An orally available non-nucleotide STING agonist with antitumor activity von Pan, Bo-Sheng, Perera, Samanthi A, Piesvaux, Jennifer A, Presland, Jeremy P, Schroeder, Gottfried K, Cumming, Jared N, Trotter, B Wesley, Altman, Michael D, Buevich, Alexei V, Cash, Brandon, Cemerski, Saso, Chang, Wonsuk, Chen, Yiping, Dandliker, Peter J, Feng, Guo, Haidle, Andrew, Henderson, Timothy, Jewell, James, Kariv, Ilona, Knemeyer, Ian, Kopinja, Johnny, Lacey, Brian M, Laskey, Jason, Lesburg, Charles A, Liang, Rui, Long, Brian J, Lu, Min, Ma, Yanhong, Minnihan, Ellen C, O'Donnell, Greg, Otte, Ryan, Price, Laura, Rakhilina, Larissa, Sauvagnat, Berengere, Sharma, Sharad, Tyagarajan, Sriram, Woo, Hyun, Wyss, Daniel F, Xu, Serena, Bennett, David Jonathan, Addona, George H

Volltext

Imidazopyridine CB2 agonists: Optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy von Trotter, B. Wesley, Nanda, Kausik K., Burgey, Christopher S., Potteiger, Craig M., Deng, James Z., Green, Ahren I., Hartnett, John C., Kett, Nathan R., Wu, Zhicai, Henze, Darrell A., Penna, Kimberly Della, Desai, Reshma, Leitl, Michael D., Lemaire, Wei, White, Rebecca B., Yeh, Suzie, Urban, Mark O., Kane, Stefanie A., Hartman, George D., Bilodeau, Mark T.

Volltext

Diastereoselective Petasis Mannich reactions accelerated by hexafluoroisopropanol: a pyrrolidine-derived arylglycine synthesis von Nanda, Kausik K., Wesley Trotter, B.

Volltext

Design and Synthesis of Novel Isoquinoline-3-nitriles as Orally Bioavailable Kv1.5 Antagonists for the Treatment of Atrial Fibrillation von Trotter, B. Wesley, Nanda, Kausik K, Kett, Nathan R, Regan, Christopher P, Lynch, Joseph J, Stump, Gary L, Kiss, Laszlo, Wang, Jixin, Spencer, Robert H, Kane, Stefanie A, White, Rebecca B, Zhang, Rena, Anderson, Kenneth D, Liverton, Nigel J, McIntyre, Charles J, Beshore, Douglas C, Hartman, George D, Dinsmore, Christopher J

Volltext

A kinase-cGAS cascade to synthesize a therapeutic STING activator von McIntosh, John A., Liu, Zhijian, Andresen, Brian M., Marzijarani, Nastaran Salehi, Moore, Jeffrey C., Marshall, Nicholas M., Borra-Garske, Margie, Obligacion, Jennifer V., Fier, Patrick S., Peng, Feng, Forstater, Jacob H., Winston, Matthew S., An, Chihui, Chang, Wonsuk, Lim, Jongwon, Huffman, Mark A., Miller, Steven P., Tsay, Fuh-Rong, Altman, Michael D., Lesburg, Charles A., Steinhuebel, Dietrich, Trotter, B. Wesley, Cumming, Jared N., Northrup, Alan, Bu, Xiaodong, Mann, Benjamin F., Biba, Mirlinda, Hiraga, Kaori, Murphy, Grant S., Kolev, Joshua N., Makarewicz, Amanda, Pan, Weilan, Farasat, Iman, Bade, Rachel S., Stone, Kevin, Duan, Da, Alvizo, Oscar, Adpressa, Donovan, Guetschow, Erik, Hoyt, Erik, Regalado, Erik L., Castro, Steve, Rivera, Nelo, Smith, Joseph P., Wang, Fengqiang, Crespo, Alejandro, Verma, Deeptak, Axnanda, Stephanus, Dance, Zachary E. X., Devine, Paul N., Tschaen, David, Canada, Keith A., Bulger, Paul G., Sherry, Benjamin D., Truppo, Matthew D., Ruck, Rebecca T., Campeau, Louis-Charles, Bennett, David Jonathan, Humphrey, Guy R., Campos, Kevin R., Maddess, Matthew L.

Volltext

Total Syntheses of Vancomycin and Eremomycin Aglycons von Evans, David A., Wood, Michael R., Trotter, B. Wesley, Richardson, Timothy I., Barrow, James C., Katz, Jeffrey L.

