SUPPA2: fast, accurate, and uncertainty-aware differential splicing analysis across multiple conditions von Trincado, Juan L, Entizne, Juan C, Hysenaj, Gerald, Singh, Babita, Skalic, Miha, Elliott, David J, Eyras, Eduardo

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Leveraging transcript quantification for fast computation of alternative splicing profiles von Alamancos, Gael P, Pagès, Amadís, Trincado, Juan L, Bellora, Nicolás, Eyras, Eduardo

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ISOTOPE: ISOform-guided prediction of epiTOPEs in cancer von Trincado, Juan L., Reixachs-Sole, Marina, Perez-Granado, Judith, Fugmann, Tim, Sanz, Ferran, Yokota, Jun, Eyras, Eduardo, Markowetz, Florian, Sonkin, Dmitriy, Markowetz, Florian, Sonkin, Dmitriy, Markowetz, Florian, Sonkin, Dmitriy, Markowetz, Florian, Sonkin, Dmitriy

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A single-cell tumor immune atlas for precision oncology von Nieto, Paula, Elosua-Bayes, Marc, Trincado, Juan L., Marchese, Domenica, Massoni-Badosa, Ramon, Salvany, Maria, Henriques, Ana, Nieto, Juan, Aguilar-Fernandez, Sergio, Mereu, Elisabetta, Moutinho, Catia, Ruiz, Sara, Lorden, Patricia, Chin, Vanessa T., Kaczorowski, Dominik, Chan, Chia-Ling, Gallagher, Richard, Chou, Angela, Planas-Rigol, Ester, Rubio-Perez, Carlota, Gut, Ivo, Piulats, Josep M., Seoane, Joan, Powell, Joseph E., Batlle, Eduard, Heyn, Holger

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Immune cell profiling of the cerebrospinal fluid enables the characterization of the brain metastasis microenvironment von Rubio-Perez, Carlota, Planas-Rigol, Ester, Trincado, Juan L., Bonfill-Teixidor, Ester, Arias, Alexandra, Marchese, Domenica, Moutinho, Catia, Serna, Garazi, Pedrosa, Leire, Iurlaro, Raffaella, Martínez-Ricarte, Francisco, Escudero, Laura, Cordero, Esteban, Cicuendez, Marta, Ruiz, Sara, Parra, Genís, Nuciforo, Paolo, Gonzalez, Josep, Pineda, Estela, Sahuquillo, Juan, Tabernero, Josep, Heyn, Holger, Seoane, Joan

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Converging and evolving immuno-genomic routes toward immune escape in breast cancer von Blanco-Heredia, Juan, Souza, Carla Anjos, Trincado, Juan L., Gonzalez-Cao, Maria, Gonçalves-Ribeiro, Samuel, Gil, Sara Ruiz, Pravdyvets, Dmytro, Cedeño, Samandhy, Callari, Maurizio, Marra, Antonio, Gazzo, Andrea M., Weigelt, Britta, Pareja, Fresia, Vougiouklakis, Theodore, Jungbluth, Achim A., Rosell, Rafael, Brander, Christian, Tresserra, Francesc, Reis-Filho, Jorge S., Tiezzi, Daniel Guimarães, de la Iglesia, Nuria, Heyn, Holger, De Mattos-Arruda, Leticia

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Impaired condensin complex and Aurora B kinase underlie mitotic and chromosomal defects in hyperdiploid B-cell ALL von Molina, Oscar, Vinyoles, Meritxell, Granada, Isabel, Roca-Ho, Heleia, Gutierrez-Agüera, Francisco, Valledor, Luis, López-López, Carlos M., Rodríguez-González, Pablo, Trincado, Juan L., Menéndez, Sofía T., Pal, Deepali, Ballerini, Paola, den Boer, Monique L., Plensa, Isabel, Mar Perez-Iribarne, M., Rodríguez-Perales, Sandra, Calasanz, María José, Ramírez-Orellana, Manuel, Rodríguez, René, Camós, Mireia, Calvo, Maria, Bueno, Clara, Menéndez, Pablo

