Cholesterol esterification inhibition and imatinib treatment synergistically inhibit growth of BCR-ABL mutation-independent resistant chronic myelogenous leukemia von Bandyopadhyay, Shovik, Li, Junjie, Traer, Elie, Tyner, Jeffrey W, Zhou, Amy, Oh, Stephen T, Cheng, Ji-Xin

Volltext

The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells von Nechiporuk, Tamilla, Kurtz, Stephen E, Nikolova, Olga, Liu, Tingting, Jones, Courtney L, D'Alessandro, Angelo, Culp-Hill, Rachel, d'Almeida, Amanda, Joshi, Sunil K, Rosenberg, Mara, Tognon, Cristina E, Danilov, Alexey V, Druker, Brian J, Chang, Bill H, McWeeney, Shannon K, Tyner, Jeffrey W

Volltext

CSF3R T618I is a highly prevalent and specific mutation in chronic neutrophilic leukemia von Pardanani, A, Lasho, T L, Laborde, R R, Elliott, M, Hanson, C A, Knudson, R A, Ketterling, R P, Maxson, J E, Tyner, J W, Tefferi, A

Volltext

FGF2 from Marrow Microenvironment Promotes Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia von Traer, Elie, Martinez, Jacqueline, Javidi-Sharifi, Nathalie, Agarwal, Anupriya, Dunlap, Jennifer, English, Isabel, Kovacsovics, Tibor, Tyner, Jeffrey W, Wong, Melissa, Druker, Brian J

Volltext

The new genetics of chronic neutrophilic leukemia and atypical CML: implications for diagnosis and treatment von Gotlib, Jason, Maxson, Julia E., George, Tracy I., Tyner, Jeffrey W.

Volltext

Identification of Interleukin-1 by Functional Screening as a Key Mediator of Cellular Expansion and Disease Progression in Acute Myeloid Leukemia von Carey, Alyssa, Edwards, David K., Eide, Christopher A., Newell, Laura, Traer, Elie, Medeiros, Bruno C., Pollyea, Daniel A., Deininger, Michael W., Collins, Robert H., Tyner, Jeffrey W., Druker, Brian J., Bagby, Grover C., McWeeney, Shannon K., Agarwal, Anupriya

Volltext

Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms von Zhang, Haijiao, Savage, Samantha, Schultz, Anna Reister, Bottomly, Daniel, White, Libbey, Segerdell, Erik, Wilmot, Beth, McWeeney, Shannon K., Eide, Christopher A., Nechiporuk, Tamilla, Carlos, Amy, Henson, Rachel, Lin, Chenwei, Searles, Robert, Ho, Hoang, Lam, Yee Ling, Sweat, Richard, Follit, Courtney, Jain, Vinay, Lind, Evan, Borthakur, Gautam, Garcia-Manero, Guillermo, Ravandi, Farhad, Kantarjian, Hagop M., Cortes, Jorge, Collins, Robert, Buelow, Daelynn R., Baker, Sharyn D., Druker, Brian J., Tyner, Jeffrey W.

Volltext

Effect of naturally occurring Wolbachia in Anopheles gambiae s.l. mosquitoes from Mali on Plasmodium falciparum malaria transmission von Gomes, Fabio M., Hixson, Bretta L., Tyner, Miles D. W., Ramirez, Jose Luis, Canepa, Gaspar E., Silva, Thiago Luiz Alves e, Molina-Cruz, Alvaro, Keita, Moussa, Kane, Fouseyni, Traoré, Boïssé, Sogoba, Nafomon, Barillas-Mury, Carolina

Volltext

Integrated analysis of patient samples identifies biomarkers for venetoclax efficacy and combination strategies in acute myeloid leukemia von Zhang, Haijiao, Nakauchi, Yusuke, Köhnke, Thomas, Stafford, Melissa, Bottomly, Daniel, Thomas, Rozario, Wilmot, Beth, McWeeney, Shannon K, Majeti, Ravindra, Tyner, Jeffrey W

Volltext

Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma von Yuan, Jiang, Jiang, Yan-Yi, Mayakonda, Anand, Huang, Moli, Ding, Ling-Wen, Lin, Han, Yu, Fenggang, Lu, Yanan, Loh, Thomas Kwok Seng, Chow, Marilynn, Savage, Samantha, Tyner, Jeffrey W, Lin, De-Chen, Koeffler, H Phillip

