Tofacitinib Ameliorates Murine Lupus and Its Associated Vascular Dysfunction von Furumoto, Yasuko, Smith, Carolyne K., Blanco, Luz, Zhao, Wenpu, Brooks, Stephen R., Thacker, Seth G., Zarzour, Abdalrahman, Sciumè, Giuseppe, Tsai, Wanxia L., Trier, Anna M., Nunez, Leti, Mast, Laurel, Hoffmann, Victoria, Remaley, Alan T., O'Shea, John J., Kaplan, Mariana J., Gadina, Massimo

Volltext

Whole Chromosome Instability induces senescence and promotes SASP von Andriani, Grasiella Angelina, Almeida, Vinnycius Pereira, Faggioli, Francesca, Mauro, Maurizio, Tsai, Wanxia Li, Santambrogio, Laura, Maslov, Alexander, Gadina, Massimo, Campisi, Judith, Vijg, Jan, Montagna, Cristina

Volltext

Deficiency of adenosine deaminase 2 triggers adenosine-mediated NETosis and TNF production in patients with DADA2 von Carmona-Rivera, Carmelo, Khaznadar, Sami S., Shwin, Kyawt W., Irizarry-Caro, Jorge A., O'Neil, Liam J., Liu, Yudong, Jacobson, Kenneth A., Ombrello, Amanda K., Stone, Deborah L., Tsai, Wanxia L., Kastner, Daniel L., Aksentijevich, Ivona, Kaplan, Mariana J., Grayson, Peter C.

Volltext

Somatic Mutations in UBA1 Define a Distinct Subset of Relapsing Polychondritis Patients With VEXAS von Ferrada, Marcela A., Sikora, Keith A., Luo, Yiming, Wells, Kristina V., Patel, Bhavisha, Groarke, Emma M., Ospina Cardona, Daniela, Rominger, Emily, Hoffmann, Patrycja, Le, Mimi T., Deng, Zuoming, Quinn, Kaitlin A., Rose, Emily, Tsai, Wanxia L., Wigerblad, Gustaf, Goodspeed, Wendy, Jones, Anne, Wilson, Lorena, Schnappauf, Oskar, Laird, Ryan S., Kim, Jeff, Allen, Clint, Sirajuddin, Arlene, Chen, Marcus, Gadina, Massimo, Calvo, Katherine R., Kaplan, Mariana J., Colbert, Robert A., Aksentijevich, Ivona, Young, Neal S., Savic, Sinisa, Kastner, Daniel L., Ombrello, Amanda K., Beck, David B., Grayson, Peter C.

Volltext

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease von Lalaoui, Najoua, Boyden, Steven E., Oda, Hirotsugu, Wood, Geryl M., Stone, Deborah L., Chau, Diep, Liu, Lin, Stoffels, Monique, Kratina, Tobias, Lawlor, Kate E., Zaal, Kristien J. M., Hoffmann, Patrycja M., Etemadi, Nima, Shield-Artin, Kristy, Biben, Christine, Tsai, Wanxia Li, Blake, Mary D., Kuehn, Hye Sun, Yang, Dan, Anderton, Holly, Silke, Natasha, Wachsmuth, Laurens, Zheng, Lixin, Moura, Natalia Sampaio, Beck, David B., Gutierrez-Cruz, Gustavo, Ombrello, Amanda K., Pinto-Patarroyo, Gineth P., Kueh, Andrew J., Herold, Marco J., Hall, Cathrine, Wang, Hongying, Chae, Jae Jin, Dmitrieva, Natalia I., McKenzie, Mark, Light, Amanda, Barham, Beverly K., Jones, Anne, Romeo, Tina M., Zhou, Qing, Aksentijevich, Ivona, Mullikin, James C., Gross, Andrew J., Shum, Anthony K., Hawkins, Edwin D., Masters, Seth L., Lenardo, Michael J., Boehm, Manfred, Rosenzweig, Sergio D., Pasparakis, Manolis, Voss, Anne K., Gadina, Massimo, Kastner, Daniel L., Silke, John

Volltext

Expression of interferon-regulated genes in juvenile dermatomyositis versus Mendelian autoinflammatory interferonopathies von Kim, Hanna, Gunter-Rahman, Fatima, McGrath, John A., Lee, Esther, de Jesus, Adriana A., Targoff, Ira N., Huang, Yan, O'Hanlon, Terrance P., Tsai, Wanxia L., Gadina, Massimo, Miller, Frederick W., Goldbach-Mansky, Raphaela, Rider, Lisa G.

