Recent advances in the development of Mcl-1 inhibitors for cancer therapy von Hird, Alexander W., Tron, Adriana E.

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Structure of a Glomulin-RBX1-CUL1 Complex: Inhibition of a RING E3 Ligase through Masking of Its E2-Binding Surface von Duda, David M., Olszewski, Jennifer L., Tron, Adriana E., Hammel, Michal, Lambert, Lester J., Waddell, M. Brett, Mittag, Tanja, DeCaprio, James A., Schulman, Brenda A.

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Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies von Montero, Joan, Gstalder, Cécile, Kim, Daniel J., Sadowicz, Dorota, Miles, Wayne, Manos, Michael, Cidado, Justin R., Paul Secrist, J., Tron, Adriana E., Flaherty, Keith, Stephen Hodi, F., Yoon, Charles H., Letai, Anthony, Fisher, David E., Haq, Rizwan

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The Glomuvenous Malformation Protein Glomulin Binds Rbx1 and Regulates Cullin RING Ligase-Mediated Turnover of Fbw7 von Tron, Adriana E., Arai, Takehiro, Duda, David M., Kuwabara, Hiroshi, Olszewski, Jennifer L., Fujiwara, Yuko, Bahamon, Brittany N., Signoretti, Sabina, Schulman, Brenda A., DeCaprio, James A.

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Negative Regulation of the Stability and Tumor Suppressor Function of Fbw7 by the Pin1 Prolyl Isomerase von Min, Sang-Hyun, Lau, Alan W., Lee, Tae Ho, Inuzuka, Hiroyuki, Wei, Shuo, Huang, Pengyu, Shaik, Shavali, Lee, Daniel Yenhong, Finn, Greg, Balastik, Martin, Chen, Chun-Hau, Luo, Manli, Tron, Adriana E., DeCaprio, James A., Zhou, Xiao Zhen, Wei, Wenyi, Lu, Kun Ping

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Discovery of M‑1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression von Zhang, Meng, Aguilar, Angelo, Xu, Shilin, Huang, Liyue, Chinnaswamy, Krishnapriya, Sleger, Taryn, Wang, Bo, Gross, Stefan, Nicolay, Brandon N, Ronseaux, Sebastien, Harvey, Kaitlin, Wang, Yu, McEachern, Donna, Kirchhoff, Paul D, Liu, Zhaomin, Stuckey, Jeanne, Tron, Adriana E, Liu, Tao, Wang, Shaomeng

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Concurrent Inhibition of Pim and FLT3 Kinases Enhances Apoptosis of FLT3-ITD Acute Myeloid Leukemia Cells through Increased Mcl-1 Proteasomal Degradation von Kapoor, Shivani, Natarajan, Karthika, Baldwin, Patrick R, Doshi, Kshama A, Lapidus, Rena G, Mathias, Trevor J, Scarpa, Mario, Trotta, Rossana, Davila, Eduardo, Kraus, Manfred, Huszar, Dennis, Tron, Adriana E, Perrotti, Danilo, Baer, Maria R

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Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia von Tron, Adriana E., Belmonte, Matthew A., Adam, Ammar, Aquila, Brian M., Boise, Lawrence H., Chiarparin, Elisabetta, Cidado, Justin, Embrey, Kevin J., Gangl, Eric, Gibbons, Francis D., Gregory, Gareth P., Hargreaves, David, Hendricks, J. Adam, Johannes, Jeffrey W., Johnstone, Ricky W., Kazmirski, Steven L., Kettle, Jason G., Lamb, Michelle L., Matulis, Shannon M., Nooka, Ajay K., Packer, Martin J., Peng, Bo, Rawlins, Philip B., Robbins, Daniel W., Schuller, Alwin G., Su, Nancy, Yang, Wenzhan, Ye, Qing, Zheng, Xiaolan, Secrist, J. Paul, Clark, Edwin A., Wilson, David M., Fawell, Stephen E., Hird, Alexander W.

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Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity von Wu, Meng-Ju, Kondo, Hiroshi, Kammula, Ashwin V, Shi, Lei, Xiao, Yi, Dhiab, Sofiene, Xu, Qin, Slater, Chloe J, Avila, Omar I, Merritt, Joshua, Kato, Hiroyuki, Kattel, Prabhat, Sussman, Jonathan, Gritti, Ilaria, Eccleston, Jason, Sun, Yi, Cho, Hyo Min, Olander, Kira, Katsuda, Takeshi, Shi, Diana D, Savani, Milan R, Smith, Bailey C, Cleary, James M, Mostoslavsky, Raul, Vijay, Vindhya, Kitagawa, Yosuke, Wakimoto, Hiroaki, Jenkins, Russell W, Yates, Kathleen B, Paik, Jihye, Tassinari, Ania, Saatcioglu, Duygu Hatice, Tron, Adriana E, Haas, Wilhelm, Cahill, Daniel, McBrayer, Samuel K, Manguso, Robert T, Bardeesy, Nabeel