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Formation of an invasion-permissive matrix requires TGFβ/SNAIL1-regulated alternative splicing of fibronectin von Franco-Valls, Héctor, Tusquets-Uxó, Elsa, Sala, Laura, Val, Maria, Peña, Raúl, Iaconcig, Alessandra, Villarino, Álvaro, Jiménez-Arriola, Martín, Massó, Pere, Trincado, Juan L, Eyras, Eduardo, Muro, Andrés F, Otero, Jorge, García de Herreros, Antonio, Baulida, Josep

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CD34+CD19-CD22+ B-cell progenitors may underlie phenotypic escape in patients treated with CD19-directed therapies von Bueno, Clara, Barrera, Susana, Bataller, Alex, Ortiz-Maldonado, Valentín, Elliot, Natalina, O'Byrne, Sorcha, Wang, Guanlin, Rovira, Montse, Gutierrez-Agüera, Francisco, Trincado, Juan L, González-González, María, Morgades, Mireia, Sorigué, Marc, Bárcena, Paloma, Zanetti, Samanta Romina, Torrebadell, Montse, Vega-Garcia, Nerea, Rives, Susana, Mallo, Mar, Sole, Francesc, Mead, Adam J, Roberts, Irene, Thongjuea, Supat, Psaila, Bethan, Juan, Manel, Delgado, Julio, Urbano-Ispizúa, Alvaro, Ribera, Josep María, Orfao, Alberto, Roy, Anindita, Menendez, Pablo

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Genome Sequencing and RNA-Motif Analysis Reveal Novel Damaging Noncoding Mutations in Human Tumors von Singh, Babita, Trincado, Juan L, Tatlow, P J, Piccolo, Stephen R, Eyras, Eduardo

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The prognostic potential of alternative transcript isoforms across human tumors von Trincado, Juan L, Sebestyén, E, Pagés, A, Eyras, E

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β‐Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T‐cell acute lymphoblastic leukemia von García‐Hernández, Violeta, Arambilet, David, Guillén, Yolanda, Lobo‐Jarne, Teresa, Maqueda, María, Gekas, Christos, González, Jessica, Iglesias, Arnau, Vega‐García, Nerea, Sentís, Inés, Trincado, Juan L, Márquez‐López, Ian, Heyn, Holger, Camós, Mireia, Espinosa, Lluis, Bigas, Anna

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HDAC7 is a major contributor in the pathogenesis of infant t(4;11) proB acute lymphoblastic leukemia von de Barrios, Oriol, Galaras, Alexandros, Trincado, Juan L., Azagra, Alba, Collazo, Olga, Meler, Ainara, Agraz-Doblas, Antonio, Bueno, Clara, Ballerini, Paola, Cazzaniga, Giovanni, Stam, Ronald W., Varela, Ignacio, De Lorenzo, Paola, Valsecchi, Maria Grazia, Hatzis, Pantelis, Menéndez, Pablo, Parra, Maribel

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Clonal heterogeneity and rates of specific chromosome gains are risk predictors in childhood high‐hyperdiploid B‐cell acute lymphoblastic leukemia von Ramos‐Muntada, Mireia, Trincado, Juan L., Blanco, Joan, Bueno, Clara, Rodríguez‐Cortez, Virginia C., Bataller, Alex, López‐Millán, Belén, Schwab, Claire, Ortega, Margarita, Velasco, Pablo, Blanco, Maria L., Nomdedeu, Josep, Ramírez‐Orellana, Manuel, Minguela, Alfredo, Fuster, Jose L., Cuatrecasas, Esther, Camós, Mireia, Ballerini, Paola, Escherich, Gabriele, Boer, Judith, DenBoer, Monique, Hernández‐Rivas, Jesús M., Calasanz, Maria J., Cazzaniga, Giovanni, Harrison, Christine J., Menéndez, Pablo, Molina, Oscar