Volltext

Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus von Hasni, Sarfaraz A., Gupta, Sarthak, Davis, Michael, Poncio, Elaine, Temesgen-Oyelakin, Yenealem, Carlucci, Philip M., Wang, Xinghao, Naqi, Mohammad, Playford, Martin P., Goel, Rishi R., Li, Xiaobai, Biehl, Ann J., Ochoa-Navas, Isabel, Manna, Zerai, Shi, Yinghui, Thomas, Donald, Chen, Jinguo, Biancotto, Angélique, Apps, Richard, Cheung, Foo, Kotliarov, Yuri, Babyak, Ashley L., Zhou, Huizhi, Shi, Rongye, Stagliano, Katie, Tsai, Wanxia Li, Vian, Laura, Gazaniga, Nathalia, Giudice, Valentina, Lu, Shajia, Brooks, Stephen R., MacKay, Meggan, Gregersen, Peter, Mehta, Nehal N., Remaley, Alan T., Diamond, Betty, O’Shea, John J., Gadina, Massimo, Kaplan, Mariana J.

Volltext

Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production von Brehm, Anja, Liu, Yin, Sheikh, Afzal, Marrero, Bernadette, Omoyinmi, Ebun, Zhou, Qing, Montealegre, Gina, Biancotto, Angelique, Reinhardt, Adam, Almeida de Jesus, Adriana, Pelletier, Martin, Tsai, Wanxia L, Remmers, Elaine F, Kardava, Lela, Hill, Suvimol, Kim, Hanna, Lachmann, Helen J, Megarbane, Andre, Chae, Jae Jin, Brady, Jilian, Castillo, Rhina D, Brown, Diane, Casano, Angel Vera, Gao, Ling, Chapelle, Dawn, Huang, Yan, Stone, Deborah, Chen, Yongqing, Sotzny, Franziska, Lee, Chyi-Chia Richard, Kastner, Daniel L, Torrelo, Antonio, Zlotogorski, Abraham, Moir, Susan, Gadina, Massimo, McCoy, Phil, Wesley, Robert, Rother, Kristina I, Rother, Kristina, Hildebrand, Peter W, Brogan, Paul, Krüger, Elke, Aksentijevich, Ivona, Goldbach-Mansky, Raphaela

Volltext

Pleiotropic consequences of metabolic stress for the major histocompatibility complex class II molecule antigen processing and presentation machinery von Clement, Cristina C., Nanaware, Padma P., Yamazaki, Takahiro, Negroni, Maria Pia, Ramesh, Karthik, Morozova, Kateryna, Thangaswamy, Sangeetha, Graves, Austin, Kim, Hei Jung, Li, Tsai Wanxia, Vigano’, Marco, Soni, Rajesh K., Gadina, Massimo, Tse, Harley Y., Galluzzi, Lorenzo, Roche, Paul A., Denzin, Lisa K., Stern, Lawrence J., Santambrogio, Laura

