Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers von Wooten, David J, Groves, Sarah M, Tyson, Darren R, Liu, Qi, Lim, Jing S, Albert, Réka, Lopez, Carlos F, Sage, Julien, Quaranta, Vito

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An unbiased metric of antiproliferative drug effect in vitro von Harris, Leonard A, Frick, Peter L, Garbett, Shawn P, Hardeman, Keisha N, Paudel, B Bishal, Lopez, Carlos F, Quaranta, Vito, Tyson, Darren R

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An in vitro model of tumor heterogeneity resolves genetic, epigenetic, and stochastic sources of cell state variability von Hayford, Corey E., Tyson, Darren R., Robbins, C. Jack, Frick, Peter L., Quaranta, Vito, Harris, Leonard A.

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Fractional proliferation: a method to deconvolve cell population dynamics from single-cell data von Tyson, Darren R, Garbett, Shawn P, Frick, Peter L, Quaranta, Vito

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Real-time luminescence enables continuous drug-response analysis in adherent and suspension cell lines von Wandishin, Clayton M., Robbins, Charles John, Tyson, Darren R., Harris, Leonard A., Quaranta, Vito

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Reverse-Phase Protein Array Profiling of Oropharyngeal Cancer and Significance of PIK3CA Mutations in HPV-Associated Head and Neck Cancer von SEWELL, Andrew, BROWN, Brandee, BIKTASOVA, Asel, MILLS, Gordon B, YILING LU, TYSON, Darren R, ISSAEVA, Natalia, YARBROUGH, Wendell G

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A Predictive Mathematical Modeling Approach for the Study of Doxorubicin Treatment in Triple Negative Breast Cancer von McKenna, Matthew T., Weis, Jared A., Barnes, Stephanie L., Tyson, Darren R., Miga, Michael I., Quaranta, Vito, Yankeelov, Thomas E.

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Beyond Programmed Death-Ligand 1: B7-H6 Emerges as a Potential Immunotherapy Target in SCLC von Thomas, Portia L., Groves, Sarah M., Zhang, Yun-Kai, Li, Jia, Gonzalez-Ericsson, Paula, Sivagnanam, Shamilene, Betts, Courtney B., Chen, Hua-Chang, Liu, Qi, Lowe, Cindy, Chen, Heidi, Boyd, Kelli L., Kopparapu, Prasad R., Yan, Yingjun, Coussens, Lisa M., Quaranta, Vito, Tyson, Darren R., Iams, Wade, Lovly, Christine M.

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A drift-diffusion checkpoint model predicts a highly variable and growth-factor-sensitive portion of the cell cycle G1 phase von Jones, Zack W, Leander, Rachel, Quaranta, Vito, Harris, Leonard A, Tyson, Darren R

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What lies beneath: looking beyond tumor genetics shows the complexity of signaling networks underlying drug sensitivity von Quaranta, Vito, Tyson, Darren R

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Inhibition of phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model von Tsunoda, Toshiyuki, Ota, Takeharu, Fujimoto, Takahiro, Doi, Keiko, Tanaka, Yoko, Yoshida, Yasuhiro, Ogawa, Masahiro, Matsuzaki, Hiroshi, Hamabashiri, Masato, Tyson, Darren R, Kuroki, Masahide, Miyamoto, Shingo, Shirasawa, Senji

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ACDC: Automated Cell Detection and Counting for Time-Lapse Fluorescence Microscopy von Rundo, Leonardo, Tangherloni, Andrea, Tyson, Darren R., Betta, Riccardo, Militello, Carmelo, Spolaor, Simone, Nobile, Marco S., Besozzi, Daniela, Lubbock, Alexander L. R., Quaranta, Vito, Mauri, Giancarlo, Lopez, Carlos F., Cazzaniga, Paolo

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Quantifying Drug Combination Synergy along Potency and Efficacy Axes von Meyer, Christian T., Wooten, David J., Paudel, B. Bishal, Bauer, Joshua, Hardeman, Keisha N., Westover, David, Lovly, Christine M., Harris, Leonard A., Tyson, Darren R., Quaranta, Vito

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Thunor: visualization and analysis of high-throughput dose–response datasets von Lubbock, Alexander L R, Harris, Leonard A, Quaranta, Vito, Tyson, Darren R, Lopez, Carlos F

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A Nonquiescent “Idling” Population State in Drug-Treated, BRAF-Mutated Melanoma von Paudel, B. Bishal, Harris, Leonard A., Hardeman, Keisha N., Abugable, Arwa A., Hayford, Corey E., Tyson, Darren R., Quaranta, Vito

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Extracellular Matrix/Integrin Signaling Promotes Resistance to Combined Inhibition of HER2 and PI3K in HER2 + Breast Cancer von Hanker, Ariella B, Estrada, Mónica Valeria, Bianchini, Giampaolo, Moore, Preston D, Zhao, Junfei, Cheng, Feixiong, Koch, James P, Gianni, Luca, Tyson, Darren R, Sánchez, Violeta, Rexer, Brent N, Sanders, Melinda E, Zhao, Zhongming, Stricker, Thomas P, Arteaga, Carlos L

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Purinergic Ca2+ Signaling as a Novel Mechanism of Drug Tolerance in BRAF-Mutant Melanoma von Stauffer, Philip E., Brinkley, Jordon, Jacobson, David A., Quaranta, Vito, Tyson, Darren R.

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Involvement of Epithelial-Mesenchymal Transition Genes in Small Cell Lung Cancer Phenotypic Plasticity von Groves, Sarah M, Panchy, Nicholas, Tyson, Darren R, Harris, Leonard A, Quaranta, Vito, Hong, Tian

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Culture requirements of prostatic epithelial cell lines for acinar morphogenesis and lumen formation in vitro: Role of extracellular calcium von Tyson, Darren R., Inokuchi, Junichi, Tsunoda, Toshiyuki, Lau, Alice, Ornstein, David K.

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A global sensitivity analysis of a mechanistic model of neoadjuvant chemotherapy for triple negative breast cancer constrained by in vitro and in vivo imaging data von Lorenzo, Guillermo, Jarrett, Angela M., Meyer, Christian T., DiCarlo, Julie C., Virostko, John, Quaranta, Vito, Tyson, Darren R., Yankeelov, Thomas E.

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