The role of airway mucus and diseased pulmonary epithelium on the absorption of inhaled antibodies von Ledo, Adriana Martinez, Dimke, Thomas, Tschantz, William R., Rowlands, David, Growcott, Ellena

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TEM8/ANTXR1 Blockade Inhibits Pathological Angiogenesis and Potentiates Tumoricidal Responses against Multiple Cancer Types von Chaudhary, Amit, Hilton, Mary Beth, Seaman, Steven, Haines, Diana C., Stevenson, Susan, Lemotte, Peter K., Tschantz, William R., Zhang, Xiaoyan M., Saha, Saurabh, Fleming, Tony, St. Croix, Brad

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Structure of lipoprotein lipase in complex with GPIHBP1 von Arora, Rishi, Nimonkar, Amitabh V., Baird, Daniel, Wang, Chunhua, Chiu, Chun-Hao, Horton, Patricia A., Hanrahan, Susan, Cubbon, Rose, Weldon, Stephen, Tschantz, William R., Mueller, Sascha, Brunner, Reto, Lehr, Philipp, Meier, Peter, Ottl, Johannes, Voznesensky, Andrei, Pandey, Pramod, Smith, Thomas M., Stojanovic, Aleksandar, Flyer, Alec, Benson, Timothy E., Romanowski, Michael J., Trauger, John W.

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TRIAMF: A New Method for Delivery of Cas9 Ribonucleoprotein Complex to Human Hematopoietic Stem Cells von Yen, Jonathan, Fiorino, Michael, Liu, Yi, Paula, Steve, Clarkson, Scott, Quinn, Lisa, Tschantz, William R., Klock, Heath, Guo, Ning, Russ, Carsten, Yu, Vionnie W. C., Mickanin, Craig, Stevenson, Susan C., Lee, Cameron, Yang, Yi

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Design, Synthesis, and In Vitro and In Vivo Evaluation of Cereblon Binding Bruton’s Tyrosine Kinase (BTK) Degrader CD79b Targeted Antibody–Drug Conjugates von Zhang, Alan, Seiss, Katherine, Laborde, Laurent, Palacio-Ramirez, Sebastian, Guthy, Daniel, Lanter, Mylene, Lorber, Julien, Vulpetti, Anna, Arista, Luca, Zoller, Thomas, Radimerski, Thomas, Thoma, Claudio, Hebach, Christina, Tschantz, William R., Karpov, Alexei, Hollingworth, Gregory J., D’Alessio, Joseph A., Ferretti, Stephane, Burger, Matthew T.

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PCA062, a P-cadherin Targeting Antibody-Drug Conjugate, Displays Potent Antitumor Activity Against P-cadherin-expressing Malignancies von Sheng, Qing, D'Alessio, Joseph A., Menezes, Daniel L., Karim, Christopher, Tang, Yan, Tam, Angela, Clark, Suzanna, Ying, Chi, Connor, Anu, Mansfield, Keith G., Rondeau, Jean-Michel, Ghoddusi, Majid, Geyer, Felipe C., Gu, Jane, McLaughlin, Margaret E., Newcombe, Rick, Elliot, GiNell, Tschantz, William R., Lehmann, Sylvie, Fanton, Christie P., Miller, Kathy, Huber, Thomas, Rendahl, Katherine G., Jeffry, Ursula, Pryer, Nancy K., Lees, Emma, Kwon, Paul, Abraham, Judith A., Damiano, Jason S., Abrams, Tinya J.

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Pre-clinical validation of B cell maturation antigen (BCMA) as a target for T cell immunotherapy of multiple myeloma von Bu, De-Xiu, Singh, Reshma, Choi, Eugene E, Ruella, Marco, Nunez-Cruz, Selene, Mansfield, Keith G, Bennett, Paul, Barton, Nathanial, Wu, Qilong, Zhang, Jiquan, Wang, Yongqiang, Wei, Lai, Cogan, Shawn, Ezell, Tucker, Joshi, Shree, Latimer, Kellie J, Granda, Brian, Tschantz, William R, Young, Regina M, Huet, Heather A, Richardson, Celeste J, Milone, Michael C

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Identification of small-molecule inhibitors of the JIP-JNK interaction von Chen, Tracy, Kablaoui, Natasha, Little, Jeremy, Timofeevski, Sergei, Tschantz, William R, Chen, Ping, Feng, Junli, Charlton, Maura, Stanton, Robert, Bauer, Paul

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A CRISPR Screen Reveals Resistance Mechanisms to CD3-Bispecific Antibody Therapy von Liu, Si-Qi, Grantham, Alyssa, Landry, Casey, Granda, Brian, Chopra, Rajiv, Chakravarthy, Srinivas, Deutsch, Sabine, Vogel, Markus, Russo, Katie, Seiss, Katherine, Tschantz, William R., Rejtar, Tomas, Ruddy, David A., Hu, Tiancen, Aardalen, Kimberly, Wagner, Joel P., Dranoff, Glenn, D'Alessio, Joseph A.

