Expression of mitochondrial genes predicts survival in pediatric acute myeloid leukemia von Tyagi, Anudishi, Pramanik, Raja, Bakhshi, Radhika, Singh, Archna, Vishnubhatla, Sreenivas, Bakhshi, Sameer

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Targeting Myeloid Epithelial Tyrosine Kinase (MERTK) Receptor in Acute Myeloid Leukemia Using a Novel Antibody Drug Conjugate, Rgx-019-MMAE von Tyagi, Anudishi, Siddiqui, Maryam, Kurth, Isabel, Takeda, Shugaku, Eckstrom, Amanda, Borgman, Jenny, Maiti, Abhishek, Battula, Venkata Lokesh

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FT538, iPSC-Derived NK Cells Are Potent Inducers of Apoptosis in AML Cells and Their Effect Is Synergistic in Combination with Approved Therapeutic Strategies von Eckstrom, Amanda, Tyagi, Anudishi, Siddiqui, Maryam, Mahmood, Sajid, Wong, Lilly, Valamehr, Bahram Bob, Daver, Naval, Battula, Venkata Lokesh

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Abstract P2-20-06: Anti-B7-H3 Antibody (T-1A5) Blocks Immunomodulatory Function of B7-H3 and Enhances NK and T Cell–Mediated Cytotoxicity against Breast Cancer Cells von Anand, Vivek, Tyagi, Anudishi, Battula, Venkata Lokesh

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TP-0184, a Novel FLT3-ALK2 Dual Inhibitor, Targets Amino Acid Transport and Biosynthesis in AML Cells and Sensitizes AML Cells to Chemotherapy and BCL2 Inhibition von Tyagi, Anudishi, Ly, Stanley, Yuan, Bin, El-Dana, Fouad, Jaggupilli, Appalaraju, Foulks, Jason M, Warner, Steven L., Battula, Venkata Lokesh

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Anti-B7-H3 Antibody (T-1A5) Blocks Immunomodulatory Function of B7-H3 and Enhances NK Cell-Mediated Cytotoxicity Against Acute Myeloid Leukemia Cells von Tyagi, Anudishi, Ly, Stanley, El-Dana, Fouad, Yuan, Bin, Grimm, Sabrina, Bühring, Hans-Jörg, Battula, Venkata Lokesh

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Evidence supporting a role for the immune checkpoint protein B7-H3 in NK cell-mediated cytotoxicity against AML von Tyagi, Anudishi, Ly, Stanley, El-Dana, Fouad, Yuan, Bin, Jaggupilli, Appalaraju, Grimm, Sabrina, Konopleva, Marina, Bühring, Hans-Jörg, Battula, V. Lokesh

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Activin-like Kinase 2 (ALK2/ACVR1) Is a Resistance Factor and Therapeutic Vulnerability to FLT3 Inhibition in Acute Myeloid Leukemia von Tyagi, Anudishi, Ly, Stanley, Yuan, Bin, El-Dana, Fouad, Anand, Vivek, Jaggupilli, Appalaraju, Borthakur, Gautam, Foulks, Jason M, Warner, Steven L., Battula, Venkata Lokesh

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Prognostic impact of mitochondrial DNA D-loop variations in pediatric acute myeloid leukemia von Tyagi, Anudishi, Pramanik, Raja, Vishnubhatla, Sreenivas, Bakhshi, Radhika, Bakhshi, Sameer

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ERK1/2 Inhibition Overcomes Resistance to Venetoclax in AML By Inhibiting Drp1 Dependent Mitochondrial Fission von Sharma, Priyanka, Ostermann, Lauren B., Piya, Sujan, Ke, Baozhen, Baran, Natalia, Tyagi, Anudishi, Muftuoglu, Muharrem, Basyal, Mahesh, Zhang, Qi, Munck, Joanne, Dao, Kim-Hien, Sims, Martin, Carter, Bing Z., Battula, Venkata Lokesh, Andreeff, Michael, Borthakur, Gautam