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Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progression von Molina, Oscar, Ortega-Sabater, Carmen, Thampi, Namitha, Fernández-Fuentes, Narcís, Guerrero-Murillo, Mercedes, Martínez-Moreno, Alba, Vinyoles, Meritxell, Velasco-Hernández, Talía, Bueno, Clara, Trincado, Juan L, Granada, Isabel, Campos, Diana, Giménez, Carles, Boer, Judith M, den Boer, Monique L, Calvo, Gabriel F, Camós, Mireia, Fuster, Jose-Luis, Velasco, Pablo, Ballerini, Paola, Locatelli, Franco, Mullighan, Charles G, Spierings, Diana C J, Foijer, Floris, Pérez-García, Víctor M, Menéndez, Pablo

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Integrative single‐cell expression and functional studies unravels a sensitization to cytarabine‐based chemotherapy through HIF pathway inhibition in AML leukemia stem cells von Velasco‐Hernandez, Talia, Trincado, Juan L., Vinyoles, Meritxell, Closa, Adria, Martínez‐Moreno, Alba, Gutiérrez‐Agüera, Francisco, Molina, Oscar, Rodríguez‐Cortez, Virginia C., Ximeno‐Parpal, Pau, Fernández‐Fuentes, Narcís, Petazzi, Paolo, Beneyto‐Calabuig, Sergi, Velten, Lars, Romecin, Paola, Casquero, Raquel, Abollo‐Jiménez, Fernando, Guardia, Rafael D., Lorden, Patricia, Bataller, Alex, Lapillonne, Hélène, Stam, Ronald W., Vives, Susana, Torrebadell, Montserrat, Fuster, Jose L., Bueno, Clara, Sarry, Jean‐Emmanuel, Eyras, Eduardo, Heyn, Holger, Menéndez, Pablo

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Integrative single-cell multi-omics of CD19-CARpos and CARneg T cells suggest drivers of immunotherapy response in B cell neoplasias von Guerrero-Murillo, Mercedes, Rill-Hinarejos, Aina, Trincado, Juan L., Bataller, Alex, Ortiz-Maldonado, Valentín, Benítez-Ribas, Daniel, Español-Rego, Marta, González-Navarro, E Azucena, Martínez-Cibrián, Nuria, Marchese, Doménica, Martín-Martín, Lourdes, Martín García-Sancho, Alejandro, Rives, Susana, Heyn, Holger, Juan, Manel, Urbano-Ispizúa, Álvaro, Delgado, Julio, Orfao, Alberto, Mereu, Elisabetta, Bueno, Clara, Menendez, Pablo

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Identification of novel small molecule-based strategies of COL7A1 upregulation and readthrough activity for the treatment of recessive dystrophic epidermolysis bullosa von Jover, Irene, Ramos, Maria C., Escámez, María José, Lozoya, Estrella, Tormo, José R., de Prado-Verdún, Diana, Mencía, Ángeles, Pont, Mercè, Puig, Carles, Larraufie, Marie-Helene, Gutiérrez-Caballero, Cristina, Reyes, Fernando, Trincado, Juan Luis, García-González, Vicente, Cerrato, Rosario, Andrés, Miriam, Crespo, Maribel, Vicente, Francisca, Godessart, Nuria, Genilloud, Olga, Larcher, Fernando, Nueda, Arsenio

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3215 – A SINGLE-CELL EXPRESSION ATLAS OF HUMAN AML LEUKEMIA-INITIATING CELLS UNRAVELS THE CONTRIBUTION OF HIF PATHWAY AND ITS THERAPEUTIC POTENTIAL von Velasco, Talia, Trincado, Juan, Vinyoles, Meritxell, Closa, Adria, Molina, Oscar, Bueno, Clara, Eyras, Eduardo, Heyn, Holger, Menéndez, Pablo

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Formation of an invasion-permissive matrix requires TGF[beta]/SNAIL1-regulated alternative splicing of fibronectin von Franco-Valls, Héctor, Tusquets-Uxó, Elsa, Sala, Laura, Val, Maria, Peéa, Raúl, Iaconcig, Alessandra, Villarino, Ãlvaro, Jiménez-Arriola, Martín, Massó, Pere, Trincado, Juan L, Eyras, Eduardo, Muro, Andrés F, Otero, Jorge, García de Herreros, Antonio, Baulida, Josep

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