Volltext

Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors von Richters, André, Doyle, Shelby K., Freeman, David B., Lee, Christina, Leifer, Becky S., Jagannathan, Sajjeev, Kabinger, Florian, Koren, Jošt Vrabič, Struntz, Nicholas B., Urgiles, Julie, Stagg, Ryan A., Curtin, Brice H., Chatterjee, Deep, Mathea, Sebastian, Mikochik, Peter J., Hopkins, Tamara D., Gao, Hua, Branch, Jonathan R., Xin, Hong, Westover, Lori, Bignan, Gilles C., Rupnow, Brent A., Karlin, Kristen L., Olson, Calla M., Westbrook, Thomas F., Vacca, Joseph, Wilfong, Chris M., Trotter, B. Wesley, Saffran, Douglas C., Bischofberger, Norbert, Knapp, Stefan, Russo, Joshua W., Hickson, Ian, Bischoff, James R., Gottardis, Marco M., Balk, Steven P., Lin, Charles Y., Pop, Marius S., Koehler, Angela N.

Volltext

Discovery of KB-0742, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of CDK9 for MYC-Dependent Cancers von Freeman, David B., Hopkins, Tamara D., Mikochik, Peter J., Vacca, Joseph P., Gao, Hua, Naylor-Olsen, Adel, Rudra, Sonali, Li, Huixu, Pop, Marius S., Villagomez, Rosa A., Lee, Christina, Li, Heng, Zhou, Minyun, Saffran, Douglas C., Rioux, Nathalie, Hood, Tressa R., Day, Melinda A. L., McKeown, Michael R., Lin, Charles Y., Bischofberger, Norbert, Trotter, B. Wesley

Volltext

NMR Data‐Driven Docking of HDM2‐Inhibitor Complexes von Fradera, Xavier, Reutershan, Michael H., Machacek, Michelle R., Trotter, B. Wesley, McCoy, Mark A.

Volltext

Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer von Chang, Wonsuk, Altman, Michael D, Lesburg, Charles A, Perera, Samanthi A, Piesvaux, Jennifer A, Schroeder, Gottfried K, Wyss, Daniel F, Cemerski, Saso, Chen, Yiping, DiNunzio, Edward, Haidle, Andrew M, Ho, Thu, Kariv, Ilona, Knemeyer, Ian, Kopinja, Johnny E, Lacey, Brian M, Laskey, Jason, Lim, Jongwon, Long, Brian J, Ma, Yanhong, Maddess, Matthew L, Pan, Bo-Sheng, Presland, Jeremy P, Spooner, Edward, Steinhuebel, Dietrich, Truong, Quang, Zhang, Zhibo, Fu, Jianmin, Addona, George H, Northrup, Alan B, Parmee, Emma, Tata, James R, Bennett, David Jonathan, Cumming, Jared N, Siu, Tony, Trotter, B. Wesley

Volltext

Identification of an allosteric binding site for RORγt inhibition von Scheepstra, Marcel, Leysen, Seppe, van Almen, Geert C., Miller, J. Richard, Piesvaux, Jennifer, Kutilek, Victoria, van Eenennaam, Hans, Zhang, Hongjun, Barr, Kenneth, Nagpal, Sunil, Soisson, Stephen M., Kornienko, Maria, Wiley, Kristen, Elsen, Nathaniel, Sharma, Sujata, Correll, Craig C., Trotter, B. Wesley, van der Stelt, Mario, Oubrie, Arthur, Ottmann, Christian, Parthasarathy, Gopal, Brunsveld, Luc

Volltext

Decahydroquinoline amides as highly selective CB2 agonists: Role of selectivity on in vivo efficacy in a rodent model of analgesia von Manley, Peter J., Zartman, Amy, Paone, Daniel V., Burgey, Christopher S., Henze, Darrell A., Penna, Kimberly Della, Desai, Reshma, Leitl, Michael D., Lemaire, Wei, White, Rebecca B., Yeh, Suzie, Urban, Mark O., Kane, Stefanie A., Hartman, George D., Bilodeau, Mark T., Trotter, B. Wesley

Volltext

Discovery of MK-4688: an Efficient Inhibitor of the HDM2–p53 Protein–Protein Interaction von Reutershan, Michael H, Machacek, Michelle R, Altman, Michael D, Bogen, Stephane, Cai, Mingmei, Cammarano, Carolyn, Chen, Dapeng, Christopher, Matthew, Cryan, John, Daublain, Pierre, Fradera, Xavier, Geda, Prasanthi, Goldenblatt, Peter, Hill, Armetta D, Kemper, Raymond A, Kutilek, Victoria, Li, Chaomin, Martinez, Michelle, McCoy, Mark, Nair, Latha, Pan, Weidong, Thompson, Christopher F, Scapin, Giovanna, Shizuka, Manami, Spatz, Marianne L, Steinhuebel, Dietrich, Sun, Binyuan, Voss, Matthew E, Wang, Xiao, Yang, Liping, Yeh, Tammie C, Dussault, Isabelle, Marshall, C. Gary, Trotter, B. Wesley

