CH5424802, a Selective ALK Inhibitor Capable of Blocking the Resistant Gatekeeper Mutant von Sakamoto, Hiroshi, Tsukaguchi, Toshiyuki, Hiroshima, Sayuri, Kodama, Tatsushi, Kobayashi, Takamitsu, Fukami, Takaaki A., Oikawa, Nobuhiro, Tsukuda, Takuo, Ishii, Nobuya, Aoki, Yuko

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Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802) von Kinoshita, Kazutomo, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Hara, Sousuke, Ohwada, Jun, Miyagi, Takuho, Kobayashi, Takamitsu, Takanashi, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro

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Self-enhancement of hepatitis C virus replication by promotion of specific sphingolipid biosynthesis von Hirata, Yuichi, Ikeda, Kazutaka, Sudoh, Masayuki, Tokunaga, Yuko, Suzuki, Akemi, Weng, Leiyun, Ohta, Masatoshi, Tobita, Yoshimi, Okano, Ken, Ozeki, Kazuhisa, Kawasaki, Kenichi, Tsukuda, Takuo, Katsume, Asao, Aoki, Yuko, Umehara, Takuya, Sekiguchi, Satoshi, Toyoda, Tetsuya, Shimotohno, Kunitada, Soga, Tomoyoshi, Nishijima, Masahiro, Taguchi, Ryo, Kohara, Michinori

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Host sphingolipid biosynthesis as a target for hepatitis C virus therapy von Sakamoto, Hiroshi, Okamoto, Koichi, Aoki, Masahiro, Kato, Hideyuki, Katsume, Asao, Ohta, Atsunori, Tsukuda, Takuo, Shimma, Nobuo, Aoki, Yuko, Arisawa, Mikio, Kohara, Michinori, Sudoh, Masayuki

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Enhanced antitumor activity of erlotinib in combination with the Hsp90 inhibitor CH5164840 against non‐small‐cell lung cancer von Ono, Naomi, Yamazaki, Toshikazu, Tsukaguchi, Toshiyuki, Fujii, Toshihiko, Sakata, Kiyoaki, Suda, Atsushi, Tsukuda, Takuo, Mio, Toshiyuki, Ishii, Nobuya, Kondoh, Osamu, Aoki, Yuko

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A Serine Palmitoyltransferase Inhibitor Blocks Hepatitis C Virus Replication in Human Hepatocytes von Katsume, Asao, Tokunaga, Yuko, Hirata, Yuichi, Munakata, Tsubasa, Saito, Makoto, Hayashi, Hitohisa, Okamoto, Koichi, Ohmori, Yusuke, Kusanagi, Isamu, Fujiwara, Shinya, Tsukuda, Takuo, Aoki, Yuko, Klumpp, Klaus, Tsukiyama–Kohara, Kyoko, El–Gohary, Ahmed, Sudoh, Masayuki, Kohara, Michinori

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Preclinical antitumor activity of the novel heat shock protein 90 inhibitor CH5164840 against human epidermal growth factor receptor 2 (HER2)‐overexpressing cancers von Ono, Naomi, Yamazaki, Toshikazu, Nakanishi, Yoshito, Fujii, Toshihiko, Sakata, Kiyoaki, Tachibana, Yukako, Suda, Atsushi, Hada, Kihito, Miura, Takaaki, Sato, Shigeo, Saitoh, Ryoichi, Nakano, Kohnosuke, Tsukuda, Takuo, Mio, Toshiyuki, Ishii, Nobuya, Kondoh, Osamu, Aoki, Yuko

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An orally available, small-molecule interferon inhibits viral replication von Konishi, Hideyuki, Okamoto, Koichi, Ohmori, Yusuke, Yoshino, Hitoshi, Ohmori, Hiroshi, Ashihara, Motooki, Hirata, Yuichi, Ohta, Atsunori, Sakamoto, Hiroshi, Hada, Natsuko, Katsume, Asao, Kohara, Michinori, Morikawa, Kazumi, Tsukuda, Takuo, Shimma, Nobuo, Foster, Graham R., Alazawi, William, Aoki, Yuko, Arisawa, Mikio, Sudoh, Masayuki

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Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors von Suda, Atsushi, Koyano, Hiroshi, Hayase, Tadakatsu, Hada, Kihito, Kawasaki, Ken-ichi, Komiyama, Susumu, Hasegawa, Kiyoshi, Fukami, Takaaki A., Sato, Shigeo, Miura, Takaaki, Ono, Naomi, Yamazaki, Toshikazu, Saitoh, Ryoichi, Shimma, Nobuo, Shiratori, Yasuhiko, Tsukuda, Takuo

