Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes von Hess, Gaelen T., Tycko, Josh, Yao, David, Bassik, Michael C.

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Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity von Tycko, Josh, Myer, Vic E., Hsu, Patrick D.

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Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements von Mumbach, Maxwell R, Satpathy, Ansuman T, Boyle, Evan A, Dai, Chao, Gowen, Benjamin G, Cho, Seung Woo, Nguyen, Michelle L, Rubin, Adam J, Granja, Jeffrey M, Kazane, Katelynn R, Wei, Yuning, Nguyen, Trieu, Greenside, Peyton G, Corces, M Ryan, Tycko, Josh, Simeonov, Dimitre R, Suliman, Nabeela, Li, Rui, Xu, Jin, Flynn, Ryan A, Kundaje, Anshul, Khavari, Paul A, Marson, Alexander, Corn, Jacob E, Quertermous, Thomas, Greenleaf, William J, Chang, Howard Y

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Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements von Tycko, Josh, Wainberg, Michael, Marinov, Georgi K., Ursu, Oana, Hess, Gaelen T., Ego, Braeden K., Aradhana, Li, Amy, Truong, Alisa, Trevino, Alexandro E., Spees, Kaitlyn, Yao, David, Kaplow, Irene M., Greenside, Peyton G., Morgens, David W., Phanstiel, Douglas H., Snyder, Michael P., Bintu, Lacramioara, Greenleaf, William J., Kundaje, Anshul, Bassik, Michael C.

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CasKAS: direct profiling of genome-wide dCas9 and Cas9 specificity using ssDNA mapping von Marinov, Georgi K, Kim, Samuel H, Bagdatli, S Tansu, Higashino, Soon Il, Trevino, Alexandro E, Tycko, Josh, Wu, Tong, Bintu, Lacramioara, Bassik, Michael C, He, Chuan, Kundaje, Anshul, Greenleaf, William J

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Pairwise library screen systematically interrogates Staphylococcus aureus Cas9 specificity in human cells von Tycko, Josh, Barrera, Luis A., Huston, Nicholas C., Friedland, Ari E., Wu, Xuebing, Gootenberg, Jonathan S., Abudayyeh, Omar O., Myer, Vic E., Wilson, Christopher J., Hsu, Patrick D.

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Modeling the efficacy of CRISPR gene drive for snail immunity on schistosomiasis control von Grewelle, Richard E, Perez-Saez, Javier, Tycko, Josh, Namigai, Erica K. O, Rickards, Chloe G, De Leo, Giulio A

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Gene drives for schistosomiasis transmission control von Maier, Theresa, Wheeler, Nicolas James, Namigai, Erica K O, Tycko, Josh, Grewelle, Richard Ernest, Woldeamanuel, Yimtubezinash, Klohe, Katharina, Perez-Saez, Javier, Sokolow, Susanne H, De Leo, Giulio A, Yoshino, Timothy P, Zamanian, Mostafa, Reinhard-Rupp, Jutta

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Lessons learned from the clinical development and market authorization of Glybera von Bryant, Laura M, Christopher, Devin M, Giles, April R, Hinderer, Christian, Rodriguez, Jesse L, Smith, Jenessa B, Traxler, Elizabeth A, Tycko, Josh, Wojno, Adam P, Wilson, James M

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Publisher Correction: Pairwise library screen systematically interrogates Staphylococcus aureus Cas9 specificity in human cells von Tycko, Josh, Barrera, Luis A., Huston, Nicholas C., Friedland, Ari E., Wu, Xuebing, Gootenberg, Jonathan S., Abudayyeh, Omar O., Myer, Vic E., Wilson, Christopher J., Hsu, Patrick D.

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Large-scale mapping and mutagenesis of human transcriptional effector domains von DelRosso, Nicole, Tycko, Josh, Suzuki, Peter, Andrews, Cecelia, Aradhana, Mukund, Adi, Liongson, Ivan, Ludwig, Connor, Spees, Kaitlyn, Fordyce, Polly, Bassik, Michael C., Bintu, Lacramioara

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Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome von Durrant, Matthew G., Fanton, Alison, Tycko, Josh, Hinks, Michaela, Chandrasekaran, Sita S., Perry, Nicholas T., Schaepe, Julia, Du, Peter P., Lotfy, Peter, Bassik, Michael C., Bintu, Lacramioara, Bhatt, Ami S., Hsu, Patrick D.

