Crystalizing our view of the contact system von Tucker, Erik I.

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The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial von Lorentz, Christina U., Tucker, Erik I., Verbout, Norah G., Shatzel, Joseph J., Olson, Sven R., Markway, Brandon D., Wallisch, Michael, Ralle, Martina, Hinds, Monica T., McCarty, Owen J.T., Gailani, David, Weitz, Jeffrey I., Gruber, András

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Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial von Lorentz, Christina U, Verbout, Norah G, Wallisch, Michael, Hagen, Matthew W, Shatzel, Joseph J, Olson, Sven R, Puy, Cristina, Hinds, Monica T, McCarty, Owen J.T, Gailani, David, Gruber, András, Tucker, Erik I

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Cross-Talk between the Complement Pathway and the Contact Activation System of Coagulation: Activated Factor XI Neutralizes Complement Factor H von Puy, Cristina, Pang, Jiaqing, Reitsma, Stéphanie E, Lorentz, Christina U, Tucker, Erik I, Gailani, David, Gruber, András, Lupu, Florea, McCarty, Owen J T

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Factor XI Deficiency Alters the Cytokine Response and Activation of Contact Proteases during Polymicrobial Sepsis in Mice von Bane, Jr, Charles E, Ivanov, Ivan, Matafonov, Anton, Boyd, Kelli L, Cheng, Qiufang, Sherwood, Edward R, Tucker, Erik I, Smiley, Stephen T, McCarty, Owen J T, Gruber, Andras, Gailani, David

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Revised model of the tissue factor pathway of thrombin generation: Role of the feedback activation of FXI von Lakshmanan, Hari Hara Sudhan, Estonilo, Aldrich, Reitsma, Stéphanie E., Melrose, Alexander R., Subramanian, Jayaram, Zheng, Tony J., Maddala, Jeevan, Tucker, Erik I., Gailani, David, McCarty, Owen J. T., Jurney, Patrick L., Puy, Cristina

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Factor XII inhibition reduces thrombus formation in a primate thrombosis model von Matafonov, Anton, Leung, Philberta Y., Gailani, Adam E., Grach, Stephanie L., Puy, Cristina, Cheng, Qiufang, Sun, Mao-fu, McCarty, Owen J.T., Tucker, Erik I., Kataoka, Hiroaki, Renné, Thomas, Morrissey, James H., Gruber, Andras, Gailani, David

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Pharmacological reduction of coagulation factor XI reduces macrophage accumulation and accelerates deep vein thrombosis resolution in a mouse model of venous thrombosis von Jordan, Kelley R., Wyatt, Cory R., Fallon, Meghan E., Woltjer, Randy, Neuwelt, Edward A., Cheng, Quifang, Gailani, David, Lorentz, Christina, Tucker, Erik I., McCarty, Owen J. T., Hinds, Monica T., Nguyen, Khanh P.

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Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus von Silasi, Robert, Keshari, Ravi S., Regmi, Girija, Lupu, Cristina, Georgescu, Constantin, Simmons, Joe H., Wallisch, Michael, Kohs, Tia C.L., Shatzel, Joseph J., Olson, Sven R., Lorentz, Christina U., Puy, Cristina, Tucker, Erik I., Gailani, David, Strickland, Sidney, Gruber, András, McCarty, Owen J.T., Lupu, Florea

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Role of platelets in regulating activated coagulation factor XI activity von Reitsma, Stéphanie E, Pang, Jiaqing, Raghunathan, Vikram, Shatzel, Joseph J, Lorentz, Christina U, Tucker, Erik I, Gruber, András, Gailani, David, McCarty, Owen J T, Puy, Cristina

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Red blood cell-derived microparticles isolated from blood units initiate and propagate thrombin generation von Rubin, Olivier, Delobel, Julien, Prudent, Michel, Lion, Niels, Kohl, Kid, Tucker, Erik I., Tissot, Jean-Daniel, Angelillo-Scherrer, Anne

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Antithrombotic Effect of Antisense Factor XI Oligonucleotide Treatment in Primates von Crosby, Jeffrey R, Marzec, Ulla, Revenko, Alexey S, Zhao, Chenguang, Gao, Dacao, Matafonov, Anton, Gailani, David, MacLeod, A Robert, Tucker, Erik I, Gruber, Andras, Hanson, Stephen R, Monia, Brett P

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A role for factor XIIa–mediated factor XI activation in thrombus formation in vivo von Cheng, Qiufang, Tucker, Erik I., Pine, Meghann S., Sisler, India, Matafonov, Anton, Sun, Mao-fu, White-Adams, Tara C., Smith, Stephanie A., Hanson, Stephen R., McCarty, Owen J.T., Renné, Thomas, Gruber, András, Gailani, David

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Titanium is a potent inducer of contact activation: implications for intravascular devices von Litvak, Maxim, Shamanaev, Aleksandr, Zalawadiya, Sandip, Matafonov, Anton, Kobrin, Anton, Feener, Edward P., Wallisch, Michael, Tucker, Erik I., McCarty, Owen J.T., Gailani, David

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Platelet-Derived Short-Chain Polyphosphates Enhance the Inactivation of Tissue Factor Pathway Inhibitor by Activated Coagulation Factor XI von Puy, Cristina, Tucker, Erik I, Ivanov, Ivan S, Gailani, David, Smith, Stephanie A, Morrissey, James H, Gruber, András, McCarty, Owen J T

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Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis von Tucker, Erik I., Verbout, Norah G., Leung, Philberta Y., Hurst, Sawan, McCarty, Owen J.T., Gailani, David, Gruber, András

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Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI von Tucker, Erik I., Marzec, Ulla M., White, Tara C., Hurst, Sawan, Rugonyi, Sandra, McCarty, Owen J.T., Gailani, David, Gruber, András, Hanson, Stephen R.

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Pharmacological targeting of coagulation factor XI mitigates the development of experimental atherosclerosis in low‐density lipoprotein receptor‐deficient mice von Ngo, Anh T. P., Jordan, Kelley R., Mueller, Paul A., Hagen, Matthew W., Reitsma, Stéphanie E., Puy, Cristina, Revenko, Alexey S., Lorentz, Christina U., Tucker, Erik I., Cheng, Quifang, Hinds, Monica T., Fazio, Sergio, Monia, Brett P., Gailani, David, Gruber, András, Tavori, Hagai, McCarty, Owen J. T.

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Antibody inhibition of contact factor XII reduces platelet deposition in a model of extracorporeal membrane oxygenator perfusion in nonhuman primates von Wallisch, Michael, Lorentz, Christina U., Lakshmanan, Hari H.S., Johnson, Jennifer, Carris, Marschelle R., Puy, Cristina, Gailani, David, Hinds, Monica T., McCarty, Owen J.T., Gruber, András, Tucker, Erik I.

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Factor XI contributes to thrombin generation in the absence of factor XII von Kravtsov, Dmitri V., Matafonov, Anton, Tucker, Erik I., Sun, Mao-fu, Walsh, Peter N., Gruber, Andras, Gailani, David

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