TRLS-02. SAFETY AND EFFICACY OF BRAF INHIBITOR PLIXORAFENIB (FORE8394; PLX8394) IN CHILDREN AND ADULTS WITH RECURRENT, BRAF-ALTERED PRIMARY CENTRAL NERVOUS SYSTEM TUMORS (PCNST) von de la Fuente, Macarena, Butowski, Nicholas A, Taylor, Jennie, Yaeger, Rona, Tsai, Frank Y-C, Janku, Filip, Allen, Carl E, Ammakkanavar, Natraj, Michelson, Glenn, Jiang, Ping, Samara, Emil, Paz, Michael, Tussay-Lindenberg, Alexia, Wang, Kongming, Shepherd, Stacie P, Kline, Irina, Sherman, Eric, Rodon, Jordi

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Flow characteristics in models of arterial stenoses — I. Steady flow von Young, Donald F., Tsai, Frank Y.

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Flow characteristics in models of arterial stenoses — II. Unsteady flow von Young, Donald F., Tsai, Frank Y.

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Gabapentinoid consumption in 65 countries and regions from 2008 to 2018: a longitudinal trend study von Chan, Adrienne Y. L., Yuen, Andrew S. C., Tsai, Daniel H. T., Lau, Wallis C. Y., Jani, Yogini H., Hsia, Yingfen, Osborn, David P. J., Hayes, Joseph F., Besag, Frank M. C., Lai, Edward C. C., Wei, Li, Taxis, Katja, Wong, Ian C. K., Man, Kenneth K. C.

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Music, Search, and IoT: How People (Really) Use Voice Assistants von Ammari, Tawfiq, Kaye, Jofish, Tsai, Janice Y., Bentley, Frank

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Four-decades of bed elevation changes in the heavily regulated upper Atchafalaya River, Louisiana, USA von Xu, Y. Jun, Wang, Bo, Xu, Wei, Tang, Ming, Tsai, Frank T.-C., Smith, Laurence C.

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High-Density Lipoprotein Subspecies Defined by Presence of Apolipoprotein C-III and Incident Coronary Heart Disease in Four Cohorts von Jensen, Majken K, Aroner, Sarah A, Mukamal, Kenneth J, Furtado, Jeremy D, Post, Wendy S, Tsai, Michael Y, Tjønneland, Anne, Polak, Joseph F, Rimm, Eric B, Overvad, Kim, McClelland, Robyn L, Sacks, Frank M

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Artificial bifurcation effect on downstream channel dynamics of a large lowland river, the Atchafalaya von Tang, Ming, Xu, Y. Jun, Wang, Bo, Xu, Wei, Cheng, Heqin, Tsai, Frank T.‐C.

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Supramolecular Perylene Bisimide-Polysulfide Gel Networks as Nanostructured Redox Mediators in Dissolved Polysulfide Lithium–Sulfur Batteries von Frischmann, Peter D, Gerber, Laura C. H, Doris, Sean E, Tsai, Erica Y, Fan, Frank Y, Qu, Xiaohui, Jain, Anubhav, Persson, Kristin A, Chiang, Yet-Ming, Helms, Brett A

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In vivo CRISPR editing with no detectable genome-wide off-target mutations von Akcakaya, Pinar, Bobbin, Maggie L., Guo, Jimmy A., Malagon-Lopez, Jose, Clement, Kendell, Garcia, Sara P., Fellows, Mick D., Porritt, Michelle J., Firth, Mike A., Carreras, Alba, Baccega, Tania, Seeliger, Frank, Bjursell, Mikael, Tsai, Shengdar Q., Nguyen, Nhu T., Nitsch, Roberto, Mayr, Lorenz M., Pinello, Luca, Bohlooly-Y, Mohammad, Aryee, Martin J., Maresca, Marcello, Joung, J. Keith

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Hepatocyte Nuclear Factor 4‐Alpha Is Essential for the Active Epigenetic State at Enhancers in Mouse Liver von Thakur, Avinash, Wong, Jasper C.H., Wang, Evan Y., Lotto, Jeremy, Kim, Donghwan, Cheng, Jung‐Chien, Mingay, Matthew, Cullum, Rebecca, Moudgil, Vaishali, Ahmed, Nafeel, Tsai, Shu‐Huei, Wei, Wei, Walsh, Colum P., Stephan, Tabea, Bilenky, Misha, Fuglerud, Bettina M., Karimi, Mohammad M., Gonzalez, Frank J., Hirst, Martin, Hoodless, Pamela A.