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Development of a multiplex UPLC-MRM MS method for quantification of human membrane transport proteins OATP1B1, OATP1B3 and OATP2B1 in in vitro systems and tissues von Ji, Chengjie, Tschantz, William R., Pfeifer, Nathan D., Ullah, Mohammed, Sadagopan, Nalini

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Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers von Bialucha, Carl U, Collins, Scott D, Li, Xiao, Saxena, Parmita, Zhang, Xiamei, Dürr, Clemens, Lafont, Bruno, Prieur, Pierric, Shim, Yeonju, Mosher, Rebecca, Lee, David, Ostrom, Lance, Hu, Tiancen, Bilic, Sanela, Rajlic, Ivana Liric, Capka, Vladimir, Jiang, Wei, Wagner, Joel P, Elliott, GiNell, Veloso, Artur, Piel, Jessica C, Flaherty, Meghan M, Mansfield, Keith G, Meseck, Emily K, Rubic-Schneider, Tina, London, Anne Serdakowski, Tschantz, William R, Kurz, Markus, Nguyen, Duc, Bourret, Aaron, Meyer, Matthew J, Faris, Jason E, Janatpour, Mary J, Chan, Vivien W, Yoder, Nicholas C, Catcott, Kalli C, McShea, Molly A, Sun, Xiuxia, Gao, Hui, Williams, Juliet, Hofmann, Francesco, Engelman, Jeffrey A, Ettenberg, Seth A, Sellers, William R, Lees, Emma

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Endotoxin removal and prevention for pre-clinical biologics production von Serdakowski London, Anne, Kerins, Brendan, Tschantz, William R., Mackay, Kasey

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High yield expression of non-phosphorylated protein tyrosine kinases in insect cells von Wang, Leyu, Foster, Meta, Zhang, Yan, Tschantz, William R., Yang, Lily, Worrall, Joe, Loh, Christine, Xu, Xu

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Prenylcysteine Lyase Deficiency in Mice Results in the Accumulation of Farnesylcysteine and Geranylgeranylcysteine in Brain and Liver von Beigneux, Anne, Withycombe, Shannon K., Digits, Jennifer A., Tschantz, William.R., Weinbaum, Carolyn A., Griffey, Stephen M., Bergo, Martin, Casey, Patrick J., Young, Stephen G.

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Expression, purification and characterization of the human membrane transporter protein OATP2B1 from Sf9 insect cells von Tschantz, William R., Pfeifer, Nathan D., Meade, Caryl Lane, Wang, Leyu, Lanzetti, Anthony, Kamath, Ajith V., Berlioz-Seux, Francoise, Hashim, Muhammed F.

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Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin von Xie, Yang, Zamponi, Raffaella, Charlat, Olga, Ramones, Melissa, Swalley, Susanne, Jiang, Xiaomo, Rivera, Daniel, Tschantz, William, Lu, Bo, Quinn, Lisa, Dimitri, Chris, Parker, Jefferson, Jeffery, Doug, Wilcox, Sheri K, Watrobka, Mike, LeMotte, Peter, Granda, Brian, Porter, Jeffrey A, Myer, Vic E, Loew, Andreas, Cong, Feng

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Abstract 4743: Using genome-wide CRISPR screen to understand resistance mechanisms to PCA062, a P-cadherin targeting antibody-drug conjugate von Tam, Angela, Zambrowski, Mark, Seiss, Katherine, Liu, Si-Qi, Abrams, Tinya, Caponigro, Giordano, Tschantz, William, Campbell, Jennifer, DAlessio, Tony, Sheng, Qing

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Substrate Binding Is Required for Release of Product from Mammalian Protein Farnesyltransferase von Tschantz, W R, Furfine, E S, Casey, P J

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Characterization of a soluble, catalytically active form of Escherichia coli leader peptidase: requirement of detergent or phospholipid for optimal activity von Tschantz, William, Paetzel, Mark, Cao, Guoqing, Suciu, Dominic, Inouye, Masayori, Dalbey, Ross E

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A CRISPR Screen Reveals Resistance Mechanisms to CD3-Bispecific Antibody Therapy von Liu, Si-Qi, Grantham, Alyssa, Landry, Casey, Granda, Brian, Chopra, Rajiv, Chakravarthy, Srinivas, Deutsch, Sabine, Vogel, Markus, Russo, Katie, Seiss, Katherine, Tschantz, William R., Rejtar, Tomas, Ruddy, David A., Hu, Tiancen, Aardalen, Kimberly, Wagner, Joel P., Dranoff, Glenn, D'Alessio, Joseph A.

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