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Enantioselective synthesis of derivatives and structure–activity relationship study in the development of NA255 as a novel host-targeting anti-HCV agent von Kawasaki, Ken-ichi, Masubuchi, Miyako, Hayase, Tadakatsu, Komiyama, Susumu, Watanabe, Fumio, Fukuda, Hiroshi, Murata, Takeshi, Matsubara, Yasuaki, Koyama, Kouhei, Shindoh, Hidetoshi, Sakamoto, Hiroshi, Okamato, Kohichi, Ohta, Atsunori, Katsume, Asao, Aoki, Masahiro, Aoki, Yuko, Shimma, Nobuo, Sudoh, Masayuki, Tsukuda, Takuo

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9-Substituted 6,6-Dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as Highly Selective and Potent Anaplastic Lymphoma Kinase Inhibitors von Kinoshita, Kazutomo, Kobayashi, Takamitsu, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Hara, Sousuke, Ohwada, Jun, Hattori, Kazuo, Miyagi, Takuho, Hong, Woo-Sang, Park, Min-Jeong, Takanashi, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro

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Design and synthesis of 2-amino-6-(1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel Hsp90 inhibitors von Suda, Atsushi, Kawasaki, Ken-ichi, Komiyama, Susumu, Isshiki, Yoshiaki, Yoon, Dong-Oh, Kim, Sung-Jin, Na, Young-Jun, Hasegawa, Kiyoshi, Fukami, Takaaki A., Sato, Shigeo, Miura, Takaaki, Ono, Naomi, Yamazaki, Toshikazu, Saitoh, Ryoichi, Shimma, Nobuo, Shiratori, Yasuhiko, Tsukuda, Takuo

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Modification of a dihydropyrrolopyrimidine phosphoinositide 3-kinase (PI3K) inhibitor to improve oral bioavailability von Kawada, Hatsuo, Ebiike, Hirosato, Tsukazaki, Masao, Yamamoto, Shun, Koyama, Kohei, Nakamura, Mitsuaki, Morikami, Kenji, Yoshinari, Kiyoshi, Yoshida, Miyuki, Ogawa, Kotaro, Shinma, Nobuo, Tsukuda, Takuo, Ohwada, Jun

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Optimization of the phenylurea moiety in a phosphoinositide 3-kinase (PI3K) inhibitor to improve water solubility and the PK profile by introducing a solubilizing group and ortho s... von Kawada, Hatsuo, Ebiike, Hirosato, Tsukazaki, Masao, Yamamoto, Shun, Koyama, Kohei, Nakamura, Mitsuaki, Morikami, Kenji, Yoshinari, Kiyoshi, Yoshida, Miyuki, Ogawa, Kotaro, Shimma, Nobuo, Tsukuda, Takuo, Ohwada, Jun

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Discovery of novel tetracyclic compounds as anaplastic lymphoma kinase inhibitors von Kinoshita, Kazutomo, Ono, Yoshiyuki, Emura, Takashi, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Tanaka, Shota, Morikami, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro

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Lead optimization of a dihydropyrrolopyrimidine inhibitor against phosphoinositide 3-kinase (PI3K) to improve the phenol glucuronic acid conjugation von Kawada, Hatsuo, Ebiike, Hirosato, Tsukazaki, Masao, Nakamura, Mitsuaki, Morikami, Kenji, Yoshinari, Kiyoshi, Yoshida, Miyuki, Ogawa, Kotaro, Shimma, Nobuo, Tsukuda, Takuo, Ohwada, Jun

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Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design von Miura, Takaaki, Fukami, Takaaki A., Hasegawa, Kiyoshi, Ono, Naomi, Suda, Atsushi, Shindo, Hidetoshi, Yoon, Dong-Oh, Kim, Sung-Jin, Na, Young-Jun, Aoki, Yuko, Shimma, Nobuo, Tsukuda, Takuo, Shiratori, Yasuhiko

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Angiogenesis inhibitors identified by cell-based high-throughput screening: Synthesis, structure–activity relationships and biological evaluation of 3-[(E)-styryl]benzamides that s... von Hada, Kihito, Suda, Atsushi, Asoh, Kohsuke, Tsukuda, Takuo, Hasegawa, Masami, Sato, Yasuko, Ogawa, Kotaro, Kuramoto, Shino, Aoki, Yuko, Shimma, Nobuo, Ishikawa, Tsutomu, Koyano, Hiroshi

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Abstract DDT01-02: CH5424802: A selective ALK inhibitor von Sakamoto, Hiroshi, Oikawa, Nobuhiro, Tsukuda, Takuo, Shimma, Nobuo, Ishii, Nobuya, Aoki, Yuko

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Enhanced antitumor activity of erlotinib in combination with the H sp90 inhibitor CH 5164840 against non‐small‐cell lung cancer von Ono, Naomi, Yamazaki, Toshikazu, Tsukaguchi, Toshiyuki, Fujii, Toshihiko, Sakata, Kiyoaki, Suda, Atsushi, Tsukuda, Takuo, Mio, Toshiyuki, Ishii, Nobuya, Kondoh, Osamu, Aoki, Yuko

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