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E2F6 functions as a competing endogenous RNA, and transcriptional repressor, to promote ovarian cancer stemness von Cheng, Frank H. C., Lin, Hon‐Yi, Hwang, Tzy‐Wei, Chen, Yin‐Chen, Huang, Rui‐Lan, Chang, Chia‐Bin, Yang, Weiqin, Lin, Ru‐Inn, Lin, Ching‐Wen, Chen, Gary C. W., Mai, Shu‐Yuan, Lin, Jora M. J., Chuang, Yu‐Ming, Chou, Jian‐Liang, Kuo, Li‐Wei, Li, Chin, Cheng, Alfred S. L., Lai, Hung‐Cheng, Wu, Shu‐Fen, Tsai, Je‐Chiang, Chan, Michael W. Y.

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Human mammalian cell sorting using a highly integrated micro-fabricated fluorescence-activated cell sorter (μFACS) von Cho, Sung Hwan, Chen, Chun H, Tsai, Frank S, Godin, Jessica M, Lo, Yu-Hwa

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DISC1–ATF4 transcriptional repression complex: dual regulation of the cAMP-PDE4 cascade by DISC1 von Soda, T, Frank, C, Ishizuka, K, Baccarella, A, Park, Y-U, Flood, Z, Park, S K, Sawa, A, Tsai, L-H

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Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling von Mao, Yingwei, Ge, Xuecai, Frank, Christopher L., Madison, Jon M., Koehler, Angela N., Doud, Mary Kathryn, Tassa, Carlos, Berry, Erin M., Soda, Takahiro, Singh, Karun K., Biechele, Travis, Petryshen, Tracey L., Moon, Randall T., Haggarty, Stephen J., Tsai, Li-Huei

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Editorial Expression of Concern: p63 and p73 are required for p53-dependent apoptosis in response to DNA damage von Flores, Elsa R., Tsai, Kenneth Y., Crowley, Denise, Sengupta, Shomit, Yang, Annie, McKeon, Frank, Jacks, Tyler

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Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity von Kim, Dohoon, Frank, Christopher L., Dobbin, Matthew M., Tsunemoto, Rachel K., Tu, Weihong, Peng, Peter L., Guan, Ji-Song, Lee, Byung-Hoon, Moy, Lily Y., Giusti, Paola, Broodie, Nisha, Mazitschek, Ralph, Delalle, Ivanna, Haggarty, Stephen J., Neve, Rachael L., Lu, YouMing, Tsai, Li-Huei

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Interplay between ceRNA and Epigenetic Control of microRNA: Modelling Approaches with Application to the Role of Estrogen in Ovarian Cancer von Huang, Tzy-Wei, Cheng, Frank H C, Yan, Ching-Cher Sanders, Chuang, Yu-Ming, Cho, Chien-Hong, Lai, Hung-Cheng, Shieh, Shih-Feng, Chan, Michael W Y, Tsai, Je-Chiang

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n–6 fatty acid biomarkers and incident atrial fibrillation: an individual participant-level pooled analysis of 11 international prospective studies von Garg, Parveen K., Guan, Weihua, Nomura, Sarah, Weir, Natalie L., Tintle, Nathan, Virtanen, Jyrki K., Hirakawa, Yoichiro, Qian, Frank, Sun, Qi, Rimm, Eric, Lemaitre, Rozenn N., Jensen, Paul N., Heckbert, Susan R., Imamura, Fumiaki, Steur, Marinka, Leander, Karin, Laguzzi, Federica, Voortman, Trudy, Ninomiya, Toshiharu, Mozaffarian, Dariush, Harris, William S., Siscovick, David S., Tsai, Michael Y.

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ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies von Del Gobbo, Liana C, Imamura, Fumiaki, Aslibekyan, Stella, Marklund, Matti, Virtanen, Jyrki K, Wennberg, Maria, Yakoob, Mohammad Y, Chiuve, Stephanie E, dela Cruz, Luicito, Frazier-Wood, Alexis C, Fretts, Amanda M, Guallar, Eliseo, Matsumoto, Chisa, Prem, Kiesha, Tanaka, Tosh, Wu, Jason H. Y, Zhou, Xia, Helmer, Catherine, Ingelsson, Erik, Yuan, Jian-Min, Barberger-Gateau, Pascale, Campos, Hannia, Chaves, Paulo H. M, Djoussé, Luc, Giles, Graham G, Gómez-Aracena, Jose, Hodge, Allison M, Hu, Frank B, Jansson, Jan-Håkan, Johansson, Ingegerd, Khaw, Kay-Tee, Koh, Woon-Puay, Lemaitre, Rozenn N, Lind, Lars, Luben, Robert N, Rimm, Eric B, Risérus, Ulf, Samieri, Cecilia, Franks, Paul W, Siscovick, David S, Stampfer, Meir, Steffen, Lyn M, Steffen, Brian T, Tsai, Michael Y, van Dam, Rob M, Voutilainen, Sari, Willett, Walter C, Woodward, Mark, Mozaffarian, Dariush

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