Volltext

Brief Report: Deficiency of Complement 1r Subcomponent in Early‐Onset Systemic Lupus Erythematosus: The Role of Disease‐Modifying Alleles in a Monogenic Disease von Demirkaya, Erkan, Zhou, Qing, Smith, Carolyne K., Ombrello, Michael J., Deuitch, Natalie, Tsai, Wanxia L., Hoffmann, Patrycja, Remmers, Elaine F., Takeuchi, Masaki, Park, Yong Hwan, Chae, JaeJin, Barut, Kenan, Simsek, Dogan, Adrovic, Amra, Sahin, Sezgin, Caliskan, Salim, Chandrasekharappa, Settara C., Hasni, Sarfaraz A., Ombrello, Amanda K., Gadina, Massimo, Kastner, Daniel L., Kaplan, Mariana J., Kasapcopur, Ozgur, Aksentijevich, Ivona

Volltext

CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus von Faridi, Mohd Hafeez, Khan, Samia Q, Zhao, Wenpu, Lee, Ha Won, Altintas, Mehmet M, Zhang, Kun, Kumar, Vinay, Armstrong, Andrew R, Carmona-Rivera, Carmelo, Dorschner, Jessica M, Schnaith, Abigail M, Li, Xiaobo, Ghodke-Puranik, Yogita, Moore, Erica, Purmalek, Monica, Irizarry-Caro, Jorge, Zhang, Tingting, Day, Rachael, Stoub, Darren, Hoffmann, Victoria, Khaliqdina, Shehryar Jehangir, Bhargava, Prachal, Santander, Ana M, Torroella-Kouri, Marta, Issac, Biju, Cimbaluk, David J, Zloza, Andrew, Prabhakar, Rajeev, Deep, Shashank, Jolly, Meenakshi, Koh, Kwi Hye, Reichner, Jonathan S, Bradshaw, Elizabeth M, Chen, JianFeng, Moita, Luis F, Yuen, Peter S, Li Tsai, Wanxia, Singh, Bhupinder, Reiser, Jochen, Nath, Swapan K, Niewold, Timothy B, Vazquez-Padron, Roberto I, Kaplan, Mariana J, Gupta, Vineet

Volltext

The Aconitate Decarboxylase 1/Itaconate Pathway Modulates Immune Dysregulation and Associates with Cardiovascular Disease Markers and Disease Activity in Systemic Lupus Erythematos... von Patiño-Martinez, Eduardo, Nakabo, Shuichiro, Jiang, Kan, Carmona-Rivera, Carmelo, Tsai, Wanxia Li, Claybaugh, Dillon, Yu, Zu-Xi, Romero, Aracely, Bohrnsen, Eric, Schwarz, Benjamin, Solís-Barbosa, Miguel A, Blanco, Luz P, Naqi, Mohammad, Temesgen-Oyelakin, Yenealem, Davis, Michael, Manna, Zerai, Gupta, Sarthak, Mehta, Nehal, Naz, Faiza, dell'Orso, Stefania, Hasni, Sarfaraz, Kaplan, Mariana J

Volltext

3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine von Clement, Cristina C., D’Alessandro, Angelo, Thangaswamy, Sangeetha, Chalmers, Samantha, Furtado, Raquel, Spada, Sheila, Mondanelli, Giada, Ianni, Federica, Gehrke, Sarah, Gargaro, Marco, Manni, Giorgia, Cara, Luisa Carlota Lopez, Runge, Peter, Tsai, Wanxia Li, Karaman, Sinem, Arasa, Jorge, Fernandez-Rodriguez, Ruben, Beck, Amanda, Macchiarulo, Antonio, Gadina, Massimo, Halin, Cornelia, Fallarino, Francesca, Skobe, Mihaela, Veldhoen, Marc, Moretti, Simone, Formenti, Silvia, Demaria, Sandra, Soni, Rajesh K., Galarini, Roberta, Sardella, Roccaldo, Lauvau, Gregoire, Putterman, Chaim, Alitalo, Kari, Grohmann, Ursula, Santambrogio, Laura

Volltext

Reversal of CD8 T-Cell–Mediated Mucocutaneous Graft-Versus-Host-Like Disease by the JAK Inhibitor Tofacitinib von Okiyama, Naoko, Furumoto, Yasuko, Villarroel, Vadim A., Linton, Jay T., Tsai, Wanxia L., Gutermuth, Jan, Ghoreschi, Kamran, Gadina, Massimo, O'Shea, John J., Katz, Stephen I.

