang, Canterbury, Daniel, Niosi, Mark, Vera, Nicholas B, Li, Zhenhong, Khunte, Bhagyashree, Siderewicz, Jaclyn, Rolph, Timothy, Erion, Derek M

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Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections von Brown, Matthew F, Reilly, Usa, Abramite, Joseph A, Arcari, Joel T, Oliver, Robert, Barham, Rose A, Che, Ye, Chen, Jinshan Michael, Collantes, Elizabeth M, Chung, Seung Won, Desbonnet, Charlene, Doty, Jonathan, Doroski, Matthew, Engtrakul, Juntyma J, Harris, Thomas M, Huband, Michael, Knafels, John D, Leach, Karen L, Liu, Shenping, Marfat, Anthony, Marra, Andrea, McElroy, Eric, Melnick, Michael, Menard, Carol A, Montgomery, Justin I, Mullins, Lisa, Noe, Mark. C, O’Donnell, John, Penzien, Joseph, Plummer, Mark S, Price, Loren M, Shanmugasundaram, Veerabahu, Thoma, Christy, Uccello, Daniel P, Warmus, Joseph S, Wishka, Donn G

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Intramolecular Ring-Opening Decomposition of Aryl Azetidines von Bai, Guoyun, O’Connell, Thomas N, Brodney, Michael A, Butler, Christopher R, Czabaniuk, Lara C, Gilbert, Adam M, LaChapelle, Erik A, Li, Chao, McAllister, Laura A, Ogilvie, Kevin, Philippe, Laurence, Salomon-Ferrer, Romelia, Shapiro, Michael J, Starr, Jeremy T, Uccello, Daniel P, Withka, Jane M, Yan, Jiangli, Brown, Matthew F

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Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents von McAllister, Laura A., Montgomery, Justin I., Abramite, Joseph A., Reilly, Usa, Brown, Matthew F., Chen, Jinshan M., Barham, Rose A., Che, Ye, Chung, Seung Won, Menard, Carol A., Mitton-Fry, Mark, Mullins, Lisa M., Noe, Mark C., O’Donnell, John P., Oliver, Robert M., Penzien, Joseph B., Plummer, Mark, Price, Loren M., Shanmugasundaram, Veerabahu, Tomaras, Andrew P., Uccello, Daniel P.

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The synthesis of C-13 functionalized pleuromutilins via C–H amidation and subsequent novel rearrangement product von Uccello, Daniel P., Miller, Shawn M., Dieterich, Noah A., Stepan, Antonia F., Chung, SeungWon, Farley, Kathleen A., Samas, Brian, Chen, Jinshan, Montgomery, Justin I.

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Effect of Solvent and Temperature on the Lithium−Bromine Exchange of Vinyl Bromides: Reactions of n-Butyllithium and t-Butyllithium with (E)-5-Bromo-5-decene von Bailey, William F, Luderer, Mark R, Uccello, Daniel P, Bartelson, Ashley L

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One-Pot (1-Ethoxycarbonylcyclopropyl)triphenylphosphonium Tetrafluoroborate Ring-Opening and Wittig Reaction von Chung, Seung Won, Plummer, Mark S, McAllister, Laura A, Oliver, Robert M, Abramite, Joseph A, Shen, Yue, Sun, Jianmin, Uccello, Daniel P, Arcari, Joel T, Price, Loren M, Montgomery, Justin I

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Intrinsic reactivity profile of electrophilic moieties to guide covalent drug design: N-α-acetyl- l -lysine as an amine nucleophile von Dahal, Upendra P., Gilbert, Adam M., Obach, R. Scott, Flanagan, Mark E., Chen, Jinshan M., Garcia-Irizarry, Carmen, Starr, Jeremy T., Schuff, Brandon, Uccello, Daniel P., Young, Jennifer A.

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Intrinsic reactivity profile of electrophilic moieties to guide covalent drug design: N-α-acetyl-l-lysine as an amine nucleophileThe authors declare no competing interests von Dahal, Upendra P, Gilbert, Adam M, Obach, R. Scott, Flanagan, Mark E, Chen, Jinshan M, Garcia-Irizarry, Carmen, Starr, Jeremy T, Schuff, Brandon, Uccello, Daniel P, Young, Jennifer A

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