LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency von Tsanov, Kaloyan M., Pearson, Daniel S., Wu, Zhaoting, Han, Areum, Triboulet, Robinson, Seligson, Marc T., Powers, John T., Osborne, Jihan K., Kane, Susan, Gygi, Steven P., Gregory, Richard I., Daley, George Q.

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Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma von Powers, John T., Tsanov, Kaloyan M., Pearson, Daniel S., Roels, Frederik, Spina, Catherine S., Ebright, Richard, Seligson, Marc, de Soysa, Yvanka, Cahan, Patrick, Theißen, Jessica, Tu, Ho-Chou, Han, Areum, Kurek, Kyle C., LaPier, Grace S., Osborne, Jihan K., Ross, Samantha J., Cesana, Marcella, Collins, James J., Berthold, Frank, Daley, George Q.

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Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis von Leibold, Josef, Ruscetti, Marcus, Cao, Zhen, Ho, Yu-Jui, Baslan, Timour, Zou, Min, Abida, Wassim, Feucht, Judith, Han, Teng, Barriga, Francisco M, Tsanov, Kaloyan M, Zamechek, Leah, Kulick, Amanda, Amor, Corina, Tian, Sha, Rybczyk, Katarzyna, Salgado, Nelson R, Sánchez-Rivera, Francisco J, Watson, Philip A, de Stanchina, Elisa, Wilkinson, John E, Dow, Lukas E, Abate-Shen, Cory, Sawyers, Charles L, Lowe, Scott W

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A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development von Cesana, Marcella, Guo, Michael H., Cacchiarelli, Davide, Wahlster, Lara, Barragan, Jessica, Doulatov, Sergei, Vo, Linda T., Salvatori, Beatrice, Trapnell, Cole, Clement, Kendell, Cahan, Patrick, Tsanov, Kaloyan M., Sousa, Patricia M., Tazon-Vega, Barbara, Bolondi, Adriano, Giorgi, Federico M., Califano, Andrea, Rinn, John L., Meissner, Alexander, Hirschhorn, Joel N., Daley, George Q.

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Lin28 Enhances Tissue Repair by Reprogramming Cellular Metabolism von Shyh-Chang, Ng, Zhu, Hao, Yvanka de Soysa, T., Shinoda, Gen, Seligson, Marc T., Tsanov, Kaloyan M., Nguyen, Liem, Asara, John M., Cantley, Lewis C., Daley, George Q.

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Hypoxia Potentiates the Inflammatory Fibroblast Phenotype Promoted by Pancreatic Cancer Cell-Derived Cytokines von Schwörer, Simon, Cimino, Francesco V, Ros, Manon, Tsanov, Kaloyan M, Ng, Charles, Lowe, Scott W, Carmona-Fontaine, Carlos, Thompson, Craig B

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A gene–environment-induced epigenetic program initiates tumorigenesis von Alonso-Curbelo, Direna, Ho, Yu-Jui, Burdziak, Cassandra, Maag, Jesper L. V., Morris, John P., Chandwani, Rohit, Chen, Hsuan-An, Tsanov, Kaloyan M., Barriga, Francisco M., Luan, Wei, Tasdemir, Nilgun, Livshits, Geulah, Azizi, Elham, Chun, Jaeyoung, Wilkinson, John E., Mazutis, Linas, Leach, Steven D., Koche, Richard, Pe’er, Dana, Lowe, Scott W.

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Ordered and deterministic cancer genome evolution after p53 loss von Baslan, Timour, Morris, John P., Zhao, Zhen, Reyes, Jose, Ho, Yu-Jui, Tsanov, Kaloyan M., Bermeo, Jonathan, Tian, Sha, Zhang, Sean, Askan, Gokce, Yavas, Aslihan, Lecomte, Nicolas, Erakky, Amanda, Varghese, Anna M., Zhang, Amy, Kendall, Jude, Ghiban, Elena, Chorbadjiev, Lubomir, Wu, Jie, Dimitrova, Nevenka, Chadalavada, Kalyani, Nanjangud, Gouri J., Bandlamudi, Chaitanya, Gong, Yixiao, Donoghue, Mark T. A., Socci, Nicholas D., Krasnitz, Alex, Notta, Faiyaz, Leach, Steve D., Iacobuzio-Donahue, Christine A., Lowe, Scott W.

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Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants von Sánchez-Rivera, Francisco J., Diaz, Bianca J., Kastenhuber, Edward R., Schmidt, Henri, Katti, Alyna, Kennedy, Margaret, Tem, Vincent, Ho, Yu-Jui, Leibold, Josef, Paffenholz, Stella V., Barriga, Francisco M., Chu, Kevan, Goswami, Sukanya, Wuest, Alexandra N., Simon, Janelle M., Tsanov, Kaloyan M., Chakravarty, Debyani, Zhang, Hongxin, Leslie, Christina S., Lowe, Scott W., Dow, Lukas E.