Volltext

Understanding Drug Sensitivity and Tackling Resistance in Cancer von Tyner, Jeffrey W, Haderk, Franziska, Kumaraswamy, Anbarasu, Baughn, Linda B, Van Ness, Brian, Liu, Song, Marathe, Himangi, Alumkal, Joshi J, Bivona, Trever G, Chan, Keith Syson, Druker, Brian J, Hutson, Alan D, Nelson, Peter S, Sawyers, Charles L, Willey, Christopher D

Volltext

AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance von O'Hare, Thomas, Shakespeare, William C., Zhu, Xiaotian, Eide, Christopher A., Rivera, Victor M., Wang, Frank, Adrian, Lauren T., Zhou, Tianjun, Huang, Wei-Sheng, Xu, Qihong, Metcalf, Chester A., Tyner, Jeffrey W., Loriaux, Marc M., Corbin, Amie S., Wardwell, Scott, Ning, Yaoyu, Keats, Jeffrey A., Wang, Yihan, Sundaramoorthi, Raji, Thomas, Mathew, Zhou, Dong, Snodgrass, Joseph, Commodore, Lois, Sawyer, Tomi K., Dalgarno, David C., Deininger, Michael W.N., Druker, Brian J., Clackson, Tim

Volltext

Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins von Davare, Monika A., Saborowski, Anna, Eide, Christopher A., Tognon, Cristina, Smith, Rebecca L., Elferich, Johannes, Agarwal, Anupriya, Tyner, Jeffrey W., Shinde, Ujwal P., Lowe, Scott W., Druker, Brian J.

Volltext

Proteolysis targeting chimeric molecules as therapy for multiple myeloma: efficacy, biomarker and drug combinations von Lim, Su Lin, Damnernsawad, Alisa, Shyamsunder, Pavithra, Chng, Wee Joo, Han, Bing Chen, Xu, Liang, Pan, Jian, Pravin, Dakle Pushkar, Alkan, Serhan, Tyner, Jeffrey W, Koeffler, H Phillip

Volltext

Keys to drug sensitivity from updated functional work flows von Kurtz, Stephen E, Tyner, Jeffrey W

Volltext

Crosstalk between ROR1 and the Pre-B Cell Receptor Promotes Survival of t(1;19) Acute Lymphoblastic Leukemia von Bicocca, Vincent T., Chang, Bill H., Masouleh, Behzad Kharabi, Muschen, Markus, Loriaux, Marc M., Druker, Brian J., Tyner, Jeffrey W.

Volltext

Functional integration of acute myeloid leukemia into the vascular niche von Cogle, C R, Goldman, D C, Madlambayan, G J, Leon, R P, Al Masri, A, Clark, H A, Asbaghi, S A, Tyner, J W, Dunlap, J, Fan, G, Kovacsovics, T, Liu, Q, Meacham, A, Hamlin, K L, Hromas, R A, Scott, E W, Fleming, W H

Volltext

Crosstalk between KIT and FGFR3 Promotes Gastrointestinal Stromal Tumor Cell Growth and Drug Resistance von Javidi-Sharifi, Nathalie, Traer, Elie, Martinez, Jacqueline, Gupta, Anu, Taguchi, Takehiro, Dunlap, Jennifer, Heinrich, Michael C, Corless, Christopher L, Rubin, Brian P, Druker, Brian J, Tyner, Jeffrey W

Volltext

CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms von Tyner, Jeffrey W., Bumm, Thomas G., Deininger, Jutta, Wood, Lisa, Aichberger, Karl J., Loriaux, Marc M., Druker, Brian J., Burns, Christopher J., Fantino, Emmanuelle, Deininger, Michael W.

Volltext

Gain-of-function mutations in granulocyte colony–stimulating factor receptor (CSF3R) reveal distinct mechanisms of CSF3R activation von Zhang, Haijiao, Coblentz, Cody, Watanabe-Smith, Kevin, Means, Sophie, Means, Jasmine, Maxson, Julia E., Tyner, Jeffrey W.

Volltext