Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation von Morris, Luc G T, Kaufman, Andrew M, Gong, Yongxing, Ramaswami, Deepa, Walsh, Logan A, Turcan, Şevin, Eng, Stephanie, Kannan, Kasthuri, Zou, Yilong, Peng, Luke, Banuchi, Victoria E, Paty, Phillip, Zeng, Zhaoshi, Vakiani, Efsevia, Solit, David, Singh, Bhuvanesh, Ganly, Ian, Liau, Linda, Cloughesy, Timothy C, Mischel, Paul S, Mellinghoff, Ingo K, Chan, Timothy A

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TERT and DNMT1 expression predict sensitivity to decitabine in gliomas von Park, Jong-Whi, Sahm, Felix, Steffl, Bianca, Arrillaga-Romany, Isabel, Cahill, Daniel, Monje, Michelle, Herold-Mende, Christel, Wick, Wolfgang, Turcan, Şevin

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Phenotypic and molecular states of IDH1 mutation-induced CD24-positive glioma stem-like cells von Haddock, Sara, Alban, Tyler J., Turcan, Şevin, Husic, Hana, Rosiek, Eric, Ma, Xiaoxiao, Wang, Yuxiang, Bale, Tejus, Desrichard, Alexis, Makarov, Vladimir, Monette, Sebastien, Wu, Wei, Gardner, Rui, Manova, Katia, Boire, Adrienne, Chan, Timothy A.

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Integrated genomic characterization of IDH1-mutant glioma malignant progression von Bai, Hanwen, Harmancı, Akdes Serin, Erson-Omay, E Zeynep, Li, Jie, Coşkun, Süleyman, Simon, Matthias, Krischek, Boris, Özduman, Koray, Omay, S Bülent, Sorensen, Eric A, Turcan, Şevin, Bakırcığlu, Mehmet, Carrión-Grant, Geneive, Murray, Phillip B, Clark, Victoria E, Ercan-Sencicek, A Gulhan, Knight, James, Sencar, Leman, Altınok, Selin, Kaulen, Leon D, Gülez, Burcu, Timmer, Marco, Schramm, Johannes, Mishra-Gorur, Ketu, Henegariu, Octavian, Moliterno, Jennifer, Louvi, Angeliki, Chan, Timothy A, Tannheimer, Stacey L, Pamir, M Necmettin, Vortmeyer, Alexander O, Bilguvar, Kaya, Yasuno, Katsuhito, Günel, Murat

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CIC reduces xCT/SLC7A11 expression and glutamate release in glioma von Park, Jong-Whi, Kilic, Omer, Deo, Minh, Jimenez-Cowell, Kevin, Demirdizen, Engin, Kim, Hyunggee, Turcan, Şevin

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TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing von Demirdizen, Engin, Al-Ali, Ruslan, Narayanan, Ashwin, Sun, Xueyuan, Varga, Julianna Patricia, Steffl, Bianca, Brom, Manuela, Krunic, Damir, Schmidt, Claudia, Schmidt, Gabriele, Bestvater, Felix, Taranda, Julian, Turcan, Şevin

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An Integrated Systems Biology Approach Identifies TRIM25 as a Key Determinant of Breast Cancer Metastasis von Walsh, Logan A., Alvarez, Mariano J., Sabio, Erich Y., Reyngold, Marsha, Makarov, Vladimir, Mukherjee, Suranjit, Lee, Ken-Wing, Desrichard, Alexis, Turcan, Şevin, Dalin, Martin G., Rajasekhar, Vinagolu K., Chen, Shuibing, Vahdat, Linda T., Califano, Andrea, Chan, Timothy A.

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A microdeletion event at 19q13.43 in IDH-mutant astrocytomas is strongly correlated with MYC overexpression von Ülgen, Ege, Gerlevik, Umut, Gerlevik, Sıla, Oktay, Yavuz, Sezerman, Osman Uğur, Turcan, Şevin, Ozduman, Koray

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Repurposing FDA-Approved Drugs for Temozolomide-Resistant IDH1 Mutant Glioma Using High-Throughput Miniaturized Screening on Droplet Microarray Chip von Cui, Haijun, Sun, Xueyuan, Schilling, Marcel, Herold-Mende, Christel, Reischl, Markus, Levkin, Pavel A, Popova, Anna A, Turcan, Şevin

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IDH-mutant glioma specific association of rs55705857 located at 8q24.21 involves MYC deregulation von Oktay, Yavuz, Ülgen, Ege, Can, Özge, Akyerli, Cemaliye B., Yüksel, Şirin, Erdemgil, Yiğit, Durası, İ. Melis, Henegariu, Octavian Ioan, Nanni, E. Paolo, Selevsek, Nathalie, Grossmann, Jonas, Erson-Omay, E. Zeynep, Bai, Hanwen, Gupta, Manu, Lee, William, Turcan, Şevin, Özpınar, Aysel, Huse, Jason T., Sav, M. Aydın, Flanagan, Adrienne, Günel, Murat, Sezerman, O. Uğur, Yakıcıer, M. Cengiz, Pamir, M. Necmettin, Özduman, Koray