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Interferon-ε loss is elusive 9p21 link to immune-cold tumors, resistant to immune-checkpoint therapy and endogenous CXCL9/10 induction von Zhao, Xin, Liu, Bin, William, William N., Tsanov, Kaloyan M., Ho, Yu-Jui, Barriga, Francisco M., Lim, Raymond J., Trifas, Maria, Du, Yushen, Lowe, Scott W., Dubinett, Steven M., Davoli, Teresa, Lippman, Scott M.

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MACHETE identifies interferon-encompassing chromosome 9p21.3 deletions as mediators of immune evasion and metastasis von Barriga, Francisco M, Tsanov, Kaloyan M, Ho, Yu-Jui, Sohail, Noor, Zhang, Amy, Baslan, Timour, Wuest, Alexandra N, Del Priore, Isabella, Meškauskaitė, Brigita, Livshits, Geulah, Alonso-Curbelo, Direna, Simon, Janelle, Chaves-Perez, Almudena, Bar-Sagi, Dafna, Iacobuzio-Donahue, Christine A, Notta, Faiyaz, Chaligne, Ronan, Sharma, Roshan, Pe'er, Dana, Lowe, Scott W

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LIN28B alters ribosomal dynamics to promote metastasis in MYCN-driven malignancy von Missios, Pavlos, da Rocha, Edroaldo Lummertz, Pearson, Daniel S, Philipp, Julia, Aleman, Maria M, Pirouz, Mehdi, Farache, Dorian, Franses, Joseph W, Kubaczka, Caroline, Tsanov, Kaloyan M, Jha, Deepak K, Pepe-Mooney, Brian, Powers, John T, Gregory, Richard I, Lee, Amy Sy, Dominguez, Daniel, Ting, David T, Daley, George Q

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Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms von Sun, Siyu, You, Eunae, Hong, Jungeui, Hoyos, David, Del Priore, Isabella, Tsanov, Kaloyan M., Mattagajasingh, Om, Di Gioacchino, Andrea, Marhon, Sajid A., Chacon-Barahona, Jonathan, Li, Hao, Jiang, Hua, Hozeifi, Samira, Rosas-Bringas, Omar, Xu, Katherine H., Song, Yuhui, Lang, Evan R., Rojas, Alexandra S., Nieman, Linda T., Patel, Bidish K., Murali, Rajmohan, Chanda, Pharto, Karacay, Ali, Vabret, Nicolas, De Carvalho, Daniel D., Zenklusen, Daniel, LaCava, John, Lowe, Scott W., Ting, David T., Iacobuzio-Donahue, Christine A., Solovyov, Alexander, Greenbaum, Benjamin D.

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Signaling through RNA-binding proteins as a cell fate regulatory mechanism von Tsanov, Kaloyan M., Daley, George Q.

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Lin28 paralogs regulate lung branching morphogenesis von Osborne, Jihan K., Kinney, Melissa A., Han, Areum, Akinnola, Kemi E., Yermalovich, Alena V., Vo, Linda T., Pearson, Daniel S., Sousa, Patricia M., Ratanasirintrawoot, Sutheera, Tsanov, Kaloyan M., Barragan, Jessica, North, Trista E., Metzger, Ross J., Daley, George Q.

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Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease von Leibold, Josef, Tsanov, Kaloyan M, Amor, Corina, Ho, Yu-Jui, Sánchez-Rivera, Francisco J, Feucht, Judith, Baslan, Timour, Chen, Hsuan-An, Tian, Sha, Simon, Janelle, Wuest, Alexandra, Wilkinson, John E, Lowe, Scott W

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An embryonic stem cell-based system for rapid analysis of transcriptional enhancers von Tsanov, Kaloyan M., Nishi, Yuichi, Peterson, Kevin A., Liu, Jing, Baetscher, Manfred, McMahon, Andrew P.

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Abstract 3512: Organ-specific effects of Smad4 in metastatic pancreatic cancer von Tsanov, Kaloyan M., Barriga, Francisco M., Ho, Yu-Jui, Alonso-Curbelo, Direna, Livshits, Geulah, Koche, Richard, Baslan, Timour, Wuest, Alexandra N., Simon, Janelle, Tian, Sha, Luan, Wei, Lowe, Scott W.

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Abstract LB-290: Multiple distinct mechanisms disrupt let-7 miRNA biogenesis and function in neuroblastoma von Powers, John T., Tsanov, Kaloyan M., Roles, Frederik, Ebright, Richard, Seligson, Marc, de Soysa, Yvanka, Cahan, Patrick, Theissen, Jessica, LaPier, Grace S., Pearson, Dan S., Berthold, Frank, Daley, George Q.

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Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma von Powers, John T, Tsanov, Kaloyan M, Pearson, Daniel S, Roels, Frederik, Spina, Catherine S, Ebright, Richard, Seligson, Marc, de Soysa, Yvanka, Cahan, Patrick, Theiβen, Jessica, Tu, Ho-Chou, Han, Areum, Kurek, Kyle C, LaPier, Grace S, Osborne, Jihan K, Ross, Samantha J, Cesana, Marcella, Collins, James J, Berthold, Frank, Daley, George Q

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