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Safety, efficacy, and PK/PD of vorasidenib in previously treated patients with mIDH1/2 hematologic malignancies: A phase 1 study von DiNardo, Courtney D., De Botton, Stéphane, Pollyea, Daniel A., Stone, Richard M., Altman, Jessica K., Fathi, Amir T., Limsakun, Tharin, Liang, Min, Choe, Sung, Hossain, Mohammad, Tron, Adriana E., Meng, Qian, Kapsalis, Stephanie M., Pandya, Shuchi S., Stein, Eytan M.

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Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells von Gruber, Emily, So, Joan, Lewis, Alexander C., Franich, Rheana, Cole, Rachel, Martelotto, Luciano G., Rogers, Amy J., Vidacs, Eva, Fraser, Peter, Stanley, Kym, Jones, Lisa, Trigos, Anna, Thio, Niko, Li, Jason, Nicolay, Brandon, Daigle, Scott, Tron, Adriana E., Hyer, Marc L., Shortt, Jake, Johnstone, Ricky W., Kats, Lev M.

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SCF β-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration von Zhong, Jiateng, Shaik, Shavali, Wan, Lixin, Tron, Adriana E, Wang, Zhiwei, Sun, Liankun, Inuzuka, Hiroyuki, Wei, Wenyi

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Rictor Forms a Complex with Cullin-1 to Promote SGK1 Ubiquitination and Destruction von Gao, Daming, Wan, Lixin, Inuzuka, Hiroyuki, Berg, Anders H., Tseng, Alan, Zhai, Bo, Shaik, Shavali, Bennett, Eric, Tron, Adriana E., Gasser, Jessica A., Lau, Alan, Gygi, Steven P., Harper, J. Wade, DeCaprio, James A., Toker, Alex, Wei, Wenyi

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Inhibition of D-2HG leads to upregulation of a proinflammatory gene signature in a novel HLA-A2/HLA-DR1 transgenic mouse model of IDH1R132H-expressing glioma von Chuntova, Pavlina, Yamamichi, Akane, Chen, Tiffany, Narayanaswamy, Rohini, Ronseaux, Sebastien, Hudson, Christine, Tron, Adriana E, Hyer, Marc L, Montoya, Megan, Mende, Abigail L, Nejo, Takahide, Downey, Kira M, Diebold, David, Lu, Min, Nicolay, Brandon, Okada, Hideho

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Multiscale Model Identifies Improved Schedule for Treatment of Acute Myeloid Leukemia In Vitro With the Mcl‐1 Inhibitor AZD5991 von Goliaei, Ardeshir, Woods, Haley A., Tron, Adriana E., Belmonte, Matthew A., Secrist, J. Paul, Ferguson, Douglas, Drew, Lisa, Fretland, Adrian J., Aldridge, Bree B., Gibbons, Francis D.

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Redox Regulation of Plant Homeodomain Transcription Factors von Tron, Adriana E, Bertoncini, Carlos W, Chan, Raquel L, Gonzalez, Daniel H

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Pim kinase inhibition sensitizes FLT3-ITD acute myeloid leukemia cells to topoisomerase 2 inhibitors through increased DNA damage and oxidative stress von Doshi, Kshama A, Trotta, Rossana, Natarajan, Karthika, Rassool, Feyruz V, Tron, Adriana E, Huszar, Dennis, Perrotti, Danilo, Baer, Maria R

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Engineering the Loop Region of a Homeodomain-Leucine Zipper Protein Promotes Efficient Binding to a Monomeric DNA Binding Site von Tron, Adriana E, Welchen, Elina, Gonzalez, Daniel H

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Structure of Homeodomain-Leucine Zipper/DNA Complexes Studied Using Hydroxyl Radical Cleavage of DNA and Methylation Interference von Tron, Adriana E, Comelli, Raúl N, Gonzalez, Daniel H

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RTID-02. A PHASE 1, SAFETY LEAD-IN AND RANDOMIZED, OPEN-LABEL, PERIOPERATIVE STUDY OF VORASIDENIB COMBINED WITH PEMBROLIZUMAB IN RECURRENT OR PROGRESSIVE ENHANCING IDH-1 MUTANT AST... von Wen, Patrick, Mellinghoff, Ingo, Clarke, Jennifer, Puduvalli, Vinay, de Groot, John, Liu, Hua, Tron, Adriana, Chisamore, Michael, Steelman, Lori, Hassan, Islam, Cloughesy, Timothy

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