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Tumor heterogeneity and tumor-microglia interactions in primary and recurrent IDH1-mutant gliomas von Blanco-Carmona, Enrique, Narayanan, Ashwin, Hernandez, Inmaculada, Nieto, Juan C., Elosua-Bayes, Marc, Sun, Xueyuan, Schmidt, Claudia, Pamir, Necmettin, Özduman, Koray, Herold-Mende, Christel, Pagani, Francesca, Cominelli, Manuela, Taranda, Julian, Wick, Wolfgang, von Deimling, Andreas, Poliani, Pietro Luigi, Rehli, Michael, Schlesner, Matthias, Heyn, Holger, Turcan, Şevin

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Epigenetic Reprogramming for Targeting IDH-Mutant Malignant Gliomas von Park, Jong-Whi, Turcan, Şevin

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From Laboratory Studies to Clinical Trials: Temozolomide Use in IDH-Mutant Gliomas von Sun, Xueyuan, Turcan, Sevin

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An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells von Rohle, Dan, Popovici-Muller, Janeta, Palaskas, Nicolaos, Turcan, Sevin, Grommes, Christian, Campos, Carl, Tsoi, Jennifer, Clark, Owen, Oldrini, Barbara, Komisopoulou, Evangelia, Kunii, Kaiko, Pedraza, Alicia, Schalm, Stefanie, Silverman, Lee, Miller, Alexandra, Wang, Fang, Yang, Hua, Chen, Yue, Kernytsky, Andrew, Rosenblum, Marc K., Liu, Wei, Biller, Scott A., Su, Shinsan M., Brennan, Cameron W., Chan, Timothy A., Graeber, Thomas G., Yen, Katharine E., Mellinghoff, Ingo K.

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IDH mutation impairs histone demethylation and results in a block to cell differentiation von Lu, Chao, Ward, Patrick S., Kapoor, Gurpreet S., Rohle, Dan, Turcan, Sevin, Abdel-Wahab, Omar, Edwards, Christopher R., Khanin, Raya, Figueroa, Maria E., Melnick, Ari, Wellen, Kathryn E., O’Rourke, Donald M., Berger, Shelley L., Chan, Timothy A., Levine, Ross L., Mellinghoff, Ingo K., Thompson, Craig B.

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IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype von Turcan, Sevin, Rohle, Daniel, Goenka, Anuj, Walsh, Logan A., Fang, Fang, Yilmaz, Emrullah, Campos, Carl, Fabius, Armida W. M., Lu, Chao, Ward, Patrick S., Thompson, Craig B., Kaufman, Andrew, Guryanova, Olga, Levine, Ross, Heguy, Adriana, Viale, Agnes, Morris, Luc G. T., Huse, Jason T., Mellinghoff, Ingo K., Chan, Timothy A.

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Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence von Turcan, Sevin, Makarov, Vladimir, Taranda, Julian, Wang, Yuxiang, Fabius, Armida W. M., Wu, Wei, Zheng, Yupeng, El-Amine, Nour, Haddock, Sara, Nanjangud, Gouri, LeKaye, H. Carl, Brennan, Cameron, Cross, Justin, Huse, Jason T., Kelleher, Neil L., Osten, Pavel, Thompson, Craig B., Chan, Timothy A.

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MEOX2 homeobox gene promotes growth of malignant gliomas von Schönrock, Anna, Heinzelmann, Elisa, Steffl, Bianca, Demirdizen, Engin, Narayanan, Ashwin, Krunic, Damir, Bähr, Marion, Park, Jong-Whi, Schmidt, Claudia, Özduman, Koray, Pamir, M Necmettin, Wick, Wolfgang, Bestvater, Felix, Weichenhan, Dieter, Plass, Christoph, Taranda, Julian, Mall, Moritz, Turcan, Şevin

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BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1 von Tönjes, Martje, Barbus, Sebastian, Park, Yoon Jung, Wang, Wei, Schlotter, Magdalena, Lindroth, Anders M, Pleier, Sabrina V, Bai, Alfa H C, Karra, Daniela, Piro, Rosario M, Felsberg, Jörg, Addington, Adele, Lemke, Dieter, Weibrecht, Irene, Hovestadt, Volker, Rolli, Claudio G, Campos, Benito, Turcan, Sevin, Sturm, Dominik, Witt, Hendrik, Chan, Timothy A, Herold-Mende, Christel, Kemkemer, Ralf, König, Rainer, Schmidt, Kathrin, Hull, William-Edmund, Pfister, Stefan M, Jugold, Manfred, Hutson, Susan M, Plass, Christoph, Okun, Jürgen G, Reifenberger, Guido, Lichter, Peter, Radlwimmer, Bernhard

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Epigenetic Drugs and Their Immune Modulating Potential in Cancers von Liang, Yingying, Turcan, Sevin

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