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Abstract 5098: B7-H3 blockade in combination with natural killer cell activity enhancers including NKTR-255 and venetoclax synergistically induces cytotoxicity in B7-H3+ AML cells von Tyagi, Anudishi, Marcondes, A. Mario, Overwijk, Willem, Battula, Venkata Lokesh

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Cytogenetic Profiles of 472 Indian Children with Acute Myeloid Leukemia von Tyagi, Anudishi, Pramanik, Raja, Chaudhary, Shilpi, Chopra, Anita, Bakhshi, Sameer

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Evaluation of Vascular Endothelial Growth Factor (VEGF) and Thrombospondin-1 as Biomarkers of Metronomic Chemotherapy in Progressive Pediatric Solid Malignancies von Pramanik, Raja, Tyagi, Anudishi, Agarwala, Sandeep, Vishnubhatla, Sreenivas, Dhawan, Deepa, Bakhshi, Sameer

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Dysregulation of miRNA expression and their prognostic significance in paediatric cytogenetically normal acute myeloid leukaemia von Gaur, Vikas, Chaudhary, Shilpi, Tyagi, Anudishi, Agarwal, Suyash, Sharawat, Surender K., Sarkar, Siddik, Singh, Harpreet, Bakhshi, Sameer, Sharma, Pankaj, Kumar, Sachin

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TP-0184 inhibits FLT3/ACVR1 to overcome FLT3 inhibitor resistance and hinder AML growth synergistically with venetoclax von Tyagi, Anudishi, Jaggupilli, Appalaraju, Ly, Stanley, Yuan, Bin, El-Dana, Fouad, Hegde, Venkatesh L., Anand, Vivek, Kumar, Bijender, Puppala, Mamta, Yin, Zheng, Wong, Stephen T. C., Mollard, Alexis, Vankayalapati, Hariprasad, Foulks, Jason M., Warner, Steven L., Daver, Naval, Borthakur, Gautam, Battula, V. Lokesh

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Poster: AML-326 Novel FLT3-ALK2 Dual Inhibitor TP-0184 Inhibits Leukemia Growth by Targeting Serine Biosynthesis in FLT3-ITD-Positive AML Cells von Tyagi, Anudishi, Ly, Stanley, Yuan, Bin, El-Dana, Fouad, Jaggupilli, Appalaraju, Foulks, Jason, Warner, Steven, Battula, V Lokesh

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Myeloid Sarcoma Predicts Superior Outcome in Pediatric AML; Can Cytogenetics Solve the Puzzle? von Pramanik, Raja, Tyagi, Anudishi, Chopra, Anita, Kumar, Akash, Vishnubhatla, Sreenivas, Bakhshi, Sameer

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AML Cells Alter Bone Homeostasis By Promoting the Formation of Immature Bone and Resorption of Mature Bone That Supports Leukemia Progression von Tyagi, Anudishi, Yuan, Bin, Ly, Stanley, El-Dana, Fouad, Kuruvilla, Vinitha Mary, Zhang, Qi, Peterson, Christine B, Zhou, Xin, deCrombrugghe, Benoit, Andreeff, Michael, Konopleva, Marina, Amini, Behrang, Battula, Venkata Lokesh

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Poster: AML-327 Novel Anti–B7-H3 Blocking Antibody Enhances NK Cell–Mediated Cytotoxicity and Improves Outcomes in AML-Bearing Mice von Tyagi, Anudishi, Ly, Stanley, El-Dana, Fouad, Yuan, Bin, Jaggupilli, Appalaraju, Grimm, Sabrina, Bover, Laura, Buhring, Hans-Jorg, Battula, V Lokesh

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AML-326 Novel FLT3-ALK2 Dual Inhibitor TP-0184 Inhibits Leukemia Growth by Targeting Serine Biosynthesis in FLT3-ITD-Positive AML Cells von Tyagi, Anudishi, Ly, Stanley, Yuan, Bin, El-Dana, Fouad, Jaggupilli, Appalaraju, Foulks, Jason, Warner, Steven, Battula, V Lokesh

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