Volltext

Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists von Melamed, Jeffrey Y., Zartman, Amy E., Kett, Nathan R., Gotter, Anthony L., Uebele, Victor N., Reiss, Duane R., Condra, Cindra L., Fandozzi, Christine, Lubbers, Laura S., Rowe, Blake A., McGaughey, Georgia B., Henault, Martin, Stocco, Rino, Renger, John J., Hartman, George D., Bilodeau, Mark T., Trotter, B. Wesley

Volltext

STimulator of INterferon Genes Agonism Accelerates Antitumor Activity in Poorly Immunogenic Tumors von Perera, Samanthi A, Kopinja, Johnny E, Ma, Yanhong, Muise, Eric S, Laskey, Jason, Chakravarthy, Kalyan, Chen, Yiping, Cui, Long, Presland, Jeremy, Sathe, Manjiri, Javaid, Sarah, Minnihan, Ellen C, Ferguson, Heidi M, Piesvaux, Jennifer, Pan, Bo-Sheng, Zhao, Shuxia, Sharma, Sharad K, Woo, Hyun Chong, Pucci, Vincenzo, Knemeyer, Ian, Cemerski, Saso, Cumming, Jared, Trotter, B Wesley, Tse, Archie, Khilnani, Anuradha, Ranganath, Sheila, Long, Brian J, Bennett, David Jonathan, Addona, George H

Volltext

Optimization of Versatile Oxindoles as Selective PI3Kδ Inhibitors von Methot, Joey L, Achab, Abdelghani, Christopher, Matthew, Zhou, Hua, McGowan, Meredeth A, Trotter, B. Wesley, Fradera, Xavier, Lesburg, Charles A, Goldenblatt, Peter, Hill, Armetta, Chen, Dapeng, Otte, Karin M, Augustin, Martin, Shah, Sanjiv, Katz, Jason D

Volltext

Discovery of N‑(Indazol-3-yl)piperidine-4-carboxylic Acids as RORγt Allosteric Inhibitors for Autoimmune Diseases von Zhang, Hongjun, Lapointe, Blair T, Anthony, Neville, Azevedo, Rita, Cals, Jos, Correll, Craig C, Daniels, Matthew, Deshmukh, Sujal, van Eenenaam, Hans, Ferguson, Heidi, Hegde, Laxminarayan G, Karstens, Willem Jan, Maclean, John, Miller, J. Richard, Moy, Lily Y, Simov, Vladimir, Nagpal, Sunil, Oubrie, Arthur, Palte, Rachel L, Parthasarathy, Gopal, Sciammetta, Nunzio, van der Stelt, Mario, Woodhouse, Janice D, Trotter, B. Wesley, Barr, Kenneth

Volltext

Benzimidazole CB2 agonists: design, synthesis and SAR von Nanda, Kausik K, Henze, Darrell A, Della Penna, Kimberly, Desai, Reshma, Leitl, Michael, Lemaire, Wei, White, Rebecca B, Yeh, Suzie, Brouillette, Janine N, Hartman, George D, Bilodeau, Mark T, Trotter, B Wesley

Volltext

Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen von Bukhtiyarova, Marina, Cook, Erica M, Hancock, Paula J, Hruza, Alan W, Shaw, Anthony W, Adam, Gregory C, Barnard, Richard J O, McKenna, Philip M, Holloway, M Katharine, Bell, Ian M, Carroll, Steve, Cornella-Taracido, Ivan, Cox, Christopher D, Kutchukian, Peter S, Powell, David A, Strickland, Corey, Trotter, B Wesley, Tudor, Matthew, Wolkenberg, Scott, Li, Jing, Tellers, David M

Volltext

Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics von Wolkenberg, Scott E., Nolt, M. Brad, Bilodeau, Mark T., Trotter, B. Wesley, Manley, Peter J., Kett, Nathan R., Nanda, Kausik K., Wu, Zhicai, Cato, Matthew J., Kane, Stefanie A., Kiss, Laszlo, Spencer, Robert H., Wang, Jixin, Lynch, Joseph J., Regan, Christopher P., Stump, Gary L., Li, Bing, White, Rebecca, Yeh, Suzie, Dinsmore, Christopher J., Lindsley, Craig W., Hartman, George D.

Volltext