Volltext

Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation von Scarno, Gianluca, Mazej, Julija, Laffranchi, Mattia, Di Censo, Chiara, Mattiola, Irene, Candelotti, Arianna M, Pietropaolo, Giuseppe, Stabile, Helena, Fionda, Cinzia, Peruzzi, Giovanna, Brooks, Stephen R, Tsai, Wanxia Li, Mikami, Yohei, Bernardini, Giovanni, Gismondi, Angela, Sozzani, Silvano, Di Santo, James P, Vosshenrich, Christian A J, Diefenbach, Andreas, Gadina, Massimo, Santoni, Angela, Sciumè, Giuseppe

Volltext

Neutrophil subsets and their gene signature associate with vascular inflammation and coronary atherosclerosis in lupus von Carlucci, Philip M, Purmalek, Monica M, Dey, Amit K, Temesgen-Oyelakin, Yenealem, Sakhardande, Simantini, Joshi, Aditya A, Lerman, Joseph B, Fike, Alice, Davis, Michael, Chung, Jonathan H, Playford, Martin P, Naqi, Mohammad, Mistry, Pragnesh, Gutierrez-Cruz, Gustavo, Dell'Orso, Stefania, Naz, Faiza, Salahuddin, Taufiq, Natarajan, Balaji, Manna, Zerai, Tsai, Wanxia L, Gupta, Sarthak, Grayson, Peter, Teague, Heather, Chen, Marcus Y, Sun, Hong-Wei, Hasni, Sarfaraz, Mehta, Nehal N, Kaplan, Mariana J

Volltext

Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease von Zhou, Qing, Yu, Xiaomin, Demirkaya, Erkan, Deuitch, Natalie, Stone, Deborah, Tsai, Wanxia Li, Kuehn, Hye Sun, Wang, Hongying, Yang, Dan, Park, Yong Hwan, Ombrello, Amanda K., Blake, Mary, Romeo, Tina, Remmers, Elaine F., Chae, Jae Jin, Mullikin, James C., Güzel, Ferhat, Milner, Joshua D., Boehm, Manfred, Rosenzweig, Sergio D., Gadina, Massimo, Welch, Steven B., Özen, Seza, Topaloglu, Rezan, Abinun, Mario, Kastner, Daniel L., Aksentijevich, Ivona

Volltext

Pharmacokinetics, Pharmacodynamics, and Proposed Dosing of the Oral JAK1 and JAK2 Inhibitor Baricitinib in Pediatric and Young Adult CANDLE and SAVI Patients von Kim, Hanna, Brooks, Kristina M., Tang, Cheng Cai, Wakim, Paul, Blake, Mary, Brooks, Stephen R., Montealegre Sanchez, Gina A., de Jesus, Adriana A., Huang, Yan, Tsai, Wanxia Li, Gadina, Massimo, Prakash, Apurva, Janes, Jonathan Marcus, Zhang, Xin, Macias, William L., Kumar, Parag, Goldbach‐Mansky, Raphaela

Volltext

Identification of Fibroinflammatory and Fibrotic Transcriptomic Subsets of Human Cutaneous Sclerotic Chronic Graft-Versus-Host Disease von Rosenstein, Rachel K., Rose, Jeremy J., Brooks, Stephen R., Tsai, Wanxia L., Gadina, Massimo, Pavletic, Steven Z., Nagao, Keisuke, Cowen, Edward W.

Volltext

Homozygous variant p. Arg90His in NCF1 is associated with early-onset Interferonopathy: a case report von Schnappauf, Oskar, Heale, Liane, Dissanayake, Dilan, Tsai, Wanxia L., Gadina, Massimo, Leto, Thomas L., Kastner, Daniel L., Malech, Harry L., Kuhns, Douglas B., Aksentijevich, Ivona, Laxer, Ronald M.

Volltext