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High-Throughput Discovery and Characterization of Human Transcriptional Effectors von Tycko, Josh, DelRosso, Nicole, Hess, Gaelen T., Aradhana, Banerjee, Abhimanyu, Mukund, Aditya, Van, Mike V., Ego, Braeden K., Yao, David, Spees, Kaitlyn, Suzuki, Peter, Marinov, Georgi K., Kundaje, Anshul, Bassik, Michael C., Bintu, Lacramioara

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A genome-wide genetic screen uncovers determinants of human pigmentation von Bajpai, Vivek K, Swigut, Tomek, Mohammed, Jaaved, Naqvi, Sahin, Arreola, Martin, Tycko, Josh, Kim, Tayne C, Pritchard, Jonathan K, Bassik, Michael C, Wysocka, Joanna

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Adeno-Associated Virus Vector-Mediated Expression of Antirespiratory Syncytial Virus Antibody Prevents Infection in Mouse Airways von Tycko, Josh, Adam, Virginie S., Crosariol, Marco, Ohlstein, Jason, Sanmiguel, Julio, Tretiakova, Anna P., Roy, Soumitra, Worgall, Stefan, Wilson, James M., Limberis, Maria P.

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Development of compact transcriptional effectors using high-throughput measurements in diverse contexts von Tycko, Josh, Van, Mike V., Aradhana, DelRosso, Nicole, Ye, Hanrong, Yao, David, Valbuena, Raeline, Vaughan-Jackson, Alun, Xu, Xiaoshu, Ludwig, Connor, Spees, Kaitlyn, Liu, Katherine, Gu, Mingxin, Khare, Venya, Mukund, Adi Xiyal, Suzuki, Peter H., Arana, Sophia, Zhang, Catherine, Du, Peter P., Ornstein, Thea S., Hess, Gaelen T., Kamber, Roarke A., Qi, Lei S., Khalil, Ahmad S., Bintu, Lacramioara, Bassik, Michael C.

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Multicenter integrated analysis of noncoding CRISPRi screens von Yao, David, Tycko, Josh, Oh, Jin Woo, Bounds, Lexi R., Gosai, Sager J., Lataniotis, Lazaros, Mackay-Smith, Ava, Doughty, Benjamin R., Gabdank, Idan, Schmidt, Henri, Guerrero-Altamirano, Tania, Siklenka, Keith, Guo, Katherine, White, Alexander D., Youngworth, Ingrid, Andreeva, Kalina, Ren, Xingjie, Barrera, Alejandro, Luo, Yunhai, Yardımcı, Galip Gürkan, Tewhey, Ryan, Kundaje, Anshul, Greenleaf, William J., Sabeti, Pardis C., Leslie, Christina, Pritykin, Yuri, Moore, Jill E., Beer, Michael A., Gersbach, Charles A., Reddy, Timothy E., Shen, Yin, Engreitz, Jesse M., Bassik, Michael C., Reilly, Steven K.

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The sound of silence: Transgene silencing in mammalian cell engineering von Cabrera, Alan, Edelstein, Hailey I., Glykofrydis, Fokion, Love, Kasey S., Palacios, Sebastian, Tycko, Josh, Zhang, Meng, Lensch, Sarah, Shields, Cara E., Livingston, Mark, Weiss, Ron, Zhao, Huimin, Haynes, Karmella A., Morsut, Leonardo, Chen, Yvonne Y., Khalil, Ahmad S., Wong, Wilson W., Collins, James J., Rosser, Susan J., Polizzi, Karen, Elowitz, Michael B., Fussenegger, Martin, Hilton, Isaac B., Leonard, Joshua N., Bintu, Lacramioara, Galloway, Kate E., Deans, Tara L.

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High-throughput functional characterization of combinations of transcriptional activators and repressors von Mukund, Adi X., Tycko, Josh, Allen, Sage J., Robinson, Stephanie A., Andrews, Cecelia, Sinha, Joydeb, Ludwig, Connor H., Spees, Kaitlyn, Bassik, Michael C., Bintu, Lacramioara

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High-throughput discovery and characterization of viral transcriptional effectors in human cells von Ludwig, Connor H., Thurm, Abby R., Morgens, David W., Yang, Kevin J., Tycko, Josh, Bassik, Michael C., Glaunsinger, Britt A., Bintu, Lacramioara

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