Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution von Bharadwaj, Uddalak, Kasembeli, Moses M., Robinson, Prema, Tweardy, David J.

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Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment von Kasembeli, Moses M, Bharadwaj, Uddalak, Robinson, Prema, Tweardy, David J

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Stat3 Activation Links a C/EBPδ to Myostatin Pathway to Stimulate Loss of Muscle Mass von Zhang, Liping, Pan, Jenny, Dong, Yanjun, Tweardy, David J., Dong, Yanlan, Garibotto, Giacomo, Mitch, William E.

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Inhibition of Stat3 Activation Suppresses Caspase-3 and the Ubiquitin-Proteasome System, Leading to Preservation of Muscle Mass in Cancer Cachexia von Silva, Kleiton Augusto Santos, Dong, Jiangling, Dong, Yanjun, Dong, Yanlan, Schor, Nestor, Tweardy, David J., Zhang, Liping, Mitch, William E.

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STAT‐3 contributes to pulmonary fibrosis through epithelial injury and fibroblast‐myofibroblast differentiation von Pedroza, Mesias, Le, Thuy T., Lewis, Katherine, Karmouty‐Quintana, Harry, To, Sarah, George, Anuh T., Blackburn, Michael R., Tweardy, David J., Agarwal, Sandeep K.

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Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy von Sharma, Meenu, Khong, Hiep, Fa’ak, Faisal, Bentebibel, Salah-Eddine, Janssen, Louise M. E., Chesson, Brent C., Creasy, Caitlin A., Forget, Marie-Andrée, Kahn, Laura Maria S., Pazdrak, Barbara, Karki, Binisha, Hailemichael, Yared, Singh, Manisha, Vianden, Christina, Vennam, Srinivas, Bharadwaj, Uddalak, Tweardy, David J., Haymaker, Cara, Bernatchez, Chantale, Huang, Shixia, Rajapakshe, Kimal, Coarfa, Cristian, Hurwitz, Michael E., Sznol, Mario, Hwu, Patrick, Hoch, Ute, Addepalli, Murali, Charych, Deborah H., Zalevsky, Jonathan, Diab, Adi, Overwijk, Willem W.

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Chemical probes that competitively and selectively inhibit Stat3 activation von Xu, Xuejun, Kasembeli, Moses M, Jiang, Xueqing, Tweardy, Benjamin J, Tweardy, David J

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Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor von Redell, Michele S., Ruiz, Marcos J., Alonzo, Todd A., Gerbing, Robert B., Tweardy, David J.

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Modulation of STAT3 folding and function by TRiC/CCT chaperonin von Kasembeli, Moses, Lau, Wilson Chun Yu, Roh, Soung-Hun, Eckols, T Kris, Frydman, Judith, Chiu, Wah, Tweardy, David J

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STAT3 Signaling Is Activated Preferentially in Tumor‐Initiating Cells in Claudin‐Low Models of Human Breast Cancer von Wei, Wei, Tweardy, David J., Zhang, Mei, Zhang, Xiaomei, Landua, John, Petrovic, Ivana, Bu, Wen, Roarty, Kevin, Hilsenbeck, Susan G., Rosen, Jeffrey M., Lewis, Michael T.

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Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain von Singh, Manisha, Vianden, Christina, Cantwell, Mark J., Dai, Zhimin, Xiao, Zhilan, Sharma, Meenu, Khong, Hiep, Jaiswal, Ashvin R., Faak, Faisal, Hailemichael, Yared, Janssen, L. M. E., Bharadwaj, Uddalak, Curran, Michael A., Diab, Adi, Bassett, Roland L., Tweardy, David J., Hwu, Patrick, Overwijk, Willem W.

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PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2 von Li, Nan, Feng, Lin, Liu, Hui, Wang, Jiadong, Kasembeli, Moses, Tran, My Kim, Tweardy, David J., Lin, Steven Hsesheng, Chen, Junjie

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Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis von Hox, Valerie, MD, PhD, O'Connell, Michael P., PhD, Lyons, Jonathan J., MD, Sackstein, Paul, BS, Dimaggio, Thomas, ADN, RN, Jones, Nina, BSN, RN, Nelson, Celeste, MS CRNP, Boehm, Manfred, MD, Holland, Steven M., MD, Freeman, Alexandra F., MD, Tweardy, David J., MD, Olivera, Ana, PhD, Metcalfe, Dean D., MD, Milner, Joshua D., MD

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Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma von Bharadwaj, Uddalak, Eckols, T Kris, Xu, Xuejun, Kasembeli, Moses M, Chen, Yunyun, Adachi, Makoto, Song, Yongcheng, Mo, Qianxing, Lai, Stephen Y, Tweardy, David J

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Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer von Lewis, Katherine M, Bharadwaj, Uddalak, Eckols, T. Kris, Kolosov, Mikhail, Kasembeli, Moses M, Fridley, Colleen, Siller, Ricardo, Tweardy, David J

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Spatial molecular and cellular determinants of STAT3 activation in liver fibrosis progression in non-alcoholic fatty liver disease von Jiao, Jingjing, Sanchez, Jessica I., Saldarriaga, Omar A., Solis, Luisa M., Tweardy, David J., Maru, Dipen M., Stevenson, Heather L., Beretta, Laura

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Signal Transducer and Activator of Transcription-3 Modulation of Cardiac Pathology in Chronic Chagasic Cardiomyopathy von Hoffman, Kristyn A, Villar, Maria Jose, Poveda, Cristina, Bottazzi, Maria Elena, Hotez, Peter J, Tweardy, David J, Jones, Kathryn M

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Selective small molecule Stat3 inhibitor reduces breast cancer tumor-initiating cells and improves recurrence free survival in a human-xenograft model von Dave, Bhuvanesh, Landis, Melissa D, Tweardy, David J, Chang, Jenny C, Dobrolecki, Lacey E, Wu, Meng-Fen, Zhang, Xiaomei, Westbrook, Thomas F, Hilsenbeck, Susan G, Liu, Dan, Lewis, Michael T

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Synthetic and Biological Studies of Phaeosphaerides von Chatzimpaloglou, Anthoula, Kolosov, Mikhail, Eckols, T. Kris, Tweardy, David J, Sarli, Vasiliki

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Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species von Yuan, Hengjie, Houck, Katie L, Tian, Ye, Bharadwaj, Uddalak, Hull, Ken, Zhou, Zhou, Zhu, Mingzhao, Zhou, Mingzhao, Wu, Xiaoping, Tweardy, David J, Romo, Daniel, Fu, Xiaoyun, Zhang, Yanjun, Zhang, Jianning, Dong, Jing-fei

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